DK3455232T3 - Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid - Google Patents
Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid Download PDFInfo
- Publication number
- DK3455232T3 DK3455232T3 DK17725886.0T DK17725886T DK3455232T3 DK 3455232 T3 DK3455232 T3 DK 3455232T3 DK 17725886 T DK17725886 T DK 17725886T DK 3455232 T3 DK3455232 T3 DK 3455232T3
- Authority
- DK
- Denmark
- Prior art keywords
- stereodefined
- oxazaphospholidine
- nucleoside
- oligonucleotide
- improved coupling
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16169429 | 2016-05-12 | ||
| EP17163513 | 2017-03-29 | ||
| EP17163604 | 2017-03-29 | ||
| PCT/EP2017/060985 WO2017194498A1 (en) | 2016-05-12 | 2017-05-09 | Enhanced coupling of stereodefined oxazaphospholidine phosphoramidite monomers to nucleoside or oligonucleotide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3455232T3 true DK3455232T3 (da) | 2020-07-06 |
Family
ID=58772850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK17725886.0T DK3455232T3 (da) | 2016-05-12 | 2017-05-09 | Forbedret kobling af stereodefinerede oxazaphospholidin-phosphoramidit-monomerer til nukleosid eller oligonukleotid |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US11261209B2 (da) |
| EP (1) | EP3455232B1 (da) |
| JP (1) | JP7097820B2 (da) |
| CN (1) | CN109311925B (da) |
| DK (1) | DK3455232T3 (da) |
| WO (1) | WO2017194498A1 (da) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101881596B1 (ko) | 2008-12-02 | 2018-07-24 | 웨이브 라이프 사이언시스 재팬 인코포레이티드 | 인 원자 변형된 핵산의 합성 방법 |
| SG177564A1 (en) | 2009-07-06 | 2012-02-28 | Ontorii Inc | Novel nucleic acid prodrugs and methods of use thereof |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| EP2734208B1 (en) | 2011-07-19 | 2017-03-01 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| EP2872485B1 (en) | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| KR102213609B1 (ko) | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| AU2015207773B2 (en) | 2014-01-16 | 2021-06-17 | Wave Life Sciences Ltd. | Chiral design |
| JP7164540B2 (ja) | 2017-03-29 | 2022-11-01 | ロシュ イノベーション センター コペンハーゲン エーエス | 立体的に規定されたホスホロチオエートオリゴヌクレオチドの調製のための直交保護基 |
| JP2020525503A (ja) | 2017-06-28 | 2020-08-27 | ロシュ イノベーション センター コペンハーゲン エーエス | 多重カップリングおよび酸化の方法 |
| EP3717646A4 (en) | 2017-12-01 | 2021-12-01 | The Texas A&M University System | ANTISENSE TREATMENT OF ANGELMAN'S SYNDROME |
| WO2020104492A1 (en) * | 2018-11-22 | 2020-05-28 | Roche Innovation Center Copenhagen A/S | Pyridinium salts as activators in the synthesis of stereodefined oligonucleotides |
| KR20220083704A (ko) * | 2019-10-18 | 2022-06-20 | 후지필름 와코 준야쿠 가부시키가이샤 | 포스포아미다이트 활성화제 |
| JP2023503985A (ja) * | 2019-11-27 | 2023-02-01 | アルニラム ファーマスーティカルズ インコーポレイテッド | ３’－ｒｎａオリゴヌクレオチドの合成 |
| CN112898363A (zh) * | 2021-01-25 | 2021-06-04 | 苏州金唯智生物科技有限公司 | 一种亚磷酰胺单体组合物及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130042043A (ko) * | 2006-01-27 | 2013-04-25 | 아이시스 파마수티컬즈 인코포레이티드 | 6-변형된 바이시클릭 핵산 유사체 |
| DK2666859T3 (da) | 2006-04-03 | 2019-04-08 | Roche Innovation Ct Copenhagen As | FARMACEUTISK SAMMENSÆTNING, DER OMFATTER ANTI-miRNA-ANTISENSE-OLIGONUKLEOTIDER |
| US20090326042A1 (en) * | 2006-05-05 | 2009-12-31 | Isis Pharmaceuticals, Inc | Compounds and methods for modulating expression of crp |
| ES2463665T3 (es) | 2007-10-04 | 2014-05-28 | Stella Aps | Tratamiento de combinación para el tratamiento de infección por virus de la hepatitis C |
| EP2285819B1 (en) | 2008-04-04 | 2013-10-16 | Isis Pharmaceuticals, Inc. | Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides |
| WO2010036698A1 (en) | 2008-09-24 | 2010-04-01 | Isis Pharmaceuticals, Inc. | Substituted alpha-l-bicyclic nucleosides |
| KR102213609B1 (ko) * | 2012-07-13 | 2021-02-08 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| EP2872485B1 (en) * | 2012-07-13 | 2020-12-16 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| PL231078B1 (pl) * | 2012-08-05 | 2019-01-31 | Inst Chemii Bioorganicznej Polskiej Akademii Nauk | Sposób syntezy polifosforanów |
| US10449210B2 (en) * | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
-
2017
- 2017-05-09 JP JP2018559225A patent/JP7097820B2/ja active Active
- 2017-05-09 DK DK17725886.0T patent/DK3455232T3/da active
- 2017-05-09 EP EP17725886.0A patent/EP3455232B1/en active Active
- 2017-05-09 CN CN201780029201.6A patent/CN109311925B/zh active Active
- 2017-05-09 WO PCT/EP2017/060985 patent/WO2017194498A1/en unknown
- 2017-05-09 US US16/300,309 patent/US11261209B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3455232A1 (en) | 2019-03-20 |
| JP7097820B2 (ja) | 2022-07-08 |
| US20190153012A1 (en) | 2019-05-23 |
| US11261209B2 (en) | 2022-03-01 |
| JP2019514999A (ja) | 2019-06-06 |
| CN109311925B (zh) | 2022-06-03 |
| CN109311925A (zh) | 2019-02-05 |
| EP3455232B1 (en) | 2020-05-06 |
| WO2017194498A1 (en) | 2017-11-16 |
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