KR860002490A - 2,3-디히드로벤조푸란-5-설폰아미드 유도체의 제조방법 - Google Patents

2,3-디히드로벤조푸란-5-설폰아미드 유도체의 제조방법 Download PDF

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KR860002490A
KR860002490A KR1019850006459A KR850006459A KR860002490A KR 860002490 A KR860002490 A KR 860002490A KR 1019850006459 A KR1019850006459 A KR 1019850006459A KR 850006459 A KR850006459 A KR 850006459A KR 860002490 A KR860002490 A KR 860002490A
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South Korea
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lower alkyl
group
general formula
hydrogen
different
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KR1019850006459A
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KR930002100B1 (ko
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히로시 하라다 (외 3)
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요시또시 가즈오
시오노기 세이야꾸 가부시기가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

2,3-디히드로벤조푸란-5-설폰아미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식(Ⅱ), 필요하다면 보호시킨 유도체의, 5-위치를 클로로설폰화하여 하기 일반식(Ⅲ)의 5-클로로설포닐 화합물을 수득하고, 일반식(Ⅲ) 화합물을 일반식(Ⅳ)의 암모니아, 아민 또는 카르바민산 유도체와 반응시킨후 필요하다면 탈보호 및/또는 변형시킴을 특징으로 하는 하기 일반식(Ⅰ)의 2,3-디히드로벤조 푸란-5-설폰아미드의 제조방법.
    [상기식중, R1및 R2는 서로 같거나 다르고, 각각 수소, 저급알킬, 4-~7-원 시클로알킬, 치환된 또는 비치환 된 페닐, 페닐(저급 알킬), 저급 알콕시카르보닐 또는 모르폴리노(저급 알킬)이고; 또는 R1및 R2는 인접한 질소원자와 함께 고리를 형성하여 1개 또는 그 이상의 첨가된 이형원자를 갖는 치환된 또는 비치환된 5-또는 6-원 복소환을 형성할 수도 있으며, R3는 COR4또는 CH2R5기이고, R4는 히드록시 또는 OR6또는 NR7R8기이며, R5는 히드록시, 저급알콕시, 저급 지방족 아실옥시 또는 할로겐원자이고, R5는 저급 알킬, 아릴, 카르복시메틸 또는 그의 에스테르, 히드록시메틸 또는 그의 지방족 아실레이트, 또는 1-프탈리딜이며, R7및 R8은 서로 같거나 다르고, 각각 수소 또는 저급 알킬이고 및 X 및 X′는 서로 같거나 다르고, 각각 수소 또는 할로겐원자이다.]
  2. 제1항에 있어서, R3가 COR4기이고 R4가 OR6기이며, 및 R6가 저급 알킬기일 경우에 상기 탈보호가 에스테르의 가수분해인 방법.
  3. 제1항에 있어서, R3가 -COOH 기일 경우에는 상기 변형이 상기 탈보호의 뒤이은 에스테르화인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850006459A 1984-09-05 1985-09-04 2, 3-디히드로벤조푸란-5-설폰아미드 유도체의 제조방법 KR930002100B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP186971/1984 1984-09-05
JP59186971A JPS6163671A (ja) 1984-09-05 1984-09-05 ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤

Publications (2)

Publication Number Publication Date
KR860002490A true KR860002490A (ko) 1986-04-26
KR930002100B1 KR930002100B1 (ko) 1993-03-26

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KR1019850006459A KR930002100B1 (ko) 1984-09-05 1985-09-04 2, 3-디히드로벤조푸란-5-설폰아미드 유도체의 제조방법

Country Status (15)

Country Link
US (1) US4659709A (ko)
EP (1) EP0173899B1 (ko)
JP (1) JPS6163671A (ko)
KR (1) KR930002100B1 (ko)
AT (1) ATE70534T1 (ko)
AU (1) AU592060B2 (ko)
CA (1) CA1265800A (ko)
DE (1) DE3584919D1 (ko)
DK (1) DK165954C (ko)
GB (1) GB2164039B (ko)
IE (1) IE58911B1 (ko)
NO (1) NO169487C (ko)
NZ (1) NZ213197A (ko)
PT (1) PT81033B (ko)
ZA (1) ZA856277B (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5116874A (en) * 1985-09-23 1992-05-26 Eli Lilly And Company Anti-tumor method and compounds
JPH01100164A (ja) * 1987-10-12 1989-04-18 Shionogi & Co Ltd スルファモイル−２−ベンゾフランカルボン酸誘導体
DE3861963D1 (de) * 1987-12-24 1991-04-11 Boehringer Mannheim Gmbh Heterocyclisch substituierte alkylsulfonamide, verfahren zu ihrer herstellung sowie arzneimittel.
GB9110636D0 (en) * 1991-05-16 1991-07-03 Glaxo Group Ltd Chemical compounds
US5254582A (en) * 1992-02-05 1993-10-19 Eli Lilly And Company Antitumor compositions and methods
US5387681A (en) * 1992-08-19 1995-02-07 Eli Lilly And Company Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides and sulfonamides
US6150402A (en) * 1994-08-15 2000-11-21 Loma Linda University Medical Center Natriuretic compounds
DE10135499A1 (de) * 2001-07-20 2003-01-30 Merck Patent Gmbh Indanverbindungen mit negativem Delta-epsilon
US7795242B2 (en) * 2003-10-15 2010-09-14 The Brigham And Women's Hospital, Inc. Methods and compositions for immunomodulation
EP1805158B1 (en) 2004-10-29 2018-06-27 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as modulators of ppar
WO2007051095A1 (en) 2005-10-25 2007-05-03 Kalypsys, Inc. Salts of modulators of ppar and methods of treating metabolic disorders
US20080176861A1 (en) 2007-01-23 2008-07-24 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6004073A (en) * 1972-09-09 1975-03-06 Basf Ag Fluorescent benzofuran compounds
US4401669A (en) * 1978-01-27 1983-08-30 Merck & Co., Inc. 2,3-Dihydro-substituted-5-benzoyl benzofuran-2-carboxylic acids and their use in treating hypertension
CA1145758A (en) * 1979-05-16 1983-05-03 Shell Canada Limited 2,3-dihydro-2-benzofurancarboxamide derivatives
US4237130A (en) * 1979-06-21 1980-12-02 Merck & Co., Inc. 2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids
DE3317884A1 (de) * 1983-05-17 1984-11-22 Hoechst Ag, 6230 Frankfurt 5-(4-chlor-3-sulfamoylbenzoyl)-2,3-dihydro-2-benzofurancarbonsaeuren und verfahren zu ihrer herstellung
US4544667A (en) * 1984-02-09 1985-10-01 Merck & Co., Inc. 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure

Also Published As

Publication number Publication date
NO169487B (no) 1992-03-23
PT81033A (en) 1985-09-01
GB8521967D0 (en) 1985-10-09
US4659709A (en) 1987-04-21
AU592060B2 (en) 1990-01-04
ZA856277B (en) 1986-04-30
JPH0354945B2 (ko) 1991-08-21
IE58911B1 (en) 1993-12-01
AU4621585A (en) 1986-03-13
DK165954B (da) 1993-02-15
EP0173899A3 (en) 1988-07-20
GB2164039B (en) 1988-05-18
EP0173899B1 (en) 1991-12-18
NZ213197A (en) 1989-01-06
NO853441L (no) 1986-03-06
DK403185A (da) 1986-03-06
PT81033B (pt) 1987-09-18
KR930002100B1 (ko) 1993-03-26
CA1265800A (en) 1990-02-13
DK165954C (da) 1993-07-05
EP0173899A2 (en) 1986-03-12
DK403185D0 (da) 1985-09-04
NO169487C (no) 1992-07-01
GB2164039A (en) 1986-03-12
JPS6163671A (ja) 1986-04-01
IE852188L (en) 1986-03-05
DE3584919D1 (de) 1992-01-30
ATE70534T1 (de) 1992-01-15

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