ES2062974T3 - Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos. - Google Patents

Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos.

Info

Publication number
ES2062974T3
ES2062974T3 ES87109416T ES87109416T ES2062974T3 ES 2062974 T3 ES2062974 T3 ES 2062974T3 ES 87109416 T ES87109416 T ES 87109416T ES 87109416 T ES87109416 T ES 87109416T ES 2062974 T3 ES2062974 T3 ES 2062974T3
Authority
ES
Spain
Prior art keywords
group
antibacterial agents
preparation procedures
cephalosporin compounds
heterociclico
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87109416T
Other languages
English (en)
Inventor
Yoshiyuki Zama
Nobuo Ishiyama
Tsuneo Saita
Takanobu Naito
Masao Hirose
Masaaki Yokoyama
Taiji Asano
Hisato Senda
Keiji Sekine
Shigeru Sanai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2062974T3 publication Critical patent/ES2062974T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

UN COMPUESTO DE CEFALOSPORINA QUE TIENE LA FORMULA (I) DONDE R1 ES UN ATOMO DE HIDROGENO, UN ATOMO DE HALOGENO, UN GRUPO METOXI, UN GRUPO VINILO, SUSTITUIDO O NO, O -CH2-A, DONDE A ES UN ATOMO DE HIDROGENO, UN GRUPO AZIDO, UN GRUPO ACIXLOXI, UN GRUPO CARBAMOILOXI, UN GRUPO HETEROCICLICO, SUSTITUIDO O NO, (DONDE EL ANILLO HETEROCICLICO ES DE 5 O 6 MIEMBROS Y TIENE DE 1 A 4 ATOMOS DE OXIGENO, NITROGENO O AZUFRE ), O UN GRUPO TIO HETEROCICLICO, SUSTITUIDO O NO, (DONDE EL ANILLO HETEROCICLICO ES MONOCICLICO O BICICLICO Y TIENE DE 1 A 5 ATOMOS DE OXIGENO, NITROGENO O AZUFRE), O SUS SALES FARMACOLOGICAMENTE ACEPTABLES.
ES87109416T 1986-07-01 1987-06-30 Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos. Expired - Lifetime ES2062974T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15270686 1986-07-01
JP19159086 1986-08-18

Publications (1)

Publication Number Publication Date
ES2062974T3 true ES2062974T3 (es) 1995-01-01

Family

ID=26481559

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87109416T Expired - Lifetime ES2062974T3 (es) 1986-07-01 1987-06-30 Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos.

Country Status (10)

Country Link
US (2) US4822786A (es)
EP (1) EP0251299B1 (es)
KR (1) KR930007418B1 (es)
CN (1) CN1022036C (es)
AT (1) ATE110729T1 (es)
AU (3) AU597676B2 (es)
CA (1) CA1283404C (es)
DE (1) DE3750443T2 (es)
ES (1) ES2062974T3 (es)
HU (3) HU198500B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028601A (en) * 1987-04-30 1991-07-02 Meiji Saika Kaisha, Ltd. Cephalosporin compounds and antibacterial agents
JPH0633281B2 (ja) * 1987-11-11 1994-05-02 明治製菓株式会社 新規セファロスポリン化合物及び抗菌剤
JPH0686463B2 (ja) * 1988-07-01 1994-11-02 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JPH0248580A (ja) * 1988-08-10 1990-02-19 Meiji Seika Kaisha Ltd 新規セファロスポリン系化合物及び抗菌剤
EP0400805A1 (en) * 1989-04-25 1990-12-05 Toshiyasu Ishimaru Cephalosporin compounds and their use
JPH03176473A (ja) * 1989-12-01 1991-07-31 Kaken Pharmaceut Co Ltd ピリジン―ｎ―オキシド誘導体及びその製法
EP0579221A1 (en) * 1992-07-17 1994-01-19 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
JPH11124384A (ja) * 1997-10-17 1999-05-11 Otsuka Chem Co Ltd ３−セフェム化合物の製造法
US6352770B1 (en) 1999-01-15 2002-03-05 Bic Corporation Correction tape having dye migration blocking properties
CN101410111B (zh) 2005-12-07 2012-12-12 巴斯利尔药物股份公司 单环-内酰胺类抗生素与β-内酰胺酶抑制剂的有效的联合应用
KR101320718B1 (ko) 2007-03-23 2013-10-21 바실리어 파마슈티카 아게 세균 감염 치료용 조합 약제
ES2789177T3 (es) 2010-08-10 2020-10-26 Melinta Therapeutics Inc Derivados de éster del ácido borónico cíclicos, procedimiento para la preparación y usos terapéuticos de los mismos
WO2013033461A1 (en) 2011-08-31 2013-03-07 Rempex Pharmaceuticals, Inc. Heterocyclic boronic acid ester derivatives and therapeutic uses thereof
US9156858B2 (en) 2012-05-23 2015-10-13 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US10561675B2 (en) 2012-06-06 2020-02-18 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
US9101638B2 (en) 2013-01-04 2015-08-11 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
AU2014204046B2 (en) 2013-01-04 2017-02-23 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
US9241947B2 (en) 2013-01-04 2016-01-26 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CA2894891A1 (en) 2013-01-04 2014-07-10 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
EP3139930A4 (en) 2014-05-05 2018-01-17 Rempex Pharmaceuticals, Inc. Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof
EP3140310B1 (en) 2014-05-05 2019-08-07 Rempex Pharmaceuticals, Inc. Synthesis of boronate salts and uses thereof
CN106459096B (zh) 2014-05-19 2019-03-08 莱姆派克斯制药公司 硼酸衍生物及其治疗用途
CA2952968A1 (en) 2014-07-01 2016-01-07 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
WO2016081297A1 (en) 2014-11-18 2016-05-26 Rempex Pharmaceuticals, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
ES2761778T3 (es) 2014-12-19 2020-05-21 Rempex Pharmaceuticals Inc Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico
US20180051041A1 (en) 2015-03-17 2018-02-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
ES2894251T3 (es) 2016-06-30 2022-02-14 Qpex Biopharma Inc Derivados de ácido borónico y usos terapéuticos de los mismos
CN107641119B (zh) 2016-07-21 2019-11-08 中国科学院上海药物研究所 单环β-内酰胺-铁载体轭合物及其制备方法和用途
CN111212843A (zh) 2017-10-11 2020-05-29 Qpex生物制药有限公司 硼酸衍生物及其合成
CN112409383A (zh) * 2020-11-30 2021-02-26 上海交通大学医学院 一种氨噻肟哌啶酮头孢菌素的制备及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
JPS5849382A (ja) * 1981-09-18 1983-03-23 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
US4616081A (en) * 1982-07-07 1986-10-07 Asahi Kasei Kogyo Kabushiki Kaisha Cephalosporin compounds
JPS59167576A (ja) * 1983-03-15 1984-09-21 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物
JPS59219282A (ja) * 1983-05-28 1984-12-10 Kyowa Hakko Kogyo Co Ltd β−ラクタム化合物およびその中間体
GB8329043D0 (en) * 1983-10-31 1983-11-30 Hider R C Pharmaceutical compositions
GB8410289D0 (en) * 1984-04-19 1984-05-31 Callingham B A Pharmaceutical compositions
AU586229B2 (en) * 1985-04-01 1989-07-06 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
DE3826846A1 (de) * 1988-08-06 1990-02-08 Goedecke Ag Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel

Also Published As

Publication number Publication date
CN87104590A (zh) 1988-01-13
EP0251299A3 (en) 1989-10-11
US4822786A (en) 1989-04-18
AU635174B2 (en) 1993-03-11
HUT56071A (en) 1991-07-29
KR930007418B1 (ko) 1993-08-10
HUT44259A (en) 1988-02-29
AU6214390A (en) 1990-12-20
HU198500B (en) 1989-10-30
AU7493187A (en) 1988-01-07
AU597676B2 (en) 1990-06-07
AU1962892A (en) 1992-09-10
HU908257D0 (en) 1991-06-28
EP0251299A2 (en) 1988-01-07
CN1022036C (zh) 1993-09-08
US4883879A (en) 1989-11-28
AU627067B2 (en) 1992-08-13
EP0251299B1 (en) 1994-08-31
ATE110729T1 (de) 1994-09-15
DE3750443D1 (de) 1994-10-06
DE3750443T2 (de) 1995-04-20
KR880001674A (ko) 1988-04-26
HUT56099A (en) 1991-07-29
CA1283404C (en) 1991-04-23

Similar Documents

Publication Publication Date Title
ES2062974T3 (es) Compuestos de cefalosporina, procedimientos para su preparacion y agentes antibacterianos.
ES2055056T3 (es) Derivados de pirimidopirimidina.
ES2031513T3 (es) Quinazolindionas y piridopirimidinadionas.
ES2070175T3 (es) Derivados de acido 4-oxoquinolino-3-carboxilico, su preparacion y su uso.
ATE180773T1 (de) N-sulfonyl-2-oxoindol-derivate mit einer affinität für die vasopressin und/oder ocytocin rezeptoren
NO904377L (no) Tricykliske karbapenemforbindelser.
JPS568361A (en) Pyroglutamic acid derivative and analogue
FI862757A (fi) Pyridonkarbonsyraderivat och foerfarande foer framstaellning av dessa.
DK0625977T3 (da) Piperazinderivater som 5-1A-antagonister
ES2053439T3 (es) Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
DE3572170D1 (de) Quinolonecarboxylic acid derivatives
AR241180A1 (es) Compuesto de benzisoxazol que incluye esteroisomeros del mismo y formulacion herbicida que lo contiene.
DK0589322T3 (da) 5-Oxo-dibenzo a,d cyclohepta-1,4-diener samt deres anvendelse som retrovirale midler.
ES2051954T3 (es) 2-aminotiazoles substituidos.
ES547129A0 (es) Un procedimiento para la produccion de derivados de benzoilurea.
ES2051674T3 (es) Derivados de benzoxazinona y benzotiazinona dotados de actividad cardiovascular.
FI871637A (fi) Foerfarande foer framstaellning av 1,5-benzotiazepinderivat.
FI915979A0 (fi) Fenylalkylaminoalkylfoereningar samt foerfaranden foer deras framstaellning och laekemedel som innehaoller dessa foereningar.
ES8706129A1 (es) Un procedimiento para la preparacion de derivados de imidazol triciclicos
ES509553A0 (es) "procedimiento para la preparacion de nuevas cefalosporinas".
ES545617A0 (es) Procedimiento para la preparacion de derivados de carboci- clina
DK535388A (da) Anvendelse af piperidinopropiophenonforbindelse til fremstilling af et hypotensivt middel
ES2060711T3 (es) 2-aminotiazoles substituidos.
ES2036577T3 (es) Procedimiento de preparacion de bencensulfonamidas utiles como agentes anti-arritmicos.
CO4180609A1 (es) Derivados de timosina alfa-1

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 251299

Country of ref document: ES