BR112014006535A2 - regulação dos canais de sódio através das proteínas plunc - Google Patents
regulação dos canais de sódio através das proteínas pluncInfo
- Publication number
- BR112014006535A2 BR112014006535A2 BR112014006535A BR112014006535A BR112014006535A2 BR 112014006535 A2 BR112014006535 A2 BR 112014006535A2 BR 112014006535 A BR112014006535 A BR 112014006535A BR 112014006535 A BR112014006535 A BR 112014006535A BR 112014006535 A2 BR112014006535 A2 BR 112014006535A2
- Authority
- BR
- Brazil
- Prior art keywords
- sodium channels
- sodium
- plunc
- regulation
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
regulation of sodium channels by plunc proteins abstract the present invention relates to the ability of plunc proteins, such as splunc1 and splunc2, to bind to sodium channels and inhibit activation of the sodium channels. the invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of plunc proteins to sodium channels. 78 ********************************************************* tradução do resumo resumo patente de invenção: "regulação dos canais de sódio através das proteínas plunc". a presente invenção refere-se à capacidade das proteínas plunc, tais como splunc1 e splunc2, em se ligar aos canais de sódio e inibir a ativação dos canais de sódio. a invenção refere-se ainda aos métodos para a regulação da absorção de sódio e do volume de fluido e tratamento dos distúrbios sensíveis à modulação da absorção de sódio mediante a modulação da ligação de proteínas plunc aos canais de sódio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161536647P | 2011-09-20 | 2011-09-20 | |
| PCT/US2012/056112 WO2013043720A1 (en) | 2011-09-20 | 2012-09-19 | Regulation of sodium channels by plunc proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014006535A2 true BR112014006535A2 (pt) | 2017-03-28 |
Family
ID=47914825
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014006535A BR112014006535A2 (pt) | 2011-09-20 | 2012-09-19 | regulação dos canais de sódio através das proteínas plunc |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9127040B2 (pt) |
| EP (1) | EP2760463B1 (pt) |
| AU (2) | AU2012312520A1 (pt) |
| BR (1) | BR112014006535A2 (pt) |
| CA (1) | CA2849267A1 (pt) |
| DK (1) | DK2760463T3 (pt) |
| ES (1) | ES2716723T3 (pt) |
| HK (1) | HK1200729A1 (pt) |
| HU (1) | HUE041740T2 (pt) |
| IL (1) | IL231614B (pt) |
| PL (1) | PL2760463T3 (pt) |
| PT (1) | PT2760463T (pt) |
| WO (1) | WO2013043720A1 (pt) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9549967B2 (en) | 2009-05-29 | 2017-01-24 | The University Of North Carolina At Chapel Hill | Regulation of sodium channels by PLUNC proteins |
| BR112017007224A2 (pt) * | 2014-10-08 | 2018-03-06 | Spyryx Biosciences Inc | inibidores de canais de sódio, de peptídeo, aperfeiçoados |
| JP2018516932A (ja) | 2015-06-02 | 2018-06-28 | アッヴィ・エス・ア・エール・エル | 置換ピリジンおよび使用方法 |
| US9840513B2 (en) | 2015-07-16 | 2017-12-12 | Abbvie S.Á.R.L. | Substituted tricyclics and method of use |
| PT3359541T (pt) | 2015-10-09 | 2020-11-11 | Galapagos Nv | Pirazol[3,4-b]piridin-6-carboxamidas n-sulfoniladas e método de utilização |
| BR112018007165A2 (pt) | 2015-10-09 | 2019-01-22 | AbbVie S.à.r.l. | novos compostos para tratamento da fibrose cística |
| EP3359539A1 (en) | 2015-10-09 | 2018-08-15 | AbbVie S.À.R.L. | Substituted pyrazolo[3,4-b]pyridin-6-carboxylic acids and their use |
| WO2017147128A1 (en) | 2016-02-22 | 2017-08-31 | The University Of North Carolina At Chapel Hill | Peptide inhibitors of calcium channels |
| WO2017187321A1 (en) | 2016-04-26 | 2017-11-02 | AbbVie S.à.r.l. | Modulators of cystic fibrosis transmembrane conductance regulator protein |
| US10138227B2 (en) | 2016-06-03 | 2018-11-27 | Abbvie S.Á.R.L. | Heteroaryl substituted pyridines and methods of use |
| WO2018064499A1 (en) * | 2016-09-29 | 2018-04-05 | Spyryx Biosciences, Inc. | Peptide inhibitors of sodium channels |
| US9981910B2 (en) | 2016-10-07 | 2018-05-29 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| US10399940B2 (en) | 2016-10-07 | 2019-09-03 | Abbvie S.Á.R.L. | Substituted pyrrolidines and methods of use |
| CA3046361A1 (en) * | 2016-12-13 | 2018-06-21 | Spyryx Biosciences, Inc. | Saline formulations of splunc1 peptides |
| US20200123137A1 (en) | 2016-12-20 | 2020-04-23 | AbbVie S.à.r.l. | Deuterated cftr modulators and methods of use |
| CN106749679A (zh) * | 2017-01-10 | 2017-05-31 | 中国人民解放军疾病预防控制所 | 抗P选择素单链抗体靶向抑制物融合蛋白ScFv‑SPLUNC1及其表达方法与应用 |
| TW201831471A (zh) | 2017-02-24 | 2018-09-01 | 盧森堡商艾伯維公司 | 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法 |
| US10988454B2 (en) | 2017-09-14 | 2021-04-27 | Abbvie Overseas S.À.R.L. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| WO2019193062A1 (en) | 2018-04-03 | 2019-10-10 | Abbvie S.Á.R.L | Substituted pyrrolidines and their use |
| US11345691B2 (en) | 2019-06-03 | 2022-05-31 | AbbVie Global Enterprises Ltd. | Prodrug modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| US11236067B2 (en) | 2019-07-12 | 2022-02-01 | Orphomed, Inc. | Compound for treating cystic fibrosis |
| IL292965A (en) | 2019-11-12 | 2022-07-01 | Genzyme Corp | Heteroarylaminosulfonamides with 6 positions and methods of using them |
| WO2021113806A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| WO2021113809A1 (en) | 2019-12-05 | 2021-06-10 | Genzyme Corporation | Arylamides and methods of use thereof |
| EP4274828A1 (en) | 2021-01-06 | 2023-11-15 | AbbVie Global Enterprises Ltd. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| WO2022150173A1 (en) | 2021-01-06 | 2022-07-14 | AbbVie Global Enterprises Ltd. | Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use |
| JP2024511119A (ja) * | 2021-03-22 | 2024-03-12 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 修飾されたペプチド模倣薬および使用方法 |
| IL311038A (en) | 2021-09-03 | 2024-04-01 | Genzyme Corp | Indole compounds and methods of use |
| WO2023034946A1 (en) | 2021-09-03 | 2023-03-09 | Genzyme Corporation | Indole compounds and uses thereof in the treatement of cystic fibrosis |
| WO2024054840A1 (en) | 2022-09-07 | 2024-03-14 | Sionna Therapeutics | Macrocyclic compounds, compositions, and methods of using thereof |
| WO2024054845A1 (en) | 2022-09-07 | 2024-03-14 | Sionna Therapeutics | Macrocycic compounds, compositions, and methods of using thereof |
| WO2024054851A1 (en) | 2022-09-07 | 2024-03-14 | Sionna Therapeutics | Macrocyclic compounds, compositions and methods of using thereof |
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| DE3023787A1 (de) | 1980-06-25 | 1982-01-21 | Studiengesellschaft Kohle mbH, 4330 Mülheim | Verfahren zur erhoehung der inkorporation und der expression von genetischem material in die kerne von intakten zellen mit hilfe von liposomen |
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| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
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| US7951781B2 (en) | 2006-11-02 | 2011-05-31 | University Of Iowa Research Foundation | Methods and compositions related to PLUNC surfactant polypeptides |
| US9549967B2 (en) | 2009-05-29 | 2017-01-24 | The University Of North Carolina At Chapel Hill | Regulation of sodium channels by PLUNC proteins |
-
2012
- 2012-09-19 US US14/345,975 patent/US9127040B2/en not_active Expired - Fee Related
- 2012-09-19 HU HUE12833524A patent/HUE041740T2/hu unknown
- 2012-09-19 CA CA2849267A patent/CA2849267A1/en not_active Abandoned
- 2012-09-19 BR BR112014006535A patent/BR112014006535A2/pt not_active Application Discontinuation
- 2012-09-19 PL PL12833524T patent/PL2760463T3/pl unknown
- 2012-09-19 WO PCT/US2012/056112 patent/WO2013043720A1/en active Application Filing
- 2012-09-19 AU AU2012312520A patent/AU2012312520A1/en not_active Abandoned
- 2012-09-19 DK DK12833524.7T patent/DK2760463T3/en active
- 2012-09-19 ES ES12833524T patent/ES2716723T3/es active Active
- 2012-09-19 EP EP12833524.7A patent/EP2760463B1/en not_active Not-in-force
- 2012-09-19 PT PT12833524T patent/PT2760463T/pt unknown
-
2014
- 2014-03-19 IL IL231614A patent/IL231614B/en active IP Right Grant
-
2015
- 2015-02-06 HK HK15101340.8A patent/HK1200729A1/xx not_active IP Right Cessation
- 2015-12-16 US US14/971,523 patent/US20160159879A1/en not_active Abandoned
-
2018
- 2018-02-06 AU AU2018200871A patent/AU2018200871A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2760463A1 (en) | 2014-08-06 |
| EP2760463B1 (en) | 2018-11-21 |
| US20140228276A1 (en) | 2014-08-14 |
| AU2012312520A1 (en) | 2014-05-08 |
| US9127040B2 (en) | 2015-09-08 |
| IL231614B (en) | 2019-02-28 |
| US20160159879A1 (en) | 2016-06-09 |
| CA2849267A1 (en) | 2013-03-28 |
| AU2018200871A1 (en) | 2018-02-22 |
| PL2760463T3 (pl) | 2019-05-31 |
| HK1200729A1 (en) | 2015-08-14 |
| EP2760463A4 (en) | 2015-07-29 |
| ES2716723T3 (es) | 2019-06-14 |
| HUE041740T2 (hu) | 2019-05-28 |
| IL231614A0 (en) | 2014-05-28 |
| DK2760463T3 (en) | 2019-03-18 |
| WO2013043720A1 (en) | 2013-03-28 |
| PT2760463T (pt) | 2019-02-27 |
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