MX356947B - Anticuerpos bioespecíficos específicos para antígenos que activan células t y un antígeno tumoral y métodos de uso. - Google Patents
Anticuerpos bioespecíficos específicos para antígenos que activan células t y un antígeno tumoral y métodos de uso.Info
- Publication number
- MX356947B MX356947B MX2014002097A MX2014002097A MX356947B MX 356947 B MX356947 B MX 356947B MX 2014002097 A MX2014002097 A MX 2014002097A MX 2014002097 A MX2014002097 A MX 2014002097A MX 356947 B MX356947 B MX 356947B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- tumor antigen
- cell activating
- bispecific antibodies
- antibodies specific
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La presente invención se refiere a anticuerpos bisespecíficos que se enlazan específicamente a un antígeno activador de célula T y un antígeno de tumor (TA), que comprende un primer fragmento de Fab y un segundo fragmento de Fab, en donde ya sea una u otra de las regiones variables o las regiones constantes de las cadena pesada y cadena ligera del segundo Fab son intercambiadas y en donde el anticuerpo bisespecífico no comprende un dominio de Fc; métodos para su producción, composiciones farmacéuticas que contienen dichos anticuerpos y usos de los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11178410 | 2011-08-23 | ||
PCT/EP2012/066226 WO2013026839A1 (en) | 2011-08-23 | 2012-08-21 | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2014002097A MX2014002097A (es) | 2014-05-28 |
MX356947B true MX356947B (es) | 2018-06-20 |
Family
ID=46704675
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014002097A MX356947B (es) | 2011-08-23 | 2012-08-21 | Anticuerpos bioespecíficos específicos para antígenos que activan células t y un antígeno tumoral y métodos de uso. |
Country Status (11)
Country | Link |
---|---|
US (2) | US20130058936A1 (es) |
EP (1) | EP2747781B1 (es) |
JP (2) | JP6159724B2 (es) |
KR (2) | KR101870555B1 (es) |
CN (2) | CN103889452B (es) |
BR (1) | BR112014004168A2 (es) |
CA (1) | CA2844540C (es) |
HK (1) | HK1249529A1 (es) |
MX (1) | MX356947B (es) |
RU (1) | RU2605390C2 (es) |
WO (1) | WO2013026839A1 (es) |
Families Citing this family (124)
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RU2617970C2 (ru) * | 2011-08-23 | 2017-04-28 | Рош Гликарт Аг | Антитела, не содержащие fc-фрагмента, включающие два fab-фрагмента, и способы их применения |
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2012
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- 2012-08-21 US US13/591,024 patent/US20130058936A1/en not_active Abandoned
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EP2747781A1 (en) | 2014-07-02 |
CN103889452A (zh) | 2014-06-25 |
CN103889452B (zh) | 2017-11-03 |
CN107586340B (zh) | 2022-01-21 |
BR112014004168A2 (pt) | 2017-12-12 |
EP2747781B1 (en) | 2017-11-15 |
RU2014109551A (ru) | 2015-09-27 |
KR20140041856A (ko) | 2014-04-04 |
MX2014002097A (es) | 2014-05-28 |
KR20160138583A (ko) | 2016-12-05 |
KR101870555B1 (ko) | 2018-06-22 |
KR101681818B1 (ko) | 2016-12-01 |
CN107586340A (zh) | 2018-01-16 |
US20150274845A1 (en) | 2015-10-01 |
US20130058936A1 (en) | 2013-03-07 |
CA2844540C (en) | 2018-10-16 |
US11639397B2 (en) | 2023-05-02 |
HK1249529A1 (zh) | 2018-11-02 |
CA2844540A1 (en) | 2013-02-28 |
WO2013026839A1 (en) | 2013-02-28 |
JP2014529600A (ja) | 2014-11-13 |
JP6159724B2 (ja) | 2017-07-05 |
RU2605390C2 (ru) | 2016-12-20 |
JP2017137329A (ja) | 2017-08-10 |
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