GB9106894D0 - Conjugate compounds of polymers with other organic molecular entities - Google Patents
Conjugate compounds of polymers with other organic molecular entitiesInfo
- Publication number
- GB9106894D0 GB9106894D0 GB919106894A GB9106894A GB9106894D0 GB 9106894 D0 GB9106894 D0 GB 9106894D0 GB 919106894 A GB919106894 A GB 919106894A GB 9106894 A GB9106894 A GB 9106894A GB 9106894 D0 GB9106894 D0 GB 9106894D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- polymers
- molecular entities
- organic molecular
- conjugate compounds
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/338—Polymers modified by chemical after-treatment with inorganic and organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909007384A GB9007384D0 (en) | 1990-04-02 | 1990-04-02 | Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups |
Publications (2)
Publication Number | Publication Date |
---|---|
GB9106894D0 true GB9106894D0 (en) | 1991-05-22 |
GB2244491A GB2244491A (en) | 1991-12-04 |
Family
ID=10673725
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB909007384A Pending GB9007384D0 (en) | 1990-04-02 | 1990-04-02 | Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups |
GB9106894A Withdrawn GB2244491A (en) | 1990-04-02 | 1991-04-02 | Conjugate compounds of polymers with other organic molecular entities. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB909007384A Pending GB9007384D0 (en) | 1990-04-02 | 1990-04-02 | Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU7563891A (en) |
GB (2) | GB9007384D0 (en) |
WO (1) | WO1991015242A1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0683676A4 (en) * | 1993-02-02 | 1998-09-30 | Neorx Corp | Directed biodistribution of small molecules. |
EP0622394A1 (en) * | 1993-04-30 | 1994-11-02 | S.A. Laboratoires S.M.B. | Reversible modification of sulfur-containing molecules with polyalkylene glycol derivatives and their use |
US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
US6232434B1 (en) | 1996-08-02 | 2001-05-15 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
US5770645A (en) * | 1996-08-02 | 1998-06-23 | Duke University Medical Center | Polymers for delivering nitric oxide in vivo |
US7229841B2 (en) | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
US6407218B1 (en) | 1997-11-10 | 2002-06-18 | Cytimmune Sciences, Inc. | Method and compositions for enhancing immune response and for the production of in vitro mabs |
JP2008504216A (en) | 2003-12-02 | 2008-02-14 | サイトイミューン サイエンシズ インコーポレイテッド | Methods and compositions for the production of monoclonal antibodies |
CA2706700A1 (en) | 2007-11-08 | 2009-05-14 | Cytimmune Sciences, Inc. | Compositions and methods for generating antibodies |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5130599B2 (en) * | 1972-09-07 | 1976-09-01 | ||
SE431758B (en) * | 1977-03-04 | 1984-02-27 | Pharmacia Fine Chemicals Ab | AS THE USE OF THE TIOLATION REAGENT OR BERRY MATRIX FOR ENZYMERS DERIVATIVE OF A SH GROUPING POLYMER |
SE448631B (en) * | 1978-04-28 | 1987-03-09 | Toyo Jozo Kk | DISULFIDE ASSOCIATION OF A SAR-S REPLACTER REACTIVITY |
EP0040506B1 (en) * | 1980-05-21 | 1986-08-20 | Teijin Limited | Reactive polymer and process for the preparation thereof |
JPS57130911A (en) * | 1981-02-06 | 1982-08-13 | Kao Corp | Second composition for permanent wave treatment |
JPS59159828A (en) * | 1983-03-02 | 1984-09-10 | Teijin Ltd | Reactive polymer and its production |
JPS59215321A (en) * | 1983-05-23 | 1984-12-05 | Sumitomo Chem Co Ltd | Reactive polymer having bound bifunctional ligand |
CA1223222A (en) * | 1984-02-22 | 1987-06-23 | Nanibhushan Dattagupta | Immobilized nucleic acid-containing probes |
US4886755A (en) * | 1984-12-07 | 1989-12-12 | Bioprobe International, Inc. | Preparation of polymeric thiol gels for covalent bonding of biologically active ligands |
FR2601680B1 (en) * | 1986-07-15 | 1990-06-29 | Sanofi Sa | PROTEIN SYNTHESIS INHIBITOR, ISOLATION METHOD, USE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
FR2605237B1 (en) * | 1986-10-20 | 1990-10-12 | Centre Nat Rech Scient | SUPPORT FOR THE PURIFICATION AND SEPARATION OF PROTEINS, PREPARATION METHOD AND APPLICATION IN CHROMATOGRAPHY |
DE3726454A1 (en) * | 1987-08-08 | 1989-02-16 | Behringwerke Ag | POLYMERS CONTAINING THIOL GROUPS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE |
DE3889063T2 (en) * | 1987-10-30 | 1994-12-01 | American Cyanamid Co | Disulfur analogs of LL-E33288 antitumor compounds. |
GB2233654A (en) * | 1989-07-07 | 1991-01-16 | Nat Res Dev | Immobilised polynucleotides |
-
1990
- 1990-04-02 GB GB909007384A patent/GB9007384D0/en active Pending
-
1991
- 1991-04-02 WO PCT/GB1991/000515 patent/WO1991015242A1/en active Application Filing
- 1991-04-02 GB GB9106894A patent/GB2244491A/en not_active Withdrawn
- 1991-04-02 AU AU75638/91A patent/AU7563891A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GB2244491A (en) | 1991-12-04 |
AU7563891A (en) | 1991-10-30 |
WO1991015242A1 (en) | 1991-10-17 |
GB9007384D0 (en) | 1990-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |