AR088403A1 - Anticuerpo de union a multiples antigenos estable - Google Patents

Anticuerpo de union a multiples antigenos estable

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Publication number
AR088403A1
AR088403A1 ARP120103914A ARP120103914A AR088403A1 AR 088403 A1 AR088403 A1 AR 088403A1 AR P120103914 A ARP120103914 A AR P120103914A AR P120103914 A ARP120103914 A AR P120103914A AR 088403 A1 AR088403 A1 AR 088403A1
Authority
AR
Argentina
Prior art keywords
antibody
chain variable
antibodies
multiple antigens
domains
Prior art date
Application number
ARP120103914A
Other languages
English (en)
Original Assignee
Esbatech A Novartis Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esbatech A Novartis Co Llc filed Critical Esbatech A Novartis Co Llc
Publication of AR088403A1 publication Critical patent/AR088403A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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Abstract

Proporciona anticuerpos que se unen a múltiples antígenos, teniendo dichos anticuerpos por lo menos dos dominios variables de cadena liviana de anticuerpo y dos dominios variables de cadena pesada de anticuerpo, donde cada dominio variable de cadena liviana está ligado a un dominio variable de cadena pesada para formar una construcción VH/VL, y donde por lo menos uno de los dominios VH comprende un aminoácido en particular en posición AHo 12, 103 y/o 144, y por lo menos uno de los dominios VL comprende un aminoácido en particular en posición AHo 47 y/o 50. También se describen moléculas de ácido nucleico, vectores y células huéspedes para la expresión de los anticuerpos recombinantes, métodos para su aislamiento, y el uso de dichos anticuerpos en medicina. Proporciona un anticuerpo bioespecífico que tiene especificidad para VEGF y TNFa.
ARP120103914A 2011-10-20 2012-10-19 Anticuerpo de union a multiples antigenos estable AR088403A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161549482P 2011-10-20 2011-10-20

Publications (1)

Publication Number Publication Date
AR088403A1 true AR088403A1 (es) 2014-05-28

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ARP120103914A AR088403A1 (es) 2011-10-20 2012-10-19 Anticuerpo de union a multiples antigenos estable

Country Status (15)

Country Link
US (2) US20130101586A1 (es)
EP (2) EP2768855B1 (es)
JP (3) JP2014533239A (es)
KR (1) KR20140082700A (es)
CN (2) CN109608543A (es)
AR (1) AR088403A1 (es)
AU (1) AU2012325232B2 (es)
BR (1) BR112014009030A2 (es)
CA (1) CA2850572A1 (es)
ES (1) ES2687245T3 (es)
MX (1) MX2014004521A (es)
RU (2) RU2652886C2 (es)
TW (1) TWI577696B (es)
UY (1) UY34404A (es)
WO (1) WO2013056851A2 (es)

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