KR870010005A - 퀴놀린 유도체 및 그의 에스테르 또는 염의 제조법 - Google Patents

퀴놀린 유도체 및 그의 에스테르 또는 염의 제조법 Download PDF

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Publication number
KR870010005A
KR870010005A KR870004013A KR870004013A KR870010005A KR 870010005 A KR870010005 A KR 870010005A KR 870004013 A KR870004013 A KR 870004013A KR 870004013 A KR870004013 A KR 870004013A KR 870010005 A KR870010005 A KR 870010005A
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South Korea
Prior art keywords
ester
general formula
compound
iii
lower alkyl
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KR870004013A
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English (en)
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준이찌 마쓰모또
데루유끼 미야모또
히로시 에가와
싱 이찌 나까무라
Original Assignee
후지와라 도미오
다이닛뽕 세이야꾸 가부시끼가이샤
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Publication of KR870010005A publication Critical patent/KR870010005A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

퀴놀린 유도체 및 그의 에스테르 또는 염의 제조법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 일반식
    (식중, Z는 아미노기 또는 할로겐원자이고,
    R는
    또는
    이다. 여기서,
    R1은 수소원자, 저급알킬기 또는 할로알킬이고,
    R2는 수소원자 또는 저급알킬기이고,
    R3은 저급알킬기 또는 할로알킬기이고,
    R4는 수소원자 또는 저급알킬기이고,
    R5및 R6은 동일 또는 상이하고, 수소원자 또는 저급 알킬기이거나, 결합하고 있는 질소원자와 함께 헤테로고리를 형성해도 좋고, n은 0 또는 1이다.
    단, Z가 아미노기 일때, R는 (B)이다.)로 표시되는 퀴놀린 유도체 또는 그 에스테르, 또는 염을 제조함에 있어서,
    (ⅰ)하기 일반식
    (식중, X는 할로겐원자이고, Y는 수소원자 또는 저급 알킬기이고, Z는 상기와 동일하다. 단 Z가 할로겐 원자 일때, Y는 수소원자이다.)로 표시되는 화합물과, 하기 일반식
    R-H (Ⅲ)
    (식중, R는 상기와 같다.)
    로 표시되는 화합물을 반응시켜서, 상기 일반식(Ⅰ)의 화합물 또는 그 에스테르를 제조하거나,
    (ⅱ)하기 일반식
    (식중, R, X 및 Y는 상기와 같다.)
    로 표시되는 화합물과 암모니아를 반응시켜서, 상기 일반식(Ⅰ)의 화합물 또는 그 에스테를 제조하거나,
    (ⅲ)하기 일반식
    (식중, Z'는 아미노기, 할로겐원자 또는 보호기에 의해서 보호된 아미노기이고,
    R'는
    또는
    이고, 여기서,
    W'는 수소원자 또는 아미노 보호기이고,
    R1,R2,R3,R4,R5,Y 및 n는 상기와 같다.
    단, 적어도 Z'가 보호된 아미노기이거나, 또는 W'가 아미노 보호기이다.)로 표시되는 화합물을 보호기의 탈리반응에 의해서, 상기 일반식(Ⅰ)의 화합물 또는 그 에스테르를 제조하거나,
    (ⅳ)하기 일반식
    (식중, Y'는 저급알킬기를 뜻하며, R,X, 및 Z는 상기와 같다.)
    로 표시되는 β-아미노아크릴산 에스테르를 폐환시켜, 상기 일반식(Ⅰ)의 화합물 에스테르를 제조하거나,
    (ⅴ)하기 일반식
    (식중, R, Y'및 Z는 상기와 같다.)
    로 표시되는 에스테르를 가수분해시킴으로서, 상기 일반식(Ⅰ)의 화합물을 제조하거나,
    (ⅵ)하기 일반식
    (식중, R 및 Z는 상기와 같다.)
    로 표시되는 카르복실산을 에스테르화 시킴으로써, 상기 일반식(Ⅰ)의 화합물 에스테르를 제조하고,
    (ⅶ) 또 원한다면, 하기 일반식
    (식중, R 및 Z는 상기와 같다.)
    로 표시되는 퀴놀린 유도체 또는 그 에스테르를 산, 염기 또는 금속염으로 처리및으로써, 상기 일반식(Ⅰ)의 화합물 또는 그 에스테르의 염을 제조함을 특징으로 하는 상기 일반식(Ⅰ)의 화합물 또는 퀴놀린 유도체 및 그의 에스테르, 또는 염의 제조법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870004013A 1986-04-25 1987-04-25 퀴놀린 유도체 및 그의 에스테르 또는 염의 제조법 KR870010005A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP97543 1986-04-25
JP9754386 1986-04-25

Publications (1)

Publication Number Publication Date
KR870010005A true KR870010005A (ko) 1987-11-30

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KR870004013A KR870010005A (ko) 1986-04-25 1987-04-25 퀴놀린 유도체 및 그의 에스테르 또는 염의 제조법

Country Status (17)

Country Link
US (1) US4886810A (ko)
EP (1) EP0242789A3 (ko)
JP (1) JP2572591B2 (ko)
KR (1) KR870010005A (ko)
CN (1) CN87103138A (ko)
AU (1) AU7190987A (ko)
DD (1) DD263290A5 (ko)
DK (1) DK208787A (ko)
FI (1) FI871788A (ko)
HU (1) HU198198B (ko)
IL (1) IL82246A0 (ko)
NO (1) NO871727L (ko)
PH (1) PH23326A (ko)
PT (1) PT84749B (ko)
SU (3) SU1582986A3 (ko)
YU (4) YU73987A (ko)
ZA (1) ZA872874B (ko)

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DE69811367T2 (de) 1997-06-24 2003-11-27 Daiichi Seiyaku Co Cis-substituierte fluoromethylpyrrolidin-derivate
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Publication number Publication date
AU7190987A (en) 1987-10-29
JP2572591B2 (ja) 1997-01-16
YU27788A (en) 1990-04-30
SU1582986A3 (ru) 1990-07-30
HU198198B (en) 1989-08-28
HUT45520A (en) 1988-07-28
NO871727D0 (no) 1987-04-24
FI871788A0 (fi) 1987-04-23
EP0242789A3 (en) 1990-09-05
EP0242789A2 (en) 1987-10-28
FI871788A (fi) 1987-10-26
DK208787D0 (da) 1987-04-24
SU1588281A3 (ru) 1990-08-23
DD263290A5 (de) 1988-12-28
PT84749A (en) 1987-05-01
DK208787A (da) 1987-10-26
PT84749B (en) 1989-06-07
PH23326A (en) 1989-07-14
CN87103138A (zh) 1987-11-04
ZA872874B (en) 1987-10-12
YU27688A (en) 1988-12-31
IL82246A0 (en) 1987-10-30
SU1588282A3 (ru) 1990-08-23
YU73987A (en) 1988-08-31
JPS6345261A (ja) 1988-02-26
US4886810A (en) 1989-12-12
YU27488A (en) 1988-10-31
NO871727L (no) 1987-10-26

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