ES2059464T3 - Formas especificamente dirigidas de agentes antitumorales de metiltritio. - Google Patents

Formas especificamente dirigidas de agentes antitumorales de metiltritio.

Info

Publication number
ES2059464T3
ES2059464T3 ES88116338T ES88116338T ES2059464T3 ES 2059464 T3 ES2059464 T3 ES 2059464T3 ES 88116338 T ES88116338 T ES 88116338T ES 88116338 T ES88116338 T ES 88116338T ES 2059464 T3 ES2059464 T3 ES 2059464T3
Authority
ES
Spain
Prior art keywords
methyltritio
specifically directed
tumoral agents
directed forms
tumoral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88116338T
Other languages
English (en)
Inventor
William James Mcgahren
Martin Leon Sassiver
George A Ellestad
Philip R Hamann
Lois M Hinman
Janis Upeslacis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of ES2059464T3 publication Critical patent/ES2059464T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTE DESCUBRIMIENTO DESCRIBE UN METODO PARA CONSTRUIR CHAPAS PORTADORAS CONJUGADAS DE LA FAMILIA DE AGENTES ANTITUMORALES Y METILTRITIO ANTIBACTERIAL.
ES88116338T 1987-10-30 1988-10-03 Formas especificamente dirigidas de agentes antitumorales de metiltritio. Expired - Lifetime ES2059464T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30

Publications (1)

Publication Number Publication Date
ES2059464T3 true ES2059464T3 (es) 1994-11-16

Family

ID=22358378

Family Applications (2)

Application Number Title Priority Date Filing Date
ES88116338T Expired - Lifetime ES2059464T3 (es) 1987-10-30 1988-10-03 Formas especificamente dirigidas de agentes antitumorales de metiltritio.
ES88116339T Expired - Lifetime ES2061586T3 (es) 1987-10-30 1988-10-03 Analogos disulfuricos de agentes antitumorales ll-e33288.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES88116339T Expired - Lifetime ES2061586T3 (es) 1987-10-30 1988-10-03 Analogos disulfuricos de agentes antitumorales ll-e33288.

Country Status (19)

Country Link
EP (2) EP0313874B1 (es)
JP (2) JP2820256B2 (es)
KR (2) KR970011385B1 (es)
AR (1) AR246083A1 (es)
AT (2) ATE104309T1 (es)
AU (2) AU612714B2 (es)
BR (1) BR1100939A (es)
CA (1) CA1321582C (es)
DE (2) DE3851682T2 (es)
DK (2) DK174739B1 (es)
ES (2) ES2059464T3 (es)
FI (2) FI91262C (es)
HK (2) HK131997A (es)
IE (2) IE65989B1 (es)
IL (2) IL87947A (es)
NO (2) NO176480C (es)
NZ (2) NZ226727A (es)
PT (2) PT88881B (es)
ZA (2) ZA888127B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL115770A (en) * 1989-04-14 1999-03-12 American Cyanamid Co Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
CN101469329B (zh) 1998-11-27 2012-10-24 达尔文发现有限公司 增加骨矿化的组合物和方法
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
EA015166B1 (ru) 2003-06-16 2011-06-30 Ю-Си-Би Мэньюфэкчуринг, Инк. Иммуногенные пептиды склеростина (sost), индуцирующие образование специфических антител
WO2008028050A2 (en) * 2006-08-30 2008-03-06 Wisconsin Alumni Research Foundation Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
KR101932824B1 (ko) * 2013-11-04 2018-12-27 화이자 인코포레이티드 칼리케아미신 유도체를 합성하기 위한, 중간체 및 방법
WO2018138591A1 (en) * 2017-01-24 2018-08-02 Pfizer Inc. Calicheamicin derivatives and antibody drug conjugates thereof
KR20210118945A (ko) 2019-02-15 2021-10-01 유니버시티 오브 써던 캘리포니아 Lym-1 및 lym-2 항체 조성물 및 개선된 car 구성물
WO2022085762A1 (ja) * 2020-10-22 2022-04-28 富士フイルム株式会社 皮膚感作性測定試薬、化合物、及び皮膚感作性の測定方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
DE3175151D1 (en) * 1980-05-21 1986-09-25 Teijin Ltd Reactive polymer and process for the preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
IL76878A (en) * 1984-11-16 1991-12-15 American Cyanamid Co Antitumor antibiotic ll-33288alpha-br complex and process for its preparation
EP0330874A3 (en) * 1988-02-29 1989-10-18 American Cyanamid Company Antibacterial and antitumor agents LL-E33288 epsilon-I and LL-E33288-epsilonBr, with processes and intermediates for producing said agents
EP0342341A3 (en) * 1988-05-17 1991-07-24 American Cyanamid Company Process for producing antitumor antibiotic ll-e33288gamma2

Also Published As

Publication number Publication date
ATE104309T1 (de) 1994-04-15
ZA888123B (en) 1989-07-26
CA1321582C (en) 1993-08-24
EP0313874A3 (en) 1990-05-09
EP0313874A2 (en) 1989-05-03
FI884983A (fi) 1989-05-01
NO176480B (no) 1995-01-02
DE3851682T2 (de) 1995-05-04
NO884833L (no) 1989-05-02
KR0133130B1 (ko) 1998-04-17
IE65053B1 (en) 1995-10-04
BR1100939A (pt) 1999-08-31
KR890006244A (ko) 1989-06-12
DK602588A (da) 1989-05-01
DE3851682D1 (de) 1994-11-03
FI95204C (fi) 1996-01-10
FI91262B (fi) 1994-02-28
IL87946A0 (en) 1989-03-31
PT88882B (pt) 1993-01-29
NO884834L (no) 1989-05-02
DK602488A (da) 1989-05-01
DK174739B1 (da) 2003-10-13
IL87946A (en) 1995-06-29
DE3889063T2 (de) 1994-12-01
NO176480C (no) 1995-04-12
ATE112172T1 (de) 1994-10-15
FI884983A0 (fi) 1988-10-28
IL87947A (en) 1995-05-26
IL87947A0 (en) 1989-03-31
JPH0296599A (ja) 1990-04-09
NZ226727A (en) 1991-12-23
FI884984A0 (fi) 1988-10-28
AU2448988A (en) 1989-05-04
AU618763B2 (en) 1992-01-09
JP2720933B2 (ja) 1998-03-04
HK131997A (en) 1997-10-03
HK131897A (en) 1997-10-03
EP0313873A1 (en) 1989-05-03
NO173506B (no) 1993-09-13
KR970011385B1 (ko) 1997-07-10
FI95204B (fi) 1995-09-29
EP0313873B1 (en) 1994-09-28
NO884834D0 (no) 1988-10-28
KR890006245A (ko) 1989-06-12
ZA888127B (en) 1989-07-26
JPH01193282A (ja) 1989-08-03
EP0313874B1 (en) 1994-04-13
IE883262L (en) 1989-04-30
NO884833D0 (no) 1988-10-28
PT88881B (pt) 1993-01-29
DK602588D0 (da) 1988-10-28
ES2061586T3 (es) 1994-12-16
IE65989B1 (en) 1995-11-29
AR246083A1 (es) 1994-03-30
FI884984A (fi) 1989-05-01
NO173506C (no) 1993-12-22
AU2449488A (en) 1989-05-04
AU612714B2 (en) 1991-07-18
NZ226726A (en) 1991-08-27
DE3889063D1 (de) 1994-05-19
DK602488D0 (da) 1988-10-28
FI91262C (fi) 1994-06-10
JP2820256B2 (ja) 1998-11-05
IE883261L (en) 1989-04-30

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