GB9007384D0 - Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups - Google Patents

Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups

Info

Publication number
GB9007384D0
GB9007384D0 GB909007384A GB9007384A GB9007384D0 GB 9007384 D0 GB9007384 D0 GB 9007384D0 GB 909007384 A GB909007384 A GB 909007384A GB 9007384 A GB9007384 A GB 9007384A GB 9007384 D0 GB9007384 D0 GB 9007384D0
Authority
GB
United Kingdom
Prior art keywords
utilising
thiol
polymers
coupling
reactive groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB909007384A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SCHACHT ETIENNE H
Original Assignee
SCHACHT ETIENNE H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SCHACHT ETIENNE H filed Critical SCHACHT ETIENNE H
Priority to GB909007384A priority Critical patent/GB9007384D0/en
Publication of GB9007384D0 publication Critical patent/GB9007384D0/en
Priority to GB9106894A priority patent/GB2244491A/en
Priority to PCT/GB1991/000515 priority patent/WO1991015242A1/en
Priority to AU75638/91A priority patent/AU7563891A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/338—Polymers modified by chemical after-treatment with inorganic and organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GB909007384A 1990-04-02 1990-04-02 Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups Pending GB9007384D0 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB909007384A GB9007384D0 (en) 1990-04-02 1990-04-02 Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
GB9106894A GB2244491A (en) 1990-04-02 1991-04-02 Conjugate compounds of polymers with other organic molecular entities.
PCT/GB1991/000515 WO1991015242A1 (en) 1990-04-02 1991-04-02 Conjugate compounds of polymers with other organic molecular entities
AU75638/91A AU7563891A (en) 1990-04-02 1991-04-02 Conjugate compounds of polymers with other organic molecular entities

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909007384A GB9007384D0 (en) 1990-04-02 1990-04-02 Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups

Publications (1)

Publication Number Publication Date
GB9007384D0 true GB9007384D0 (en) 1990-05-30

Family

ID=10673725

Family Applications (2)

Application Number Title Priority Date Filing Date
GB909007384A Pending GB9007384D0 (en) 1990-04-02 1990-04-02 Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
GB9106894A Withdrawn GB2244491A (en) 1990-04-02 1991-04-02 Conjugate compounds of polymers with other organic molecular entities.

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB9106894A Withdrawn GB2244491A (en) 1990-04-02 1991-04-02 Conjugate compounds of polymers with other organic molecular entities.

Country Status (3)

Country Link
AU (1) AU7563891A (en)
GB (2) GB9007384D0 (en)
WO (1) WO1991015242A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0683676A4 (en) * 1993-02-02 1998-09-30 Neorx Corp Directed biodistribution of small molecules.
EP0622394A1 (en) * 1993-04-30 1994-11-02 S.A. Laboratoires S.M.B. Reversible modification of sulfur-containing molecules with polyalkylene glycol derivatives and their use
US20010055581A1 (en) 1994-03-18 2001-12-27 Lawrence Tamarkin Composition and method for delivery of biologically-active factors
US5770645A (en) * 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US6232434B1 (en) 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US7229841B2 (en) 2001-04-30 2007-06-12 Cytimmune Sciences, Inc. Colloidal metal compositions and methods
US6407218B1 (en) 1997-11-10 2002-06-18 Cytimmune Sciences, Inc. Method and compositions for enhancing immune response and for the production of in vitro mabs
EP1694301A4 (en) 2003-12-02 2009-11-18 Cytimmune Sciences Inc Methods and compositions for the production of monoclonal antibodies
CA2706700A1 (en) 2007-11-08 2009-05-14 Cytimmune Sciences, Inc. Compositions and methods for generating antibodies

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5130599B2 (en) * 1972-09-07 1976-09-01
SE431758B (en) * 1977-03-04 1984-02-27 Pharmacia Fine Chemicals Ab AS THE USE OF THE TIOLATION REAGENT OR BERRY MATRIX FOR ENZYMERS DERIVATIVE OF A SH GROUPING POLYMER
DE2917001A1 (en) * 1978-04-28 1979-11-08 Toyo Jozo Kk NEW DISULFIDE COMPOUNDS
EP0040506B1 (en) * 1980-05-21 1986-08-20 Teijin Limited Reactive polymer and process for the preparation thereof
JPS57130911A (en) * 1981-02-06 1982-08-13 Kao Corp Second composition for permanent wave treatment
JPS59159828A (en) * 1983-03-02 1984-09-10 Teijin Ltd Reactive polymer and its production
JPS59215321A (en) * 1983-05-23 1984-12-05 Sumitomo Chem Co Ltd Reactive polymer having bound bifunctional ligand
CA1223222A (en) * 1984-02-22 1987-06-23 Nanibhushan Dattagupta Immobilized nucleic acid-containing probes
US4886755A (en) * 1984-12-07 1989-12-12 Bioprobe International, Inc. Preparation of polymeric thiol gels for covalent bonding of biologically active ligands
FR2601680B1 (en) * 1986-07-15 1990-06-29 Sanofi Sa PROTEIN SYNTHESIS INHIBITOR, ISOLATION METHOD, USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
FR2605237B1 (en) * 1986-10-20 1990-10-12 Centre Nat Rech Scient SUPPORT FOR THE PURIFICATION AND SEPARATION OF PROTEINS, PREPARATION METHOD AND APPLICATION IN CHROMATOGRAPHY
DE3726454A1 (en) * 1987-08-08 1989-02-16 Behringwerke Ag POLYMERS CONTAINING THIOL GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
ATE112172T1 (en) * 1987-10-30 1994-10-15 American Cyanamid Co TARGETFORMERS OF ANTITUMORIC METHYLTRITHIOAGENTS.
GB2233654A (en) * 1989-07-07 1991-01-16 Nat Res Dev Immobilised polynucleotides

Also Published As

Publication number Publication date
GB2244491A (en) 1991-12-04
AU7563891A (en) 1991-10-30
GB9106894D0 (en) 1991-05-22
WO1991015242A1 (en) 1991-10-17

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