EA202092691A1 - Соединения для устранения боли, композиции, содержащие их, и способы их применения - Google Patents

Соединения для устранения боли, композиции, содержащие их, и способы их применения

Info

Publication number
EA202092691A1
EA202092691A1 EA202092691A EA202092691A EA202092691A1 EA 202092691 A1 EA202092691 A1 EA 202092691A1 EA 202092691 A EA202092691 A EA 202092691A EA 202092691 A EA202092691 A EA 202092691A EA 202092691 A1 EA202092691 A1 EA 202092691A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compositions
methods
application
pain relief
opioid
Prior art date
Application number
EA202092691A
Other languages
English (en)
Inventor
Скотт Л. Дэкс
Паскуале Н. Конфалоне
Original Assignee
Церси Терапьютикс, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Церси Терапьютикс, Инк. filed Critical Церси Терапьютикс, Инк.
Publication of EA202092691A1 publication Critical patent/EA202092691A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I), композициям, содержащих их, и способам, предназначенным для устранения и/или уменьшения боли у субъекта, нуждающегося в этом. Соединения формулы (I) являются эффективными для лечения опиоид-индуцированной тахифилаксии и опиоид-индуцированной гипералгезии.
EA202092691A 2018-05-29 2019-05-20 Соединения для устранения боли, композиции, содержащие их, и способы их применения EA202092691A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862677496P 2018-05-29 2018-05-29
PCT/US2019/033140 WO2019231739A1 (en) 2018-05-29 2019-05-20 Compounds for pain treatment, compositions comprising same, and methods of using same

Publications (1)

Publication Number Publication Date
EA202092691A1 true EA202092691A1 (ru) 2021-04-21

Family

ID=66770595

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202092691A EA202092691A1 (ru) 2018-05-29 2019-05-20 Соединения для устранения боли, композиции, содержащие их, и способы их применения

Country Status (14)

Country Link
US (3) US11091473B2 (ru)
EP (1) EP3802524A1 (ru)
JP (1) JP2021525269A (ru)
KR (1) KR20210015892A (ru)
CN (1) CN112204025B (ru)
AU (1) AU2019279761A1 (ru)
BR (1) BR112020024261B8 (ru)
CA (1) CA3101738A1 (ru)
EA (1) EA202092691A1 (ru)
IL (1) IL278904A (ru)
MX (1) MX2020012805A (ru)
SG (1) SG11202011534YA (ru)
WO (1) WO2019231739A1 (ru)
ZA (1) ZA202007320B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022265960A1 (en) * 2021-06-13 2022-12-22 Daya Drug Discoveries, Inc. Prevention and treatment of neuronal damage with pyridoindolobenz[b, d] azepine compositions
WO2022266211A1 (en) * 2021-06-17 2022-12-22 Acadia Pharmaceuticals Inc. Methods of treating, ameliorating, and/or preventing osteoarthritic pain

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Also Published As

Publication number Publication date
BR112020024261A2 (pt) 2021-02-23
SG11202011534YA (en) 2020-12-30
CN112204025B (zh) 2022-05-31
AU2019279761A1 (en) 2020-12-10
US20220153731A1 (en) 2022-05-19
BR112020024261B8 (pt) 2022-05-17
CN112204025A (zh) 2021-01-08
ZA202007320B (en) 2022-04-28
US20190367499A1 (en) 2019-12-05
KR20210015892A (ko) 2021-02-10
JP2021525269A (ja) 2021-09-24
WO2019231739A1 (en) 2019-12-05
BR112020024261B1 (pt) 2022-05-03
IL278904A (en) 2021-01-31
US10844054B2 (en) 2020-11-24
CA3101738A1 (en) 2019-12-05
US20200131170A1 (en) 2020-04-30
US11091473B2 (en) 2021-08-17
EP3802524A1 (en) 2021-04-14
MX2020012805A (es) 2021-02-15

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