AR240820A2 - Procedimiento para obtener derivados de tetrahidro-4,5,6,7-furo o 1h-pirrol(2,3-c)-piridina y sus sales - Google Patents
Procedimiento para obtener derivados de tetrahidro-4,5,6,7-furo o 1h-pirrol(2,3-c)-piridina y sus salesInfo
- Publication number
- AR240820A2 AR240820A2 AR30083085A AR30083085A AR240820A2 AR 240820 A2 AR240820 A2 AR 240820A2 AR 30083085 A AR30083085 A AR 30083085A AR 30083085 A AR30083085 A AR 30083085A AR 240820 A2 AR240820 A2 AR 240820A2
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- formula
- group
- bencilo
- alkyl
- Prior art date
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F21—LIGHTING
- F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
- F21V7/00—Reflectors for light sources
- F21V7/04—Optical design
- F21V7/08—Optical design with elliptical curvature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
PROCEDIMIENTO PARA OBTENER COMPUESTOS DE 4,5,6,7-TETRAHIDROFURO O 1H-PIRROL(2,3-C) PIRIDINA FORMULA (I), DONDE R2 ES H, ALQUILO O BENCILO; X ES -0- O -NH-; R1 ES NAFTILO, BENZODIOXANILO, FENILO EVENTUALMENTE SUSTITUIDO POR 4-ALCOXI, 4-AMINO, 4-FENILO, 4-ALQUILO, 4-HALO, 3-AMINO, 3-ALCOXI, 3,4-DIHALO, 3-ALQUILO, 2-ALQUILO, 3-CF3 O 3-HALO SIENDO R2 ALQUILO SOLO COMPATIBLE CON X COMO GRUPO -0- Y R2 ES H O BENCILO ES SOLO COMPATIBLE CON X COMO -0- O -NH; ASI COMO SUS SALES DE ADICION CON ACIDOS ACEPTABLES EN FARMACOLOGIA. SE CICLIZA UN COMPUESTO (II), EN PRESENCIA DE UN HIDRURO ALCALINO Y SE HACE REACCIONAR EL PRODUCTO OBTENIDO, DE FORMULA III; CON UNA ACETOFENONA DE FORMULA IV, DONDE R1 TIENE LOS VALORES INDICADOS Y ADEMAS 4-NITROFENILO, OBTENIENDOSE LA FORMULA (V). LOS COMPUESTOS DE FORMULA (I) EN LOS QUE X ES NH, CICLIZANDO LOS COMPUESTOS (V) CON ACETATO DE AMONIO/ACIDO ACETICO OBTENIENDO LA FORMULA (VI), HIDROLIZAR EL GRUPO CARBOXILO ESTERIFICADO CON SODA Y SE DESCARBOXILA EL GRUPO CARBOXIDO CON AC IDO CLORHIDICO, PARA FORMAR LOS COMPUESTOS (I) EN LOS QUE R2 ES UN GRUPO BENCILO. LOS COMPUESTOS DE FORMULA (I) EN LOS QUE X ES -0- CICLIZANDO LOS COMPUESTOS (V) EN PRESENCIA DE ACIDOS FUERTES, PARA OBTENER LOS COMPUESTOS (I) EN LOS QUE R2 ES UN GRUPO BENCILO, SEPARANDO DICHOS GRUPO BENCILO POR HIDROGENACION CON HIDROGENO CATALITICAMENTE ACTIVADO PAR FORMAR LOS COMPUESTOS (I) DONDE R2 ES H, CON LA REDUCCION SIMULTANEA DEL GRUPO 4-NITROFENILO SI ESTA PRESENTE, A 4-AMINOFENILO, O CON CLOROFORMIATO DE 2,2,2- TRICLOROETILO Y POSTERIORTRATAMIENTO ZN/ACIDO ACETICO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8410108A FR2566775B1 (fr) | 1984-06-27 | 1984-06-27 | Derives de tetrahydro-4,5,6,7 furo ou 1h-pyrrolo(2,3-c)pyridine, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AR240820A1 AR240820A1 (es) | 1991-02-28 |
| AR240820A2 true AR240820A2 (es) | 1991-02-28 |
Family
ID=9305484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR300830A AR240820A1 (es) | 1984-06-27 | 1985-06-27 | Procedimiento para obtener derivados de tetrahidro-4,5,6,7-furo o 1h-pirrol(2,3-c)-piridina y sus sales |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4621087A (es) |
| EP (1) | EP0170549B1 (es) |
| JP (1) | JPS6118778A (es) |
| KR (1) | KR860000283A (es) |
| AR (1) | AR240820A1 (es) |
| AT (1) | ATE40367T1 (es) |
| AU (1) | AU573856B2 (es) |
| CA (1) | CA1273340A (es) |
| DE (1) | DE3567869D1 (es) |
| DK (1) | DK158952C (es) |
| ES (1) | ES8604583A1 (es) |
| FI (1) | FI82052C (es) |
| FR (1) | FR2566775B1 (es) |
| GR (1) | GR851567B (es) |
| HU (1) | HU192236B (es) |
| IL (1) | IL75632A0 (es) |
| MX (1) | MX156795A (es) |
| NO (1) | NO161742C (es) |
| NZ (1) | NZ212556A (es) |
| PT (1) | PT80718B (es) |
| ZA (1) | ZA854827B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2635977B1 (fr) * | 1988-09-07 | 1992-05-15 | Synthelabo | Utilisation de derives de tetrahydro-4,5,6,7 furopyridines pour obtenir des medicaments destines au traitement de l'obesite |
| CA1337695C (en) * | 1988-09-23 | 1995-12-05 | Jacques Gosteli | Process for the production of 4,5,6,7-tetrahydrothieno-¬3,2-c|-pyridines |
| EP1147113B1 (en) | 1999-01-19 | 2006-06-07 | Neurosearch A/S | Fused heterocyclic compounds and their use in the treatment of neurodegenerative diseases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2215948B1 (es) * | 1973-02-01 | 1976-05-14 | Centre Etd Ind Pharma | |
| US4075215A (en) * | 1973-02-01 | 1978-02-21 | Centre D'etudes Pour L'industrie Pharmaceutique | Thieno-pyridine derivatives |
| GB1484140A (en) * | 1974-04-24 | 1977-08-24 | Wyeth John & Brother Ltd | Pyrrolopyridine derivatives |
| US4520025A (en) * | 1982-07-21 | 1985-05-28 | William H. Rorer, Inc. | Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses |
| IL71661A0 (en) * | 1983-04-27 | 1984-07-31 | Boehringer Ingelheim Kg | 4-phenyl-tetrahydro-furano-pyridines,their preparation and pharmaceutical compositions containing them |
| FR2570701B1 (fr) * | 1984-09-27 | 1987-05-22 | Synthelabo | Derives de furo(3,2-c)pyridines, leur preparation et leur application en therapeutique |
-
1984
- 1984-06-27 FR FR8410108A patent/FR2566775B1/fr not_active Expired
-
1985
- 1985-06-18 EP EP85401198A patent/EP0170549B1/fr not_active Expired
- 1985-06-18 AT AT85401198T patent/ATE40367T1/de not_active IP Right Cessation
- 1985-06-18 DE DE8585401198T patent/DE3567869D1/de not_active Expired
- 1985-06-25 MX MX205767A patent/MX156795A/es unknown
- 1985-06-26 HU HU852509A patent/HU192236B/hu unknown
- 1985-06-26 DK DK288685A patent/DK158952C/da not_active IP Right Cessation
- 1985-06-26 US US06/748,765 patent/US4621087A/en not_active Expired - Fee Related
- 1985-06-26 AU AU44177/85A patent/AU573856B2/en not_active Ceased
- 1985-06-26 ES ES544564A patent/ES8604583A1/es not_active Expired
- 1985-06-26 NO NO852563A patent/NO161742C/no unknown
- 1985-06-26 NZ NZ212556A patent/NZ212556A/en unknown
- 1985-06-26 ZA ZA854827A patent/ZA854827B/xx unknown
- 1985-06-26 FI FI852523A patent/FI82052C/fi not_active IP Right Cessation
- 1985-06-26 KR KR1019850004557A patent/KR860000283A/ko not_active Application Discontinuation
- 1985-06-26 GR GR851567A patent/GR851567B/el unknown
- 1985-06-26 JP JP60141457A patent/JPS6118778A/ja active Pending
- 1985-06-26 IL IL75632A patent/IL75632A0/xx not_active IP Right Cessation
- 1985-06-26 PT PT80718A patent/PT80718B/pt not_active IP Right Cessation
- 1985-06-26 CA CA000485324A patent/CA1273340A/en not_active Expired - Fee Related
- 1985-06-27 AR AR300830A patent/AR240820A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| CA1273340A (en) | 1990-08-28 |
| ES8604583A1 (es) | 1986-02-01 |
| DK288685D0 (da) | 1985-06-26 |
| NO161742C (no) | 1989-09-20 |
| FI852523L (fi) | 1985-12-28 |
| KR860000283A (ko) | 1986-01-27 |
| HUT38345A (en) | 1986-05-28 |
| FR2566775B1 (fr) | 1986-10-31 |
| EP0170549B1 (fr) | 1989-01-25 |
| ZA854827B (en) | 1986-02-26 |
| NO161742B (no) | 1989-06-12 |
| ES544564A0 (es) | 1986-02-01 |
| NZ212556A (en) | 1987-10-30 |
| HU192236B (en) | 1987-05-28 |
| AU573856B2 (en) | 1988-06-23 |
| IL75632A0 (en) | 1985-10-31 |
| DK158952C (da) | 1991-01-21 |
| FI82052C (fi) | 1991-01-10 |
| AR240820A1 (es) | 1991-02-28 |
| FI852523A0 (fi) | 1985-06-26 |
| US4621087A (en) | 1986-11-04 |
| FI82052B (fi) | 1990-09-28 |
| JPS6118778A (ja) | 1986-01-27 |
| FR2566775A1 (fr) | 1986-01-03 |
| AU4417785A (en) | 1986-01-02 |
| NO852563L (no) | 1985-12-30 |
| PT80718B (fr) | 1987-04-23 |
| PT80718A (fr) | 1985-07-01 |
| DE3567869D1 (en) | 1989-03-02 |
| GR851567B (es) | 1985-11-25 |
| DK158952B (da) | 1990-08-06 |
| DK288685A (da) | 1985-12-28 |
| MX156795A (es) | 1988-10-04 |
| ATE40367T1 (de) | 1989-02-15 |
| EP0170549A1 (fr) | 1986-02-05 |
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