KR850006177A - 신남산 유도체의 제조방법 - Google Patents

신남산 유도체의 제조방법 Download PDF

Info

Publication number
KR850006177A
KR850006177A KR1019850000936A KR850000936A KR850006177A KR 850006177 A KR850006177 A KR 850006177A KR 1019850000936 A KR1019850000936 A KR 1019850000936A KR 850000936 A KR850000936 A KR 850000936A KR 850006177 A KR850006177 A KR 850006177A
Authority
KR
South Korea
Prior art keywords
formula
pharmaceutically acceptable
cinnamic acid
compound
salts
Prior art date
Application number
KR1019850000936A
Other languages
English (en)
Inventor
다께오 이와꾸마 (외 4)
Original Assignee
마쓰바라이찌로
다나베 세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 마쓰바라이찌로, 다나베 세이야꾸 가부시끼가이샤 filed Critical 마쓰바라이찌로
Publication of KR850006177A publication Critical patent/KR850006177A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

신남산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식(Ⅱ)의 화합물을 가수분해 시키고, 그 생성물을 임의로 그의 제약학적으로 허용되는 염으로 전환시킴을 특징으로 하는 하기 일반식(Ⅰ)의 신남산 유도체 또는 그의 제약학적으로 허용되는 염의 제조방법.
    (I)
    (Ⅱ)
    (상기식중, R1및 R3는 저급 알킬기이고, Y는 히드록시메틸렌, 저급 알콕시메틸렌, 아미노메틸렌, 히드록시이미노메틸렌, 할로게노메틸렌 또는 카르보닐기이다.)
  2. 하기 일반식(Ⅲ)의 화합물을 하기 일반식(Ⅳ)의 화합물과 반응시키고, 그 생성물을 임의로 그의 제약학적으로 허용되는 염으로 전환시킴을 특징으로 하는 하기 일반식(Ⅰ-a)의 신남산 유도체 또는 그의 제약학적으로 허용되는 염의 제조방법.
    (I-a)
    (Ⅲ)
    (Ⅳ)
    (상기식중, R1및 R3는 저급 알킬기이고, M은 페닐이다.)
  3. 하기 일반식(Ⅰ-a)의 화합물을 산화시키고, 그 생성물을 임의로 그의 제약학적으로 허용되는 염으로 전환시킴을 특징으로 하는 하기 일반식(Ⅰ-b)의 신남산 유도체 또는 그의 제약학적으로 허용되는 염의 제조방법.
    (I-b)
    (I-a)
    (상기 식중, R1및 R3는 저급알킬기이다.)
  4. 하기 일반식(Ⅰ-b)의 화합물을 히드록실아민과 반응시키고, 그 생성물을 임의로 그의 제약학적으로 허용되는 염으로 전환시킴을 특징으로 하는 일반식(Ⅰ-c)의 신남산 유도체 또는 그의 제약학적으로 허용되는 염의 제조방법.
    (I-c)
    (I-b)
    (상기 식중, R1및 R3는 저급알킬기이다.)
  5. 하기 일반식(Ⅰ-c)의 화합물을 환원시키고, 그 생성물을 임의로 그의 제약학적으로 허용되는 염으로 전환기킴을 특징으로 하는 하기 일반식(Ⅰ-d)의 신남산 유도체 또는 그의 제약학적으로 허용되는 염의 제조방법.
    (I-d)
    (I-c)
    (상기 식중, R1및 R3는 저급알킬기이다.)
  6. 하기 일반식(Ⅰ-a)의 화합물을 환원시키고, 그 생성물을 임의로 그의 제약학적으로 허용되는 염으로 전환기킴을 특징으로 하는 하기 일반식(Ⅰ-e)의 신남산 유도체 또는 그의 제약학적으로 허용되는 염의 제조방법.
    (I-a)
    (I-e)
    (상기 식중, R1및 R3는 저급알킬기이고, X는 할로겐원자이다.)
  7. 하기 일반식(Ⅰ-e)의 화합물을 환원시키고, 그 생성물을 임의로 그의 제약학적으로 허용되는 염으로 전환기킴을 특징으로 하는 하기 일반식(Ⅰ-f)의 신남산 유도체 또는 그의 제약학적으로 허용되는 염의 제조방법.
    (I-f)
    (I-e)
    (상기 식중, R1, R3및 R4는 저급알킬기이고, X는 할로겐원자이다.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000936A 1984-02-15 1985-02-15 신남산 유도체의 제조방법 KR850006177A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59027952A JPS60172964A (ja) 1984-02-15 1984-02-15 桂皮酸誘導体及びその製法
JP27952/84 1984-02-15

Publications (1)

Publication Number Publication Date
KR850006177A true KR850006177A (ko) 1985-10-02

Family

ID=12235225

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850000936A KR850006177A (ko) 1984-02-15 1985-02-15 신남산 유도체의 제조방법

Country Status (3)

Country Link
EP (1) EP0153678A1 (ko)
JP (1) JPS60172964A (ko)
KR (1) KR850006177A (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
JPS63501215A (ja) * 1985-10-30 1988-05-12 ジ・アップジョン・カンパニー ３’−ピリジニルアルキルインデン−および３’−ピリジニルアルキルインドール−２−カルボン酸および同族体
GB9107043D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Therapeutic agents
US7018627B1 (en) 1995-06-07 2006-03-28 Icos Corporation Macrophage derived chemokine (MDC), MDC analogs, MDC inhibitor substances, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1134828A (en) * 1978-12-28 1982-11-02 Tadao Tanouchi Pyridine derivatives

Also Published As

Publication number Publication date
EP0153678A1 (en) 1985-09-04
JPS60172964A (ja) 1985-09-06

Similar Documents

Publication Publication Date Title
KR850000033A (ko) 8-클로로-1,5-벤조티아제핀 유도체의 제조방법
KR870004019A (ko) 퀴놀린 유도체의 제조방법
JPS5490195A (en) Novel benzodiazepine compound
KR850000406A (ko) 4-클로로-2-페닐이미다졸-5-아세트산유도체의 제조방법
KR860000243A (ko) 아민유도체의 제조방법
KR850004754A (ko) 3-인돌 카르복사미드 화합물류의 제조방법
KR850005845A (ko) 7-아미노-3-치환된-메틸-3-세펨-4-카복실산 및 그의 저급 알킬실릴 유도체의 제조방법
KR830007626A (ko) 2-(1,4-벤조디옥산-2-일알킬) 이미다졸류의 제조방법
KR850001746A (ko) 퀴나졸린 화합물의 제조방법
KR830005090A (ko) 3,7,11,15-테트라메틸-2,4,6,10,14-헥사데카펜타엔 산(酸)
KR850006177A (ko) 신남산 유도체의 제조방법
KR840001555A (ko) 치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법
KR860003239A (ko) 퀴놀론 카복실산 유도체의 제조방법
KR840001152A (ko) 신규 복소환(複素環) 화합물의 제법
KR860002450A (ko) 아미노-알콜유도체의 제조방법
KR830004320A (ko) 퀴나졸린 유도체의 제조방법
KR850000421A (ko) 벤조티아제핀 유도체의 제조방법
KR840000530A (ko) 신규 벤조트리아졸의 제조방법
EP0220381A3 (en) Process for synthesis of aluminum coordination compounds
KR840002821A (ko) N-(2,3-에폭시프로필렌)-n-아르알킬술폰아미드 유도체의 제조방법
KR850002979A (ko) 1,2,3-트리티안화합물의 신규 제조방법
KR840003632A (ko) 푸릴옥사졸릴 아세트산 유도체의 제조방법
KR860004051A (ko) 치환된 페닐피페라진 유도체의 제조방법
KR840008647A (ko) 대칭 1,4-디하이드로피리딘디카복실 에스테르의 제조방법
KR870003093A (ko) 퀴놀론카복실산 유도체의 제조방법

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid