CR20220541A - Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usos - Google Patents
Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usosInfo
- Publication number
- CR20220541A CR20220541A CR20220541A CR20220541A CR20220541A CR 20220541 A CR20220541 A CR 20220541A CR 20220541 A CR20220541 A CR 20220541A CR 20220541 A CR20220541 A CR 20220541A CR 20220541 A CR20220541 A CR 20220541A
- Authority
- CR
- Costa Rica
- Prior art keywords
- binding
- antigen
- dll3
- binding molecules
- multispecific antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 8
- 102000036639 antigens Human genes 0.000 title abstract 8
- 108091007433 antigens Proteins 0.000 title abstract 8
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 abstract 3
- 102100036466 Delta-like protein 3 Human genes 0.000 abstract 2
- 229940127276 delta-like ligand 3 Drugs 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000053255 human DLL3 Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La divulgación proporciona moléculas de unión a antígenos multiespecíficas que comprenden una primera fracción de unión a antígenos y una segunda fracción de unión a antígenos, cada una de las cuales es capaz de unirse a CD3 y CD137, pero no se une a CD3 y CD137 al mismo tiempo; y una tercera fracción de unión a antígenos que es capaz de unirse a DLL3, preferiblemente DLL3 humana, que inducen la citotoxidad dependiente de células T de manera más eficiente al tiempo que evitan los problemas de toxicidad adversa o los efectos secundarios que pueden tener otras moléculas multiespecíficas de unión a antígenos. La presente invención proporciona moléculas multiespecíficas de unión a antígenos y composiciones farmacéuticas que pueden tratar diversos tipos de cáncer, especialmente los asociados con DLL3, al comprender la molécula de unión al antígeno como ingrediente activo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020062326 | 2020-03-31 | ||
PCT/JP2021/013460 WO2021200898A1 (en) | 2020-03-31 | 2021-03-30 | Dll3-targeting multispecific antigen-binding molecules and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20220541A true CR20220541A (es) | 2022-11-28 |
Family
ID=77855554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20220541A CR20220541A (es) | 2020-03-31 | 2021-03-30 | Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usos |
Country Status (18)
Country | Link |
---|---|
US (3) | US11274151B2 (es) |
EP (1) | EP4126969A4 (es) |
JP (2) | JP7085666B2 (es) |
KR (2) | KR20230035138A (es) |
CN (1) | CN115397866A (es) |
AR (1) | AR121695A1 (es) |
AU (1) | AU2021250186A1 (es) |
BR (1) | BR112022019498A2 (es) |
CA (1) | CA3173587A1 (es) |
CL (1) | CL2022002624A1 (es) |
CO (1) | CO2022015305A2 (es) |
CR (1) | CR20220541A (es) |
IL (1) | IL296803A (es) |
MX (1) | MX2022012091A (es) |
PE (1) | PE20230077A1 (es) |
SG (1) | SG11202105302PA (es) |
TW (2) | TW202325741A (es) |
WO (1) | WO2021200898A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201600354A1 (ru) | 2013-11-11 | 2016-12-30 | Чугаи Сеияку Кабушики Каиша | Антигенсвязывающая молекула, содержащая вариабельную область антитела |
TW201938194A (zh) | 2017-12-05 | 2019-10-01 | 日商中外製藥股份有限公司 | 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子 |
TWI817974B (zh) | 2017-12-28 | 2023-10-11 | 日商中外製藥股份有限公司 | 細胞毒性誘導治療劑 |
KR20220161375A (ko) * | 2020-03-31 | 2022-12-06 | 추가이 세이야쿠 가부시키가이샤 | 다중 특이성 항원 결합 분자를 제조하기 위한 방법 |
CN115397866A (zh) | 2020-03-31 | 2022-11-25 | 中外制药株式会社 | 靶向dll3的多特异性抗原结合分子及其用途 |
WO2023053272A1 (en) * | 2021-09-29 | 2023-04-06 | Chugai Seiyaku Kabushiki Kaisha | Uses of dll3-targeting multispecific antigen-binding molecules |
WO2023164474A1 (en) | 2022-02-23 | 2023-08-31 | Amgen Inc. | Cancer treatment targeting dll3 |
CN116813784B (zh) * | 2023-05-17 | 2024-03-01 | 星奕昂(上海)生物科技有限公司 | 靶向dll3的抗体及其应用 |
Family Cites Families (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0328966Y2 (es) | 1987-10-16 | 1991-06-20 | ||
EP0511011B1 (en) | 1991-04-26 | 1996-10-23 | Surface Active Limited | Novel antibodies and methods for their use |
WO1994018221A1 (en) | 1993-02-02 | 1994-08-18 | The Scripps Research Institute | Methods for producing polypeptide binding sites |
US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
WO2000047602A1 (en) | 1999-02-10 | 2000-08-17 | Human Genome Sciences, Inc. | 33 human secreted proteins |
JP4139508B2 (ja) | 1998-02-19 | 2008-08-27 | 旭化成株式会社 | ヒトデルター3 |
JP4332581B2 (ja) | 1998-02-19 | 2009-09-16 | 旭化成株式会社 | ヒトデルタ−3 |
US6344443B1 (en) | 1998-07-08 | 2002-02-05 | University Of South Florida | Peptide antagonists of tumor necrosis factor alpha |
KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
EP1206487A2 (en) | 1999-08-19 | 2002-05-22 | Chiron Corporation | Notch receptor ligands and uses thereof |
US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
DK2857516T3 (en) | 2000-04-11 | 2017-08-07 | Genentech Inc | Multivalent antibodies and uses thereof |
EP1309614A2 (en) | 2000-08-11 | 2003-05-14 | Eli Lilly And Company | Novel secreted proteins and their uses |
DE60124912T2 (de) | 2001-09-14 | 2007-06-14 | Affimed Therapeutics Ag | Multimerische, einzelkettige, Tandem-Fv-Antikörper |
WO2003025138A2 (en) | 2001-09-17 | 2003-03-27 | Protein Design Labs, Inc. | Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer |
US20070224201A1 (en) | 2002-10-02 | 2007-09-27 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
US20040115204A1 (en) | 2002-12-11 | 2004-06-17 | Fanger Gary R. | Antibodies to treat cancer |
US8388955B2 (en) | 2003-03-03 | 2013-03-05 | Xencor, Inc. | Fc variants |
ES2364147T3 (es) | 2004-01-16 | 2011-08-25 | Regeneron Pharmaceuticals, Inc. | Polipéptidos de fusión capaces de activar receptores. |
US20050175619A1 (en) | 2004-02-05 | 2005-08-11 | Robert Duffy | Methods of producing antibody conjugates |
AU2005272993B2 (en) | 2004-07-15 | 2010-02-11 | Xencor, Inc | Optimized Fc variants |
EP1797127B1 (en) | 2004-09-24 | 2017-06-14 | Amgen Inc. | Modified fc molecules |
NZ554520A (en) | 2004-10-22 | 2010-03-26 | Amgen Inc | Methods for refolding of recombinant antibodies |
CA2585717A1 (en) | 2004-10-27 | 2006-05-04 | Medimmune Inc. | Modulation of antibody specificity by tailoring the affinity to cognate antigens |
CN101123983A (zh) | 2004-10-27 | 2008-02-13 | 米迪缪尼股份有限公司 | 特定修饰对相关抗原的亲和力来调节抗体的特异性 |
EP1752471B9 (en) | 2005-01-05 | 2009-04-15 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
US20090068224A1 (en) | 2005-01-31 | 2009-03-12 | Vaxinnate Corporation | Method to identify polypeptide toll-like receptor (tlr) ligands |
ES2592271T3 (es) | 2005-03-31 | 2016-11-29 | Chugai Seiyaku Kabushiki Kaisha | Métodos de producción de polipéptidos mediante la regulación de la asociación de los polipéptidos |
US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
MX2008007650A (es) | 2005-12-16 | 2008-10-20 | Genentech Inc | Metodo para diagnostico, pronostico y tratamiento de glioma. |
EP1973945A4 (en) | 2006-01-16 | 2009-11-18 | Compugen Ltd | NEW NUCLEOTIDE AND AMINO ACID SEQUENCES AND METHOD FOR THEIR APPLICATION IN DIAGNOSIS |
WO2007121354A2 (en) | 2006-04-14 | 2007-10-25 | Trubion Pharmaceuticals Inc. | Binding proteins comprising immunoglobulin hinge and fc regions having altered fc effector functions |
US20080014205A1 (en) | 2006-05-15 | 2008-01-17 | Lawrence Horowitz | Neutralizing Antibodies to Influenza Viruses |
AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
AU2007311957A1 (en) | 2006-10-20 | 2008-04-24 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-HB-EGF antibody as active ingredient |
AU2008234020B2 (en) | 2007-04-03 | 2013-02-07 | Amgen Research (Munich) Gmbh | Cross-species-specific CD3-epsilon binding domain |
PL2155783T5 (pl) | 2007-04-03 | 2023-03-13 | Amgen Research (Munich) Gmbh | Swoista międzygatunkowo domena wiążąca CD3epsilon |
MX2009013816A (es) | 2007-06-21 | 2010-02-24 | Macrogenics Inc | Diacuerpos covalentes y usos de los mismos. |
CA2697032C (en) | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
WO2009099961A2 (en) | 2008-01-31 | 2009-08-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Engineered antibody constant domain molecules |
CA2720763A1 (en) | 2008-04-07 | 2009-10-15 | Ablynx Nv | Amino acid sequences directed against the notch pathways and uses thereof |
KR101705911B1 (ko) | 2008-09-03 | 2017-02-10 | 제넨테크, 인크. | 다중특이적 항체 |
BRPI0918947A2 (pt) | 2008-09-26 | 2015-12-01 | Ucb Pharma Sa | proteína de fusão de anticorpo |
SI2786762T1 (sl) | 2008-12-19 | 2019-07-31 | Macrogenics, Inc. | Kovalentna diatelesa in njihove uporabe |
SI2530091T1 (en) | 2010-01-29 | 2018-06-29 | Chugai Seiyaku Kabushiki Kaisha | PROTITELO ANTI-DLL3 |
EP2543730B1 (en) | 2010-03-04 | 2018-10-31 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
EP2555622A4 (en) | 2010-04-09 | 2013-09-18 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
RU2624027C2 (ru) | 2010-04-23 | 2017-06-30 | Дженентек, Инк. | Получение гетеромультимерных белков |
BR112013011811A2 (pt) | 2010-11-05 | 2023-02-23 | Zymeworks Inc | Modelo de anticorpo heterodimérico estável com mutações no domínio fc |
WO2012064792A2 (en) | 2010-11-09 | 2012-05-18 | Altimab Therapeutics, Inc. | Protein complexes for antigen binding and methods of use |
PT2647707T (pt) * | 2010-11-30 | 2018-11-15 | Chugai Pharmaceutical Co Ltd | Agente terapêutico indutor de toxicidade |
AU2012205663B2 (en) | 2011-01-10 | 2017-02-02 | Emory University | Antibodies directed against influenza |
US20140170149A1 (en) | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 and cd3 |
BR122016016837A2 (pt) | 2011-05-21 | 2019-08-27 | Macrogenics Inc | moléculas de ligação a cd3; anticorpos de ligação a cd3; composições farmacêuticas; e usos da molécula de ligação a cd3 |
CA2839539C (en) | 2011-06-30 | 2021-06-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
EP2731970B1 (en) | 2011-07-15 | 2018-11-28 | MorphoSys AG | Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt) |
LT2748201T (lt) | 2011-08-23 | 2018-02-26 | Roche Glycart Ag | Dvigubai specifinė t ląsteles aktyvinantį antigeną surišanti molekulė |
MX356947B (es) | 2011-08-23 | 2018-06-20 | Roche Glycart Ag | Anticuerpos bioespecíficos específicos para antígenos que activan células t y un antígeno tumoral y métodos de uso. |
PL3418306T3 (pl) | 2011-10-11 | 2024-04-15 | F. Hoffmann-La Roche Ag | Ulepszone składanie przeciwciał dwuswoistych |
WO2013059593A1 (en) | 2011-10-20 | 2013-04-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-cd22 chimeric antigen receptors |
PE20190658A1 (es) | 2012-02-24 | 2019-05-08 | Abbvie Stemcentrx Llc | Moduladores y metodos de empleo novedosos |
WO2013180200A1 (ja) | 2012-05-30 | 2013-12-05 | 中外製薬株式会社 | 標的組織特異的抗原結合分子 |
EP2862875B1 (en) | 2012-06-14 | 2023-09-06 | Chugai Seiyaku Kabushiki Kaisha | ANTIGEN-BINDING MOLECULE CONTAINING MODIFIED Fc REGION |
US10766960B2 (en) | 2012-12-27 | 2020-09-08 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
WO2014116846A2 (en) | 2013-01-23 | 2014-07-31 | Abbvie, Inc. | Methods and compositions for modulating an immune response |
GB201302447D0 (en) | 2013-02-12 | 2013-03-27 | Oxford Biotherapeutics Ltd | Therapeutic and diagnostic target |
EA201600354A1 (ru) | 2013-11-11 | 2016-12-30 | Чугаи Сеияку Кабушики Каиша | Антигенсвязывающая молекула, содержащая вариабельную область антитела |
US10308721B2 (en) | 2014-02-21 | 2019-06-04 | Abbvie Stemcentrx Llc | Anti-DLL3 antibodies and drug conjugates for use in melanoma |
BR112016020065A2 (pt) | 2014-03-12 | 2018-02-20 | Novartis Ag | sítios específicos para modificar anticorpos para fazer imunoconjugados |
WO2015146438A1 (ja) | 2014-03-26 | 2015-10-01 | 国立大学法人東北大学 | ヒト上皮増殖因子受容体を標的とした二重特異性抗体 |
EP3130606B1 (en) | 2014-04-07 | 2021-10-13 | Chugai Seiyaku Kabushiki Kaisha | Immunoactivating bispecific antibodies |
AU2015295242B2 (en) | 2014-07-31 | 2020-10-22 | Amgen Research (Munich) Gmbh | Bispecific single chain antibody construct with enhanced tissue distribution |
EP3174901B1 (en) | 2014-07-31 | 2019-06-26 | Amgen Research (Munich) GmbH | Optimized cross-species specific bispecific single chain antibody constructs |
EP2982692A1 (en) * | 2014-08-04 | 2016-02-10 | EngMab AG | Bispecific antibodies against CD3epsilon and BCMA |
EP3191521A2 (en) | 2014-09-12 | 2017-07-19 | F. Hoffmann-La Roche AG | Cysteine engineered antibodies and conjugates |
JP7125248B2 (ja) | 2014-11-11 | 2022-08-24 | 中外製薬株式会社 | 改変された抗体可変領域を含む抗原結合分子のライブラリ |
JP6826529B2 (ja) | 2015-06-05 | 2021-02-03 | 中外製薬株式会社 | 免疫活性化剤の併用 |
LT3115376T (lt) | 2015-07-10 | 2018-11-12 | Merus N.V. | Antikūnai, kurie jungiasi su žmogaus cd3 |
TW202346349A (zh) * | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Dll3及cd3抗體構築體 |
UA123323C2 (uk) | 2016-05-02 | 2021-03-17 | Ф. Хоффманн-Ля Рош Аг | Димерний злитий поліпептид |
EP3494139B1 (en) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
EP3554542A1 (en) | 2016-12-19 | 2019-10-23 | H. Hoffnabb-La Roche Ag | Combination therapy with targeted 4-1bb (cd137) agonists |
MX2019006954A (es) | 2016-12-20 | 2019-08-01 | Hoffmann La Roche | Terapia de combinacion de anticuerpos biespecificos anti-cd20/anti-cd3 y agonistas de 4-1bb (cd137). |
AU2018261951A1 (en) | 2017-05-05 | 2019-10-31 | Amgen Inc. | Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration |
TW201938194A (zh) | 2017-12-05 | 2019-10-01 | 日商中外製藥股份有限公司 | 包含結合cd3及cd137的改變的抗體可變區之抗原結合分子 |
TWI817974B (zh) | 2017-12-28 | 2023-10-11 | 日商中外製藥股份有限公司 | 細胞毒性誘導治療劑 |
TW202016151A (zh) * | 2018-06-09 | 2020-05-01 | 德商百靈佳殷格翰國際股份有限公司 | 針對癌症治療之多特異性結合蛋白 |
AU2019315226A1 (en) | 2018-08-03 | 2021-03-18 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing two antigen-binding domains that are linked to each other |
JP2022502010A (ja) | 2018-09-28 | 2022-01-11 | 中外製薬株式会社 | Cd3およびcd137に結合することができるが、同時には結合しない、抗原結合分子 |
BR112021005472A2 (pt) | 2018-09-28 | 2021-06-15 | Chugai Seiyaku Kabushiki Kaisha | molécula de ligação ao antígeno compreendendo uma região variável do anticorpo alterada |
CA3115089A1 (en) * | 2018-10-11 | 2020-04-16 | Inhibrx, Inc. | Dll3 single domain antibodies and therapeutic compositions thereof |
JP2023512390A (ja) | 2020-02-05 | 2023-03-27 | 中外製薬株式会社 | 組換え抗原結合分子を製造するおよび/または濃縮するための方法 |
CN115397866A (zh) | 2020-03-31 | 2022-11-25 | 中外制药株式会社 | 靶向dll3的多特异性抗原结合分子及其用途 |
KR20220161375A (ko) * | 2020-03-31 | 2022-12-06 | 추가이 세이야쿠 가부시키가이샤 | 다중 특이성 항원 결합 분자를 제조하기 위한 방법 |
-
2021
- 2021-03-30 CN CN202180026335.9A patent/CN115397866A/zh active Pending
- 2021-03-30 US US17/216,981 patent/US11274151B2/en active Active
- 2021-03-30 AR ARP210100792A patent/AR121695A1/es unknown
- 2021-03-30 TW TW112110624A patent/TW202325741A/zh unknown
- 2021-03-30 KR KR1020237006522A patent/KR20230035138A/ko active Application Filing
- 2021-03-30 SG SG11202105302PA patent/SG11202105302PA/en unknown
- 2021-03-30 JP JP2021056413A patent/JP7085666B2/ja active Active
- 2021-03-30 EP EP21781866.5A patent/EP4126969A4/en active Pending
- 2021-03-30 BR BR112022019498A patent/BR112022019498A2/pt unknown
- 2021-03-30 PE PE2022002150A patent/PE20230077A1/es unknown
- 2021-03-30 CR CR20220541A patent/CR20220541A/es unknown
- 2021-03-30 TW TW110111556A patent/TWI799824B/zh active
- 2021-03-30 IL IL296803A patent/IL296803A/en unknown
- 2021-03-30 CA CA3173587A patent/CA3173587A1/en active Pending
- 2021-03-30 KR KR1020217035325A patent/KR102505383B1/ko active IP Right Grant
- 2021-03-30 AU AU2021250186A patent/AU2021250186A1/en active Pending
- 2021-03-30 MX MX2022012091A patent/MX2022012091A/es unknown
- 2021-03-30 WO PCT/JP2021/013460 patent/WO2021200898A1/en active Application Filing
-
2022
- 2022-02-14 US US17/670,917 patent/US11718672B2/en active Active
- 2022-06-06 JP JP2022091351A patent/JP2022122972A/ja active Pending
- 2022-09-27 CL CL2022002624A patent/CL2022002624A1/es unknown
- 2022-10-27 CO CONC2022/0015305A patent/CO2022015305A2/es unknown
-
2023
- 2023-06-29 US US18/343,850 patent/US20240010725A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AR121695A1 (es) | 2022-06-29 |
SG11202105302PA (en) | 2021-11-29 |
JP2022122972A (ja) | 2022-08-23 |
KR20230035138A (ko) | 2023-03-10 |
MX2022012091A (es) | 2022-10-13 |
TW202204409A (zh) | 2022-02-01 |
CO2022015305A2 (es) | 2022-11-08 |
CA3173587A1 (en) | 2021-10-07 |
IL296803A (en) | 2022-11-01 |
CN115397866A (zh) | 2022-11-25 |
KR20220100520A (ko) | 2022-07-15 |
TW202325741A (zh) | 2023-07-01 |
US11718672B2 (en) | 2023-08-08 |
BR112022019498A2 (pt) | 2022-11-16 |
AU2021250186A1 (en) | 2022-12-01 |
CL2022002624A1 (es) | 2023-06-02 |
EP4126969A1 (en) | 2023-02-08 |
TWI799824B (zh) | 2023-04-21 |
JP2021159081A (ja) | 2021-10-11 |
JP7085666B2 (ja) | 2022-06-16 |
EP4126969A4 (en) | 2024-05-29 |
US20210301016A1 (en) | 2021-09-30 |
PE20230077A1 (es) | 2023-01-11 |
US20220251201A1 (en) | 2022-08-11 |
US11274151B2 (en) | 2022-03-15 |
KR102505383B1 (ko) | 2023-03-02 |
US20240010725A1 (en) | 2024-01-11 |
WO2021200898A1 (en) | 2021-10-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022012091A (es) | Moleculas de union al antigeno multiespecificas dirigidas a ligando de tipo delta 3 (dll3) y sus usos. | |
EP4219563A3 (en) | Methods of treating cancer with anti-pd-1 antibodies | |
MX2019009358A (es) | Anticuerpo anti-gprc5d y molecula que comprende el anticuerpo. | |
EA202091135A1 (ru) | Гидрофильные линкеры для конъюгатов антитело-лекарственное средство | |
PH12019501387A1 (en) | Anti-cd3 antibody and molecules comprising the antibody | |
MX2021005350A (es) | Compuestos de piridazinona y usos de los mismos. | |
JOP20220163A1 (ar) | مركب بيريدازينيل-ثيازول كربوكساميد | |
ZA200709481B (en) | Diaryl-purine, azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of HIV | |
BR112021024956A2 (pt) | Anticorpos multiespecíficos de cadeia pesada que se ligam a cd22 e cd3 | |
MX2022013944A (es) | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). | |
MX2022012092A (es) | Moleculas de union al antigeno multiespecificas dirigidas a claudina-6 y sus usos. | |
MX2022013453A (es) | Anticuerpos de cadena pesada multiespecificos con regiones constantes de cadena pesada modificadas. | |
WO2020257278A3 (en) | Small molecule target bromo/acetyl proteins and uses thereof | |
CR20210258A (es) | Uso de ciclodextrinas como sistema de suministro de productos agroquímicos | |
PH12021500011A1 (en) | Anti-cd137 antigen-binding molecule and utilization thereof | |
MX2023004869A (es) | Anticuerpos contra sars-cov-2 y usos de los mismos. | |
MX2022009819A (es) | Moleculas de union al antigeno anti-grupo de diferenciacion 137 (cd137) para usarse en el tratamiento contra el cancer. | |
AU2020264106A8 (en) | Small molecule bromodomain inhibitors and uses thereof | |
WO2023240082A3 (en) | Combination therapy of anti-pd-1 active agent, anti-tim-3 active agent, and anti-lag-3 active agent for treating cancer | |
EA202092691A1 (ru) | Соединения для устранения боли, композиции, содержащие их, и способы их применения | |
WO2022084355A3 (en) | Agonistic trkb binding molecules for the treatment of eye diseases | |
BR112022002761A2 (pt) | Proteínas de ligação a 4-1bb e ox40 e composições e métodos relacionados, anticorpos contra 4-1bb, anticorpos contra ox40 | |
MX2020008082A (es) | Compuestos y composiciones para el tratamiento del dolor. | |
WO2023034923A3 (en) | BISPECIFIC AND TRISPECIFIC BINDING PROTEINS TO PD-L1, CD137, AND/OR TGFβ AND USES THEREOF | |
MX2022014538A (es) | Moleculas de union para el tratamiento de cancer. |