KR830001954A - 세팔로스포린 항생제 - Google Patents

세팔로스포린 항생제 Download PDF

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Publication number
KR830001954A
KR830001954A KR1019800001190A KR800001190A KR830001954A KR 830001954 A KR830001954 A KR 830001954A KR 1019800001190 A KR1019800001190 A KR 1019800001190A KR 800001190 A KR800001190 A KR 800001190A KR 830001954 A KR830001954 A KR 830001954A
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KR
South Korea
Prior art keywords
group
compound
formula
carboxyl blocking
carboxyl
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KR1019800001190A
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English (en)
Inventor
에드워드 아이레스 바리
갈브레이트 웨이어 니알
Original Assignee
헤롤드 월터 마틴
글락소 그룹 리미티드
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Application filed by 헤롤드 월터 마틴, 글락소 그룹 리미티드 filed Critical 헤롤드 월터 마틴
Publication of KR830001954A publication Critical patent/KR830001954A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • C07D213/20—Quaternary compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

세팔로스포린 항생제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 구조식(Ⅱ)의 화합물 또는 그의 산부가염이나 N-실릴유도체 또는 4-위치에 구조식-COOR1인 그룹(이때 R1은 수소원자 또는 카복실 차단그룹)을 함유하고 음이온 A를 지닌 상응하는 화합물을 구조식(Ⅲ)의 산 또는 그에 상응하는 아실화제로 아실화시티거나, 구조식(Ⅳ)의 화합물 또는 그의 염을 3-위치에 -CH2SY그룹을 생성하도록 유황 친핵체화 반응시키거나, 구조식(Ⅴ)의 화합물을 피리딜핵의 질소원자에 치환체로써 카바모일메틸 그룹을 도입시키기 위해 카바모일메틸화제와 반응시키며, 각 경우 필요 하다면 그리고/또는 원한다면 다음 반응 즉, Δ2-이성체를 원하는 Δ3-이성체로 변환, B가 >SO인 화합물을 B가 >S인 화합물로 환원, 카복실 그룹을 무독성염이나 무독성의 대사적르호 불안정한 에스테르로 변환, 카복실 차단 그룹 및/또는 N-보호그룹중의 몇몇을 제거시키는 반응중의몇몇을 적절한 연속반응으로 시행함을 특징으로 하여 구조식 (Ⅰ)의 화합물이나 그의 무독성염 또는 무독성의 대사적으로 불안정한 에스테르를 제조하는방법.
    상기 구조식중
    Ra및 Rb는 동일하거나 상이할 수 있으며 각기 C1-2알킬 그룹을 나타내고이들이 부착된탄소와 함께 C3-6사이클로알킬리덴 그룹을 형성하며,
    Y는 N-카바모일메틸피리디니움 그룹을 나타낸다.
    B는 >S 또는 >SO(α-또는β-)이며 2-, 3- 및 4-위치의 점선 브리지는 화합물이 세프-2-엠 또는 세프-3-엠 화합물임을 나타낸다.
    R2는 카복실 차단그룹(예를들면 R1에서 기술된 바와 같음)을 나타내고
    R3는 아미노 또는 보호된 아미노그룹이다
    R4와 R4a는 구조식 Ⅳ에서는 독립적으로 수소 또는 카복실 차단그룹을 나타내며 구조식 Ⅴ에서는 R4, R4a모두 카복실 차단그룹이다.
    X는 치환될 수 있는 친핵체 잔류물이며,
    Y1는 피리딜 그룹을 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800001190A 1979-03-22 1980-03-21 세팔로스포린 항생제 KR830001954A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7910088 1979-03-22
GB7910088 1979-03-22

Publications (1)

Publication Number Publication Date
KR830001954A true KR830001954A (ko) 1983-05-21

Family

ID=10504053

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800001190A KR830001954A (ko) 1979-03-22 1980-03-21 세팔로스포린 항생제

Country Status (7)

Country Link
JP (1) JPS55167290A (ko)
KR (1) KR830001954A (ko)
AT (1) AT368511B (ko)
AU (1) AU535373B2 (ko)
BE (1) BE882359A (ko)
NL (1) NL160860B (ko)
ZA (1) ZA801661B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000002217A (ko) * 1998-06-18 2000-01-15 김종인 신규 세팔로스포린계 항생제 및 이의 제조 방법

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
ZA823722B (en) * 1981-06-22 1983-03-30 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
JPS60215690A (ja) * 1984-04-09 1985-10-29 Meiji Seika Kaisha Ltd セフアロスポリン化合物及びそれを有効成分とする抗菌剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20000002217A (ko) * 1998-06-18 2000-01-15 김종인 신규 세팔로스포린계 항생제 및 이의 제조 방법

Also Published As

Publication number Publication date
JPS55167290A (en) 1980-12-26
AT368511B (de) 1982-10-25
ZA801661B (en) 1981-04-29
AU5670080A (en) 1980-09-25
BE882359A (fr) 1980-09-22
NL160860B (nl)
AU535373B2 (en) 1984-03-15
ATA154280A (de) 1982-02-15

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