BR112014009030A2 - anticorpo de ligação a antígenos múltiplos estável - Google Patents

anticorpo de ligação a antígenos múltiplos estável

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Publication number
BR112014009030A2
BR112014009030A2 BR112014009030A BR112014009030A BR112014009030A2 BR 112014009030 A2 BR112014009030 A2 BR 112014009030A2 BR 112014009030 A BR112014009030 A BR 112014009030A BR 112014009030 A BR112014009030 A BR 112014009030A BR 112014009030 A2 BR112014009030 A2 BR 112014009030A2
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BR
Brazil
Prior art keywords
antibodies
antigen binding
binding antibody
chain variable
multiple antigen
Prior art date
Application number
BR112014009030A
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English (en)
Inventor
Astrid C Riegler
Leonardo Borras
Roberto Sommavilla
Original Assignee
Esbatech A Novartis Co Llc
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Publication date
Application filed by Esbatech A Novartis Co Llc filed Critical Esbatech A Novartis Co Llc
Publication of BR112014009030A2 publication Critical patent/BR112014009030A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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Abstract

resumo patente de invenção: "anticorpo de ligação a antígenos múltiplos estável". a invenção refere-se a anticorpos que ligam antígenos múltiplos, os ditos anticorpos tendo pelo menos dois domínios variáveis de cadeia leve de anticorpo e dois domínios variáveis de cadeia pesada de anticorpo, em que cada domínio variável de cadeia leve é ligado a um domínio variável de cadeia pesada para formar um constructo vh/vl, e em que pelo menos um dos domínios vh compreende um aminoácido particular na posição aho 12, 103 e/ou 144, e pelo menos um dos domínios vl compreende um aminoácido particular na posição aho 47 e/ou 50. moléculas de ácido nucleico, vetores e células hospedeiras para expressão dos anticorpos recombinantes da invenção, métodos para isolar os mesmos e o uso dos ditos anticorpos em medicina também são divulgados. 21035454v1
BR112014009030A 2011-10-20 2012-10-19 anticorpo de ligação a antígenos múltiplos estável BR112014009030A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161549482P 2011-10-20 2011-10-20
PCT/EP2012/004404 WO2013056851A2 (en) 2011-10-20 2012-10-19 Stable multiple antigen-binding antibody

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BR112014009030A2 true BR112014009030A2 (pt) 2017-09-12

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US (2) US20130101586A1 (pt)
EP (2) EP3431495A1 (pt)
JP (3) JP2014533239A (pt)
KR (1) KR20140082700A (pt)
CN (2) CN103890005A (pt)
AR (1) AR088403A1 (pt)
AU (1) AU2012325232B2 (pt)
BR (1) BR112014009030A2 (pt)
CA (1) CA2850572A1 (pt)
ES (1) ES2687245T3 (pt)
MX (1) MX2014004521A (pt)
RU (2) RU2652886C2 (pt)
TW (1) TWI577696B (pt)
UY (1) UY34404A (pt)
WO (1) WO2013056851A2 (pt)

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US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
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AU2014205086B2 (en) 2013-01-14 2019-04-18 Xencor, Inc. Novel heterodimeric proteins
US10487155B2 (en) 2013-01-14 2019-11-26 Xencor, Inc. Heterodimeric proteins
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