KR840000563A - 세펨 화합물의 제조방법 - Google Patents

세펨 화합물의 제조방법 Download PDF

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Publication number
KR840000563A
KR840000563A KR1019820002681A KR820002681A KR840000563A KR 840000563 A KR840000563 A KR 840000563A KR 1019820002681 A KR1019820002681 A KR 1019820002681A KR 820002681 A KR820002681 A KR 820002681A KR 840000563 A KR840000563 A KR 840000563A
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KR
South Korea
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formula
group
compound
salt
alkyl
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KR1019820002681A
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English (en)
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쯔도무 데라지 (외 2)
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후지시와 유우기찌로어
후지사와 야꾸힝 고교 가부시기가이샤
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Application filed by 후지시와 유우기찌로어, 후지사와 야꾸힝 고교 가부시기가이샤 filed Critical 후지시와 유우기찌로어
Publication of KR840000563A publication Critical patent/KR840000563A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

세펨 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. a) 다음 구조식 (Ⅱ) 화합물 또는 이들의 염을 다음 구조식 (Ⅲ) 또는 이들의 염과 반응시켜 다음 구조식 (Ⅰ) 화합물을 얻거나 또는
    b) 다음 구조식 (Ia) 화합물 또는 이들의 염을 아미노의 보호성 그룹 제거반응으로 맞춰 다음 구조식 (Ib) 또는 이들의 염을 얻거나 또는
    c) 다음 구조식 (Ⅳ) 화합물 또는 카르복시 그룹에서 이것의 반응성 유도체 또는 이들의 염을 다음 구조식 (Ⅴ) 화합물 또는 아미노 그룹에서 이것의 반응성 유도체 또는 이들의 염과 반응시켜 다음 구조식 (Ⅰ) 화합물을 얻거나 또는
    d) 다음 구조식 (Ic) 화합물 또는 이들의 염을 카르복시의 보호성 그룹 제거반응으로 맞춰 다음 구조식 (Id) 화합물 또는 이들의 염을 얻거나 또는
    e) 다음 구조식 (Ie) 화합물 또는 이들의 염의 하이드록시의 보호 그룹 제거반응으로 맞춰 다음 구조식 (If) 화합물 또는 이들의 염을 제조하는 방법으로 구성되는 다음 구조식 (Ⅰ) 화합물 또는 약학적으로 허용될 수 있는 이들의 염류를 제조하는 방법.
    상기 구조식에서,
    R1는 아미노 또는 보호된 아미노 그룹 ;
    R2는 수소, 적합한 치환체로 치환될 수 있는 저급 지방족 탄화수소 그룹, 사이클로(저급)알킬, 또는 사이클로(저급) 알켄일 ;
    R3는 적합한 치환체로 치환될 수 있는 저급 알킬 ;
    R3a는 수소, 저급 알킬 또는 아미노 ; 이고
    R3b는 수소 또는 저급 알킬 ;
    R4는 구조식의 그룹으로 치환할 수 있는 그룹,
    R5는 질소원자상 구조식 R3와 탄소원자상 구조식 R3a와 R3b의 그룹을 갖는 피
    리딘,
    R3c는 보호된 아미노(저급) 알킬,
    R3d는 아미노(저급) 알킬,
    R2a는 보호된 카르복시(저급)알킬,
    R2b는 카르복시(저급) 알킬,
    R2c는 하이드록시의 보호 그룹.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019820002681A 1981-06-22 1982-06-16 세펨 화합물의 제조방법 KR840000563A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP8119173 1981-06-22
GB8119173 1981-06-22
JP8129325 1981-09-29
GB8129325 1981-09-29
JP8212051 1982-04-26
GB8212051 1982-04-26

Publications (1)

Publication Number Publication Date
KR840000563A true KR840000563A (ko) 1984-02-25

Family

ID=27261211

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820002681A KR840000563A (ko) 1981-06-22 1982-06-16 세펨 화합물의 제조방법

Country Status (11)

Country Link
US (1) US4495182A (ko)
EP (1) EP0069872B1 (ko)
KR (1) KR840000563A (ko)
AU (1) AU8420482A (ko)
DE (1) DE3277534D1 (ko)
DK (1) DK276582A (ko)
ES (1) ES513296A0 (ko)
FI (1) FI822043L (ko)
GR (1) GR75487B (ko)
NO (1) NO822053L (ko)
PT (1) PT75066B (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210060957A (ko) * 2019-11-19 2021-05-27 삼우시스템 (주) 메탈필터를 적용한 지하공간 자동재생형 공기정화장치
KR20220019479A (ko) * 2020-08-10 2022-02-17 주식회사 포스코 송풍기 에어필터의 이물 제거장치

Families Citing this family (15)

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US4546101A (en) * 1982-09-10 1985-10-08 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof
US4785090A (en) * 1984-02-23 1988-11-15 Meiji Seika Kaisha, Ltd. Cephalosporin derivatives
US4880797A (en) * 1986-03-20 1989-11-14 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives and antibacterial agents
CA1293719C (en) * 1986-09-22 1991-12-31 Takao Takaya Cephem compounds and processes for preparation thereof
KR100449775B1 (ko) * 1995-11-28 2005-08-17 동아제약주식회사 신규세팔로스포린유도체및그중간체
MX2008000560A (es) 2005-07-11 2008-03-10 Mitsubishi Tanabe Pharma Corp Un derivado de oxima y sus preparaciones.
EA028342B1 (ru) 2011-09-09 2017-11-30 Мерк Шарп И Доум Корп. Способы лечения пневмонии
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140274996A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Tazobactam and ceftolozane antibiotic compositions
US20140274994A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Stabilizing ceftolozane
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
JP6327754B2 (ja) 2013-06-21 2018-05-23 クミアイ化学工業株式会社 ２−アミノ−２−ヒドロキシイミノ−ｎ−アルコキシアセトイミドイルシアニドの製造方法およびその製造中間体
EP3043797B1 (en) 2013-09-09 2020-04-08 Merck Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
JPS53144594A (en) * 1976-12-27 1978-12-15 Fujisawa Pharmaceut Co Ltd 3,7-di-substitued-3-cephem-4-carboxylic acid derivatives
AR229883A1 (es) * 1978-05-26 1983-12-30 Glaxo Group Ltd Procedimiento para la preparacion de antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)-acetamido)-3-(1-piridinometil)-cef-3-em-4-carboxilato
AR231986A1 (es) * 1978-05-26 1985-04-30 Glaxo Group Ltd Procedimiento para preparar antibioticos de cefalosporina
US4332798A (en) * 1978-12-29 1982-06-01 Fujisawa Pharmaceutical Co., Ltd. 7-Amino-thia-diazole oxyimino derivatives of cephem and cephem compounds
NL8001673A (nl) * 1979-03-22 1980-09-24 Glaxo Group Ltd Cefalosporine-antibiotica.
FI802107A (fi) * 1979-07-05 1981-01-06 Ciba Geigy Ag Aminotiadiazolylfoereningar foerfarande foer deras framstaellning farmaceutiska preparat som innehaoller saodana foereningar och anvaendning av de sistnaemda
US4381299A (en) * 1980-03-07 1983-04-26 Fujisawa Pharmaceutical Co., Ltd. 7-Amino-thiadiazole oxyimino derivatives of cephem and cepham compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210060957A (ko) * 2019-11-19 2021-05-27 삼우시스템 (주) 메탈필터를 적용한 지하공간 자동재생형 공기정화장치
KR20220019479A (ko) * 2020-08-10 2022-02-17 주식회사 포스코 송풍기 에어필터의 이물 제거장치

Also Published As

Publication number Publication date
NO822053L (no) 1982-12-23
FI822043L (fi) 1982-12-23
PT75066A (en) 1982-07-01
DK276582A (da) 1982-12-23
US4495182A (en) 1985-01-22
ES8307824A1 (es) 1983-08-01
FI822043A0 (fi) 1982-06-09
ES513296A0 (es) 1983-08-01
GR75487B (ko) 1984-07-23
EP0069872A2 (en) 1983-01-19
PT75066B (en) 1983-12-28
EP0069872B1 (en) 1987-10-28
DE3277534D1 (en) 1987-12-03
AU8420482A (en) 1983-01-06
EP0069872A3 (en) 1983-12-07

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