BR1100939A - Conjugado veìculo-droga e conjugado proteìna-droga - Google Patents

Conjugado veìculo-droga e conjugado proteìna-droga

Info

Publication number
BR1100939A
BR1100939A BR1100939-0A BR1100939A BR1100939A BR 1100939 A BR1100939 A BR 1100939A BR 1100939 A BR1100939 A BR 1100939A BR 1100939 A BR1100939 A BR 1100939A
Authority
BR
Brazil
Prior art keywords
drug conjugate
protein
vehicle
conjugate
drug
Prior art date
Application number
BR1100939-0A
Other languages
English (en)
Inventor
William J Mcgahren
Martin L Sassiver
George A Ellestad
Original Assignee
William J. Mcgahren
Martin L. Sassiver
George A. Ellestad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William J. Mcgahren, Martin L. Sassiver, George A. Ellestad filed Critical William J. Mcgahren
Publication of BR1100939A publication Critical patent/BR1100939A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
BR1100939-0A 1987-10-30 1997-05-14 Conjugado veìculo-droga e conjugado proteìna-droga BR1100939A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30

Publications (1)

Publication Number Publication Date
BR1100939A true BR1100939A (pt) 1999-08-31

Family

ID=22358378

Family Applications (1)

Application Number Title Priority Date Filing Date
BR1100939-0A BR1100939A (pt) 1987-10-30 1997-05-14 Conjugado veìculo-droga e conjugado proteìna-droga

Country Status (19)

Country Link
EP (2) EP0313873B1 (pt)
JP (2) JP2820256B2 (pt)
KR (2) KR970011385B1 (pt)
AR (1) AR246083A1 (pt)
AT (2) ATE104309T1 (pt)
AU (2) AU612714B2 (pt)
BR (1) BR1100939A (pt)
CA (1) CA1321582C (pt)
DE (2) DE3889063T2 (pt)
DK (2) DK602488A (pt)
ES (2) ES2059464T3 (pt)
FI (2) FI95204C (pt)
HK (2) HK131997A (pt)
IE (2) IE65053B1 (pt)
IL (2) IL87946A (pt)
NO (2) NO176480C (pt)
NZ (2) NZ226726A (pt)
PT (2) PT88881B (pt)
ZA (2) ZA888127B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL93733A (en) * 1989-04-14 1996-01-19 American Cyanamid Co History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
IL143266A0 (en) 1998-11-27 2002-04-21 Darwin Discovery Ltd Transforming growth factor-beta binding proteins and pharmaceutical compositions for increasing bone mineral content utilizing the same
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
CA2529623A1 (en) 2003-06-16 2005-02-17 Celltech R & D, Inc. Antibodies specific for sclerostin and methods for increasing bone mineralization
WO2008028050A2 (en) * 2006-08-30 2008-03-06 Wisconsin Alumni Research Foundation Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
JP6494240B2 (ja) * 2013-11-04 2019-04-03 ファイザー・インク カリケアマイシン誘導体を合成するための中間体および方法
US20190345186A1 (en) * 2017-01-24 2019-11-14 Pfizer Inc. Calicheamicin deratives and antibody drug conjugates thereof
KR20210118945A (ko) 2019-02-15 2021-10-01 유니버시티 오브 써던 캘리포니아 Lym-1 및 lym-2 항체 조성물 및 개선된 car 구성물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
EP0040506B1 (en) * 1980-05-21 1986-08-20 Teijin Limited Reactive polymer and process for the preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (en) * 1984-05-23 1993-03-09 Franz Jansen Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators
ATE180513T1 (de) * 1984-11-16 1999-06-15 American Cyanamid Co Antitumorale antibiotika (komplex ll-e-33288)
EP0330874A3 (en) * 1988-02-29 1989-10-18 American Cyanamid Company Antibacterial and antitumor agents LL-E33288 epsilon-I and LL-E33288-epsilonBr, with processes and intermediates for producing said agents
EP0342341A3 (en) * 1988-05-17 1991-07-24 American Cyanamid Company Process for producing antitumor antibiotic ll-e33288gamma2

Also Published As

Publication number Publication date
DK602588D0 (da) 1988-10-28
NO884834L (no) 1989-05-02
ATE112172T1 (de) 1994-10-15
JP2820256B2 (ja) 1998-11-05
IL87946A (en) 1995-06-29
AU618763B2 (en) 1992-01-09
FI884984A0 (fi) 1988-10-28
FI95204C (fi) 1996-01-10
JPH01193282A (ja) 1989-08-03
NO173506B (no) 1993-09-13
DK174739B1 (da) 2003-10-13
KR890006245A (ko) 1989-06-12
ZA888123B (en) 1989-07-26
AU2448988A (en) 1989-05-04
FI95204B (fi) 1995-09-29
JP2720933B2 (ja) 1998-03-04
IE883262L (en) 1989-04-30
KR970011385B1 (ko) 1997-07-10
NO173506C (no) 1993-12-22
PT88881B (pt) 1993-01-29
ES2061586T3 (es) 1994-12-16
DK602488D0 (da) 1988-10-28
AU2449488A (en) 1989-05-04
ES2059464T3 (es) 1994-11-16
DK602488A (da) 1989-05-01
NO884833L (no) 1989-05-02
NZ226726A (en) 1991-08-27
EP0313874A2 (en) 1989-05-03
ATE104309T1 (de) 1994-04-15
DE3889063T2 (de) 1994-12-01
EP0313874A3 (en) 1990-05-09
DK602588A (da) 1989-05-01
NO884833D0 (no) 1988-10-28
AU612714B2 (en) 1991-07-18
DE3889063D1 (de) 1994-05-19
EP0313873A1 (en) 1989-05-03
FI884983A0 (fi) 1988-10-28
IL87947A0 (en) 1989-03-31
KR890006244A (ko) 1989-06-12
HK131897A (en) 1997-10-03
FI884983A (fi) 1989-05-01
HK131997A (en) 1997-10-03
IL87947A (en) 1995-05-26
EP0313873B1 (en) 1994-09-28
IL87946A0 (en) 1989-03-31
NO884834D0 (no) 1988-10-28
IE65053B1 (en) 1995-10-04
KR0133130B1 (ko) 1998-04-17
NZ226727A (en) 1991-12-23
PT88882B (pt) 1993-01-29
IE883261L (en) 1989-04-30
FI91262C (fi) 1994-06-10
ZA888127B (en) 1989-07-26
IE65989B1 (en) 1995-11-29
JPH0296599A (ja) 1990-04-09
EP0313874B1 (en) 1994-04-13
DE3851682T2 (de) 1995-05-04
CA1321582C (en) 1993-08-24
NO176480C (no) 1995-04-12
NO176480B (no) 1995-01-02
FI91262B (fi) 1994-02-28
FI884984A (fi) 1989-05-01
DE3851682D1 (de) 1994-11-03
AR246083A1 (es) 1994-03-30

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Legal Events

Date Code Title Description
AN Processing applications according to articles 230 and 231 of law 9279/96: notification of filing an application
HHFK Processing applications according to articles 230 and 231 of law 9.279/96: republication
MT Patent procedure suspended until requirement met - articles 230 and 231 of law 9279/96
FGAN Processing applications according to articles 230 and 231 of law 9.279/96: granting
NB Patent issued - articles 230 and 231 of law 9279/96
B25D Requested change of name of applicant approved