AR246083A1 - Procedimiento para producir analogos de disulfuro de un antibiotico ll-33288 - Google Patents
Procedimiento para producir analogos de disulfuro de un antibiotico ll-33288Info
- Publication number
- AR246083A1 AR246083A1 AR88312321A AR31232188A AR246083A1 AR 246083 A1 AR246083 A1 AR 246083A1 AR 88312321 A AR88312321 A AR 88312321A AR 31232188 A AR31232188 A AR 31232188A AR 246083 A1 AR246083 A1 AR 246083A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- alfa
- beta
- divalent
- hydrogen
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
Abstract
UN PROCEDIMIENTO PARA PRODUCIR ANALOGOS DE DISULFURO DE UN ANTIBIOTICO LL- E33288ALFA(1)-BR, ALFA(1)-L, ALFA(2)-BR, ALFA(2)-L, ALFA(3)-BR, ALFA(3)-L, ALFA(4)-BR, BETA(1)-BR, BETA(1)-L, BETA(2)-L,GAMA(1)-BR,GAMA(1)-L, OMEGA (1)-L, BBM-1675, FR-900405,FR-900406,PD 114759, PD 115028, CL-1577A, CL- 1577B, CL-1577D, CL-1577E, O CL-1724 DE LA FORMULA Q-SP-SS-W, DONDE: W ES FORMULA (I), R1 ES FORMULA (II) O CH3, R2 ES FORMULA (III) O H, R3 ES FORMULA (IV) O H, R4 ES FORMULA (V) O H, R5 ES FORMULA (VI) O R6 ES FORMULA (VII) O H, R7 ES FORMULA VIII) O H, Y X ES IODO O BROMO; SP ES UN RADICAL DIVALENTE; ARILO O HETEROARILO DIVALENTES, CICLOALQUILO O HETEROCICLOALQUILO DIVALENTES, ARILALQUILO O HETEROARILALQUILO DIVALENTES, CICLOALQUILALQUILO O HETEROCICLOALQUILALQUILO DIVALENTES,O ALQUILO INSATURADOS DIVALENTES; Q ES HIDROGENO, HALOGENO, AMINO, ALQUILAMINO, DIALQUILAMINO, PIPERIDINO, PIRROLIDINO, PIPERAZINO, CARBOXILO, CARBOXALDEHIDO, ALCOXI INFERIOR, HIDROXI, TIOL ALQUILDICARBOXILO INFERIOR, -COHNH2, -NHCONHNH2, -CSNHNH2, -NHCSNHNH2, O -ONH2; CON LA CONDICION DE QUE CUANDO SP ES ETILIDENO, Q NO PUEDE SER HIDROGENO QUE COMPRENDE HACER REACCIONAR UN ANTIBIOTICO DE DE TRISULFURO DE ALQUILO ELEGIDO ENTRE LOS QUE ANTECEDEN CON UN MERCAPTANO SUSTITUIDO APROPIADO EN ACETONITRILO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11494087A | 1987-10-30 | 1987-10-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR246083A1 true AR246083A1 (es) | 1994-03-30 |
Family
ID=22358378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AR88312321A AR246083A1 (es) | 1987-10-30 | 1988-10-27 | Procedimiento para producir analogos de disulfuro de un antibiotico ll-33288 |
Country Status (19)
Country | Link |
---|---|
EP (2) | EP0313873B1 (es) |
JP (2) | JP2820256B2 (es) |
KR (2) | KR970011385B1 (es) |
AR (1) | AR246083A1 (es) |
AT (2) | ATE104309T1 (es) |
AU (2) | AU612714B2 (es) |
BR (1) | BR1100939A (es) |
CA (1) | CA1321582C (es) |
DE (2) | DE3889063T2 (es) |
DK (2) | DK602488A (es) |
ES (2) | ES2059464T3 (es) |
FI (2) | FI95204C (es) |
HK (2) | HK131997A (es) |
IE (2) | IE65053B1 (es) |
IL (2) | IL87946A (es) |
NO (2) | NO176480C (es) |
NZ (2) | NZ226726A (es) |
PT (2) | PT88881B (es) |
ZA (2) | ZA888127B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5079233A (en) * | 1987-01-30 | 1992-01-07 | American Cyanamid Company | N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same |
US5606040A (en) * | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
IL93733A (en) * | 1989-04-14 | 1996-01-19 | American Cyanamid Co | History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form |
GB9007384D0 (en) * | 1990-04-02 | 1990-05-30 | Duncan Ruth | Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups |
US5712374A (en) * | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
US5714586A (en) * | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
IL143266A0 (en) | 1998-11-27 | 2002-04-21 | Darwin Discovery Ltd | Transforming growth factor-beta binding proteins and pharmaceutical compositions for increasing bone mineral content utilizing the same |
US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
NZ511705A (en) * | 2001-05-14 | 2004-03-26 | Horticulture & Food Res Inst | Methods and rapid immunoassay device for detecting progesterone and other steroids |
CA2529623A1 (en) | 2003-06-16 | 2005-02-17 | Celltech R & D, Inc. | Antibodies specific for sclerostin and methods for increasing bone mineralization |
WO2008028050A2 (en) * | 2006-08-30 | 2008-03-06 | Wisconsin Alumni Research Foundation | Reversible natural product glycosyltransferase-catalyzed reactions, compounds and related methods |
KR100979928B1 (ko) * | 2008-07-16 | 2010-09-03 | 한주학 | 수직축형 부력풍차 |
JP6494240B2 (ja) * | 2013-11-04 | 2019-04-03 | ファイザー・インク | カリケアマイシン誘導体を合成するための中間体および方法 |
US20190345186A1 (en) * | 2017-01-24 | 2019-11-14 | Pfizer Inc. | Calicheamicin deratives and antibody drug conjugates thereof |
KR20210118945A (ko) | 2019-02-15 | 2021-10-01 | 유니버시티 오브 써던 캘리포니아 | Lym-1 및 lym-2 항체 조성물 및 개선된 car 구성물 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2430943A1 (fr) * | 1978-07-13 | 1980-02-08 | Toyo Jozo Kk | Nouveaux derives disulfures |
EP0040506B1 (en) * | 1980-05-21 | 1986-08-20 | Teijin Limited | Reactive polymer and process for the preparation thereof |
US4530835A (en) * | 1983-07-08 | 1985-07-23 | Warner-Lambert Company | CL-1577 Antibiotic compounds and their production |
CA1314245C (en) * | 1984-05-23 | 1993-03-09 | Franz Jansen | Process for the preparation of conjugates in which a monovalent carboxylic ionophore is associated by means of a covalent bond with a macromolecule, which are useful as immunotoxin potentiators |
ATE180513T1 (de) * | 1984-11-16 | 1999-06-15 | American Cyanamid Co | Antitumorale antibiotika (komplex ll-e-33288) |
EP0330874A3 (en) * | 1988-02-29 | 1989-10-18 | American Cyanamid Company | Antibacterial and antitumor agents LL-E33288 epsilon-I and LL-E33288-epsilonBr, with processes and intermediates for producing said agents |
EP0342341A3 (en) * | 1988-05-17 | 1991-07-24 | American Cyanamid Company | Process for producing antitumor antibiotic ll-e33288gamma2 |
-
1988
- 1988-10-03 DE DE3889063T patent/DE3889063T2/de not_active Expired - Lifetime
- 1988-10-03 AT AT88116339T patent/ATE104309T1/de not_active IP Right Cessation
- 1988-10-03 DE DE3851682T patent/DE3851682T2/de not_active Expired - Lifetime
- 1988-10-03 ES ES88116338T patent/ES2059464T3/es not_active Expired - Lifetime
- 1988-10-03 EP EP88116338A patent/EP0313873B1/en not_active Expired - Lifetime
- 1988-10-03 AT AT88116338T patent/ATE112172T1/de not_active IP Right Cessation
- 1988-10-03 ES ES88116339T patent/ES2061586T3/es not_active Expired - Lifetime
- 1988-10-03 EP EP88116339A patent/EP0313874B1/en not_active Expired - Lifetime
- 1988-10-06 IL IL8794688A patent/IL87946A/en active Protection Beyond IP Right Term
- 1988-10-06 IL IL8794788A patent/IL87947A/en active Protection Beyond IP Right Term
- 1988-10-26 NZ NZ226726A patent/NZ226726A/xx unknown
- 1988-10-26 NZ NZ226727A patent/NZ226727A/en unknown
- 1988-10-27 AR AR88312321A patent/AR246083A1/es active
- 1988-10-28 DK DK602488A patent/DK602488A/da not_active Application Discontinuation
- 1988-10-28 ZA ZA888127A patent/ZA888127B/xx unknown
- 1988-10-28 AU AU24494/88A patent/AU612714B2/en not_active Expired
- 1988-10-28 AU AU24489/88A patent/AU618763B2/en not_active Expired
- 1988-10-28 IE IE326188A patent/IE65053B1/en not_active IP Right Cessation
- 1988-10-28 PT PT88881A patent/PT88881B/pt not_active IP Right Cessation
- 1988-10-28 ZA ZA888123A patent/ZA888123B/xx unknown
- 1988-10-28 IE IE326288A patent/IE65989B1/en not_active IP Right Cessation
- 1988-10-28 NO NO884833A patent/NO176480C/no not_active IP Right Cessation
- 1988-10-28 PT PT88882A patent/PT88882B/pt not_active IP Right Cessation
- 1988-10-28 DK DK198806025A patent/DK174739B1/da not_active IP Right Cessation
- 1988-10-28 CA CA000581590A patent/CA1321582C/en not_active Expired - Lifetime
- 1988-10-28 FI FI884984A patent/FI95204C/fi not_active IP Right Cessation
- 1988-10-28 NO NO884834A patent/NO173506C/no not_active IP Right Cessation
- 1988-10-28 FI FI884983A patent/FI91262C/fi not_active IP Right Cessation
- 1988-10-29 JP JP63272007A patent/JP2820256B2/ja not_active Expired - Lifetime
- 1988-10-29 JP JP63272006A patent/JP2720933B2/ja not_active Expired - Lifetime
- 1988-10-30 KR KR1019880014245A patent/KR970011385B1/ko not_active IP Right Cessation
- 1988-10-30 KR KR1019880014246A patent/KR0133130B1/ko not_active IP Right Cessation
-
1997
- 1997-05-14 BR BR1100939-0A patent/BR1100939A/pt active IP Right Grant
- 1997-06-26 HK HK131997A patent/HK131997A/xx not_active IP Right Cessation
- 1997-06-26 HK HK131897A patent/HK131897A/xx not_active IP Right Cessation
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