BR112013011811A2 - Modelo de anticorpo heterodimérico estável com mutações no domínio fc - Google Patents

Modelo de anticorpo heterodimérico estável com mutações no domínio fc

Info

Publication number
BR112013011811A2
BR112013011811A2 BR112013011811A BR112013011811A BR112013011811A2 BR 112013011811 A2 BR112013011811 A2 BR 112013011811A2 BR 112013011811 A BR112013011811 A BR 112013011811A BR 112013011811 A BR112013011811 A BR 112013011811A BR 112013011811 A2 BR112013011811 A2 BR 112013011811A2
Authority
BR
Brazil
Prior art keywords
mutations
domain
antibody model
heterodimeric antibody
stable
Prior art date
Application number
BR112013011811A
Other languages
English (en)
Inventor
Kai Yuen Poon David
Escobar Cabrera Eric
Spreter Von Kreudenstein Thomas
Bhimarao Dixit Surjit
Irene Lario Paula
Edmondo Paolo D'ANGELO Igor
Original Assignee
Zymeworks Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Inc filed Critical Zymeworks Inc
Publication of BR112013011811A2 publication Critical patent/BR112013011811A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

MODELO DE ANTICORPO HETEODIMÉRICO ESTÁVEL COM MUTAÇÕES NO DOMÍNIO FC. Os esqueletos fornecidos têm cadeias pesadas que são assimétricas nos vários domínios (p. ex., CH2 e CH3) para efetuar seletividade entre os diversos receptores Fc envolvidos em função efetora de modulação, além daqueles alcançáveis com uma molécula Fc homodimérica (simétrica) natural, e estabilidade e pureza aumentadas dos heterodímeros de Fc variantes resultantes. Essas moléculas novas compreendem complexos de componentes heterogêneos destinados a alterar o comportamento de anticorpos de modo natural e encontram utilização em métodos terapêuticos.
BR112013011811A 2010-11-05 2011-11-04 Modelo de anticorpo heterodimérico estável com mutações no domínio fc BR112013011811A2 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US41074610P 2010-11-05 2010-11-05
US201061425375P 2010-12-21 2010-12-21
US201161439341P 2011-02-03 2011-02-03
US201161475614P 2011-04-14 2011-04-14
US201161491846P 2011-05-31 2011-05-31
US201161497861P 2011-06-16 2011-06-16
PCT/CA2011/001238 WO2012058768A1 (en) 2010-11-05 2011-11-04 Stable heterodimeric antibody design with mutations in the fc domain

Publications (1)

Publication Number Publication Date
BR112013011811A2 true BR112013011811A2 (pt) 2023-02-23

Family

ID=46023901

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013011811A BR112013011811A2 (pt) 2010-11-05 2011-11-04 Modelo de anticorpo heterodimérico estável com mutações no domínio fc

Country Status (19)

Country Link
US (3) US9562109B2 (pt)
EP (1) EP2635607B1 (pt)
JP (1) JP6167040B2 (pt)
KR (2) KR20130135866A (pt)
CN (2) CN103429620B (pt)
AU (1) AU2011325833C1 (pt)
BR (1) BR112013011811A2 (pt)
CA (1) CA2815266C (pt)
CY (1) CY1122409T1 (pt)
DK (1) DK2635607T3 (pt)
ES (1) ES2758994T3 (pt)
HR (1) HRP20192045T1 (pt)
HU (1) HUE047228T2 (pt)
MX (1) MX352929B (pt)
PL (1) PL2635607T3 (pt)
PT (1) PT2635607T (pt)
RS (1) RS59589B1 (pt)
RU (1) RU2604490C2 (pt)
WO (1) WO2012058768A1 (pt)

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