KR840004080A - 살리실산 유도체의 제조방법 - Google Patents
살리실산 유도체의 제조방법 Download PDFInfo
- Publication number
- KR840004080A KR840004080A KR1019830001272A KR830001272A KR840004080A KR 840004080 A KR840004080 A KR 840004080A KR 1019830001272 A KR1019830001272 A KR 1019830001272A KR 830001272 A KR830001272 A KR 830001272A KR 840004080 A KR840004080 A KR 840004080A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- carbon atoms
- formula
- compound
- carboxylic acid
- Prior art date
Links
- 150000003872 salicylic acid derivatives Chemical class 0.000 title claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 6
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- -1 amino compound Chemical class 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000005237 alkyleneamino group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000005809 transesterification reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 하기 일반식(Ⅳ)의 아미노 화합물을 하기 일반식(Ⅴ)의 카복실산 또는 카복실산의 반응성 유도체와 반응시키거나, 하기 일반식(Ⅳ)의 아미노 화합물(W=알콕시부위에 4이하의 탄소원자를 갖는 알콕시 카보닐)을 일반식(Ⅵ)의 카복실산 또는 카복실산의 반응성 유도체 또는 하기 일반식(Ⅶ)의 카복실산 또는 카복실산의 반응유도체와 반응시켜 화합물 내에서 치환체 B를 치환하여 A로 얻거나 하기 일반식(Ⅷ)의 화합물에서 D그룹을 산화시켜 CCCH (W=카복실) 그룹으로 얻거나 또는 하기 일반식(Ⅸ) 화합물에서 E그룹을 가수분해시켜 CCOH 그룹 (W=카복실)으로 얻고 필요에 따라 상술한 화합물을 에스테르화 또는 트란스에스테르화시켜 에스테르(W=알콕시 부위에 4이하의(탄소원자를 갖는 알콕시카보닐)로 또는 가수분해시켜 유리산(W=카복실)으로 또는 산 또는 염기로 생리학적으로 허용되는 염을 만듬을 특징으로 하는 하기 일반식(Ⅰ)화합물의 살리실산 유도체의 제조방법.상기식에서W는 카복실그룹 또는 알콕시부위에 4이하의 탄소원자를 갖는 알콕시카보닐그룹을 나타내고,Z는 수소 또는 할로겐원자를 나타내며,R1은 수소원자, 탄소수 1 내지 6의 알킬그룹, 탄소수 2 내지 6의 알케닐그룹 또는 총탄소수 6이하를 갖는 알콕시알킬그룹을 나타내고,Y는 탄소수 1 내지 3의 알킬렌기를 나타내며,X는 하기 일반식(Ⅱ) 화합물의 피리딘기 또는 하기 일반식(Ⅲ)화합물의 퀴놀린기를 나타내고,R2는 수소원자 또는 할로겐원자 또는 탄소수 4이하의 알킬그룹 또는 알콕시부위에 4이하의 탄소원자를 갖는 알콕시그룹을 나타내며,R3는 수소원자 또는 탄소수 4이하의 알킬그룹을 나타내고,A는 비치환 또는 탄소수 1 내지 4의 알킬그룹의 1치환 또는 2치환된 탄소수 4 내지 8의 알킬렌아미노그룹 또는 탄소수 7 내지 10의 아자비-사이클로알킬그룹을 나타내며(여기서 이들 그룹은 각각의 경소 질소원자를 통해 분자잔기에 결합한다),B는 할로겐원자를 나타내고,D는 산화하여 카복실그룹으로 전환될 수 있는 그룹을 나타내며,E는 가수분해하여 카복실그룹으로 전환될 수 있는 그룹을 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823211934 DE3211934A1 (de) | 1982-03-31 | 1982-03-31 | Salicylsaeurederivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| DE3211934,8 | 1982-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840004080A true KR840004080A (ko) | 1984-10-06 |
Family
ID=6159858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830001272A KR840004080A (ko) | 1982-03-31 | 1983-03-21 | 살리실산 유도체의 제조방법 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4542127A (ko) |
| EP (1) | EP0090369B1 (ko) |
| JP (1) | JPS58177974A (ko) |
| KR (1) | KR840004080A (ko) |
| AT (1) | ATE17350T1 (ko) |
| AU (1) | AU1300383A (ko) |
| CA (1) | CA1197240A (ko) |
| DE (2) | DE3211934A1 (ko) |
| DK (1) | DK149383A (ko) |
| ES (1) | ES8401944A1 (ko) |
| FI (1) | FI831070L (ko) |
| GR (1) | GR79241B (ko) |
| HU (1) | HU190445B (ko) |
| MA (1) | MA19764A1 (ko) |
| NO (1) | NO831170L (ko) |
| NZ (1) | NZ203743A (ko) |
| PT (1) | PT76473B (ko) |
| ZA (1) | ZA832292B (ko) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5312924A (en) | 1983-12-30 | 1994-05-17 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
| US5216167A (en) * | 1983-12-30 | 1993-06-01 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
| ES2237141T3 (es) | 1998-07-24 | 2005-07-16 | Bayer Cropscience Ag | Benzoilciclohexanodionas substituidas. |
| DE19920791A1 (de) * | 1999-05-06 | 2000-11-09 | Bayer Ag | Substituierte Benzoylisoxazole |
| DE19921424A1 (de) | 1999-05-08 | 2000-11-09 | Bayer Ag | Substituierte Benzoylketone |
| DE19946853A1 (de) * | 1999-09-30 | 2001-04-05 | Bayer Ag | Substituierte Arylketone |
| US7985743B1 (en) * | 2005-07-22 | 2011-07-26 | Gene A. Tabish | Topical pain reliever and method of making the same |
| US8653101B2 (en) | 2010-08-27 | 2014-02-18 | Gruenenthal Gmbh | Substituted 2-oxy-quinoline-3-carboxamides as KCNQ2/3 modulators |
| MX2013002121A (es) | 2010-08-27 | 2013-04-03 | Gruenenthal Gmbh | Quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| MX2013000748A (es) | 2010-08-27 | 2013-03-05 | Gruenenthal Gmbh | 2-amino-quinolina-3-carboxamidas sustituidas como moduladores de kcnq2/3. |
| CN103189357B (zh) | 2010-08-27 | 2015-11-25 | 格吕伦塔尔有限公司 | 作为kcnq2/3调节剂的取代的2-氧代-和2-硫代-二氢喹啉-3-甲酰胺 |
| EP2611780A1 (en) | 2010-09-01 | 2013-07-10 | Grünenthal GmbH | Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as kcnq2/3 modulators |
| WO2023211990A1 (en) * | 2022-04-25 | 2023-11-02 | Siteone Therapeutics, Inc. | Bicyclic heterocyclic amide inhibitors of na v1.8 for the treatment of pain |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1185180B (de) * | 1963-10-19 | 1965-01-14 | Hoechst Ag | Verfahren zur Herstellung von Benzolsulfonylharnstoffen |
| DE2500157C2 (de) * | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
| DE2706977A1 (de) * | 1977-02-18 | 1978-08-24 | Hoechst Ag | Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung |
| DE3063878D1 (en) * | 1979-07-13 | 1983-07-28 | Thomae Gmbh Dr K | Derivatives of carboxylic acids, their preparation and medicaments containing them |
| DE3100535A1 (de) * | 1981-01-10 | 1982-08-12 | Dr. Karl Thomae Gmbh, 7950 Biberach | "neue carbonsaeure-derivate, ihre herstellung und ihre verwendung als arzneimittel" |
-
1982
- 1982-03-31 DE DE19823211934 patent/DE3211934A1/de not_active Withdrawn
-
1983
- 1983-03-21 KR KR1019830001272A patent/KR840004080A/ko not_active Application Discontinuation
- 1983-03-25 DE DE8383102983T patent/DE3361757D1/de not_active Expired
- 1983-03-25 EP EP83102983A patent/EP0090369B1/de not_active Expired
- 1983-03-25 AT AT83102983T patent/ATE17350T1/de not_active IP Right Cessation
- 1983-03-29 NO NO831170A patent/NO831170L/no unknown
- 1983-03-29 US US06/479,906 patent/US4542127A/en not_active Expired - Fee Related
- 1983-03-29 FI FI831070A patent/FI831070L/fi not_active Application Discontinuation
- 1983-03-29 GR GR70927A patent/GR79241B/el unknown
- 1983-03-29 PT PT76473A patent/PT76473B/pt unknown
- 1983-03-29 ES ES521082A patent/ES8401944A1/es not_active Expired
- 1983-03-29 NZ NZ203743A patent/NZ203743A/en unknown
- 1983-03-30 AU AU13003/83A patent/AU1300383A/en not_active Abandoned
- 1983-03-30 JP JP58052808A patent/JPS58177974A/ja active Pending
- 1983-03-30 ZA ZA832292A patent/ZA832292B/xx unknown
- 1983-03-30 HU HU831092A patent/HU190445B/hu unknown
- 1983-03-30 DK DK149383A patent/DK149383A/da not_active IP Right Cessation
- 1983-03-30 CA CA000424930A patent/CA1197240A/en not_active Expired
- 1983-03-31 MA MA19984A patent/MA19764A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK149383D0 (da) | 1983-03-30 |
| EP0090369B1 (de) | 1986-01-08 |
| US4542127A (en) | 1985-09-17 |
| JPS58177974A (ja) | 1983-10-18 |
| DK149383A (da) | 1983-10-01 |
| FI831070L (fi) | 1983-10-01 |
| ES521082A0 (es) | 1984-01-01 |
| ES8401944A1 (es) | 1984-01-01 |
| FI831070A0 (fi) | 1983-03-29 |
| AU1300383A (en) | 1983-10-06 |
| NO831170L (no) | 1983-10-03 |
| MA19764A1 (fr) | 1983-10-01 |
| DE3211934A1 (de) | 1983-10-13 |
| NZ203743A (en) | 1985-07-12 |
| GR79241B (ko) | 1984-10-22 |
| ATE17350T1 (de) | 1986-01-15 |
| DE3361757D1 (en) | 1986-02-20 |
| PT76473B (de) | 1986-01-24 |
| CA1197240A (en) | 1985-11-26 |
| ZA832292B (en) | 1983-12-28 |
| EP0090369A1 (de) | 1983-10-05 |
| PT76473A (de) | 1983-04-01 |
| HU190445B (en) | 1986-09-29 |
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