SG11202105302PA - Dll3-targeting multispecific antigen-binding molecules and uses thereof - Google Patents

Dll3-targeting multispecific antigen-binding molecules and uses thereof

Info

Publication number
SG11202105302PA
SG11202105302PA SG11202105302PA SG11202105302PA SG11202105302PA SG 11202105302P A SG11202105302P A SG 11202105302PA SG 11202105302P A SG11202105302P A SG 11202105302PA SG 11202105302P A SG11202105302P A SG 11202105302PA SG 11202105302P A SG11202105302P A SG 11202105302PA
Authority
SG
Singapore
Prior art keywords
dll3
binding molecules
multispecific antigen
targeting
targeting multispecific
Prior art date
Application number
SG11202105302PA
Inventor
Sotaro Naoi
Shu Feng
Tomoyuki Igawa
Shu Wen Samantha Ho
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG11202105302PA publication Critical patent/SG11202105302PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
SG11202105302PA 2020-03-31 2021-03-30 Dll3-targeting multispecific antigen-binding molecules and uses thereof SG11202105302PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020062326 2020-03-31
PCT/JP2021/013460 WO2021200898A1 (en) 2020-03-31 2021-03-30 Dll3-targeting multispecific antigen-binding molecules and uses thereof

Publications (1)

Publication Number Publication Date
SG11202105302PA true SG11202105302PA (en) 2021-11-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202105302PA SG11202105302PA (en) 2020-03-31 2021-03-30 Dll3-targeting multispecific antigen-binding molecules and uses thereof

Country Status (18)

Country Link
US (3) US11274151B2 (en)
EP (1) EP4126969A1 (en)
JP (2) JP7085666B2 (en)
KR (2) KR102505383B1 (en)
CN (1) CN115397866A (en)
AR (1) AR121695A1 (en)
AU (1) AU2021250186A1 (en)
BR (1) BR112022019498A2 (en)
CA (1) CA3173587A1 (en)
CL (1) CL2022002624A1 (en)
CO (1) CO2022015305A2 (en)
CR (1) CR20220541A (en)
IL (1) IL296803A (en)
MX (1) MX2022012091A (en)
PE (1) PE20230077A1 (en)
SG (1) SG11202105302PA (en)
TW (2) TW202325741A (en)
WO (1) WO2021200898A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113307873A (en) 2013-11-11 2021-08-27 中外制药株式会社 Antigen binding molecules comprising altered antibody variable regions
US11952422B2 (en) 2017-12-05 2024-04-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137
US11667713B2 (en) 2017-12-28 2023-06-06 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
BR112022017526A2 (en) * 2020-03-31 2022-10-18 Chugai Pharmaceutical Co Ltd METHOD FOR PRODUCING MULTI-SPECIFIC ANTIGEN-BINDING MOLECULES
CN115397866A (en) 2020-03-31 2022-11-25 中外制药株式会社 DLL 3-targeted multispecific antigen-binding molecules and uses thereof
WO2023053272A1 (en) * 2021-09-29 2023-04-06 Chugai Seiyaku Kabushiki Kaisha Uses of dll3-targeting multispecific antigen-binding molecules
WO2023164474A1 (en) 2022-02-23 2023-08-31 Amgen Inc. Cancer treatment targeting dll3
CN116813784B (en) * 2023-05-17 2024-03-01 星奕昂(上海)生物科技有限公司 Antibodies targeting DLL3 and uses thereof

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0328966Y2 (en) 1987-10-16 1991-06-20
AP257A (en) 1991-04-26 1993-06-03 Surface Active Ltd A method of releasing an antigen from an antibody and methods for their use in diagnosis and therapy.
AU6235294A (en) 1993-02-02 1994-08-29 Scripps Research Institute, The Methods for producing polypeptide binding sites
US5981478A (en) 1993-11-24 1999-11-09 La Jolla Cancer Research Foundation Integrin-binding peptides
JP4332581B2 (en) 1998-02-19 2009-09-16 旭化成株式会社 Human delta-3
JP4139508B2 (en) 1998-02-19 2008-08-27 旭化成株式会社 Human delta 3
US6344443B1 (en) 1998-07-08 2002-02-05 University Of South Florida Peptide antagonists of tumor necrosis factor alpha
ES2694002T3 (en) 1999-01-15 2018-12-17 Genentech, Inc. Polypeptide comprising an Fc region of variant human IgG1
JP2002540763A (en) 1999-02-10 2002-12-03 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド 33 human secreted proteins
JP2003507029A (en) 1999-08-19 2003-02-25 カイロン コーポレイション Notch receptor ligands and uses thereof
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
NZ521540A (en) 2000-04-11 2004-09-24 Genentech Inc Multivalent antibodies and uses therefor
AU2001280471A1 (en) 2000-08-11 2002-02-25 Eli Lilly And Company Novel secreted proteins and their uses
DE60124912T2 (en) 2001-09-14 2007-06-14 Affimed Therapeutics Ag Multimeric, single chain, tandem Fv antibodies
AU2002330039A1 (en) 2001-09-17 2003-04-01 Eos Biotechnology, Inc. Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
US20070224201A1 (en) 2002-10-02 2007-09-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US20040115204A1 (en) 2002-12-11 2004-06-17 Fanger Gary R. Antibodies to treat cancer
US8388955B2 (en) 2003-03-03 2013-03-05 Xencor, Inc. Fc variants
DE602005027309D1 (en) 2004-01-16 2011-05-19 Regeneron Pharma FOR ACTIVATING RECEPTORS CAPABLE FUSION POLYPEPTIDES
US20050175619A1 (en) 2004-02-05 2005-08-11 Robert Duffy Methods of producing antibody conjugates
EP2471813B1 (en) 2004-07-15 2014-12-31 Xencor, Inc. Optimized Fc variants
EP1797127B1 (en) 2004-09-24 2017-06-14 Amgen Inc. Modified fc molecules
JP5553963B2 (en) 2004-10-22 2014-07-23 アムジエン・インコーポレーテツド Methods for refolding recombinant antibodies
AU2005299355A1 (en) 2004-10-27 2006-05-04 Medimmune, Llc Modulation of antibody specificity by tailoring the affinity to cognate antigens
CN101123983A (en) 2004-10-27 2008-02-13 米迪缪尼股份有限公司 Modulation of antibody specificity by tailoring the affinity to cognate antigens
CN101098891B (en) 2005-01-05 2014-05-21 F-星生物技术研究与开发有限公司 Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions
CA2596248A1 (en) 2005-01-31 2006-08-10 Vaxinnate Corporation Method to identify polypeptide toll-like receptor (tlr) ligands
WO2006106905A1 (en) 2005-03-31 2006-10-12 Chugai Seiyaku Kabushiki Kaisha Process for production of polypeptide by regulation of assembly
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US20070087005A1 (en) 2005-10-14 2007-04-19 Lazar Gregory A Anti-glypican-3 antibody
RU2008129028A (en) 2005-12-16 2010-01-27 Дженентек, Инк. (Us) METHOD FOR DIAGNOSTIC, FORECASTING AND TREATMENT OF GLIOMA
EP2216339A1 (en) 2006-01-16 2010-08-11 Compugen Ltd. Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
MX2008013057A (en) 2006-04-14 2009-04-07 Trubion Pharmaceuticals Inc Binding proteins comprising immunoglobulin hinge and fc regions having altered fc effector functions.
CN103435697A (en) 2006-05-15 2013-12-11 航道生物技术有限责任公司 Neutralizing antibodies to influenza viruses
AT503889B1 (en) 2006-07-05 2011-12-15 Star Biotechnologische Forschungs Und Entwicklungsges M B H F MULTIVALENT IMMUNE LOBULINE
EP2078731A4 (en) 2006-10-20 2012-08-01 Forerunner Pharma Res Co Ltd Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
KR101589759B1 (en) 2007-04-03 2016-01-29 암젠 리서치 (뮌헨) 게엠베하 Cross-species-specific cd3-epsilon binding domain
JP2010524851A (en) 2007-04-03 2010-07-22 マイクロメット アーゲー Species-specific binding domains
JP5718637B2 (en) 2007-06-21 2015-05-13 マクロジェニクス，インコーポレーテッド Covalently bonded diabody and its use
CA3128656A1 (en) 2007-08-22 2009-02-26 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
US8580927B2 (en) 2008-01-31 2013-11-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Engineered antibody constant domain molecules
WO2009124931A2 (en) 2008-04-07 2009-10-15 Ablynx Nv Amino acid sequences directed against the notch pathways and uses thereof
JP5796831B2 (en) 2008-09-03 2015-10-21 ジェネンテック， インコーポレイテッド Multispecific antibody
DK2334705T3 (en) 2008-09-26 2017-03-27 Ucb Biopharma Sprl BIOLOGICAL PRODUCTS
CN106432503B (en) 2008-12-19 2020-03-06 宏观基因有限公司 Covalent diabodies and uses thereof
RS62387B1 (en) 2010-01-29 2021-10-29 Chugai Pharmaceutical Co Ltd Anti-dll3 antibody
JP5889181B2 (en) 2010-03-04 2016-03-22 中外製薬株式会社 Antibody constant region variants
WO2011127350A1 (en) 2010-04-09 2011-10-13 Enanta Pharmaceuticals, Inc. Hepatitis c virus inhibitors
RU2624027C2 (en) 2010-04-23 2017-06-30 Дженентек, Инк. Heteromultimeric proteins production
JP6167040B2 (en) 2010-11-05 2017-07-19 ザイムワークス，インコーポレイテッド Design of stable heterodimeric antibodies with mutations in the Fc domain
WO2012064792A2 (en) 2010-11-09 2012-05-18 Altimab Therapeutics, Inc. Protein complexes for antigen binding and methods of use
BR112013013311A2 (en) 2010-11-30 2017-09-19 Chugai Pharmaceutical Co Ltd cytotoxicity-inducing therapeutic agent
US9469685B2 (en) 2011-01-10 2016-10-18 Emory University Antibodies directed against influenza
AU2012245116A1 (en) 2011-04-20 2013-11-07 Genmab A/S Bispecific antibodies against HER2 and CD3
UA117072C2 (en) 2011-05-21 2018-06-11 Макродженікс, Інк. CD3-Binding Molecule Able to Bind to CD3 HUMAN AND NON-HUMAN CD3
TWI687441B (en) 2011-06-30 2020-03-11 中外製藥股份有限公司 Heterodimerized polypeptide
WO2013010955A1 (en) 2011-07-15 2013-01-24 Morphosys Ag Antibodies that are cross-reactive for macrophage migration inhibitory factor (mif) and d-dopachrome tautomerase (d-dt)
HUE038225T2 (en) 2011-08-23 2018-10-29 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
RU2605390C2 (en) 2011-08-23 2016-12-20 Рош Гликарт Аг Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use
MX359384B (en) 2011-10-11 2018-09-25 Genentech Inc Improved assembly of bispecific antibodies.
EP2768863B1 (en) 2011-10-20 2017-09-27 The U.S.A. as represented by the Secretary, Department of Health and Human Services Anti-cd22 chimeric antigen receptors
EP3093293A1 (en) 2012-02-24 2016-11-16 Stemcentrx, Inc. Anti dll3 antibodies and methods of use thereof
JPWO2013180200A1 (en) 2012-05-30 2016-01-21 中外製薬株式会社 Target tissue specific antigen binding molecule
JP6628966B2 (en) 2012-06-14 2020-01-15 中外製薬株式会社 Antigen binding molecule containing an altered Fc region
CN105102618B (en) 2012-12-27 2018-04-17 中外制药株式会社 heterodimerization polypeptide
WO2014116846A2 (en) 2013-01-23 2014-07-31 Abbvie, Inc. Methods and compositions for modulating an immune response
GB201302447D0 (en) * 2013-02-12 2013-03-27 Oxford Biotherapeutics Ltd Therapeutic and diagnostic target
CN113307873A (en) 2013-11-11 2021-08-27 中外制药株式会社 Antigen binding molecules comprising altered antibody variable regions
KR20170008202A (en) 2014-02-21 2017-01-23 애브비 스템센트알엑스 엘엘씨 Anti-dll3 antibodies and drug conjugates for use in melanoma
MX2016011627A (en) 2014-03-12 2016-11-29 Novartis Ag Specific sites for modifying antibodies to make immunoconjugates.
US20170274072A1 (en) 2014-03-26 2017-09-28 Tohoku University Bispecific antibody targeting human epidermal growth factor receptor
TWI726842B (en) 2014-04-07 2021-05-11 日商中外製藥股份有限公司 Immune activation antigen binding molecule
WO2016016415A1 (en) 2014-07-31 2016-02-04 Amgen Research (Munich) Gmbh Bispecific single chain antibody construct with enhanced tissue distribution
TW201609812A (en) 2014-07-31 2016-03-16 安美基研究（慕尼黑）公司 Optimized cross-species specific bispecific single chain antibody constructs
EP2982692A1 (en) * 2014-08-04 2016-02-10 EngMab AG Bispecific antibodies against CD3epsilon and BCMA
KR20170052600A (en) 2014-09-12 2017-05-12 제넨테크, 인크. Cysteine engineered antibodies and conjugates
TWI831044B (en) 2014-11-11 2024-02-01 日商中外製藥股份有限公司 Antigen-binding molecules, pharmaceutical compositions containing antigen-binding molecules, and methods of manufacturing and selecting antigen-binding molecules
WO2016194992A1 (en) 2015-06-05 2016-12-08 中外製薬株式会社 Combined use of immune activators
LT3115376T (en) 2015-07-10 2018-11-12 Merus N.V. Human cd3 binding antibody
TW202346349A (en) * 2015-07-31 2023-12-01 德商安美基研究（慕尼黑）公司 Antibody constructs for dll3 and cd3
PE20181890A1 (en) 2016-05-02 2018-12-11 Hoffmann La Roche CONTORSBODY - A MONOCATENARIO DIANA LEAGUE
CN109963871A (en) 2016-08-05 2019-07-02 豪夫迈·罗氏有限公司 Multivalence and multi-epitope Antibody and application method with agonist activity
TWI829628B (en) 2016-12-19 2024-01-21 瑞士商赫孚孟拉羅股份公司 Combination therapy with targeted 4-1bb (cd137) agonists
BR112019007267A2 (en) 2016-12-20 2019-07-09 Hoffmann La Roche anti-cd20 / anti-cd3 bispecific antibody, pharmaceutical product, pharmaceutical composition comprising a anti-cd20 / anti-cd3 bispecific antibody, use of anti-cd20 / anti-cd3 bispecific antibody combination and a 4-1bb agonist and method of treatment or retardation of cancer progression in patients
CA3060856A1 (en) 2017-05-05 2018-11-08 Amgen Inc. Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
US11952422B2 (en) 2017-12-05 2024-04-09 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137
US11667713B2 (en) 2017-12-28 2023-06-06 Chugai Seiyaku Kabushiki Kaisha Cytotoxicity-inducing therapeutic agent
SG11202101152QA (en) 2018-08-03 2021-03-30 Chugai Pharmaceutical Co Ltd Antigen-binding molecule containing two antigen-binding domains that are linked to each other
WO2020067419A1 (en) 2018-09-28 2020-04-02 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecules capable of binding cd3 and cd137 but not simultaneously
SG11202102882YA (en) 2018-09-28 2021-04-29 Chugai Pharmaceutical Co Ltd Antigen-binding molecule comprising altered antibody variable region
CA3168510A1 (en) 2020-02-05 2021-08-12 Chugai Seiyaku Kabushiki Kaisha Methods for producing and/or enriching recombinant antigen-binding molecules
CN115397866A (en) 2020-03-31 2022-11-25 中外制药株式会社 DLL 3-targeted multispecific antigen-binding molecules and uses thereof
BR112022017526A2 (en) 2020-03-31 2022-10-18 Chugai Pharmaceutical Co Ltd METHOD FOR PRODUCING MULTI-SPECIFIC ANTIGEN-BINDING MOLECULES

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JP2022122972A (en) 2022-08-23
CR20220541A (en) 2022-11-28
KR20220100520A (en) 2022-07-15
US20210301016A1 (en) 2021-09-30
TW202325741A (en) 2023-07-01
TWI799824B (en) 2023-04-21
CO2022015305A2 (en) 2022-11-08
US11274151B2 (en) 2022-03-15
TW202204409A (en) 2022-02-01
AR121695A1 (en) 2022-06-29
EP4126969A1 (en) 2023-02-08
US11718672B2 (en) 2023-08-08
KR20230035138A (en) 2023-03-10
JP7085666B2 (en) 2022-06-16
US20220251201A1 (en) 2022-08-11
CN115397866A (en) 2022-11-25
CA3173587A1 (en) 2021-10-07
US20240010725A1 (en) 2024-01-11
WO2021200898A1 (en) 2021-10-07
IL296803A (en) 2022-11-01
KR102505383B1 (en) 2023-03-02
MX2022012091A (en) 2022-10-13
AU2021250186A1 (en) 2022-12-01
PE20230077A1 (en) 2023-01-11
JP2021159081A (en) 2021-10-11
BR112022019498A2 (en) 2022-11-16
CL2022002624A1 (en) 2023-06-02

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