KR860000283A - 피리딘 유도체의 제조방법 - Google Patents

피리딘 유도체의 제조방법 Download PDF

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Publication number
KR860000283A
KR860000283A KR1019850004557A KR850004557A KR860000283A KR 860000283 A KR860000283 A KR 860000283A KR 1019850004557 A KR1019850004557 A KR 1019850004557A KR 850004557 A KR850004557 A KR 850004557A KR 860000283 A KR860000283 A KR 860000283A
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KR
South Korea
Prior art keywords
compound
iii
formula
ethyl
methyl
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KR1019850004557A
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English (en)
Inventor
워크 알렉산더 (외 2)
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에 뚜레-레메뜨르
신 떼라보
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Application filed by 에 뚜레-레메뜨르, 신 떼라보 filed Critical 에 뚜레-레메뜨르
Publication of KR860000283A publication Critical patent/KR860000283A/ko

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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
    • F21V7/00—Reflectors for light sources
    • F21V7/04—Optical design
    • F21V7/08—Optical design with elliptical curvature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. (ⅰ) 다음 일반식(Ⅱ)의 화합물을 알카리금속 수소화물 존재하에 고리화반응시키는 단계와, (ⅱ) 다음 일반식(Ⅲ)의 얻어진 생성물을 다음 일반식(Ⅳ)의 아세톤페논과 반응시켜 다음 일반식(Ⅴ)의 화합물을 생성케 하는 단계와, (ⅲ) 그후 제조하고저 하는 물질에 따라서 (a) 아세트산 암모늄과 아세트산의 존재하에 화합물(Ⅴ)을 고리화 반응시키고, 다음 일반식(Ⅵ)의 얻어진 화합물을 처음에 가성소다로 처리하고, 다음에 염산으로 처리하여 X가 -NH-이고 R2가 벤질인 일반식(Ⅰ)의 피롤로피리딘을 생성케하거나. 또는 (b) 강산의 존재하에 화합물(Ⅴ)를 고리화반응시켜서 X가-O-이고, R2가 벤질인 일반식(Ⅰ)의 화합물을 알킬화시켜 R2가 메틸이나 에틸인 화합물을 생성케 하는 단계와, (ⅳ) 요구에 따라서는, 이와 같이 얻어진 화합물(Ⅰ)을 탈벤질화시키고, 동시에 R1이 니트로페닐을 나타내는 경우 아미노페닐이 되게 환원시켜서 R2가 수소인 일반식(Ⅰ)의 화합물을 생성케하는 단계와, (ⅴ) 또한 요구에 따라서는, R2가 수소인 일반식(Ⅰ)의 화합물을 알킬화시켜 R2가 메틸이나 에틸인 화합물을 생성케 하는 단계와, (ⅵ) 요구에 따라서, (ⅲ),(ⅳ)또는 (ⅴ)단계로부터 얻어진 일반식(Ⅰ)의 피리딘 유도체를 공지된 방법으로, 약학적으로 사용가능한 산부가염으로 저환시키는 단계로 구성되는 것을 특징으로 하는 다음 일반식(Ⅰ)의 피리딘 유도체를 제조하는 방법.
    (Ⅰ)
    (Ⅱ)
    (Ⅲ)
    (Ⅳ)
    (Ⅴ)
    (Ⅵ)
    상기식에서 X는 -0- 또는 -NH- 이고 R1은 하나 또는 두개의 할로겐원자로 임의치환된 페닐기이거나, 또는 메틸, 에틸, 트리플루오로메틸,메톡시 또는 페닐기이거나, 또는 R2가 벤질기가 아닌 경우에는 아미노기이고, 또는 나프틸이나 벤조디옥사닐기이며, R2는 수소 또는 벤질기이거나, 또는 X가 -0-인 경우 R2는 메틸이나 에틸기일 수 있고, (Ⅳ)에서의 R1은 상기와 같거나 또는 니트로페닐이다.
  2. 제1항에 있어서, X는 -0-이고 R2는 메틸이나 에틸이며, 그의 염이 제조되는 경우에는 염산염인 것을 특징으로 하는 제조방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850004557A 1984-06-27 1985-06-26 피리딘 유도체의 제조방법 KR860000283A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR84/10108 1984-06-27
FR8410108A FR2566775B1 (fr) 1984-06-27 1984-06-27 Derives de tetrahydro-4,5,6,7 furo ou 1h-pyrrolo(2,3-c)pyridine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
KR860000283A true KR860000283A (ko) 1986-01-27

Family

ID=9305484

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850004557A KR860000283A (ko) 1984-06-27 1985-06-26 피리딘 유도체의 제조방법

Country Status (21)

Country Link
US (1) US4621087A (ko)
EP (1) EP0170549B1 (ko)
JP (1) JPS6118778A (ko)
KR (1) KR860000283A (ko)
AR (1) AR240820A1 (ko)
AT (1) ATE40367T1 (ko)
AU (1) AU573856B2 (ko)
CA (1) CA1273340A (ko)
DE (1) DE3567869D1 (ko)
DK (1) DK158952C (ko)
ES (1) ES8604583A1 (ko)
FI (1) FI82052C (ko)
FR (1) FR2566775B1 (ko)
GR (1) GR851567B (ko)
HU (1) HU192236B (ko)
IL (1) IL75632A0 (ko)
MX (1) MX156795A (ko)
NO (1) NO161742C (ko)
NZ (1) NZ212556A (ko)
PT (1) PT80718B (ko)
ZA (1) ZA854827B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2635977B1 (fr) * 1988-09-07 1992-05-15 Synthelabo Utilisation de derives de tetrahydro-4,5,6,7 furopyridines pour obtenir des medicaments destines au traitement de l'obesite
CA1337695C (en) * 1988-09-23 1995-12-05 Jacques Gosteli Process for the production of 4,5,6,7-tetrahydrothieno-¬3,2-c|-pyridines
EP1147113B1 (en) 1999-01-19 2006-06-07 Neurosearch A/S Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2215948B1 (ko) * 1973-02-01 1976-05-14 Centre Etd Ind Pharma
US4075215A (en) * 1973-02-01 1978-02-21 Centre D'etudes Pour L'industrie Pharmaceutique Thieno-pyridine derivatives
GB1484140A (en) * 1974-04-24 1977-08-24 Wyeth John & Brother Ltd Pyrrolopyridine derivatives
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
IL71661A0 (en) * 1983-04-27 1984-07-31 Boehringer Ingelheim Kg 4-phenyl-tetrahydro-furano-pyridines,their preparation and pharmaceutical compositions containing them
FR2570701B1 (fr) * 1984-09-27 1987-05-22 Synthelabo Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
GR851567B (ko) 1985-11-25
AU573856B2 (en) 1988-06-23
PT80718B (fr) 1987-04-23
MX156795A (es) 1988-10-04
AR240820A1 (es) 1991-02-28
DK288685A (da) 1985-12-28
FR2566775B1 (fr) 1986-10-31
FI82052B (fi) 1990-09-28
FI852523A0 (fi) 1985-06-26
FI82052C (fi) 1991-01-10
EP0170549A1 (fr) 1986-02-05
US4621087A (en) 1986-11-04
NO161742C (no) 1989-09-20
ES544564A0 (es) 1986-02-01
DK158952C (da) 1991-01-21
FI852523L (fi) 1985-12-28
NO852563L (no) 1985-12-30
AR240820A2 (es) 1991-02-28
HUT38345A (en) 1986-05-28
AU4417785A (en) 1986-01-02
JPS6118778A (ja) 1986-01-27
ATE40367T1 (de) 1989-02-15
FR2566775A1 (fr) 1986-01-03
HU192236B (en) 1987-05-28
DE3567869D1 (en) 1989-03-02
ES8604583A1 (es) 1986-02-01
PT80718A (fr) 1985-07-01
NZ212556A (en) 1987-10-30
NO161742B (no) 1989-06-12
IL75632A0 (en) 1985-10-31
CA1273340A (en) 1990-08-28
DK288685D0 (da) 1985-06-26
EP0170549B1 (fr) 1989-01-25
DK158952B (da) 1990-08-06
ZA854827B (en) 1986-02-26

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