ES8706128A1 - Un procedimiento para la preparacion de derivados de imidazol triciclicos - Google Patents

Un procedimiento para la preparacion de derivados de imidazol triciclicos

Info

Publication number
ES8706128A1
ES8706128A1 ES551471A ES551471A ES8706128A1 ES 8706128 A1 ES8706128 A1 ES 8706128A1 ES 551471 A ES551471 A ES 551471A ES 551471 A ES551471 A ES 551471A ES 8706128 A1 ES8706128 A1 ES 8706128A1
Authority
ES
Spain
Prior art keywords
lower alkyl
imidazole derivatives
tricyclic imidazole
hydrogen
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES551471A
Other languages
English (en)
Other versions
ES551471A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES551471A0 publication Critical patent/ES551471A0/es
Publication of ES8706128A1 publication Critical patent/ES8706128A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DE IMIDAZOL TRICICLICOS. CONSISTE EN OXIDAR POR MEDIO DE UN PERCOMPUESTO, TAL COMO UN PEROXIDO O UN PERACIDO, UN COMPUESTO DE FORMULA (II), PARA OBTENER DERIVADOS DE IMIDAZOL TRICICLICOS DE FORMULA (I), Y SI SE DESEA, CONVERTIR UNA BASE LIBRE OBTENIDA EN UN SAL DE ADICION DE ACIDO Y/O CONVERTIR UNA SAL DE ADICION DE ACIDO EN UNA BASE LIBRE O EN OTRA SAL DE ADICION DE ACIDO, DONDE R1 Y R3 SON ALQUILO INFERIOR; R2 ES ALQUILO INFERIOR; Y A ES UN RADICAL DE FORMULAS (III), (IV) O (V). TIENE APLICACIONES FARMACEUTICAS PARA EL CONTROL Y PREVENCION DE ULCERAS.
ES551471A 1984-04-19 1986-01-31 Un procedimiento para la preparacion de derivados de imidazol triciclicos Expired ES8706128A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH196684 1984-04-19

Publications (2)

Publication Number Publication Date
ES551471A0 ES551471A0 (es) 1987-06-01
ES8706128A1 true ES8706128A1 (es) 1987-06-01

Family

ID=4222776

Family Applications (4)

Application Number Title Priority Date Filing Date
ES542370A Expired ES8607963A1 (es) 1984-04-19 1985-04-18 "un procedimiento para la preparacion de derivados de imi- dazol triciclicos"
ES551471A Expired ES8706128A1 (es) 1984-04-19 1986-01-31 Un procedimiento para la preparacion de derivados de imidazol triciclicos
ES551473A Expired ES8706129A1 (es) 1984-04-19 1986-01-31 Un procedimiento para la preparacion de derivados de imidazol triciclicos
ES551472A Expired ES8706124A1 (es) 1984-04-19 1986-01-31 Un procedimiento para la preparacion de derivados de imidazol triciclicos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES542370A Expired ES8607963A1 (es) 1984-04-19 1985-04-18 "un procedimiento para la preparacion de derivados de imi- dazol triciclicos"

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES551473A Expired ES8706129A1 (es) 1984-04-19 1986-01-31 Un procedimiento para la preparacion de derivados de imidazol triciclicos
ES551472A Expired ES8706124A1 (es) 1984-04-19 1986-01-31 Un procedimiento para la preparacion de derivados de imidazol triciclicos

Country Status (21)

Country Link
US (2) US4634710A (es)
EP (1) EP0163842A1 (es)
JP (1) JPS60233070A (es)
KR (1) KR850007256A (es)
AU (1) AU589555B2 (es)
CS (2) CS250248B2 (es)
DD (1) DD232277A5 (es)
DK (1) DK148585A (es)
ES (4) ES8607963A1 (es)
FI (1) FI851431L (es)
GR (1) GR850949B (es)
HU (1) HU193362B (es)
IL (1) IL74880A (es)
MC (1) MC1650A1 (es)
NO (1) NO162617C (es)
NZ (1) NZ211773A (es)
PH (1) PH21046A (es)
PT (1) PT80315B (es)
SU (2) SU1362402A3 (es)
ZA (1) ZA852765B (es)
ZW (1) ZW4585A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK337086A (da) * 1985-08-12 1987-02-13 Hoffmann La Roche Benzimidazolderivater
US5433959A (en) * 1986-02-13 1995-07-18 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
US6749864B2 (en) * 1986-02-13 2004-06-15 Takeda Chemical Industries, Ltd. Stabilized pharmaceutical composition
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
EP1534278A4 (en) * 2002-08-01 2006-09-06 Nitromed Inc NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD
RU2487126C1 (ru) * 2011-11-28 2013-07-10 Открытое акционерное общество "Федеральный научно-производственный центр "Алтай" Способ получения 1,4-диоксан-2,3-диола

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1805548A1 (de) * 1968-10-26 1970-10-08 Agfa Gevaert Ag Benzimidazol-Derivate und ihre photographische Verwendung
IN148930B (es) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
IL71665A (en) * 1983-05-03 1988-05-31 Byk Gulden Lomberg Chem Fab Fluoro-(2-pyridyl-methylthio)-dioxolo-(and dioxino-)benzimidazoles,processes for their preparation and pharmaceutical compositions containing the same
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
ES8607963A1 (es) 1986-06-16
DK148585D0 (da) 1985-04-01
NO162617B (no) 1989-10-16
PT80315A (en) 1985-05-01
NZ211773A (en) 1989-01-06
AU4122885A (en) 1985-10-24
IL74880A (en) 1988-06-30
NO162617C (no) 1990-01-24
EP0163842A1 (de) 1985-12-11
ZA852765B (en) 1985-11-27
HUT37613A (en) 1986-01-23
ES551473A0 (es) 1987-06-01
DK148585A (da) 1985-10-20
GR850949B (es) 1985-11-25
HU193362B (en) 1987-09-28
JPS60233070A (ja) 1985-11-19
CS250249B2 (en) 1987-04-16
US4634710A (en) 1987-01-06
CS250248B2 (en) 1987-04-16
ES551472A0 (es) 1987-06-01
ES8706129A1 (es) 1987-06-01
FI851431A0 (fi) 1985-04-10
AU589555B2 (en) 1989-10-19
ZW4585A1 (en) 1985-11-20
FI851431L (fi) 1985-10-20
IL74880A0 (en) 1985-07-31
MC1650A1 (fr) 1986-04-07
KR850007256A (ko) 1985-12-02
ES551471A0 (es) 1987-06-01
SU1362402A3 (ru) 1987-12-23
ES8706124A1 (es) 1987-06-01
SU1396965A3 (ru) 1988-05-15
NO851550L (no) 1985-10-21
US4981861A (en) 1991-01-01
PH21046A (en) 1987-07-03
PT80315B (en) 1987-03-16
DD232277A5 (de) 1986-01-22
ES542370A0 (es) 1986-06-16

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