EA201590136A1 - Искусственные консенсусные альбумин-связывающие домены - Google Patents

Искусственные консенсусные альбумин-связывающие домены

Info

Publication number
EA201590136A1
EA201590136A1 EA201590136A EA201590136A EA201590136A1 EA 201590136 A1 EA201590136 A1 EA 201590136A1 EA 201590136 A EA201590136 A EA 201590136A EA 201590136 A EA201590136 A EA 201590136A EA 201590136 A1 EA201590136 A1 EA 201590136A1
Authority
EA
Eurasian Patent Office
Prior art keywords
binding domains
artificial consensus
albumin
artificial
consensus albumin
Prior art date
Application number
EA201590136A
Other languages
English (en)
Other versions
EA036487B1 (ru
Inventor
Стивен ДЖЕКОБС
Original Assignee
Янссен Байотек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Байотек, Инк. filed Critical Янссен Байотек, Инк.
Publication of EA201590136A1 publication Critical patent/EA201590136A1/ru
Publication of EA036487B1 publication Critical patent/EA036487B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Искусственные альбумин-связывающие домены, кодирующие их полинуклеотиды и способы получения и применения этих доменов и полинуклеотидов позволяют контролировать период полужизни терапевтических молекул для пациентов.
EA201590136A 2012-05-25 2013-05-23 Искусственный альбумин-связывающий домен и содержащий его слитый белок для доставки биоактивного агента EA036487B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261651642P 2012-05-25 2012-05-25
US201361776918P 2013-03-12 2013-03-12
PCT/US2013/042429 WO2013177398A2 (en) 2012-05-25 2013-05-23 Non-natural consensus albumin binding domains

Publications (2)

Publication Number Publication Date
EA201590136A1 true EA201590136A1 (ru) 2016-02-29
EA036487B1 EA036487B1 (ru) 2020-11-16

Family

ID=49622071

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590136A EA036487B1 (ru) 2012-05-25 2013-05-23 Искусственный альбумин-связывающий домен и содержащий его слитый белок для доставки биоактивного агента

Country Status (16)

Country Link
US (3) US9156887B2 (ru)
EP (1) EP2855509B1 (ru)
JP (3) JP2015519345A (ru)
KR (1) KR102053674B1 (ru)
CN (1) CN104470944B (ru)
AU (2) AU2013266215B2 (ru)
BR (1) BR112014029409B1 (ru)
CA (1) CA2874646C (ru)
DK (1) DK2855509T3 (ru)
EA (1) EA036487B1 (ru)
ES (1) ES2670442T3 (ru)
HK (1) HK1209134A1 (ru)
IL (2) IL235808A (ru)
MX (1) MX355041B (ru)
PT (1) PT2855509T (ru)
WO (1) WO2013177398A2 (ru)

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US9695228B2 (en) 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules
US10093921B2 (en) * 2013-03-14 2018-10-09 The Governing Council Of The University Of Toronto Scaffolded peptidic libraries and methods of making and screening the same
CN107531771A (zh) * 2015-04-29 2018-01-02 意大利梅迪奥兰制药公司 可溶性嵌合白细胞介素‑10受体和其治疗用途
WO2016204884A1 (en) * 2015-06-18 2016-12-22 Albert Einstein College Of Medicine, Inc. Fgf receptor ligands for treating diabetes and obesity
CN106699842B (zh) * 2015-11-17 2020-06-12 上海交通大学 一种新的抗炎小分子多肽及其应用
EP3423480A1 (en) 2016-03-01 2019-01-09 The Board of Trustees of the University of Illinois L-asparaginase variants and fusion proteins with reduced l-glutaminase activity and enhanced stability
EP3554561B1 (en) 2016-12-14 2023-06-28 Janssen Biotech, Inc. Cd137 binding fibronectin type iii domains
EP3932432A1 (en) 2016-12-14 2022-01-05 Janssen Biotech, Inc. Cd8a-binding fibronectin type iii domains
EP3574094A4 (en) 2017-01-24 2020-11-11 Northwestern University LOW MOLECULAR WEIGHT ACTIVE VARIANTS OF ANGIOTENSIN II CONVERTING ENZYME (ECA II)
ES2965372T3 (es) 2017-08-11 2024-04-15 Univ Illinois Variantes de L-asparaginasa de cobaya truncada y métodos de uso
EP3765496A1 (en) 2018-03-13 2021-01-20 Affibody AB Polypeptides based on a novel scaffold
KR102282240B1 (ko) * 2018-12-06 2021-07-28 경상국립대학교산학협력단 지속형 엑센딘-4 및 이의 용도
WO2021076546A1 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Cd71 binding fibronectin type iii domains
WO2021076574A2 (en) 2019-10-14 2021-04-22 Aro Biotherapeutics Company Fn3 domain-sirna conjugates and uses thereof
AU2020405107A1 (en) * 2019-12-18 2022-07-14 Aro Biotherapeutics Company Serum albumin-binding fibronectin type III domains and uses thereof
CN113336860B (zh) * 2021-06-02 2022-07-01 北京大学 一种具有靶向和长效功能的重组水蛭素融合蛋白及其编码基因和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6267964B1 (en) 1989-08-01 2001-07-31 Affibody Technology Sweden Ab Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
EP0640135B1 (en) * 1992-05-07 2001-01-17 Affitech As Immunoglobulin binding proteins derived from l protein and their uses
AU5670194A (en) 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
EP1015576B1 (en) 1997-09-16 2005-05-04 Egea Biosciences, LLC Method for the complete chemical synthesis and assembly of genes and genomes
US20050287153A1 (en) 2002-06-28 2005-12-29 Genentech, Inc. Serum albumin binding peptides for tumor targeting
PT1240337E (pt) 1999-12-24 2007-01-31 Genentech Inc Métodos e composições para prolongar as meias-vidas de eliminação de compostos bioactivos
EP2190863B1 (en) 2007-07-31 2015-09-02 Affibody AB New albumin binding compositions, methods and uses
CA2729567C (en) 2008-06-30 2018-04-24 Kyowa Hakko Kirin Co., Ltd. Anti-cd27 antibody
PL2356269T3 (pl) * 2008-10-31 2016-12-30 Kompozycje białek rusztowania oparte na domenie fibronektyny typu III, sposoby i zastosowania
WO2010092963A1 (ja) * 2009-02-10 2010-08-19 国立大学法人 琉球大学 薬物運搬体並びにこれを利用したアジュバントおよびワクチン
MX2011008566A (es) 2009-02-12 2011-11-29 Janssen Biotech Inc Composiciones supercontigo basadas en el dominio de fibronectina tipo iii, metodos y usos.
EP2437767B1 (en) * 2009-06-01 2015-07-08 MedImmune, LLC Molecules with extended half-lives and uses thereof
SG184310A1 (en) 2010-04-13 2012-10-30 Celldex Therapeutics Inc Antibodies that bind human cd27 and uses thereof
HUE029622T2 (en) * 2010-04-30 2017-03-28 Janssen Biotech Inc Stabilized fibronectin preparations, processes and applications
US9695228B2 (en) 2012-11-21 2017-07-04 Janssen Biotech, Inc. EGFR and c-Met fibronectin type III domain binding molecules

Also Published As

Publication number Publication date
BR112014029409A2 (ru) 2017-08-15
MX2014014384A (es) 2015-05-11
EP2855509A4 (en) 2016-01-13
DK2855509T3 (en) 2018-07-23
CN104470944B (zh) 2021-09-14
IL235808A (en) 2017-10-31
AU2013266215B2 (en) 2017-12-07
KR20150016585A (ko) 2015-02-12
IL254652A0 (en) 2017-11-30
BR112014029409B1 (pt) 2022-11-29
IL254652B (en) 2019-12-31
PT2855509T (pt) 2018-08-03
JP2015519345A (ja) 2015-07-09
EA036487B1 (ru) 2020-11-16
CN104470944A (zh) 2015-03-25
AU2013266215A1 (en) 2014-12-04
EP2855509B1 (en) 2018-05-02
CA2874646A1 (en) 2013-11-28
AU2017261625A1 (en) 2017-12-07
MX355041B (es) 2018-03-28
JP2018171063A (ja) 2018-11-08
EP2855509A2 (en) 2015-04-08
US20160083436A1 (en) 2016-03-24
KR102053674B1 (ko) 2019-12-09
JP7166081B2 (ja) 2022-11-07
US20130316952A1 (en) 2013-11-28
AU2017261625B2 (en) 2019-11-21
ES2670442T3 (es) 2018-05-30
US10280200B2 (en) 2019-05-07
CA2874646C (en) 2020-12-01
WO2013177398A3 (en) 2014-03-27
US9156887B2 (en) 2015-10-13
JP2021019595A (ja) 2021-02-18
HK1209134A1 (en) 2016-03-24
US20180009854A1 (en) 2018-01-11
IL235808A0 (en) 2015-01-29
WO2013177398A2 (en) 2013-11-28

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