JPH11508232A - モノマー性カリキアミシン誘導体／キャリアー複合体の調製方法 - Google Patents

モノマー性カリキアミシン誘導体／キャリアー複合体の調製方法

Info

Publication number
JPH11508232A
JPH11508232A JP9500547A JP50054797A JPH11508232A JP H11508232 A JPH11508232 A JP H11508232A JP 9500547 A JP9500547 A JP 9500547A JP 50054797 A JP50054797 A JP 50054797A JP H11508232 A JPH11508232 A JP H11508232A
Authority
JP
Japan
Prior art keywords
coor
group
alkyl
conhr
trivalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9500547A
Other languages
English (en)
Japanese (ja)
Inventor
クンツマン，マーテイン・ポール
ホランダー，アーウイン・ジヤツク
ハマン，フイリツプ
クンズ，アーサー
Original Assignee
アメリカン・サイアナミド・カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アメリカン・サイアナミド・カンパニー filed Critical アメリカン・サイアナミド・カンパニー
Publication of JPH11508232A publication Critical patent/JPH11508232A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
JP9500547A 1995-06-07 1996-05-10 モノマー性カリキアミシン誘導体／キャリアー複合体の調製方法 Pending JPH11508232A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/475,005 US5712374A (en) 1995-06-07 1995-06-07 Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US08/475,005 1995-06-07
PCT/US1996/006738 WO1996040261A1 (en) 1995-06-07 1996-05-10 Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2008230053A Division JP2009073832A (ja) 1995-06-07 2008-09-08 モノマー性カリキアミシン誘導体／キャリアー複合体の製造方法

Publications (1)

Publication Number Publication Date
JPH11508232A true JPH11508232A (ja) 1999-07-21

Family

ID=23885856

Family Applications (2)

Application Number Title Priority Date Filing Date
JP9500547A Pending JPH11508232A (ja) 1995-06-07 1996-05-10 モノマー性カリキアミシン誘導体／キャリアー複合体の調製方法
JP2008230053A Pending JP2009073832A (ja) 1995-06-07 2008-09-08 モノマー性カリキアミシン誘導体／キャリアー複合体の製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2008230053A Pending JP2009073832A (ja) 1995-06-07 2008-09-08 モノマー性カリキアミシン誘導体／キャリアー複合体の製造方法

Country Status (27)

Country Link
US (1) US5712374A (Direct)
EP (1) EP0837698B1 (Direct)
JP (2) JPH11508232A (Direct)
KR (1) KR100499648B1 (Direct)
CN (1) CN1094063C (Direct)
AR (1) AR002360A1 (Direct)
AT (1) ATE204180T1 (Direct)
AU (1) AU703862B2 (Direct)
BG (1) BG63492B1 (Direct)
BR (1) BR9608564A (Direct)
CA (1) CA2223329A1 (Direct)
CY (1) CY2355B1 (Direct)
CZ (1) CZ298024B6 (Direct)
DE (1) DE69614551T2 (Direct)
DK (1) DK0837698T3 (Direct)
ES (1) ES2160818T3 (Direct)
GR (1) GR3036930T3 (Direct)
HU (1) HU221246B1 (Direct)
IL (1) IL118565A (Direct)
IN (1) IN182139B (Direct)
MX (1) MX9709316A (Direct)
NO (1) NO324609B1 (Direct)
NZ (1) NZ307926A (Direct)
PT (1) PT837698E (Direct)
TW (1) TW419377B (Direct)
WO (1) WO1996040261A1 (Direct)
ZA (1) ZA964614B (Direct)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005524700A (ja) * 2002-05-02 2005-08-18 ワイス・ホールディングズ・コーポレイション カリチェアミシン誘導体−キャリアコンジュゲート
JP2009500623A (ja) * 2005-07-01 2009-01-08 ワイス 標的治療薬の薬物動態特性の測定方法

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