KR870007128A - 8-알콕시퀴놀론 카복실산 유도체의 제조방법 - Google Patents
8-알콕시퀴놀론 카복실산 유도체의 제조방법 Download PDFInfo
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- KR870007128A KR870007128A KR1019870000455A KR870000455A KR870007128A KR 870007128 A KR870007128 A KR 870007128A KR 1019870000455 A KR1019870000455 A KR 1019870000455A KR 870000455 A KR870000455 A KR 870000455A KR 870007128 A KR870007128 A KR 870007128A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 아민과 축합시킴을 특징으로 하여, 일반식(Ⅳ)의 8-알콕시 퀴놀론 카복실산 유도체, 이의 수화물 또는 약학적으로 허용되는 산부가염 또는 알칼리염을 제조하는 방법.상기식에서,R은 수소원자 또는 저급알킬그룹이고,R1은 저급알킬그룹이고,R2는 수소원자, 아미노그룹 또는 니트로그룹이고,X는 할로겐원자이고,Y는 X와 같거나 다른 할로겐원자이고,Z1은 피페라지노그룹, N-메틸피페라지노그룹, 3-메틸피페라지노그룹, 3-하이드록시피롤리디노그룹 또는 하기 일반식의 피롤리디노그룹이다.(여기에서,n은 0 또는 1 이고,R3는 수소원자 또는 저급알킬그룹이고,R4는 수소원자, 저급알킬그룹 또는 치환된 저급알킬그룹이고,R5는 수소원자, 저급알킬그룹, 아실그룹 또는 알콕시카보닐그룹이다)
- 일반식(Ⅴ)의 화합물을 가수분해시킴을 특징으로 하여, 일반식(Ⅵ)의 8-알콕시퀴놀론 카복실산 유도체, 이의 수화물 또는 약학적으로 허용되는 산부가염 또는 알칼리염을 제조하는 방법.상기식에서,R1은 저급알킬그룹이고,R2는 수소원자, 아미노그룹 또는 니트로그룹이고,X는 할로겐원자이고,Z는 할로겐원자, 피페라지노그룹, N-메틸피페라지노그룹, 3-메틸피페라지노그룹, 3-하이드록시-피롤리디노그룹 또는 하기 일반식의 피롤리디노그룹이고,(여기에서,n은 0 또는 1 이고,R3는 수소원자 또는 저급알킬그룹이고,R4는 수소원자, 저급알킬그룹 또는 치환된 저급알킬그룹이고,R5는 수소원자, 저급알킬그룹, 아실그룹 또는 알콕시카보닐그룹이다), AlK는 저급알킬그룹이다.
- 일반식(Ⅶ)의 화합물을 탈아실화시킴을 특징으로 하여, 일반식(Ⅷ)의 8-알콕시퀴놀론 카복실산 유도체, 이의 수화물 또는 약학적으로 허용되는 산부가염 또는 알칼리염을 제조하는 방법.상기식에서,R은 수소원자 또는 저급알킬그룹이고,R1은 저급알킬그룹이고,R2는 수소원자, 아미노그룹 또는 니트로그룹이고,X는 할로겐원자이고,Z3는 하기 일반식의 피롤리디노그룹이고,(여기에서,n은 0 또는 1 이고,R3는 수소원자 또는 저급알킬그룹이고,R4는 수소원자, 저급알킬그룹 또는 치환된 저급알킬그룹이다) Z2는 하기 일반식의 피롤리디노그룹이다.(여기에서,n, R3및 R4는 전술한 바와 같고 R6는 아실그룹 또는 알쿡시카보닐그룹이다)
- 일반식(Ⅸ)의 화합물을 염기성 촉매 존재하에서 일반식(Ⅹ)의 알콜과 축합시킴을 특징으로 하여, 일반식(Ⅳ)의 8-알콕시퀴놀론 카복실산 유도체, 이의 수화물 또는 약학적으로 허용되는 산부가염 또는 알칼리염을 제조하는 방법.상기식에서,R은 수소원자 또는 저급알킬그룹이고,R1은 저급알킬그룹이고,R2는 수소원자, 아미노그룹 또는 니트로그룹이고,X는 할로겐원자이고,Z1은 피페라지노그룹, N-메틸피페라지노그룹, 3-메틸피페라지노그룹, 3-하이드록시피롤리디노그룹 또는 하기 일반식의 피롤리디노그룹이고,(여기에서,n은 0 또는 1 이고,R3는 수소원자 또는 저급알킬그룹이고,R4는수소원자, 저급알킬그룹 또는 치환된 저급알킬그룹이고,R5는 수소원자, 저급알킬그룹, 아실그룹 또는 알콕시카보닐그룹이다) Hal은 X와 같거나 다른 할로겐원자이다.
- 제 4 항에 있어서, 염기성 촉매가 알칼리금속 알콜레이트인 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1088086 | 1986-01-21 | ||
JP(?)61-10880 | 1986-01-21 | ||
JP61-10880 | 1986-01-21 | ||
JP61220149A JPH089597B2 (ja) | 1986-01-21 | 1986-09-18 | 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
JP61-220149 | 1986-09-18 | ||
JP(?)61-220149 | 1986-09-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870007128A true KR870007128A (ko) | 1987-08-17 |
KR940007308B1 KR940007308B1 (ko) | 1994-08-12 |
Family
ID=26346239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019870000455A KR940007308B1 (ko) | 1986-01-21 | 1987-01-21 | 8-알콕시퀴놀론카복실산 유도체의 제조방법 |
Country Status (11)
Country | Link |
---|---|
US (2) | US4980470A (ko) |
EP (1) | EP0230295B1 (ko) |
JP (1) | JPH089597B2 (ko) |
KR (1) | KR940007308B1 (ko) |
CN (1) | CN1021052C (ko) |
CA (1) | CA1340316C (ko) |
CY (1) | CY2022A (ko) |
DE (2) | DE10299006I2 (ko) |
HK (1) | HK79797A (ko) |
HU (1) | HU203339B (ko) |
NL (1) | NL300110I2 (ko) |
Cited By (1)
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KR101537911B1 (ko) * | 2014-11-11 | 2015-07-23 | 한서대학교 산학협력단 | 제어 방출형 가티플록사신 제제 및 이의 제조방법 |
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-
1986
- 1986-09-18 JP JP61220149A patent/JPH089597B2/ja not_active Expired - Lifetime
-
1987
- 1987-01-16 US US07/003,822 patent/US4980470A/en not_active Expired - Lifetime
- 1987-01-19 DE DE2002199006 patent/DE10299006I2/de active Active
- 1987-01-19 EP EP87100608A patent/EP0230295B1/en not_active Expired - Lifetime
- 1987-01-19 CA CA000527627A patent/CA1340316C/en not_active Expired - Lifetime
- 1987-01-19 HU HU87142A patent/HU203339B/hu unknown
- 1987-01-19 DE DE3789878T patent/DE3789878T2/de not_active Expired - Lifetime
- 1987-01-21 KR KR1019870000455A patent/KR940007308B1/ko not_active IP Right Cessation
- 1987-01-21 CN CN87100580A patent/CN1021052C/zh not_active Expired - Lifetime
-
1990
- 1990-10-22 US US07/600,828 patent/US5043450A/en not_active Expired - Lifetime
-
1997
- 1997-06-12 HK HK79797A patent/HK79797A/xx not_active IP Right Cessation
-
1998
- 1998-02-20 CY CY202298A patent/CY2022A/xx unknown
-
2002
- 2002-12-06 NL NL300110C patent/NL300110I2/nl unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101537911B1 (ko) * | 2014-11-11 | 2015-07-23 | 한서대학교 산학협력단 | 제어 방출형 가티플록사신 제제 및 이의 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
HK79797A (en) | 1997-06-20 |
US4980470A (en) | 1990-12-25 |
DE3789878T2 (de) | 1995-01-05 |
DE3789878D1 (de) | 1994-06-30 |
CY2022A (en) | 1998-02-20 |
DE10299006I2 (de) | 2002-11-07 |
HUT43583A (en) | 1987-11-30 |
EP0230295A3 (en) | 1987-11-04 |
EP0230295B1 (en) | 1994-05-25 |
NL300110I2 (nl) | 2003-05-01 |
US5043450A (en) | 1991-08-27 |
HU203339B (en) | 1991-07-29 |
AU6769087A (en) | 1987-07-23 |
CN87100580A (zh) | 1987-08-19 |
CA1340316C (en) | 1999-01-12 |
EP0230295A2 (en) | 1987-07-29 |
JPH089597B2 (ja) | 1996-01-31 |
JPS62252772A (ja) | 1987-11-04 |
DE10299006I1 (de) | 2002-07-04 |
KR940007308B1 (ko) | 1994-08-12 |
AU610491B2 (en) | 1991-05-23 |
NL300110I1 (nl) | 2003-02-03 |
CN1021052C (zh) | 1993-06-02 |
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