KR850007256A - 트리사이클릭 이미다졸 유도체의 제조방법 - Google Patents
트리사이클릭 이미다졸 유도체의 제조방법 Download PDFInfo
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- KR850007256A KR850007256A KR1019850002583A KR850002583A KR850007256A KR 850007256 A KR850007256 A KR 850007256A KR 1019850002583 A KR1019850002583 A KR 1019850002583A KR 850002583 A KR850002583 A KR 850002583A KR 850007256 A KR850007256 A KR 850007256A
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- methyl
- compound
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- pyridyl
- dihydro
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (21)
- a) 일반식(Ⅱ)의 화합물과 일반식(Ⅲ)의 화합물을 반응시키커나; b) n이 0인 일반식(Ⅰ)화합물을 산화시켜 n이 1인 상응하는 화합물을 생성시키거나; c) A가 일반식(b)의 잔기를 나타내고, n이 0인 일반식(Ⅰ)화합물과 일반식(Ⅳ)화합물을 반응시키거나; d) 일반식 (Ⅴ)의 화합물을 저급알콕시 그룹을 생성시키는 시약으로 처리하거나; e) 일반식(Ⅳ)의 화합물과 일반식(Ⅶ)의 화합물을 반응시키거나; f)의 일반식(Ⅷ)의 화합물과 일반식(Ⅸ)의 화합물을 반응시키고; 경우에 따라 생성된 유리염기를 산 부가염으로 전환시키고/시키거나, 생성된 산부가염을 유리염기 또는 다른 산부가염으로 전환시킴을 특징으로 하여, 일반식 (Ⅰ)의 트리사이클릭 이미다졸 유도체 및 그의 산부가염을 제조하는 방법.상기식에서, R1및 R3중의 하나는 저급알킬이고, 다른하나는 수소 또는 저급알킬이며; R2는 저급알킬이고; n은 0또는 1이며;A는 일반식의 잔기를 나타내고, 여기저기에서 R4, R5, R6및 R7은 각기 저급알킬이며, R8은 수소 또는 저급알킬이고; Y 및 Y' 중의 하나는 머캅토 그룹이며, 다른 하나는 이탈그룹이고; A'는 상기 (A)에서 정의한 일반식(a),(b) 또는 (c)의 잔기를 나타내며 단, 일반식(c)의 잔기에서 R8은 저급알킬이고; M은 알칼리 금속원자를 나타내며; Z는 이탈그룹이다.
- 제1항에 있어서, A가 일반식(b) 또는 (c)의 잔기를 나타내는 방법.
- 제2항에 있어서, A가 일반식(b)의 잔기를 나타내고 R4, R5, R6및 R7이 각기 메틸을 나타내는 방법.
- 제2항에 있어서, A가 일반식(c)의 잔기를 나타내고 R4, R5, R6및 R7이 각기 메틸을 나타내며, R8이 수소 또는 메틸을 나타내는 방법.
- 제1내지 4항중 어느 한항에 있어서, R2가 메틸 또는 에틸인 방법.
- 제1내지 5항중 어느 한항에 있어서, R1이 수소이고 R3가 메탈인 방법.
- 제1내지 5항중 어느 한항에 있어서, R1이 수소이고 R3가 수소인 방법.
- 제1내지 5항중 어느 한항에 있어서, R1및 R3가 각기 메탈인 방법.
- 제1항에 있어서, 5,7-디하이드로-2-[[(4-메톡시-3-메틸-2-피리딜)메틸]티오]-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸 -6(1H)-온을 제조하는 방법.
- 제1항에 있어서, 5,7-디하이드로-2-[[(4-메톡시-3-메틸-2-피리딜)메틸]설피닐]-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6(1H)-온을 제조하는 방법.
- 제1항에 있어서, 2-[[(4-에톡시-3-메틸-2-피리딜)메틸]티오]-5,7-디하이드로-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6(1H)-온을 제조하는 방법.
- 제1항에 있어서, 2-[[(4-에톡시-3-메틸-2-피리딜)메틸]설피닐]-5,7-디하이드로-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6-(1H)-온을 제조하는 방법.
- 제1항에 있어서, 5,7-디하이드로-2-[[(4-메톡시-3,5-디메틸-2-피리딜)메틸]티오]-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6-(1H)-온을 제조하는 방법.
- 제1항에 있어서, 5,7-디하이드로-2-[[(4-메톡시-3,5-디메틸-2-피리딜)메틸]설피닐]-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6(1H)-온을 제조하는 방법.
- 제1항에 있어서, 5,7-디하이드로-2-[[(4-메톡시-5-메틸-2-피리딜)메틸]티오]-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6-(1H)-온을 제조하는 방법.
- 제1항에 있어서,5,7-디하이드로-2-[[(4-메톡시-5-메틸-2-피리딜)메틸]티오]-5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6-(1H)-온을 제조하는 방법.
- 제1항에 있어서,2-[[(4-에톡시-5-메틸-2-피리딜)메틸]티오]-5,7-디하이드로 -5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6(1H)-온을 제조하는 방법.
- 제1항에 있어서,2-[[(4-에톡시-5-메틸-2-피리딜)메틸]설피닐]-5,7-디하이드로 -5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6(1H)-온을 제조하는 방법.
- 제1항에 있어서,5,7-디하이드로-2-[[(4-메톡시-3-메틸-2-피리딜)메틸]티오] -5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6(1H)-온 0-메탈옥심을 제조하는 방법.
- 제1항에 있어서,5,7-디하이드로-2-[[(4-메톡시-3-메틸-2-피리딜)메틸]설피닐] -5,5,7,7-테트라메틸인데노 [5,6-d] 이미다졸-6(1H)-온 0-메탈옥심을 제조하는 방법.
- 제1항에 있어서 A가 일반식(a)의 잔기를 나타내는 일반식(Ⅰ)화합물을 방법 d),e) 또는 f)에 따라 제조하는 방법.※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH196684 | 1984-04-19 | ||
CH1966/84 | 1984-04-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR850007256A true KR850007256A (ko) | 1985-12-02 |
Family
ID=4222776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850002583A KR850007256A (ko) | 1984-04-19 | 1985-04-17 | 트리사이클릭 이미다졸 유도체의 제조방법 |
Country Status (21)
Country | Link |
---|---|
US (2) | US4634710A (ko) |
EP (1) | EP0163842A1 (ko) |
JP (1) | JPS60233070A (ko) |
KR (1) | KR850007256A (ko) |
AU (1) | AU589555B2 (ko) |
CS (2) | CS250248B2 (ko) |
DD (1) | DD232277A5 (ko) |
DK (1) | DK148585A (ko) |
ES (4) | ES8607963A1 (ko) |
FI (1) | FI851431L (ko) |
GR (1) | GR850949B (ko) |
HU (1) | HU193362B (ko) |
IL (1) | IL74880A (ko) |
MC (1) | MC1650A1 (ko) |
NO (1) | NO162617C (ko) |
NZ (1) | NZ211773A (ko) |
PH (1) | PH21046A (ko) |
PT (1) | PT80315B (ko) |
SU (2) | SU1362402A3 (ko) |
ZA (1) | ZA852765B (ko) |
ZW (1) | ZW4585A1 (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK337086A (da) * | 1985-08-12 | 1987-02-13 | Hoffmann La Roche | Benzimidazolderivater |
US5433959A (en) * | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
US6749864B2 (en) * | 1986-02-13 | 2004-06-15 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
US6852739B1 (en) | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
EP1534278A4 (en) * | 2002-08-01 | 2006-09-06 | Nitromed Inc | NITROSED PROTONATE PUMP INHIBITORS, COMPOSITIONS AND USE METHOD |
RU2487126C1 (ru) * | 2011-11-28 | 2013-07-10 | Открытое акционерное общество "Федеральный научно-производственный центр "Алтай" | Способ получения 1,4-диоксан-2,3-диола |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1805548A1 (de) * | 1968-10-26 | 1970-10-08 | Agfa Gevaert Ag | Benzimidazol-Derivate und ihre photographische Verwendung |
IN148930B (ko) * | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
CH644116A5 (de) * | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
US4472409A (en) * | 1981-11-05 | 1984-09-18 | Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung | 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects |
SE8300736D0 (sv) * | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
HU195220B (en) * | 1983-05-03 | 1988-04-28 | Byk Gulden Lomberg Chem Fqb | Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them |
IL71665A (en) * | 1983-05-03 | 1988-05-31 | Byk Gulden Lomberg Chem Fab | Fluoro-(2-pyridyl-methylthio)-dioxolo-(and dioxino-)benzimidazoles,processes for their preparation and pharmaceutical compositions containing the same |
IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
-
1985
- 1985-03-15 ZW ZW45/85A patent/ZW4585A1/xx unknown
- 1985-04-01 DK DK148585A patent/DK148585A/da not_active IP Right Cessation
- 1985-04-03 EP EP85104041A patent/EP0163842A1/de not_active Withdrawn
- 1985-04-08 US US06/720,775 patent/US4634710A/en not_active Expired - Fee Related
- 1985-04-10 FI FI851431A patent/FI851431L/fi not_active Application Discontinuation
- 1985-04-11 IL IL74880A patent/IL74880A/xx unknown
- 1985-04-12 NZ NZ211773A patent/NZ211773A/xx unknown
- 1985-04-12 ZA ZA852765A patent/ZA852765B/xx unknown
- 1985-04-15 AU AU41228/85A patent/AU589555B2/en not_active Expired - Fee Related
- 1985-04-15 PH PH32137A patent/PH21046A/en unknown
- 1985-04-16 CS CS852800A patent/CS250248B2/cs unknown
- 1985-04-16 CS CS856644A patent/CS250249B2/cs unknown
- 1985-04-17 HU HU851421A patent/HU193362B/hu not_active IP Right Cessation
- 1985-04-17 MC MC851762A patent/MC1650A1/xx unknown
- 1985-04-17 KR KR1019850002583A patent/KR850007256A/ko not_active Application Discontinuation
- 1985-04-17 JP JP60080423A patent/JPS60233070A/ja active Pending
- 1985-04-18 ES ES542370A patent/ES8607963A1/es not_active Expired
- 1985-04-18 NO NO851550A patent/NO162617C/no unknown
- 1985-04-18 PT PT80315A patent/PT80315B/pt not_active IP Right Cessation
- 1985-04-18 SU SU853884504A patent/SU1362402A3/ru active
- 1985-04-18 GR GR850949A patent/GR850949B/el unknown
- 1985-04-18 DD DD85275310A patent/DD232277A5/de not_active IP Right Cessation
-
1986
- 1986-01-31 ES ES551471A patent/ES8706128A1/es not_active Expired
- 1986-01-31 ES ES551473A patent/ES8706129A1/es not_active Expired
- 1986-01-31 ES ES551472A patent/ES8706124A1/es not_active Expired
- 1986-02-25 SU SU864025045A patent/SU1396965A3/ru active
-
1990
- 1990-01-05 US US07/463,879 patent/US4981861A/en not_active Expired - Fee Related
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