KR840000578A - 포스포리피드 유도체의 제조방법 - Google Patents

포스포리피드 유도체의 제조방법 Download PDF

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KR840000578A
KR840000578A KR1019820003382A KR820003382A KR840000578A KR 840000578 A KR840000578 A KR 840000578A KR 1019820003382 A KR1019820003382 A KR 1019820003382A KR 820003382 A KR820003382 A KR 820003382A KR 840000578 A KR840000578 A KR 840000578A
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formula
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salt
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hydroxy
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쓰도무 데라지 (외 4)
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후지사와 도모기찌로
후지사와 야꾸힝 고오고 가부시끼가이사
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Publication of KR840000578A publication Critical patent/KR840000578A/ko

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Abstract

내용 없음

Description

포스포리피드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음의 방법으로 다음구조식(Ⅰ)의 화합물 및 그 약학적으로 사용 가능한 염을 제조하는 방법.
    상기식에서,
    R1은 알콕시 또는 알케닐옥시 ;
    R2는 수소, 할로겐, 하이드록시, 저급알콕시, 아르(저급)알콕시, 아릴옥시, 저급알킬티오, 아릴티오, 티아디아졸릴티오, 저급알킬설포닐, 저급알콕시카보닐아미노 또는 알킬우레이도 ;
    A는 -NHCO-기로 임의로 차단될 수 있는 저급알킬렌기 ; 및
    는 부가적으로 N,O 또는 S원자(들)을 함유할 수도 있고, 저급알킬, 저급알킬 아미노, 저급알콕시할로겐, 하이드록시, 카복시, 저급알콕시카보닐 및 하이드록시(저급)알킬기로 아루어진그룹에서 선택된
    1-3의 치환체를 함유할 수도 있는 불포화 또는 포화 5-7원의 복소환기이다 ; 단,가 피리딜기일 때에는 R1은 탄소수 15이상을 가지는 알콕시기이다.
    (1) 다음 구조식(Ⅱ)의 화합물 또는 그 염을 다음 구조식(Ⅲ) 화합물 또는 그 염과 반응시켜서 다음 구조식(Ⅰ)의 화합물 또는 그 염을 제조하든가, 또는
    상기식에서, R1, R2, A 및는 전술한 바와 같으며, X1는 산 잔기이다.
    (2) 다음 구조식(Ib)의 화합물 또는 그 염을 다음 구조식 (Ⅳ)의 화합물과 반응시켜서 다음 구조식(Ia)의 화합물 또는 그 염을 제조하든가, 또는
    상기식에서 R1, R2, A는 전술한 바와 같으며, R3는 저급알킬 ; R2는 산 잔기
    는 부가적으로 N,O 또는 S원자(들)을 함유할 수 있고, 저급알킬, 저급알킬아미노, 저급알콕시, 할로겐, 하이드록시, 카복시, 저급알콕시카보닐 및 하이드록시(저급)알킬기로 이루어진 그룹에서 선택된 1-2의 치환체를 가질 수도 있는 불포화 또는 포화 5-7원 복소환기이다.
    (3) 다음 구조식(Ⅴ)의 화합물 또는 그 염으로부터 보호기를 제거하여 다음 구조식(Ic)의 화합물 또는 그 염을 제조하거나, 또는
    상기식에서, R1, A 및는 전술한 바와 같으며, R4는 하이드록시 보호기이다.
    (4) 다음 구조식(Ⅵ)의 화합물 또는 그 염을 다음 구조식(Ⅲ)의 화합물 또는 그 염과 반응시켜서 다음 구조식(Ⅰ)의 화합물 또는 그 염을 제조하는 방법.
    상기식에서, R1, R2, A 및전술한 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019820003382A 1981-07-31 1982-07-28 포스포리피드 유도체의 제조방법 KR840000578A (ko)

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GB8123587 1981-07-31
GB8128648 1981-09-22
GB8128648 1981-09-22
GB8212259 1982-04-28
GB8212259 1982-04-28
GB8123587 1982-07-31

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KR840000578A true KR840000578A (ko) 1984-02-25

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KR (1) KR840000578A (ko)
DE (1) DE3267034D1 (ko)
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562179A (en) * 1982-04-19 1985-12-31 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, and pharmaceutical composition of the same
JPS58192825A (ja) * 1982-05-06 1983-11-10 Takeda Chem Ind Ltd グリセロール誘導体
JPS59184195A (ja) * 1983-04-04 1984-10-19 Takeda Chem Ind Ltd グリセロ−ル誘導体
JPS6081193A (ja) * 1983-10-11 1985-05-09 Takeda Chem Ind Ltd リン脂質

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DE2811667A1 (de) * 1978-03-17 1979-09-20 Hoechst Ag Mit phenolcarbonsaeuren veresterte glycerinphosphite, ihre herstellung und verwendung
US4408052A (en) * 1980-02-27 1983-10-04 Takeda Chemical Industries, Ltd. Phospholipid carbamates

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DE3267034D1 (en) 1985-11-28
DK328182A (da) 1983-02-01
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ES514596A0 (es) 1983-08-16
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ES8405021A1 (es) 1984-05-16

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