US7511131B2
(en)
|
2002-11-13 |
2009-03-31 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
DK2284269T3
(en)
|
2002-11-18 |
2017-10-23 |
Roche Innovation Ct Copenhagen As |
Antisense design
|
US20050287558A1
(en)
|
2004-05-05 |
2005-12-29 |
Crooke Rosanne M |
SNPs of apolipoprotein B and modulation of their expression
|
DE102005042073B4
(de)
*
|
2005-08-31 |
2010-11-11 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Faserlaser
|
US8288354B2
(en)
|
2005-12-28 |
2012-10-16 |
The Scripps Research Institute |
Natural antisense and non-coding RNA transcripts as drug targets
|
AU2007211080B9
(en)
*
|
2006-01-27 |
2012-05-03 |
Isis Pharmaceuticals, Inc. |
6-modified bicyclic nucleic acid analogs
|
AU2007257094B2
(en)
|
2006-05-05 |
2012-10-25 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of SGLT2
|
EP2505650A1
(en)
*
|
2006-05-05 |
2012-10-03 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of PCSK9
|
US7547684B2
(en)
*
|
2006-05-11 |
2009-06-16 |
Isis Pharmaceuticals, Inc. |
5′-modified bicyclic nucleic acid analogs
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
DK2092065T4
(da)
|
2006-10-18 |
2019-10-21 |
Ionis Pharmaceuticals Inc |
Antisense-forbindelser
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
MX2009005527A
(es)
|
2006-11-27 |
2009-06-08 |
Isis Pharmaceuticals Inc |
Metodos para el tratamiento de hipercolesterolemia.
|
JP2010522245A
(ja)
|
2007-03-24 |
2010-07-01 |
ゲンザイム コーポレイション |
ヒトアポリポタンパク質bと相補的なアンチセンスオリゴヌクレオチドの投与
|
ES2376507T5
(es)
†
|
2007-07-05 |
2015-08-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos 6-disustituidos
|
AU2008286771B2
(en)
|
2007-08-15 |
2013-08-15 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
US20110059895A1
(en)
|
2007-11-09 |
2011-03-10 |
Isis Pharmaceuticals, Inc. |
Modulation of factor 9 expression
|
JP2011502514A
(ja)
|
2007-11-09 |
2011-01-27 |
アイシス ファーマシューティカルズ インコーポレイティッド |
第7因子発現の調節
|
WO2009100320A2
(en)
*
|
2008-02-07 |
2009-08-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
EP2282744B1
(en)
*
|
2008-03-21 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
DK2285819T3
(da)
*
|
2008-04-04 |
2013-12-02 |
Isis Pharmaceuticals Inc |
Oligomere forbindelser omfattende neutralt bundne, terminale bicykliske nukleosider
|
US8846639B2
(en)
|
2008-04-04 |
2014-09-30 |
Isis Pharmaceutical, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and having reduced toxicity
|
WO2009143387A2
(en)
*
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc. |
Modulation of smrt expression
|
EP2323667A4
(en)
*
|
2008-08-07 |
2012-07-25 |
Isis Pharmaceuticals Inc |
MODULATION OF TRANSTHYRETIN EXPRESSION BY TREATMENT OF CNS DISEASES
|
WO2010019270A1
(en)
*
|
2008-08-14 |
2010-02-18 |
Isis Pharmaceuticals, Inc. |
Modulation of prion expression
|
EP2331141B1
(en)
|
2008-08-25 |
2016-01-06 |
Excaliard Pharmaceuticals, Inc. |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
WO2010027831A1
(en)
|
2008-08-25 |
2010-03-11 |
Excaliard Pharmaceuticals, Inc. |
Method for reducing scarring during wound healing using antisense compounds directed to ctgf
|
US8946172B2
(en)
*
|
2008-08-25 |
2015-02-03 |
Excaliard Pharmaceuticals, Inc. |
Method for reducing scarring during wound healing using antisense compounds directed to CTGF
|
EP2356129B1
(en)
*
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
DK2361256T3
(da)
*
|
2008-09-24 |
2013-07-01 |
Isis Pharmaceuticals Inc |
Cyclohexenyl-nukleinsyreanaloger
|
EP2352830B1
(en)
|
2008-10-03 |
2019-01-16 |
CuRNA, Inc. |
Treatment of apolipoprotein-a1 related diseases by inhibition of natural antisense transcript to apolipoprotein-a1
|
EP3335715A3
(en)
|
2008-10-15 |
2018-08-08 |
Ionis Pharmaceuticals, Inc. |
Modulation of factor 11 expression
|
WO2010048585A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
CN102282155B
(zh)
|
2008-12-02 |
2017-06-09 |
日本波涛生命科学公司 |
磷原子修饰的核酸的合成方法
|
KR20110091796A
(ko)
|
2008-12-04 |
2011-08-12 |
오피케이오 큐알엔에이, 엘엘씨 |
종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
|
MX2011005912A
(es)
|
2008-12-04 |
2011-06-17 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas con factor de crecimiento endotelial vascular por inhibicion de transcrito antisentido natural para factor de crecimiento endotelial vascular.
|
EP2370579B1
(en)
|
2008-12-04 |
2017-03-29 |
CuRNA, Inc. |
Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
|
JP5793423B2
(ja)
|
2008-12-31 |
2015-10-14 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S |
急性冠症候群の治療のためのLNAApoBアンチセンスオリゴマーの使用
|
WO2010090830A1
(en)
*
|
2009-01-20 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Modulation of sirt1 expression
|
US20120021515A1
(en)
|
2009-02-06 |
2012-01-26 |
Swayze Eric E |
Oligomeric compounds and methods
|
WO2010090969A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
KR101682735B1
(ko)
|
2009-02-12 |
2016-12-06 |
큐알엔에이, 인크. |
뇌 유래된 신경영양성 인자 (bdnf)에 대한 자연 안티센스 전사체의 저해에 의한 뇌 유래된 신경영양성 인자 (bdnf) 관련된 질환의 치료
|
EP2408796B1
(en)
|
2009-03-16 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Targeting Apolipoprotein B for the reduction of Apolipoprotein C-III
|
CN102482677B
(zh)
|
2009-03-16 |
2017-10-17 |
库尔纳公司 |
通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病
|
JP5904935B2
(ja)
|
2009-03-17 |
2016-04-20 |
クルナ・インコーポレーテッド |
デルタ様1ホモログ(dlk1)に対する天然アンチセンス転写物の抑制によるdlk1関連疾患の治療
|
US20120088814A1
(en)
|
2009-03-31 |
2012-04-12 |
Isis Pharmaceuticals, Inc. |
Methods of modulating an immune response to a viral infection
|
CA2761142C
(en)
|
2009-05-06 |
2021-06-08 |
Opko Curna, Llc |
Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
|
CA2761152A1
(en)
|
2009-05-06 |
2010-11-11 |
Opko Curna, Llc |
Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
|
ES2618572T3
(es)
|
2009-05-08 |
2017-06-21 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la familia de la distrofina mediante inhibición de un transcrito antisentido natural para la familia de dmd
|
KR101749356B1
(ko)
|
2009-05-18 |
2017-07-06 |
큐알엔에이, 인크. |
재편성 인자에 대한 천연 안티센스 전사체의 억제에 의한 재편성 인자 관련된 질환의 치료
|
KR101703695B1
(ko)
|
2009-05-22 |
2017-02-08 |
큐알엔에이, 인크. |
전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의해 tfe3 및 인슐린 수용체 기질 2(irs2)의 치료
|
EP2435571B1
(en)
|
2009-05-28 |
2016-12-14 |
CuRNA, Inc. |
Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
|
BR112012000214A2
(pt)
|
2009-06-12 |
2018-06-19 |
Santaris Pharma As |
potentes compostos anti-sentido anti - apob
|
KR101801404B1
(ko)
|
2009-06-16 |
2017-12-20 |
큐알엔에이, 인크. |
콜라겐 유전자에 대한 천연 안티센스 전사체의 억제에 의한 콜라겐 유전자 관련된 질환의 치료
|
KR101702689B1
(ko)
|
2009-06-16 |
2017-02-06 |
큐알엔에이, 인크. |
Pon1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(pon1) 관련된 질환의 치료
|
KR20120093138A
(ko)
|
2009-06-17 |
2012-08-22 |
콜드스프링하버러보러토리 |
대상에게서 smn2 스플라이싱을 조정하기 위한 조성물 및 방법
|
EP2447273A4
(en)
|
2009-06-23 |
2013-06-19 |
Takeda Pharmaceutical |
METHOD OF SYNTHESIZING A NUCLEIC ACID
|
ES2618894T3
(es)
|
2009-06-24 |
2017-06-22 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2
|
CN102482672B
(zh)
|
2009-06-26 |
2016-11-09 |
库尔纳公司 |
通过抑制唐氏综合征基因的天然反义转录物治疗唐氏综合征基因相关疾病
|
US9744183B2
(en)
|
2009-07-06 |
2017-08-29 |
Wave Life Sciences Ltd. |
Nucleic acid prodrugs and methods of use thereof
|
EP2456870A1
(en)
|
2009-07-21 |
2012-05-30 |
Santaris Pharma A/S |
Antisense oligomers targeting pcsk9
|
JP2013500017A
(ja)
|
2009-07-24 |
2013-01-07 |
カッパーアールエヌエー,インコーポレイテッド |
サ−チュイン(sirt)への天然アンチセンス転写物の阻止によるサ−チュイン(sirt)関連疾患の治療
|
CN102762731B
(zh)
|
2009-08-05 |
2018-06-22 |
库尔纳公司 |
通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
|
WO2011017521A2
(en)
|
2009-08-06 |
2011-02-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
JP6189594B2
(ja)
|
2009-08-11 |
2017-08-30 |
クルナ・インコーポレーテッド |
アディポネクチン(adipoq)に対する天然アンチセンス転写物の抑制によるアディポネクチン(adipoq)関連疾患の治療
|
EP2982755B1
(en)
|
2009-08-21 |
2020-10-07 |
CuRNA, Inc. |
Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
|
EP2470657B1
(en)
|
2009-08-25 |
2019-10-23 |
CuRNA, Inc. |
Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
|
CA2773886C
(en)
|
2009-09-11 |
2018-01-09 |
Isis Pharmaceuticals, Inc. |
Modulation of huntingtin expression
|
NO2480669T3
(US07399845-20080715-C00067.png)
|
2009-09-25 |
2018-04-07 |
|
|
WO2011048125A1
(en)
|
2009-10-20 |
2011-04-28 |
Santaris Pharma A/S |
Oral delivery of therapeutically effective lna oligonucleotides
|
WO2011054811A1
(en)
|
2009-11-03 |
2011-05-12 |
Santaris Pharma A/S |
Rna antagonists targeting hsp27 combination therapy
|
RU2639550C2
(ru)
|
2009-12-16 |
2017-12-21 |
Курна, Инк. |
Лечение заболеваний, связанных с сайт-1 мембраносвязанной пептидазой транскрипционных факторов (mbtps1), путем ингибирования природного антисмыслового транскрипта к mbtps1
|
EP2515947B1
(en)
|
2009-12-23 |
2021-10-06 |
CuRNA, Inc. |
Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
|
RU2609631C2
(ru)
|
2009-12-23 |
2017-02-02 |
Курна, Инк. |
Лечение заболеваний, связанных с фактором роста гепатоцитов (фрг), посредством ингибирования природного антисмыслового транскрипта к фрг
|
KR101838305B1
(ko)
|
2009-12-29 |
2018-03-13 |
큐알엔에이, 인크. |
NRF1(Nuclear Respiratory Factor 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료
|
CN102770540B
(zh)
|
2009-12-29 |
2017-06-23 |
库尔纳公司 |
通过抑制肿瘤蛋白63(p63)的天然反义转录物而治疗p63相关疾病
|
US20120289583A1
(en)
|
2009-12-31 |
2012-11-15 |
Curna, Inc. |
Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
|
CN102906264B
(zh)
|
2010-01-04 |
2017-08-04 |
库尔纳公司 |
通过抑制干扰素调节因子8(irf8)的天然反义转录物而治疗irf8相关疾病
|
WO2011085066A2
(en)
|
2010-01-06 |
2011-07-14 |
Curna, Inc. |
Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
|
WO2011085271A2
(en)
|
2010-01-08 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Modulation of angiopoietin-like 3 expression
|
US9200277B2
(en)
|
2010-01-11 |
2015-12-01 |
Curna, Inc. |
Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG
|
WO2011085102A1
(en)
|
2010-01-11 |
2011-07-14 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011088148A1
(en)
*
|
2010-01-12 |
2011-07-21 |
Isis Pharmaceuticals, Inc. |
Modulation of transforming growth factor-beta 1 expression
|
ES2671877T3
(es)
|
2010-01-25 |
2018-06-11 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la RNASA (H1) mediante inhibición del transcrito antisentido natural a RNASA H1
|
JP6018506B2
(ja)
|
2010-02-08 |
2016-11-02 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
対立遺伝子多様体の選択的低減
|
CA2789005A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
KR101838308B1
(ko)
|
2010-02-22 |
2018-03-13 |
큐알엔에이, 인크. |
피롤린-5-카르복실레이트 환원효소 1(pycr1)에 대한 천연 안티센스 전사체의 억제에 의한 pycr1과 관련된 질환의 치료
|
WO2011106689A1
(en)
*
|
2010-02-26 |
2011-09-01 |
Isis Pharmaceuticals, Inc. |
Modulation of smad3 expression
|
WO2011115817A1
(en)
|
2010-03-16 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
Methods of preparing 2'-o-substituted purine nucleosides
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
RU2612884C2
(ru)
|
2010-04-02 |
2017-03-13 |
Курна, Инк. |
Лечение заболеваний, связанных с колониестимулирующим фактором 3 (csf3), путем ингибирования природного антисмыслового транскрипта k csf3
|
EP2555778A4
(en)
|
2010-04-06 |
2014-05-21 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR INHIBITING CD274 / PD-L1 GENE EXPRESSION
|
KR101900962B1
(ko)
|
2010-04-09 |
2018-09-20 |
큐알엔에이, 인크. |
섬유아세포 성장 인자 21 (fgf21)에 대한 자연 안티센스 전사체의 저해에 의한 섬유아세포 성장 인자 21 (fgf21) 관련된 질환의 치료
|
US9127033B2
(en)
|
2010-04-28 |
2015-09-08 |
Isis Pharmaceuticals, Inc. |
5′ modified nucleosides and oligomeric compounds prepared therefrom
|
WO2011139695A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Modified 5' diphosphate nucleosides and oligomeric compounds prepared therefrom
|
US8993738B2
(en)
|
2010-04-28 |
2015-03-31 |
Isis Pharmaceuticals, Inc. |
Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
|
PT2563920T
(pt)
|
2010-04-29 |
2017-05-26 |
Ionis Pharmaceuticals Inc |
Modulação da expressão de transtirretina
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
US9089588B2
(en)
|
2010-05-03 |
2015-07-28 |
Curna, Inc. |
Treatment of sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a sirtuin (SIRT)
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
RU2620978C2
(ru)
|
2010-05-26 |
2017-05-30 |
Курна, Инк. |
Лечение заболеваний, связанных с метионинсульфоксидредуктазой а (msra), путем ингибирования природного антисмыслового транскрипта гена msra
|
DK2576783T3
(en)
|
2010-05-26 |
2018-03-12 |
Curna Inc |
TREATMENT OF ATONAL HOMOLOGY 1- (ATOH1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS AT ATOH1
|
CA3102008A1
(en)
|
2010-06-02 |
2011-12-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
EP2582397A4
(en)
|
2010-06-15 |
2014-10-29 |
Isis Pharmaceuticals Inc |
COMPOUNDS AND METHODS FOR MODULATING THE INTERACTION BETWEEN PROTEINS AND TARGET NUCLEIC ACIDS
|
PL2585596T3
(pl)
|
2010-06-23 |
2021-06-28 |
Curna, Inc. |
Leczenie chorób związanych z podjednostką alfa kanału sodowego bramkowanego napięciem (SCNA) poprzez hamowanie naturalnego transkryptu antysensownego SCNA
|
WO2012007477A1
(en)
|
2010-07-12 |
2012-01-19 |
Santaris Pharma A/S |
Anti hcv oligomers
|
EP2593547B1
(en)
|
2010-07-14 |
2017-11-15 |
CuRNA, Inc. |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
CN106434648A
(zh)
|
2010-07-19 |
2017-02-22 |
F·C·贝内特 |
肌强直性营养障碍蛋白激酶(dmpk)表达的调节
|
EP2601611B1
(en)
|
2010-08-02 |
2020-12-09 |
Integrated Dna Technologies, Inc. |
Methods for predicting stability and melting temperatures of nucleic acid duplexes
|
WO2012034942A1
(en)
|
2010-09-13 |
2012-03-22 |
Santaris Pharma A/S |
Compounds for the modulation of aurora kinase b expression
|
DK2620428T3
(da)
|
2010-09-24 |
2019-07-01 |
Wave Life Sciences Ltd |
Asymmetrisk hjælpegruppe
|
US8993533B2
(en)
|
2010-10-06 |
2015-03-31 |
Curna, Inc. |
Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
|
US8648053B2
(en)
|
2010-10-20 |
2014-02-11 |
Rosalind Franklin University Of Medicine And Science |
Antisense oligonucleotides that target a cryptic splice site in Ush1c as a therapeutic for Usher syndrome
|
CA2815212A1
(en)
|
2010-10-22 |
2012-04-26 |
Curna, Inc. |
Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
|
US9150864B2
(en)
|
2010-11-08 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
JP6126009B2
(ja)
|
2010-11-17 |
2017-05-10 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
α−シヌクレイン発現の調節
|
WO2012068340A2
(en)
|
2010-11-18 |
2012-05-24 |
Opko Curna Llc |
Antagonat compositions and methods of use
|
WO2012066093A1
(en)
|
2010-11-19 |
2012-05-24 |
Santaris Pharma A/S |
Compounds for the modulation of pdz-binding kinase (pbk) expression
|
WO2012066092A1
(en)
|
2010-11-19 |
2012-05-24 |
Santaris Pharma A/S |
Compounds for the modulation of aurora kinase a expression
|
KR102010598B1
(ko)
|
2010-11-23 |
2019-08-13 |
큐알엔에이, 인크. |
Nanog에 대한 자연 안티센스 전사체의 저해에 의한 nanog 관련된 질환의 치료
|
WO2012079046A2
(en)
|
2010-12-10 |
2012-06-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of klf-1 and bcl11a genes
|
US9193973B2
(en)
|
2010-12-10 |
2015-11-24 |
Alynylam Pharmaceuticals, Inc. |
Compositions and methods for increasing erythropoietin (EPO) production
|
BR112013019803A2
(pt)
|
2011-02-02 |
2019-06-11 |
Excaliard Pharmaceuticals Inc |
método de tratar quelóides ou cicatrizes hipertróficas usando os compostos anti-sentido objetivando fator de desenvolvimento de tecido conjuntivo (ctgf)
|
EP3067421B1
(en)
*
|
2011-02-08 |
2018-10-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
WO2012110457A2
(en)
|
2011-02-14 |
2012-08-23 |
Santaris Pharma A/S |
Compounds for the modulation of osteopontin expression
|
KR102104401B1
(ko)
|
2011-03-29 |
2020-04-27 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 유전자의 발현을 억제하기 위한 조성물 및 방법
|
CN107012144A
(zh)
|
2011-04-01 |
2017-08-04 |
Ionis制药公司 |
信号转导及转录激活蛋白3(stat3)表达的调节
|
JP5951752B2
(ja)
|
2011-04-13 |
2016-07-13 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Ptp1b発現のアンチセンス調節
|
WO2012143427A1
(en)
|
2011-04-19 |
2012-10-26 |
Santaris Pharma A/S |
Anti polyomavirus compounds
|
SI3505528T1
(sl)
|
2011-04-21 |
2021-04-30 |
Glaxo Group Limited |
Modulacija izražanja virusa hepatitisa B (HBV)
|
UA115652C2
(uk)
|
2011-04-25 |
2017-12-11 |
Реґюлус Терап'Ютікс Інк. |
Сполука, що містить модифікований олігонуклеотид, комплементарна mir-21
|
KR20190062511A
(ko)
|
2011-04-27 |
2019-06-05 |
아이오니스 파마수티컬즈, 인코포레이티드 |
아포지방단백질 ciii (apociii) 발현의 조정
|
WO2012151324A1
(en)
|
2011-05-02 |
2012-11-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
JP6188686B2
(ja)
|
2011-06-09 |
2017-08-30 |
カッパーアールエヌエー,インコーポレイテッド |
フラタキシン(fxn)への天然アンチセンス転写物の阻害によるfxn関連疾患の治療
|
EP3320922A1
(en)
|
2011-06-10 |
2018-05-16 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (klkb1) expression
|
WO2012170947A2
(en)
|
2011-06-10 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Methods for modulating factor 12 expression
|
EP2721156B1
(en)
|
2011-06-16 |
2016-12-21 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
EP2723758B1
(en)
|
2011-06-21 |
2018-06-20 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof
|
US20140127159A1
(en)
|
2011-06-23 |
2014-05-08 |
Stella Aps |
HCV Combination Therapy
|
WO2012178033A2
(en)
|
2011-06-23 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
AU2012275096B2
(en)
|
2011-06-29 |
2016-02-04 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating kallikrein (KLKB1) expression
|
US20140113958A1
(en)
|
2011-06-30 |
2014-04-24 |
Stella Aps |
HCV Combination Therapy
|
EP2726611A1
(en)
|
2011-06-30 |
2014-05-07 |
Stella ApS |
Hcv combination therapy
|
DK2734208T3
(en)
|
2011-07-19 |
2017-06-19 |
Wave Life Sciences Ltd |
PROCEDURES FOR SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS
|
EP2739735A2
(en)
|
2011-08-01 |
2014-06-11 |
Alnylam Pharmaceuticals, Inc. |
Method for improving the success rate of hematopoietic stem cell transplants
|
WO2013022966A1
(en)
|
2011-08-11 |
2013-02-14 |
Isis Pharmaceuticals, Inc. |
Linkage modified gapped oligomeric compounds and uses thereof
|
DK2751270T3
(en)
|
2011-08-29 |
2018-10-29 |
Ionis Pharmaceuticals Inc |
OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE
|
EP2751269B1
(en)
|
2011-08-29 |
2016-03-23 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
EA029151B1
(ru)
|
2011-09-06 |
2018-02-28 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С АЛЬФА-СУБЪЕДИНИЦАМИ ПОТЕНЦИАЛЗАВИСИМЫХ НАТРИЕВЫХ КАНАЛОВ (SCNxA), С ПОМОЩЬЮ МАЛЫХ МОЛЕКУЛ
|
JP6129844B2
(ja)
|
2011-09-14 |
2017-05-17 |
ラナ セラピューティクス インコーポレイテッド |
多量体オリゴヌクレオチド化合物
|
CA2849273C
(en)
|
2011-09-20 |
2020-07-21 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of gcgr expression
|
AU2012328680A1
(en)
|
2011-10-25 |
2014-05-01 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of GCCR expression
|
WO2013067050A1
(en)
|
2011-10-31 |
2013-05-10 |
University Of Utah Research Foundation |
Genetic alterations in glioblastoma
|
EP2776564B1
(en)
|
2011-11-07 |
2019-10-02 |
Ionis Pharmaceuticals, Inc. |
Modulation of tmprss6 expression
|
AU2012334214A1
(en)
|
2011-11-07 |
2014-05-22 |
Roche Innovation Center Copenhagen A/S |
Prognostic method for checking efficacy of micro RNA-122 inhibitors in HCV+ patients
|
WO2013068348A1
(en)
|
2011-11-07 |
2013-05-16 |
Santaris Pharma A/S |
Lna oligomers for improvement in hepatic function
|
CA2855241A1
(en)
|
2011-11-11 |
2013-05-16 |
Santaris Pharma A/S |
Compounds for the modulation of smn2 splicing
|
US9243291B1
(en)
|
2011-12-01 |
2016-01-26 |
Isis Pharmaceuticals, Inc. |
Methods of predicting toxicity
|
DK2790736T3
(en)
|
2011-12-12 |
2018-05-07 |
Oncoimmunin Inc |
In vivo delivery of oligonucleotides
|
DK2791160T3
(da)
|
2011-12-16 |
2022-05-30 |
Modernatx Inc |
Modificerede mrna-sammensætninger
|
JP6280045B2
(ja)
|
2011-12-22 |
2018-02-14 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
肺腺癌内転移関連性転写物1(metastasis−associated−in−lung−adenocarcinoma−transcript−1:malat−1)の発現調節法
|
ES2842938T3
(es)
|
2012-01-11 |
2021-07-15 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para la modulación del empalme de IKBKAP
|
US9737480B2
(en)
|
2012-02-06 |
2017-08-22 |
President And Fellows Of Harvard College |
ARRDC1-mediated microvesicles (ARMMs) and uses thereof
|
WO2013120003A1
(en)
|
2012-02-08 |
2013-08-15 |
Isis Pharmaceuticals, Inc. |
Modulation of rna by repeat targeting
|
DK2825648T3
(en)
|
2012-03-15 |
2018-10-15 |
Curna Inc |
TREATMENT OF BRAIN-DERIVATIVE NEUROTROPHIC FACTOR (BDNF) -related DISEASES BY INHIBITATION OF NATURAL ANTISENCE TRANSCRIPTION TO BDNF
|
US9340784B2
(en)
|
2012-03-19 |
2016-05-17 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating alpha-1-antitrypsin expression
|
AU2013202595B2
(en)
|
2012-03-30 |
2016-04-21 |
Biogen Ma Inc. |
Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome
|
CA2868391A1
(en)
|
2012-04-02 |
2013-10-10 |
Stephane Bancel |
Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
|
DE18200782T1
(de)
|
2012-04-02 |
2021-10-21 |
Modernatx, Inc. |
Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
WO2013154798A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
EP3336189A1
(en)
|
2012-04-20 |
2018-06-20 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
AU2013251696B2
(en)
|
2012-04-25 |
2018-11-15 |
Sanofi |
MicroRNA compounds and methods for modulating miR-21 activity
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
CA2873794A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating smn gene family expression
|
CA2873809A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics, Inc. |
Compositions and methods for modulating gene expression
|
US9574193B2
(en)
|
2012-05-17 |
2017-02-21 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for modulating apolipoprotein (a) expression
|
US20160002624A1
(en)
|
2012-05-17 |
2016-01-07 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide compositions
|
WO2013177248A2
(en)
|
2012-05-22 |
2013-11-28 |
Isis Pharmaceuticals, Inc. |
Modulation of enhancer rna mediated gene expression
|
RU2748495C2
(ru)
|
2012-05-24 |
2021-05-26 |
Ионис Фармасьютикалз, Инк. |
Способы и композиции для модулирования экспрессии аполипопротеина (а)
|
US9828602B2
(en)
|
2012-06-01 |
2017-11-28 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
US9487780B2
(en)
|
2012-06-01 |
2016-11-08 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with fibronectin
|
ES2688831T3
(es)
|
2012-06-25 |
2018-11-07 |
Ionis Pharmaceuticals, Inc. |
Modulación de la expresión de UBE3A-ATS
|
EP2872485B1
(en)
|
2012-07-13 |
2020-12-16 |
Wave Life Sciences Ltd. |
Asymmetric auxiliary group
|
CN104684923B
(zh)
|
2012-07-13 |
2018-09-28 |
株式会社新日本科学 |
手性核酸佐剂
|
RU2015104762A
(ru)
|
2012-07-13 |
2018-08-31 |
Уэйв Лайф Сайенсес Лтд. |
Хиральный контроль
|
WO2014018930A1
(en)
|
2012-07-27 |
2014-01-30 |
Isis Pharmaceuticals. Inc. |
Modulation of renin-angiotensin system (ras) related diseases by angiotensinogen
|
EP2885312A4
(en)
|
2012-08-15 |
2016-01-20 |
Isis Pharmaceuticals Inc |
PROCESS FOR THE PREPARATION OF OLIGOMERIC COMPOUNDS USING MODIFIED STREAMING PROTOCOLS
|
WO2014059364A1
(en)
|
2012-10-11 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Methods of treating kennedy's disease
|
US9695418B2
(en)
|
2012-10-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleosides and uses thereof
|
US9175291B2
(en)
|
2012-10-11 |
2015-11-03 |
Isis Pharmaceuticals Inc. |
Modulation of androgen receptor expression
|
WO2014059356A2
(en)
|
2012-10-12 |
2014-04-17 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
EP2906255B1
(en)
|
2012-10-12 |
2023-02-22 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
EP2906697A4
(en)
|
2012-10-15 |
2016-06-22 |
Ionis Pharmaceuticals Inc |
METHODS OF MONITORING C9ORF72 EXPRESSION
|
EP2906258A4
(en)
|
2012-10-15 |
2016-08-10 |
Ionis Pharmaceuticals Inc |
COMPOSITIONS FOR MODULATING THE EXPRESSION OF C90RF72
|
EP2906696B2
(en)
|
2012-10-15 |
2022-12-14 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating c9orf72 expression
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
US10723754B2
(en)
|
2012-10-22 |
2020-07-28 |
Idenix Pharmaceuticals Llc |
2′,4′-bridged nucleosides for HCV infection
|
EP2920308B1
(en)
|
2012-10-31 |
2018-12-12 |
Ionis Pharmaceuticals, Inc. |
Cancer treatment
|
WO2014071358A2
(en)
|
2012-11-05 |
2014-05-08 |
Foundation Medicine, Inc. |
Novel ntrk1 fusion molecules and uses thereof
|
EP2920304B1
(en)
|
2012-11-15 |
2019-03-06 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugates
|
RU2015120645A
(ru)
|
2012-11-26 |
2017-01-10 |
Рош Инновейшен Сентер Копенгаген А/С |
Композиции и способы модуляции экспрессии рецептора фактора роста фибробластов 3 типа (fgfr3)
|
HRP20220607T1
(hr)
|
2012-11-26 |
2022-06-24 |
Modernatx, Inc. |
Terminalno modificirana rna
|
US9695475B2
(en)
|
2012-12-11 |
2017-07-04 |
Ionis Pharmaceuticals, Inc. |
Competitive modulation of microRNAs
|
JPWO2014112463A1
(ja)
*
|
2013-01-15 |
2017-01-19 |
国立大学法人大阪大学 |
スルホンアミド構造を有するヌクレオシドおよびヌクレオチド
|
WO2014113089A2
(en)
|
2013-01-17 |
2014-07-24 |
Moderna Therapeutics, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
EP3939614A1
(en)
|
2013-01-18 |
2022-01-19 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
EP2951305B1
(en)
|
2013-01-30 |
2018-08-15 |
F.Hoffmann-La Roche Ag |
Lna oligonucleotide carbohydrate conjugates
|
US9701708B2
(en)
|
2013-01-31 |
2017-07-11 |
Ionis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified coupling protocols
|
WO2014121287A2
(en)
|
2013-02-04 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
KR20200123263A
(ko)
|
2013-02-14 |
2020-10-28 |
아이오니스 파마수티컬즈, 인코포레이티드 |
지질단백질 리파제 결핍 (lpld) 모집단에서 아포지질단백질 c-iii (apociii) 발현의 조절
|
US20150366890A1
(en)
|
2013-02-25 |
2015-12-24 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
WO2014143158A1
(en)
|
2013-03-13 |
2014-09-18 |
The Broad Institute, Inc. |
Compositions and methods for labeling of agents
|
US20160024181A1
(en)
|
2013-03-13 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
EA201591707A1
(ru)
|
2013-03-14 |
2016-03-31 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ иРНК КОМПОНЕНТА КОМПЛЕМЕНТА C5 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
US9273349B2
(en)
|
2013-03-14 |
2016-03-01 |
Affymetrix, Inc. |
Detection of nucleic acids
|
US9644207B2
(en)
|
2013-03-14 |
2017-05-09 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Tau expression
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
CN105283466A
(zh)
|
2013-03-14 |
2016-01-27 |
安第斯生物技术股份有限公司 |
用于检测和治疗多发性骨髓瘤的方法
|
HUE042738T2
(hu)
|
2013-03-14 |
2019-07-29 |
Andes Biotechnologies Global Inc |
Antiszensz oligonukleotidok rákos õssejtek kezelésére
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
WO2014172698A1
(en)
|
2013-04-19 |
2014-10-23 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation nucleic acids through nonsense mediated decay
|
EP2992098B1
(en)
|
2013-05-01 |
2019-03-27 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating hbv and ttr expression
|
AU2014259954B2
(en)
|
2013-05-01 |
2019-11-07 |
Regulus Therapeutics Inc. |
MicroRNA compounds and methods for modulating miR-122
|
CN105164261B
(zh)
|
2013-05-01 |
2022-03-18 |
莱古路斯治疗法股份有限公司 |
用于增强的细胞摄取的化合物和方法
|
KR102486617B1
(ko)
|
2013-05-22 |
2023-01-12 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 조성물 및 이의 사용 방법
|
PT2999785T
(pt)
|
2013-05-22 |
2018-07-09 |
Alnylam Pharmaceuticals Inc |
Composições de irna de serpina1 e métodos de uso das mesmas
|
EP3004352B1
(en)
|
2013-05-24 |
2017-09-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide modulators of b-cell cll/lymphoma 11a (bcl11a) and uses thereof
|
WO2014197835A2
(en)
|
2013-06-06 |
2014-12-11 |
The General Hospital Corporation |
Methods and compositions for the treatment of cancer
|
WO2014205449A2
(en)
|
2013-06-21 |
2014-12-24 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile
|
EP3730619A1
(en)
|
2013-06-21 |
2020-10-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
SG10201908122XA
(en)
|
2013-06-27 |
2019-10-30 |
Roche Innovation Ct Copenhagen As |
Antisense oligomers and conjugates targeting pcsk9
|
MX2015017863A
(es)
|
2013-07-02 |
2016-11-30 |
Ionis Pharmaceuticals Inc |
Moduladores de receptor de hormona de crecimiento.
|
PL3019619T3
(pl)
|
2013-07-11 |
2022-01-10 |
Modernatx, Inc. |
Kompozycje zawierające syntetyczne polinkleotydy kodujące białka powiązane z crispr i syntetyczne sgrna oraz sposoby ich stosowania
|
JP6617702B2
(ja)
|
2013-07-15 |
2019-12-11 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
Fty720のアザサイクリック拘束アナログ
|
TWI657819B
(zh)
|
2013-07-19 |
2019-05-01 |
美商Ionis製藥公司 |
用於調節τ蛋白表現之組合物
|
US10435430B2
(en)
|
2013-07-31 |
2019-10-08 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
HUE048710T2
(hu)
|
2013-08-08 |
2020-08-28 |
Scripps Research Inst |
Eljárás nukleinsavak in vitro helyspecifikus enzimes jelölésére nem-természetes nukleotidok beépítésével
|
TW201536329A
(zh)
|
2013-08-09 |
2015-10-01 |
Isis Pharmaceuticals Inc |
用於調節失養性肌強直蛋白質激酶(dmpk)表現之化合物及方法
|
WO2015031679A2
(en)
|
2013-08-28 |
2015-03-05 |
Isis Pharmaceuticals, Inc. |
Modulation of prekallikrein (pkk) expression
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
JP2016530294A
(ja)
|
2013-09-03 |
2016-09-29 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
キメラポリヌクレオチド
|
CN105744959B
(zh)
|
2013-09-13 |
2020-12-01 |
Ionis制药公司 |
补体因子b的调节剂
|
US9943604B2
(en)
|
2013-09-20 |
2018-04-17 |
Ionis Pharmaceuticals, Inc. |
Targeted therapeutic nucleosides and their use
|
EP3052626A1
(en)
|
2013-10-02 |
2016-08-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
EP3052521A1
(en)
|
2013-10-03 |
2016-08-10 |
Moderna Therapeutics, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
KR20220159478A
(ko)
|
2013-10-04 |
2022-12-02 |
알닐람 파마슈티칼스 인코포레이티드 |
Alas1 유전자의 발현을 억제하기 위한 조성물 및 방법
|
WO2015054676A2
(en)
|
2013-10-11 |
2015-04-16 |
Isis Pharmaceuticals, Inc. |
Compositions for modulating c9orf72 expression
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
WO2015061246A1
(en)
|
2013-10-21 |
2015-04-30 |
Isis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
EP3060680B1
(en)
|
2013-10-21 |
2019-02-27 |
The General Hospital Corporation |
Methods relating to circulating tumor cell clusters and the treatment of cancer
|
EP3060664B1
(en)
|
2013-10-25 |
2021-07-07 |
Sanofi |
Microrna compounds and methods for modulating mir-21 activity
|
WO2015070173A1
(en)
|
2013-11-08 |
2015-05-14 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for detecting oligonucleotides
|
WO2015084884A2
(en)
|
2013-12-02 |
2015-06-11 |
Isis Pharmaceuticals, Inc. |
Antisense compounds and uses thereof
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
WO2015089368A2
(en)
|
2013-12-12 |
2015-06-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component irna compositions and methods of use thereof
|
CN111729090A
(zh)
|
2013-12-20 |
2020-10-02 |
通用医疗公司 |
与循环肿瘤细胞相关的方法和测定法
|
CA2931510A1
(en)
|
2013-12-24 |
2015-07-02 |
Ionis Pharmaceuticals, Inc. |
Modulation of angiopoietin-like 3 expression
|
WO2015108048A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
JPWO2015108047A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
|
US10322173B2
(en)
|
2014-01-15 |
2019-06-18 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
|
PT3094728T
(pt)
|
2014-01-16 |
2022-05-19 |
Wave Life Sciences Ltd |
Desenho quiral
|
JP6594902B2
(ja)
|
2014-02-11 |
2019-10-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ケトヘキソキナーゼ(KHK)iRNA組成物及びその使用方法
|
EP3119789B1
(en)
|
2014-03-17 |
2020-04-22 |
Ionis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
EP3978610A3
(en)
|
2014-03-19 |
2022-08-24 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating ataxin 2 expression
|
US10006027B2
(en)
|
2014-03-19 |
2018-06-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating Ataxin 2 expression
|
JP6622214B2
(ja)
|
2014-04-01 |
2019-12-18 |
バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. |
Sod−1発現を調節するための組成物
|
EP3129493B1
(en)
|
2014-04-09 |
2021-07-07 |
The Scripps Research Institute |
Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters
|
WO2015161170A2
(en)
|
2014-04-17 |
2015-10-22 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulation of smn2 splicing in a subject
|
US10221416B2
(en)
|
2014-04-24 |
2019-03-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
DK3137476T3
(da)
|
2014-04-28 |
2019-11-18 |
Ionis Pharmaceuticals Inc |
Linker-modificerede oligomerforbindelser
|
EP4223315A3
(en)
|
2014-05-01 |
2023-08-23 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
JP6667453B2
(ja)
|
2014-05-01 |
2020-03-18 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
成長ホルモン受容体発現を調節するための組成物及び方法
|
KR102369736B1
(ko)
|
2014-05-01 |
2022-03-02 |
아이오니스 파마수티컬즈, 인코포레이티드 |
보체 인자 b 발현을 조절하기 위한 조성물 및 방법
|
BR122020024443B1
(pt)
|
2014-05-01 |
2022-02-22 |
Ionis Pharmaceuticals, Inc |
Composto e composição farmacêutica para modulação da expressão de angptl3
|
DK3137091T3
(da)
|
2014-05-01 |
2021-01-25 |
Ionis Pharmaceuticals Inc |
Konjugater af modificerede antisense-oligonukleotider og anvendelse deraf til modulation af pkk-ekspression
|
WO2015175510A1
(en)
|
2014-05-12 |
2015-11-19 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating a serpinc1-associated disorder
|
GB201408623D0
(en)
|
2014-05-15 |
2014-07-02 |
Santaris Pharma As |
Oligomers and oligomer conjugates
|
AU2015264038B2
(en)
|
2014-05-22 |
2021-02-11 |
Alnylam Pharmaceuticals, Inc. |
Angiotensinogen (AGT) iRNA compositions and methods of use thereof
|
WO2015179693A1
(en)
|
2014-05-22 |
2015-11-26 |
Isis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
MX2016015569A
(es)
|
2014-06-02 |
2017-04-25 |
Children´S Medical Center Corp |
Metodos y composiciones para inmunomodulacion.
|
USD766120S1
(en)
|
2014-06-09 |
2016-09-13 |
Gambro Lundia Ab |
Status light bar
|
GB201410693D0
(en)
|
2014-06-16 |
2014-07-30 |
Univ Southampton |
Splicing modulation
|
CA2955250A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
US20170210788A1
(en)
|
2014-07-23 |
2017-07-27 |
Modernatx, Inc. |
Modified polynucleotides for the production of intrabodies
|
US9487783B2
(en)
|
2014-08-07 |
2016-11-08 |
Regulus Therapeutics Inc. |
Targeting microRNAs for metabolic disorders
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
EP4043567B1
(en)
|
2014-08-29 |
2024-05-08 |
The Children's Medical Center Corporation |
Methods and compositions for the treatment of cancer
|
BR112017004056A2
(pt)
|
2014-09-12 |
2017-12-05 |
Biogen Ma Inc |
composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
CN107109411B
(zh)
|
2014-10-03 |
2022-07-01 |
冷泉港实验室 |
核基因输出的定向增加
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
WO2016055601A1
(en)
|
2014-10-10 |
2016-04-14 |
F. Hoffmann-La Roche Ag |
Galnac phosphoramidites, nucleic acid conjugates thereof and their use
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
WO2016069694A2
(en)
|
2014-10-30 |
2016-05-06 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
US9816080B2
(en)
|
2014-10-31 |
2017-11-14 |
President And Fellows Of Harvard College |
Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
US10287584B2
(en)
|
2014-11-12 |
2019-05-14 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of COMP
|
US10364433B2
(en)
|
2014-11-14 |
2019-07-30 |
The Regents Of The University Of California |
Modulation of AGPAT5 expression
|
EP3020813A1
(en)
|
2014-11-16 |
2016-05-18 |
Neurovision Pharma GmbH |
Antisense-oligonucleotides as inhibitors of TGF-R signaling
|
JP2017535552A
(ja)
|
2014-11-17 |
2017-11-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
アポリポタンパク質C3(APOC3)iRNA組成物およびその使用方法
|
WO2016086104A1
(en)
|
2014-11-25 |
2016-06-02 |
Ionis Pharmaceuticals, Inc. |
Modulation of ube3a-ats expression
|
CA2970177C
(en)
|
2014-12-08 |
2023-09-19 |
The Board Of Regents Of The University Of Texas System |
Lipocationic polymers and uses thereof
|
WO2016096938A1
(en)
|
2014-12-16 |
2016-06-23 |
Roche Innovation Center Copenhagen A/S |
Chiral toxicity screening method
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
CN107636159B
(zh)
|
2015-02-04 |
2022-06-14 |
百时美施贵宝公司 |
选择治疗性分子的方法
|
BR112017016663A2
(pt)
|
2015-02-04 |
2018-04-10 |
Hoffmann La Roche |
oligômero, conjugado, composição, kit, e, métodos para inibir ou reduzir a expressão de proteína tau em uma célula e para tratar ou prevenir um distúrbio neurológico
|
AU2016219263B2
(en)
|
2015-02-13 |
2022-12-01 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
|
EP3256591A4
(en)
|
2015-02-13 |
2018-08-08 |
Translate Bio Ma, Inc. |
Hybrid oligonucleotides and uses thereof
|
ES2848377T3
(es)
|
2015-02-26 |
2021-08-09 |
Ionis Pharmaceuticals Inc |
Moduladores específicos de alelo de RODOPSINA P23H
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
EP3265564B1
(en)
|
2015-03-03 |
2022-01-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating mecp2 expression
|
EP3265098A4
(en)
|
2015-03-03 |
2019-02-13 |
Ionis Pharmaceuticals, Inc. |
COMPOSITIONS FOR MODULATING MECP2 EXPRESSION
|
US10376535B2
(en)
|
2015-03-26 |
2019-08-13 |
University Of Rochester |
Therapy for malignant disease
|
US10415038B2
(en)
|
2015-04-03 |
2019-09-17 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating TMPRSS6 expression
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
SG11201708468YA
(en)
|
2015-04-16 |
2017-11-29 |
Ionis Pharmaceuticals Inc |
Compositions for modulating c9orf72 expression
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
US20180188257A1
(en)
|
2015-06-19 |
2018-07-05 |
University Of Rochester |
Septin proteins as novel biomarkers for detection and treatment of müllerian cancers
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
JP2018519811A
(ja)
|
2015-06-29 |
2018-07-26 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
修飾crispr rna及び修飾単一crispr rnaならびにその使用
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
MY192997A
(en)
|
2015-07-10 |
2022-09-20 |
Ionis Pharmaceuticals Inc |
Modulators of diacyglycerol acyltransferase 2 (dgat2)
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
US20180201937A1
(en)
|
2015-08-04 |
2018-07-19 |
The University Of Chicago |
Inhibitors of cacna1a/alpha1a subunit internal ribosomal entry site (ires) and methods of treating spinocerebellar ataxia type 6
|
KR20180043819A
(ko)
|
2015-08-24 |
2018-04-30 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
Lna-g 방법
|
KR20180051550A
(ko)
|
2015-09-02 |
2018-05-16 |
알닐람 파마슈티칼스 인코포레이티드 |
프로그램된 세포사 1 리간드 1 (PD-L1) iRNA 조성물 및 그의 사용 방법
|
EP3950003A1
(en)
|
2015-09-14 |
2022-02-09 |
The Board of Regents of the University of Texas System |
Lipocationic dendrimers and uses thereof
|
SG10201913209WA
(en)
|
2015-09-24 |
2020-02-27 |
Ionis Pharmaceuticals Inc |
Modulators of kras expression
|
CA2999177A1
(en)
|
2015-09-24 |
2017-03-30 |
The Regents Of The University Of California |
Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment
|
EP4285912A3
(en)
|
2015-09-25 |
2024-07-10 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating ataxin 3 expression
|
CA2998898A1
(en)
|
2015-10-08 |
2017-04-13 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
IL308174A
(en)
|
2015-10-09 |
2024-01-01 |
Univ Southampton |
Gene expression modulation and dysregulated protein expression scanning
|
CN108368543B
(zh)
|
2015-10-12 |
2023-06-13 |
领先细胞医疗诊断有限公司 |
高噪声样品中原位检测核苷酸变体及相关的组合物和方法
|
EP3394258B1
(en)
|
2015-10-22 |
2021-09-22 |
Roche Innovation Center Copenhagen A/S |
In vitro toxicity screening assay
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
WO2017079291A1
(en)
|
2015-11-02 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating c90rf72
|
WO2017079745A1
(en)
|
2015-11-06 |
2017-05-11 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds for use in therapy
|
BR122023026882A2
(pt)
|
2015-11-06 |
2024-01-23 |
Ionis Pharmaceuticals, Inc |
Uso de um composto oligomérico
|
EP3374498A1
(en)
|
2015-11-12 |
2018-09-19 |
H. Hoffnabb-La Roche Ag |
Standardized neuronal cell assays from primate species
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
IL259795B2
(en)
|
2015-12-07 |
2024-04-01 |
Genzyme Corp |
Methods and preparations for the treatment of diseases related to SERPINC1
|
EP3390636B1
(en)
|
2015-12-14 |
2021-05-19 |
Cold Spring Harbor Laboratory |
Antisense oligomers for treatment of dravet syndrome
|
US11096956B2
(en)
|
2015-12-14 |
2021-08-24 |
Stoke Therapeutics, Inc. |
Antisense oligomers and uses thereof
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
JPWO2017111137A1
(ja)
*
|
2015-12-22 |
2018-10-18 |
味の素株式会社 |
オリゴヌクレオチドの製造方法
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
WO2017147483A1
(en)
|
2016-02-26 |
2017-08-31 |
The Board Of Trustees Of The Leland Stanford Junior University |
Multiplexed single molecule rna visualization with a two-probe proximity ligation system
|
CA3016592A1
(en)
|
2016-03-04 |
2017-09-08 |
Rhode Island Hospital |
Targeting microrna for cancer treatment
|
AU2017229778A1
(en)
|
2016-03-09 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods and compositions for inhibiting PMP22 expression
|
RS61528B1
(sr)
|
2016-03-14 |
2021-04-29 |
Hoffmann La Roche |
Oligonukleotidi za smanjenje ekspresije pd-l1
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
AU2017234678A1
(en)
|
2016-03-16 |
2018-08-16 |
Ionis Pharmaceuticals, Inc. |
Methods of modulating KEAP1
|
JP7017517B2
(ja)
|
2016-03-18 |
2022-02-08 |
ロシュ イノベーション センター コペンハーゲン エーエス |
アシル保護l-lna-グアノシンモノマー
|
CA3017532A1
(en)
|
2016-04-13 |
2017-10-19 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing c9orf72 expression
|
WO2017178656A1
(en)
|
2016-04-14 |
2017-10-19 |
Roche Innovation Center Copenhagen A/S |
TRITYL-MONO-GalNAc COMPOUNDS AND THEIR USE
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
BR112018072362A2
(pt)
|
2016-05-06 |
2019-02-19 |
Ionis Pharmaceuticals, Inc. |
oligonucleotídeos conjugados a uma unidade de ligando do receptor glp-1 e seus usos
|
DK3455232T3
(da)
|
2016-05-12 |
2020-07-06 |
Roche Innovation Ct Copenhagen As |
Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid
|
AU2017267634C1
(en)
|
2016-05-16 |
2022-05-26 |
The Board Of Regents Of The University Of Texas System |
Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
|
JP6876383B2
(ja)
*
|
2016-06-07 |
2021-05-26 |
富士通オプティカルコンポーネンツ株式会社 |
波長可変光源
|
EP3469083A1
(en)
|
2016-06-10 |
2019-04-17 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
MX2018015654A
(es)
|
2016-06-14 |
2019-06-10 |
Biogen Ma Inc |
Cromatografía de interacción hidrofóbica para la purificación de oligonucleótidos.
|
US11105794B2
(en)
|
2016-06-17 |
2021-08-31 |
Hoffmann-La Roche Inc. |
In vitro nephrotoxicity screening assay
|
MA45496A
(fr)
|
2016-06-17 |
2019-04-24 |
Hoffmann La Roche |
Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b
|
US11236339B2
(en)
|
2016-06-17 |
2022-02-01 |
Ionis Pharmaceuticals, Inc. |
Modulation of GYS1 expression
|
CN109312403B
(zh)
|
2016-06-17 |
2023-06-27 |
豪夫迈·罗氏有限公司 |
体外肾毒性筛选测定法
|
DK3475295T3
(da)
|
2016-06-24 |
2022-10-24 |
Scripps Research Inst |
Hidtil ukendt nukleosidtriphosphat-transportør og anvendelser deraf
|
CN109415732B
(zh)
|
2016-07-01 |
2024-01-02 |
豪夫迈·罗氏有限公司 |
用于调节htra1表达的反义寡核苷酸
|
US11098077B2
(en)
|
2016-07-05 |
2021-08-24 |
Chinook Therapeutics, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
AU2017296195A1
(en)
|
2016-07-11 |
2019-01-24 |
Translate Bio Ma, Inc. |
Nucleic acid conjugates and uses thereof
|
SG11201900238UA
(en)
|
2016-07-15 |
2019-02-27 |
Ionis Pharmaceuticals Inc |
Compounds and methods for modulation of smn2
|
JOP20190065A1
(ar)
|
2016-09-29 |
2019-03-28 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن tau
|
EP3518981A4
(en)
|
2016-10-03 |
2020-06-10 |
President and Fellows of Harvard College |
DELIVERING THERAPEUTIC RNAS VIA ARRDC1-MEDIATED MICROVESICLES
|
WO2018067900A1
(en)
|
2016-10-06 |
2018-04-12 |
Ionis Pharmaceuticals, Inc. |
Method of conjugating oligomeric compounds
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
EP3538671A1
(en)
|
2016-11-11 |
2019-09-18 |
Roche Innovation Center Copenhagen A/S |
Therapeutic oligonucleotides capture and detection
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
JP2019535839A
(ja)
|
2016-11-29 |
2019-12-12 |
ピュアテック ヘルス エルエルシー |
治療剤の送達のためのエクソソーム
|
WO2018102745A1
(en)
|
2016-12-02 |
2018-06-07 |
Cold Spring Harbor Laboratory |
Modulation of lnc05 expression
|
KR20230166146A
(ko)
|
2016-12-16 |
2023-12-06 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴(TTR) iRNA 조성물을 사용하여 TTR-관련 질병을 치료하거나 예방하는 방법
|
WO2018130582A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rel expression
|
WO2018130583A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb1 expression
|
WO2018130585A1
(en)
|
2017-01-13 |
2018-07-19 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating relb expression
|
US20200216845A1
(en)
|
2017-01-13 |
2020-07-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating rela expression
|
EP3568480A1
(en)
|
2017-01-13 |
2019-11-20 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides for modulating nfkb2 expression
|
WO2018165564A1
(en)
|
2017-03-09 |
2018-09-13 |
Ionis Pharmaceuticals, Inc. |
Morpholino modified oligomeric compounds
|
JOP20190215A1
(ar)
|
2017-03-24 |
2019-09-19 |
Ionis Pharmaceuticals Inc |
مُعدّلات التعبير الوراثي عن pcsk9
|
WO2018177825A1
(en)
|
2017-03-29 |
2018-10-04 |
Roche Innovation Center Copenhagen A/S |
Orthogonal protecting groups for the preparation of stereodefined phosphorothioate oligonucleotides
|
SG11201909572QA
(en)
|
2017-04-18 |
2019-11-28 |
Alnylam Pharmaceuticals Inc |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
US20190055564A1
(en)
|
2017-06-01 |
2019-02-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for modulating htra1 expression
|
US11401519B2
(en)
|
2017-06-07 |
2022-08-02 |
University Of Massachusetts |
Anti-ADAM33 oligonucleotides and related methods
|
WO2019002237A1
(en)
|
2017-06-28 |
2019-01-03 |
Roche Innovation Center Copenhagen A/S |
METHOD OF MULTIPLE COUPLING AND OXIDATION
|
US20200131555A1
(en)
|
2017-07-11 |
2020-04-30 |
Synthorx, Inc. |
Incorporation of unnatural nucleotides and methods thereof
|
CA3069868A1
(en)
|
2017-07-13 |
2019-01-17 |
Alnylam Pharmaceuticals Inc. |
Lactate dehydrogenase a (ldha) irna compositions and methods of use thereof
|
KR102687649B1
(ko)
|
2017-08-03 |
2024-07-26 |
신톡스, 인크. |
증식성 질환 및 감염성 질환의 치료를 위한 사이토카인 접합체
|
WO2019030313A2
(en)
|
2017-08-11 |
2019-02-14 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF UBE3C EXPRESSION
|
AU2018318231A1
(en)
|
2017-08-18 |
2020-02-13 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
WO2019038228A1
(en)
|
2017-08-22 |
2019-02-28 |
Roche Innovation Center Copenhagen A/S |
OLIGONUCLEOTIDES FOR MODULATION OF TOM1 EXPRESSION
|
GB2599884B
(en)
|
2017-08-25 |
2022-08-31 |
Stoke Therapeutics Inc |
Antisense oligomers for treatment of conditions and diseases
|
US10517889B2
(en)
|
2017-09-08 |
2019-12-31 |
Ionis Pharmaceuticals, Inc. |
Modulators of SMAD7 expression
|
CN111226114A
(zh)
|
2017-10-13 |
2020-06-02 |
罗氏创新中心哥本哈根有限公司 |
用部分立体限定的寡核苷酸子文库鉴定反义寡核苷酸改进的立体限定硫代磷酸酯寡核苷酸变体的方法
|
UA126931C2
(uk)
|
2017-10-16 |
2023-02-22 |
Ф. Хоффманн-Ля Рош Аг |
МОЛЕКУЛИ НУКЛЕЇНОВИХ КИСЛОТ ДЛЯ ЗМЕНШЕННЯ РІВНЯ мРНК PAPD5 І PAPD7 ДЛЯ ЛІКУВАННЯ ІНФЕКЦІЙНОГО ГЕПАТИТУ B
|
WO2019089922A1
(en)
|
2017-11-01 |
2019-05-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
US20200385719A1
(en)
|
2017-11-16 |
2020-12-10 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
WO2019115416A2
(en)
|
2017-12-11 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating fndc3b expression
|
WO2019115417A2
(en)
|
2017-12-12 |
2019-06-20 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating rb1 expression
|
US11725208B2
(en)
|
2017-12-14 |
2023-08-15 |
Ionis Pharmaceuticals, Inc. |
Conjugated antisense compounds and their use
|
US20200308588A1
(en)
|
2017-12-18 |
2020-10-01 |
Alnylam Pharmaceuticals, Inc. |
High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
|
EP3729095A1
(en)
|
2017-12-21 |
2020-10-28 |
F. Hoffmann-La Roche AG |
Companion diagnostic for htra1 rna antagonists
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
EP3728590A1
(en)
|
2017-12-22 |
2020-10-28 |
Roche Innovation Center Copenhagen A/S |
Novel thiophosphoramidites
|
JP7476102B2
(ja)
|
2017-12-22 |
2024-04-30 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ホスホロジチオアートヌクレオシド間結合を含むオリゴヌクレオチド
|
EP4092117A1
(en)
|
2017-12-22 |
2022-11-23 |
Roche Innovation Center Copenhagen A/S |
Gapmer oligonucleotides comprising a phosphorodithioate internucleoside linkage
|
EP3737758A1
(en)
|
2018-01-10 |
2020-11-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating pias4 expression
|
US20220119811A1
(en)
|
2018-01-12 |
2022-04-21 |
Roche Innovation Center Copenhagen A/S |
Alpha-synuclein antisense oligonucleotides and uses thereof
|
PE20211749A1
(es)
|
2018-01-12 |
2021-09-06 |
Bristol Myers Squibb Co |
Oligonucleotidos antisentido que actuan sobre alfa-sinucleina, y usos de estos
|
JP7455746B2
(ja)
|
2018-01-12 |
2024-03-26 |
ブリストル-マイヤーズ スクイブ カンパニー |
アルファ-シヌクレインを標的とするアンチセンスオリゴヌクレオチドおよびその使用
|
EP3737760A1
(en)
|
2018-01-12 |
2020-11-18 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating gsk3b expression
|
MX2020007369A
(es)
|
2018-01-15 |
2020-10-28 |
Ionis Pharmaceuticals Inc |
Moduladores de la expresion de dnm2.
|
US20210095276A1
(en)
|
2018-01-17 |
2021-04-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating erc1 expression
|
JP2021511029A
(ja)
|
2018-01-18 |
2021-05-06 |
ロシュ イノベーション センター コペンハーゲン エーエス |
Srebp1を標的とするアンチセンスオリゴヌクレオチド
|
WO2019145386A1
(en)
|
2018-01-26 |
2019-08-01 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating csnk1d expression
|
PE20211197A1
(es)
|
2018-02-09 |
2021-07-01 |
Genentech Inc |
Oligonucleotidos para modular la expresion de tmem106b
|
AU2019218987A1
(en)
|
2018-02-12 |
2020-07-23 |
Ionis Pharmaceuticals, Inc. |
Modified compounds and uses thereof
|
BR112020016347A2
(pt)
|
2018-02-21 |
2021-01-12 |
Bristol-Myers Squibb Company |
Oligonucleotídeos antisense de camk2d e seus usos
|
AR114445A1
(es)
|
2018-02-26 |
2020-09-09 |
Synthorx Inc |
Conjugados de il-15, y sus usos
|
TWI840345B
(zh)
|
2018-03-02 |
2024-05-01 |
美商Ionis製藥公司 |
Irf4表現之調節劑
|
US11732260B2
(en)
|
2018-03-02 |
2023-08-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for the modulation of amyloid-β precursor protein
|
AU2019237599A1
(en)
|
2018-03-20 |
2020-11-12 |
Nissan Chemical Corporation |
Antisense oligonucleotide having reduced toxicity
|
US11661601B2
(en)
|
2018-03-22 |
2023-05-30 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating FMR1 expression
|
CA3097544A1
(en)
|
2018-04-05 |
2019-10-10 |
F. Hoffmann-La Roche Ag |
Use of fubp1 inhibitors for treating hepatitis b virus infection
|
EP4063519B1
(en)
|
2018-04-09 |
2023-09-13 |
Advanced Cell Diagnostics, Inc. |
Methods to further enhance signal amplification for the in situ detection of nucleic acids
|
JP7275164B2
(ja)
|
2018-04-11 |
2023-05-17 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Ezh2発現の調節因子
|
JP2021523227A
(ja)
|
2018-05-04 |
2021-09-02 |
ストーク セラピューティクス,インク. |
コレステリルエステル蓄積症の処置のための方法及び組成物
|
JP2021522808A
(ja)
|
2018-05-07 |
2021-09-02 |
ロシュ イノベーション センター コペンハーゲン エーエス |
オリゴヌクレオチド治療剤の超並列発見方法
|
WO2019215175A1
(en)
|
2018-05-08 |
2019-11-14 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides for modulating myh7 expression
|
CR20200604A
(es)
|
2018-05-09 |
2021-02-09 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para reducir de la expresión de atxn3
|
MX2020011913A
(es)
|
2018-05-09 |
2021-01-29 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para la reduccion de la expresion de fxi.
|
FI3794122T3
(fi)
|
2018-05-14 |
2023-11-07 |
Alnylam Pharmaceuticals Inc |
Angiotensinogeenin (AGT) IRNA-koostumuksia ja niiden käyttömenetelmä
|
US20210220387A1
(en)
|
2018-05-18 |
2021-07-22 |
Hoffmann-La Roche, Inc. |
Pharmaceutical compositions for treatment of microrna related diseases
|
WO2019224172A1
(en)
|
2018-05-25 |
2019-11-28 |
Roche Innovation Center Copenhagen A/S |
Novel process for making allofuranose from glucofuranose
|
US11066669B2
(en)
|
2018-06-05 |
2021-07-20 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
CA3103429A1
(en)
|
2018-06-14 |
2019-12-19 |
Don W. Cleveland |
Compounds and methods for increasing stmn2 expression
|
TWI833770B
(zh)
|
2018-06-27 |
2024-03-01 |
美商Ionis製藥公司 |
用於減少 lrrk2 表現之化合物及方法
|
WO2020007700A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting spi1
|
WO2020007772A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting gbp-1
|
WO2020007702A1
(en)
|
2018-07-02 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting bcl2l11
|
MX2020013366A
(es)
|
2018-07-03 |
2021-03-09 |
Hoffmann La Roche |
Oligonucleotidos para modular la expresion de tau.
|
WO2020007826A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mbtps1
|
WO2020007889A1
(en)
|
2018-07-05 |
2020-01-09 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting stat1
|
WO2020011743A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting mafb
|
WO2020011653A1
(en)
|
2018-07-09 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting kynu
|
WO2020011869A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting tlr2
|
WO2020011744A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers5
|
WO2020011745A2
(en)
|
2018-07-11 |
2020-01-16 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting cers6
|
BR112021000538A2
(pt)
|
2018-07-13 |
2021-04-06 |
F. Hoffmann-La Roche Ag |
Oligonucleotídeos para modular a expressão de rtel1
|
AU2019310097A1
(en)
|
2018-07-25 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ATXN2 expression
|
JP2021532075A
(ja)
|
2018-07-31 |
2021-11-25 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ホスホロトリチオエートヌクレオシド間結合を含むオリゴヌクレオチド
|
WO2020025563A1
(en)
|
2018-07-31 |
2020-02-06 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotides comprising a phosphorotrithioate internucleoside linkage
|
MX2021001056A
(es)
|
2018-08-13 |
2021-04-12 |
Alnylam Pharmaceuticals Inc |
Composiciones de agente de acido ribonucleico bicatenario (arnbc) de virus de la hepatitis b (vhb) y metodos de uso de las mismas.
|
SG11202100765UA
(en)
|
2018-08-15 |
2021-03-30 |
Illumina Inc |
Compositions and methods for improving library enrichment
|
EP3837367A1
(en)
|
2018-08-16 |
2021-06-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
EA202190581A1
(ru)
|
2018-08-20 |
2021-07-13 |
Рогкон, Инк. |
Антисмысловые олигонуклеотиды, нацеленные на scn2a, для лечения энцефалопатии scn1a
|
WO2020038971A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting vcan
|
CN112585280A
(zh)
|
2018-08-23 |
2021-03-30 |
罗氏创新中心哥本哈根有限公司 |
微小rna-134生物标志物
|
WO2020038976A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting usp8
|
WO2020038973A1
(en)
|
2018-08-23 |
2020-02-27 |
Roche Innovation Center Copenhagen A/S |
Antisense oligonucleotides targeting sptlc1
|
EP3844274A1
(en)
|
2018-08-28 |
2021-07-07 |
Roche Innovation Center Copenhagen A/S |
Neoantigen engineering using splice modulating compounds
|
EP3620519A1
(en)
|
2018-09-04 |
2020-03-11 |
F. Hoffmann-La Roche AG |
Use of isolated milk extracellular vesicles for delivering oligonucleotides orally
|
EP3620520A1
(en)
|
2018-09-10 |
2020-03-11 |
Universidad del Pais Vasco |
Novel target to treat a metabolic disease in an individual
|
WO2020060986A1
(en)
|
2018-09-18 |
2020-03-26 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
TW202023573A
(zh)
|
2018-09-19 |
2020-07-01 |
美商Ionis製藥公司 |
Pnpla3表現之調節劑
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
WO2020089260A1
(en)
|
2018-11-01 |
2020-05-07 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting tia1
|
MA53674A
(fr)
*
|
2018-11-08 |
2021-07-28 |
Aligos Therapeutics Inc |
Polymères oligonucléotidiques inhibant le transport de l'antigène s et procédés
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
EA202191342A1
(ru)
|
2018-11-15 |
2021-08-10 |
Айонис Фармасьютикалз, Инк. |
Модуляторы экспрессии irf5
|
TWI841633B
(zh)
|
2018-11-21 |
2024-05-11 |
美商Ionis製藥公司 |
用於減少朊病毒表現之化合物及方法
|
EP3883941A1
(en)
|
2018-11-22 |
2021-09-29 |
Roche Innovation Center Copenhagen A/S |
Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
WO2020109344A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Occular administration device for antisense oligonucleotides
|
JP2022515744A
(ja)
|
2018-12-20 |
2022-02-22 |
プラクシス プレシジョン メディシンズ, インコーポレイテッド |
Kcnt1関連障害の治療のための組成物及び方法
|
WO2020132346A1
(en)
|
2018-12-20 |
2020-06-25 |
Vir Biotechnology, Inc. |
Combination hbv therapy
|
US20220042011A1
(en)
|
2018-12-21 |
2022-02-10 |
Hoffmann-La Roche Inc. |
Antisense oligonucleotides targeting card9
|
CA3126933A1
(en)
|
2019-01-16 |
2020-07-23 |
Genzyme Corporation |
Serpinc1 irna compositions and methods of use thereof
|
CN113365607A
(zh)
|
2019-01-25 |
2021-09-07 |
豪夫迈·罗氏有限公司 |
用于口服药物递送的脂质囊泡
|
BR112021013369A2
(pt)
|
2019-01-31 |
2021-09-21 |
Ionis Pharmaceuticals, Inc. |
Moduladores de expressão de yap1
|
EP3923974A4
(en)
|
2019-02-06 |
2023-02-08 |
Synthorx, Inc. |
IL-2 CONJUGATES AND METHODS OF USE THEREOF
|
EP3924501A4
(en)
|
2019-02-15 |
2022-11-23 |
Advanced Cell Diagnostics, Inc. |
METHODS FOR MULTIPLEX DETECTION OF NUCLEIC ACIDS BY IN SITU HYBRIDIZATION
|
TW202102516A
(zh)
|
2019-02-20 |
2021-01-16 |
丹麥商羅氏創新中心哥本哈根有限公司 |
膦醯基乙酸酯間隙子寡核苷酸
|
CN113474352A
(zh)
|
2019-02-20 |
2021-10-01 |
罗氏创新中心哥本哈根有限公司 |
新型亚磷酰胺
|
WO2020173845A1
(en)
|
2019-02-26 |
2020-09-03 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide formulation method
|
US11279932B2
(en)
|
2019-02-27 |
2022-03-22 |
Ionis Pharmaceuticals, Inc. |
Modulators of MALAT1 expression
|
CN113507942A
(zh)
|
2019-03-05 |
2021-10-15 |
豪夫迈·罗氏有限公司 |
分子的细胞内靶向
|
WO2020191177A1
(en)
|
2019-03-21 |
2020-09-24 |
Sudhir Agrawal |
Antisense oligonucleotides for allele specificity
|
EP3941528A1
(en)
|
2019-03-21 |
2022-01-26 |
Codiak BioSciences, Inc. |
Extracellular vesicle conjugates and uses thereof
|
AU2020252710A1
(en)
|
2019-03-29 |
2021-11-11 |
Mitsubishi Tanabe Pharma Corporation |
COMPOUND, METHOD AND PHARMACEUTICAL COMPOSITION FOR DUX4 EXPRESSION ADJUSTMENT to COMPOUND, METHOD AND PHARMACEUTICAL COMPOSITION FOR MODULATING EXPRESSION OF DUX4
|
JP7550165B2
(ja)
|
2019-03-29 |
2024-09-12 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Ube3a-atsを調節するための化合物及び方法
|
WO2020206115A2
(en)
|
2019-04-03 |
2020-10-08 |
Bristol-Myers Squibb Company |
Angptl2 antisense oligonucleotides and uses thereof
|
US11286485B2
(en)
|
2019-04-04 |
2022-03-29 |
Hoffmann-La Roche Inc. |
Oligonucleotides for modulating ATXN2 expression
|
WO2020201339A1
(en)
|
2019-04-04 |
2020-10-08 |
F. Hoffmann-La Roche Ag |
Oligonucleotides for modulating atxn2 expression
|
US20220194976A1
(en)
|
2019-04-16 |
2022-06-23 |
Roche Innovation Center Copenhagen A/S |
Novel Process for Preparing Nucleotide P(V) Monomers
|
WO2020221705A1
(en)
|
2019-04-30 |
2020-11-05 |
Roche Innovation Center Copenhagen A/S |
Novel process for preparing rhenium chelated mag3 oligonucleotides
|
MX2021013418A
(es)
|
2019-05-03 |
2021-12-10 |
Dicerna Pharmaceuticals Inc |
Moleculas inhibidoras de acido nucleico bicatenario con cadenas de sentido acortadas.
|
EP3966328A4
(en)
|
2019-05-06 |
2023-10-18 |
University Of Massachusetts |
ANTI-C9ORF72 OLIGONUCLEOTIDES AND RELATED METHODS
|
WO2020232024A1
(en)
|
2019-05-13 |
2020-11-19 |
Vir Biotechnology, Inc. |
Compositions and methods for treating hepatitis b virus (hbv) infection
|
EP3976791A4
(en)
|
2019-05-28 |
2023-10-11 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR REDUCING FOOT EXPRESSION
|
CN113950529A
(zh)
|
2019-06-06 |
2022-01-18 |
豪夫迈·罗氏有限公司 |
靶向atxn3的反义寡核苷酸
|
CN114207129A
(zh)
|
2019-06-14 |
2022-03-18 |
斯克利普斯研究所 |
用于在半合成生物体中复制、转录和翻译的试剂和方法
|
WO2021021673A1
(en)
|
2019-07-26 |
2021-02-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating gfap
|
WO2021022108A2
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
WO2021022109A1
(en)
|
2019-08-01 |
2021-02-04 |
Alnylam Pharmaceuticals, Inc. |
SERPIN FAMILY F MEMBER 2 (SERPINF2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
EP4013870A1
(en)
|
2019-08-13 |
2022-06-22 |
Alnylam Pharmaceuticals, Inc. |
Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof
|
US20220354963A1
(en)
|
2019-08-14 |
2022-11-10 |
Codiak Biosciences, Inc. |
Extracellular vesicle linked to molecules and uses thereof
|
JP2022544934A
(ja)
|
2019-08-14 |
2022-10-24 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
Stat3-アンチセンスオリゴヌクレオチドを含む細胞外小胞
|
EP4013877A1
(en)
|
2019-08-14 |
2022-06-22 |
Codiak BioSciences, Inc. |
Extracellular vesicle-aso constructs targeting stat6
|
CA3147369A1
(en)
|
2019-08-14 |
2021-02-18 |
Dalia BURZYN |
Extracellular vesicle-aso constructs targeting cebp/beta
|
JP2022544935A
(ja)
|
2019-08-14 |
2022-10-24 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
細胞外小胞-nlrp3アンタゴニスト
|
JP2022544290A
(ja)
|
2019-08-14 |
2022-10-17 |
コディアック バイオサイエンシーズ, インコーポレイテッド |
Krasを標的とするアンチセンスオリゴヌクレオチドを有する細胞外小胞
|
MX2022001776A
(es)
|
2019-08-15 |
2022-03-17 |
Synthorx Inc |
Terapias de combinacion de inmuno oncologia con conjugados de il-2.
|
CN114555621A
(zh)
|
2019-08-15 |
2022-05-27 |
Ionis制药公司 |
键修饰的寡聚化合物及其用途
|
WO2021041206A1
(en)
|
2019-08-23 |
2021-03-04 |
Synthorx, Inc. |
Il-15 conjugates and uses thereof
|
BR112022003860A2
(pt)
|
2019-09-03 |
2022-08-16 |
Alnylam Pharmaceuticals Inc |
Composições e métodos para inibir a expressão do gene lect2
|
BR112022003335A2
(pt)
|
2019-09-10 |
2022-05-24 |
Synthorx Inc |
Conjugados de il-2 e métodos de uso para tratar doenças autoimunes
|
WO2021062058A1
(en)
|
2019-09-25 |
2021-04-01 |
Codiak Biosciences, Inc. |
Sting agonist comprising exosomes for treating neuroimmunological disorders
|
WO2021067747A1
(en)
|
2019-10-04 |
2021-04-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
EP4045062A1
(en)
|
2019-10-14 |
2022-08-24 |
Astrazeneca AB |
Modulators of pnpla3 expression
|
EP4045652A1
(en)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
JP2022553348A
(ja)
|
2019-10-22 |
2022-12-22 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
補体成分C3 iRNA組成物およびその使用方法
|
TW202132567A
(zh)
|
2019-11-01 |
2021-09-01 |
美商阿尼拉製藥公司 |
亨汀頓蛋白(HTT)iRNA劑組成物及其使用方法
|
US20230040920A1
(en)
|
2019-11-01 |
2023-02-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
WO2021091986A1
(en)
|
2019-11-04 |
2021-05-14 |
Synthorx, Inc. |
Interleukin 10 conjugates and uses thereof
|
BR112022009216A2
(pt)
|
2019-11-13 |
2022-08-02 |
Alnylam Pharmaceuticals Inc |
Métodos e composições para tratar um distúrbio associado a angiotensinogênio (agt)
|
EP4061945A1
(en)
|
2019-11-22 |
2022-09-28 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
TW202140509A
(zh)
|
2019-12-13 |
2021-11-01 |
美商阿尼拉製藥公司 |
人類染色體9開讀框72(C9ORF72)iRNA劑組成物及其使用方法
|
TW202138559A
(zh)
|
2019-12-16 |
2021-10-16 |
美商阿尼拉製藥公司 |
含類PATATIN磷脂酶結構域3(PNPLA3)iRNA組成物及其使用方法
|
JP2023506550A
(ja)
|
2019-12-19 |
2023-02-16 |
エフ. ホフマン-ラ ロシュ エージー. |
B型肝炎ウイルス感染症を処置するためのsbds阻害剤の使用
|
CN114901821A
(zh)
|
2019-12-19 |
2022-08-12 |
豪夫迈·罗氏有限公司 |
Sept9抑制剂用于治疗乙型肝炎病毒感染的用途
|
CN114829599A
(zh)
|
2019-12-19 |
2022-07-29 |
豪夫迈·罗氏有限公司 |
Scamp3抑制剂用于治疗乙型肝炎病毒感染的用途
|
WO2021122921A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of cops3 inhibitors for treating hepatitis b virus infection
|
WO2021122993A1
(en)
|
2019-12-19 |
2021-06-24 |
F. Hoffmann-La Roche Ag |
Use of saraf inhibitors for treating hepatitis b virus infection
|
US20210214727A1
(en)
|
2019-12-20 |
2021-07-15 |
Hoffmann-La Roche Inc. |
Enhanced oligonucleotides for inhibiting scn9a expression
|
TW202137987A
(zh)
|
2019-12-24 |
2021-10-16 |
瑞士商赫孚孟拉羅股份公司 |
用於治療hbv之靶向hbv的治療性寡核苷酸及tlr7促效劑之醫藥組合
|
JP2023509872A
(ja)
|
2019-12-24 |
2023-03-10 |
エフ. ホフマン-ラ ロシュ アーゲー |
Hbvを標的とする抗ウイルス剤及び/又はhbvの処置のための免疫調節剤の医薬組合せ
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
WO2021158810A1
(en)
|
2020-02-05 |
2021-08-12 |
Bristol-Myers Squibb Company |
Oligonucleotides for splice modulation of camk2d
|
MX2022009763A
(es)
|
2020-02-10 |
2022-09-09 |
Alnylam Pharmaceuticals Inc |
Composiciones y metodos para silenciar la expresion del factor de crecimiento endotelial vascular a (vegf-a).
|
WO2021167841A1
(en)
|
2020-02-18 |
2021-08-26 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
EP4110916A1
(en)
|
2020-02-28 |
2023-01-04 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating cd73 exon 7 splicing
|
AU2021225957A1
(en)
|
2020-02-28 |
2022-09-08 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating SMN2
|
TW202146651A
(zh)
|
2020-03-02 |
2021-12-16 |
日商田邊三菱製藥股份有限公司 |
miR-33b阻礙物質所致之動脈瘤的預防或治療
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
BR112022017822A2
(pt)
|
2020-03-06 |
2022-11-08 |
Alnylam Pharmaceuticals Inc |
Composições de irna de cetoexocinase (khk) e métodos de uso das mesmas
|
CN115461460A
(zh)
|
2020-03-06 |
2022-12-09 |
阿尔尼拉姆医药品有限公司 |
用于抑制转甲状腺素蛋白(ttr)的表达的组合物和方法
|
WO2021184020A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Methods of treating neuroinflammation
|
WO2021184021A1
(en)
|
2020-03-13 |
2021-09-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting pmp22
|
WO2021188611A1
(en)
|
2020-03-18 |
2021-09-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
JP2023519274A
(ja)
|
2020-03-26 |
2023-05-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
コロナウイルスiRNA組成物およびその使用方法
|
EP4127171A2
(en)
|
2020-03-30 |
2023-02-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
AR121769A1
(es)
|
2020-04-06 |
2022-07-06 |
Alnylam Pharmaceuticals Inc |
Composiciones y métodos para el silenciamiento de la expresión de myoc
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
IL297130A
(en)
|
2020-04-07 |
2022-12-01 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for silencing scn9a expression
|
WO2021206922A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
BR112022021813A2
(pt)
|
2020-04-27 |
2023-01-17 |
Alnylam Pharmaceuticals Inc |
Composições de agente de apolipoproteína e (apoe) irna e métodos de uso das mesmas
|
IL297680A
(en)
|
2020-04-30 |
2022-12-01 |
Alnylam Pharmaceuticals Inc |
IRNA compounds complement factor b (cfb) and methods of using them
|
MX2022013707A
(es)
|
2020-05-01 |
2022-12-07 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para modular atxn1.
|
CN115605592A
(zh)
|
2020-05-11 |
2023-01-13 |
基因泰克公司(Us) |
用于治疗神经系统疾病的补体组分c1r抑制剂以及相关的组合物、系统和使用它们的方法
|
WO2021231211A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component c1s inhibitors for treating a neurological disease, and related compositions, systems and methods of using same
|
KR20230022409A
(ko)
|
2020-05-11 |
2023-02-15 |
스톡 테라퓨틱스, 인크. |
병태 및 질환의 치료를 위한 opa1 안티센스 올리고머
|
WO2021231204A1
(en)
|
2020-05-11 |
2021-11-18 |
Genentech, Inc. |
Complement component 4 inhibitors for treating neurological diseases, and related compositons, systems and methods of using same
|
US20230227824A1
(en)
|
2020-05-12 |
2023-07-20 |
Mitsubishi Tanabe Pharma Corporation |
Compound, method and pharmaceutical composition for regulating expression of ataxin 3
|
US20210388357A1
(en)
|
2020-05-13 |
2021-12-16 |
Hoffmann-La Roche Inc. |
Oligonucleotide agonists targeting progranulin
|
WO2021231675A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
EP4150077A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
EP4150076A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
WO2021231673A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
EP4150087A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
EP4150078A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
EP4153746A1
(en)
|
2020-05-21 |
2023-03-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
JP2023526096A
(ja)
|
2020-05-22 |
2023-06-20 |
エフ. ホフマン-ラ ロシュ アーゲー |
Card9のスプライス調節のためのオリゴヌクレオチド
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
CN115702243A
(zh)
|
2020-06-09 |
2023-02-14 |
罗氏创新中心哥本哈根有限公司 |
用于治疗性多核苷酸的鸟苷类似物
|
WO2021252557A1
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
EP4168546A1
(en)
|
2020-06-18 |
2023-04-26 |
Alnylam Pharmaceuticals, Inc. |
Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
|
BR112022026316A2
(pt)
|
2020-06-24 |
2023-03-07 |
Vir Biotechnology Inc |
Anticorpos neutralizantes do vírus da hepatite b engenheirados e usos dos mesmos
|
EP4171648A1
(en)
|
2020-06-25 |
2023-05-03 |
Synthorx, Inc. |
Immuno oncology combination therapy with il-2 conjugates and anti-egfr antibodies
|
AR122731A1
(es)
|
2020-06-26 |
2022-10-05 |
Hoffmann La Roche |
Oligonucleótidos mejorados para modular la expresión de fubp1
|
TW202216996A
(zh)
|
2020-06-29 |
2022-05-01 |
美商Ionis製藥公司 |
調節plp1之化合物及方法
|
US20230272386A1
(en)
|
2020-07-17 |
2023-08-31 |
Mitsubishi Tanabe Pharma Corporation |
Agent for preventing or treating muscular disease
|
JP2023534557A
(ja)
|
2020-07-23 |
2023-08-09 |
エフ. ホフマン-ラ ロシュ アーゲー |
Rna結合タンパク質部位を標的とするオリゴヌクレオチド
|
WO2022018155A1
(en)
|
2020-07-23 |
2022-01-27 |
F. Hoffmann-La Roche Ag |
Lna oligonucleotides for splice modulation of stmn2
|
EP4200419A2
(en)
|
2020-08-21 |
2023-06-28 |
F. Hoffmann-La Roche AG |
Use of a1cf inhibitors for treating hepatitis b virus infection
|
TW202227102A
(zh)
|
2020-09-22 |
2022-07-16 |
瑞典商阿斯特捷利康公司 |
治療脂肪肝病之方法
|
WO2022066847A1
(en)
|
2020-09-24 |
2022-03-31 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
JP2023544413A
(ja)
|
2020-10-05 |
2023-10-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Gタンパク質共役受容体75(GPR75)iRNA組成物およびその使用方法
|
US20230364127A1
(en)
|
2020-10-06 |
2023-11-16 |
Codiak Biosciences, Inc. |
Extracellular vesicle-aso constructs targeting stat6
|
MX2023004032A
(es)
|
2020-10-09 |
2023-04-27 |
Synthorx Inc |
Terapias inmuno-oncologicas con conjugados de il-2.
|
MX2023004029A
(es)
|
2020-10-09 |
2023-04-27 |
Synthorx Inc |
Terapia de combinacion de inmunoncologia con conjugados de il-2 y pembrolizumab.
|
CA3198823A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
WO2022087329A1
(en)
|
2020-10-23 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
WO2022103999A1
(en)
|
2020-11-13 |
2022-05-19 |
Alnylam Pharmaceuticals, Inc. |
COAGULATION FACTOR V (F5) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
CA3201661A1
(en)
|
2020-11-18 |
2022-05-27 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating angiotensinogen expression
|
US20230416734A1
(en)
|
2020-11-18 |
2023-12-28 |
Lemba Bv |
Umlilo antisense transcription inhibitors
|
US20240002853A1
(en)
|
2020-11-23 |
2024-01-04 |
Alpha Anomeric Sas |
Nucleic acid duplexes
|
US11987795B2
(en)
|
2020-11-24 |
2024-05-21 |
The Broad Institute, Inc. |
Methods of modulating SLC7A11 pre-mRNA transcripts for diseases and conditions associated with expression of SLC7A11
|
WO2022119873A1
(en)
|
2020-12-01 |
2022-06-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
WO2022117745A1
(en)
|
2020-12-03 |
2022-06-09 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting atxn3
|
AR124227A1
(es)
|
2020-12-03 |
2023-03-01 |
Hoffmann La Roche |
Oligonucleótidos antisentido que actúan sobre atxn3
|
EP4259795A1
(en)
|
2020-12-08 |
2023-10-18 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
JP2023553069A
(ja)
|
2020-12-08 |
2023-12-20 |
エフ. ホフマン-ラ ロシュ アーゲー |
ホスホロジチオエートオリゴヌクレオチドの新規合成
|
GB2603454A
(en)
|
2020-12-09 |
2022-08-10 |
Ucl Business Ltd |
Novel therapeutics for the treatment of neurodegenerative disorders
|
CN116583603A
(zh)
|
2020-12-18 |
2023-08-11 |
豪夫迈·罗氏有限公司 |
靶向颗粒蛋白前体的反义寡核苷酸
|
WO2022133278A2
(en)
|
2020-12-18 |
2022-06-23 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating factor xii
|
JP2024501662A
(ja)
|
2020-12-22 |
2024-01-15 |
エフ. ホフマン-ラ ロシュ アーゲー |
Xbp1を標的とするオリゴヌクレオチド
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202246500A
(zh)
|
2021-02-02 |
2022-12-01 |
瑞士商赫孚孟拉羅股份公司 |
用於抑制 rtel1 表現之增強型寡核苷酸
|
KR20230146048A
(ko)
|
2021-02-12 |
2023-10-18 |
알닐람 파마슈티칼스 인코포레이티드 |
슈퍼옥사이드 디스뮤타제 1(sod1) irna 조성물 및 슈퍼옥사이드 디스뮤타제 1- (sod1-) 관련 신경퇴행성 질환을 치료하거나 예방하기 위한 이의 사용 방법
|
EP4291243A1
(en)
|
2021-02-12 |
2023-12-20 |
Synthorx, Inc. |
Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof
|
TW202245843A
(zh)
|
2021-02-12 |
2022-12-01 |
美商欣爍克斯公司 |
Il-2接合物及西米普利單抗(cemiplimab)之皮膚癌組合療法
|
EP4294456A1
(en)
|
2021-02-17 |
2023-12-27 |
Lonza Sales AG |
Extracellular vesicle linked to a biologically active molecule via an optimized linker and an anchoring moiety
|
CA3207944A1
(en)
|
2021-02-17 |
2022-08-25 |
Ajay Verma |
Extracellular vesicle-nlrp3 antagonist
|
WO2022182864A1
(en)
|
2021-02-25 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Prion protein (prnp) irna compositions and methods and methods of use thereof
|
EP4298218A1
(en)
|
2021-02-26 |
2024-01-03 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
WO2022187435A1
(en)
|
2021-03-04 |
2022-09-09 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
|
EP4305169A1
(en)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
MX2023011466A
(es)
|
2021-03-29 |
2024-02-01 |
Alnylam Pharmaceuticals Inc |
Composiciones de agentes de ácido ribonucleico de interferencia (arni) de huntingtina (htt) y métodos de uso de estas.
|
WO2022213118A1
(en)
|
2021-03-31 |
2022-10-06 |
Entrada Therapeutics, Inc. |
Cyclic cell penetrating peptides
|
WO2022212153A1
(en)
|
2021-04-01 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
JP2024513841A
(ja)
|
2021-04-01 |
2024-03-27 |
ロンザ セールス アーゲー |
細胞外小胞組成物
|
TW202309291A
(zh)
|
2021-04-07 |
2023-03-01 |
法商新植物Sas公司 |
用於室內空氣修復之組合物及方法
|
EP4330392A1
(en)
|
2021-04-26 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane protease, serine 6 (tmprss6) irna compositions and methods of use thereof
|
EP4330396A1
(en)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
US20240240176A1
(en)
|
2021-04-30 |
2024-07-18 |
Kyoto University |
Prevention or treatment of myopathy using mir-33b inhibitor
|
EP4337264A1
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating tissue distribution of intracellular therapeutics
|
EP4337263A1
(en)
|
2021-05-10 |
2024-03-20 |
Entrada Therapeutics, Inc. |
Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
|
CA3217463A1
(en)
|
2021-05-10 |
2022-11-17 |
Ziqing QIAN |
Compositions and methods for modulating mrna splicing
|
EP4341401A1
(en)
|
2021-05-18 |
2024-03-27 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
US20240263177A1
(en)
|
2021-05-20 |
2024-08-08 |
Korro Bio, Inc. |
Methods and Compositions for Adar-Mediated Editing
|
CA3221923A1
(en)
|
2021-05-29 |
2022-12-08 |
1Globe Health Institute Llc |
Short duplex dna as a novel gene silencing technology and use thereof
|
WO2022256351A1
(en)
|
2021-05-29 |
2022-12-08 |
1Globe Health Institute Llc |
Asymmetric short duplex dna as a novel gene silencing technology and use thereof
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
TW202317762A
(zh)
|
2021-06-02 |
2023-05-01 |
美商艾拉倫製藥股份有限公司 |
含有類PATATIN磷脂酶結構域3(PNPLA3)的iRNA組成物及其使用方法
|
TW202313117A
(zh)
|
2021-06-03 |
2023-04-01 |
美商欣爍克斯公司 |
包含il-2接合物及西妥昔單抗(cetuximab)之頭頸癌組合療法
|
KR20240017911A
(ko)
|
2021-06-04 |
2024-02-08 |
알닐람 파마슈티칼스 인코포레이티드 |
인간 염색체 9 개방 해독 프레임 72(C9orf72) iRNA 제제 조성물 및 이의 사용 방법
|
EP4351541A2
(en)
|
2021-06-08 |
2024-04-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders
|
EP4352222A1
(en)
|
2021-06-08 |
2024-04-17 |
F. Hoffmann-La Roche AG |
Oligonucleotide progranulin agonists
|
EP4105328A1
(en)
|
2021-06-15 |
2022-12-21 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Antisense-oligonucleotides for prevention of kidney dysfunction promoted by endothelial dysfunction by ephrin-b2 suppression
|
BR112023026050A2
(pt)
|
2021-06-18 |
2024-03-05 |
Ionis Pharmaceuticals Inc |
Compostos e métodos para reduzir expressão de ifnar1
|
WO2022271818A1
(en)
|
2021-06-23 |
2022-12-29 |
Entrada Therapeutics, Inc. |
Antisense compounds and methods for targeting cug repeats
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
EP4363574A1
(en)
|
2021-06-29 |
2024-05-08 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
IL309296A
(en)
|
2021-06-30 |
2024-02-01 |
Alnylam Pharmaceuticals Inc |
Methods and compositions for the treatment of angiotensinogen-related disorder (AGT-)
|
WO2023003805A1
(en)
|
2021-07-19 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder
|
TW202325312A
(zh)
|
2021-07-23 |
2023-07-01 |
美商艾拉倫製藥股份有限公司 |
β-鏈蛋白(CTNNB1)iRNA組成物及其使用方法
|
EP4377458A1
(en)
|
2021-07-29 |
2024-06-05 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
|
CN117795074A
(zh)
|
2021-08-03 |
2024-03-29 |
阿尔尼拉姆医药品有限公司 |
转甲状腺素蛋白(TTR)iRNA组合物和其使用方法
|
JP2024531914A
(ja)
|
2021-08-04 |
2024-09-03 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
アンジオテンシノーゲン(agt)をサイレンシングするためのirna組成物および方法
|
AU2022328347A1
(en)
|
2021-08-13 |
2024-02-08 |
Alnylam Pharmaceuticals, Inc. |
Factor xii (f12) irna compositions and methods of use thereof
|
CA3229305A1
(en)
|
2021-08-16 |
2023-02-23 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
MX2024002640A
(es)
|
2021-09-01 |
2024-07-19 |
Entrada Therapeutics Inc |
Compuestos y metodos para salto de exon 44 en la distrofia muscular de duchenne.
|
US11833221B2
(en)
|
2021-09-01 |
2023-12-05 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds for reducing DMPK expression
|
EP4401742A2
(en)
|
2021-09-17 |
2024-07-24 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
CA3232420A1
(en)
|
2021-09-20 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
WO2023052317A1
(en)
|
2021-09-29 |
2023-04-06 |
F. Hoffmann-La Roche Ag |
Rna editing
|
AU2022356427A1
(en)
|
2021-09-30 |
2024-05-09 |
Akouos, Inc. |
Compositions and methods for treating kcnq4-associated hearing loss
|
MX2024004011A
(es)
|
2021-10-01 |
2024-07-01 |
Adarx Pharmaceuticals Inc |
Composiciones moduladoras de precalicreína y métodos de uso de estas.
|
AU2022370009A1
(en)
|
2021-10-22 |
2024-05-16 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
EP4423273A1
(en)
|
2021-10-29 |
2024-09-04 |
Alnylam Pharmaceuticals, Inc. |
Complement factor b (cfb) irna compositions and methods of use thereof
|
EP4423272A2
(en)
|
2021-10-29 |
2024-09-04 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
EP4426833A1
(en)
|
2021-11-03 |
2024-09-11 |
F. Hoffmann-La Roche AG |
Oligonucleotides for modulating apolipoprotein e4 expression
|
CA3237769A1
(en)
|
2021-11-10 |
2023-05-19 |
University Of Rochester |
Gata4-targeted therapeutics for treatment of cardiac hypertrophy
|
WO2023086295A2
(en)
|
2021-11-10 |
2023-05-19 |
University Of Rochester |
Antisense oligonucleotides for modifying protein expression
|
IL312635A
(en)
|
2021-11-11 |
2024-07-01 |
Hoffmann La Roche |
Pharmaceutical combinations for the treatment of HBV
|
CN118434858A
(zh)
|
2021-12-07 |
2024-08-02 |
豪夫迈·罗氏有限公司 |
靶向actl6b的反义寡核苷酸
|
GB202117758D0
(en)
|
2021-12-09 |
2022-01-26 |
Ucl Business Ltd |
Therapeutics for the treatment of neurodegenerative disorders
|
WO2023111210A1
(en)
|
2021-12-17 |
2023-06-22 |
F. Hoffmann-La Roche Ag |
Combination of oligonucleotides for modulating rtel1 and fubp1
|
CN118489009A
(zh)
|
2021-12-17 |
2024-08-13 |
豪夫迈·罗氏有限公司 |
寡核苷酸gba激动剂
|
WO2023122573A1
(en)
|
2021-12-20 |
2023-06-29 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
CN118434860A
(zh)
|
2021-12-20 |
2024-08-02 |
豪夫迈·罗氏有限公司 |
苏糖核酸反义寡核苷酸及其方法
|
IL313660A
(en)
|
2021-12-22 |
2024-08-01 |
Camp4 Therapeutics Corp |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory RNAs
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
JPWO2023127857A1
(US07399845-20080715-C00067.png)
*
|
2021-12-27 |
2023-07-06 |
|
|
CN118613268A
(zh)
|
2022-01-20 |
2024-09-06 |
基因泰克公司 |
用于调节tmem106b表达的反义寡核苷酸
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
US20240167040A1
(en)
|
2022-02-21 |
2024-05-23 |
Hoffmann-La Roche Inc. |
Antisense oligonucleotide
|
WO2023178144A2
(en)
|
2022-03-16 |
2023-09-21 |
Empirico Inc. |
Galnac compositions for improving sirna bioavailability
|
WO2023217890A1
(en)
|
2022-05-10 |
2023-11-16 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting cfp-elk1 intergene region
|
AR129362A1
(es)
|
2022-05-18 |
2024-08-14 |
Hoffmann La Roche |
Oligonucleótidos mejorados que actúan sobre sitios de proteína de unión de arn
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
WO2023242324A1
(en)
|
2022-06-17 |
2023-12-21 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides for targeting progranulin
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024040041A1
(en)
|
2022-08-15 |
2024-02-22 |
Dicerna Pharmaceuticals, Inc. |
Regulation of activity of rnai molecules
|
WO2024039776A2
(en)
|
2022-08-18 |
2024-02-22 |
Alnylam Pharmaceuticals, Inc. |
Universal non-targeting sirna compositions and methods of use thereof
|
WO2024050261A1
(en)
|
2022-08-29 |
2024-03-07 |
University Of Rochester |
Antisense oligonucleotide-based anti-fibrotic therapeutics
|
EP4332221A1
(en)
|
2022-08-29 |
2024-03-06 |
Roche Innovation Center Copenhagen A/S |
Threose nucleic acid antisense oligonucleotides and methods thereof
|
TW202421206A
(zh)
|
2022-09-06 |
2024-06-01 |
瑞士商赫孚孟拉羅股份公司 |
用於投予至眼睛之雙股rna分子
|
WO2024059165A1
(en)
|
2022-09-15 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|
WO2024098061A2
(en)
|
2022-11-04 |
2024-05-10 |
Genkardia Inc. |
Oligonucleotide-based therapeutics targeting cyclin d2 for the treatment of heart failure
|
US20240182561A1
(en)
|
2022-11-04 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
US20240173426A1
(en)
|
2022-11-14 |
2024-05-30 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
WO2024119145A1
(en)
|
2022-12-01 |
2024-06-06 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2024124041A1
(en)
|
2022-12-07 |
2024-06-13 |
Advanced Cell Diagnostics, Inc. |
Multiplexed detection of nucleic acid targets
|
WO2024126654A1
(en)
|
2022-12-14 |
2024-06-20 |
F. Hoffmann-La Roche Ag |
Antisense oligonucleotides targeting actl6b
|
WO2024136899A1
(en)
|
2022-12-21 |
2024-06-27 |
Synthorx, Inc. |
Cancer therapy with il-2 conjugates and chimeric antigen receptor therapies
|
WO2024160756A1
(en)
|
2023-01-30 |
2024-08-08 |
Vib Vzw |
Suppressors of tauopathies
|
WO2024168010A2
(en)
|
2023-02-09 |
2024-08-15 |
Alnylam Pharmaceuticals, Inc. |
Reversir molecules and methods of use thereof
|
WO2024175588A1
(en)
|
2023-02-21 |
2024-08-29 |
Vib Vzw |
Oligonucleotides for modulating synaptogyrin-3 expression
|
WO2024175586A2
(en)
|
2023-02-21 |
2024-08-29 |
Vib Vzw |
Inhibitors of synaptogyrin-3 expression
|
WO2024178172A1
(en)
|
2023-02-23 |
2024-08-29 |
University Of Rochester |
Agents and methods for making closed-end dna thread molecules
|