KR830010073A - 1,4-디하이드로피리딘 유도체의 제조방법 - Google Patents
1,4-디하이드로피리딘 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830010073A KR830010073A KR1019820001696A KR820001696A KR830010073A KR 830010073 A KR830010073 A KR 830010073A KR 1019820001696 A KR1019820001696 A KR 1019820001696A KR 820001696 A KR820001696 A KR 820001696A KR 830010073 A KR830010073 A KR 830010073A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- general formula
- same
- alkyl
- compound represented
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000004983 dialkoxyalkyl group Chemical group 0.000 claims 4
- 230000005611 electricity Effects 0.000 claims 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 4
- 125000004967 formylalkyl group Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- -1 amine compound Chemical class 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000005452 alkenyloxyalkyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000005160 aryl oxy alkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- (가) 일반식(Ⅱ)(식중,R1 a은 디알콕시알킬기를, R2은 알콕시알킬기, 알케닐옥시알킬기, 아릴옥시알키기 또는 아랄킬옥시알킬기를, R5은 o-, m- 또는 p-니트로기를 각각 뜻한다)로 나타내는 화합물로 일반식(Ⅲ)[식중, R3은 알킬기, 할로알킬기, 알콕시알킬기, 알케닐옥시알킬기, 아릴옥시알킬기, 아랄킬옥시알킬기또는 N,N-디치환아미노알킬기(치환기로서는 동일 또는 다른 알킬기, 아랄킬기 또는 아릴기를 뜻한다.)을, R4 a은 알킬기 또는 디알콕시알킬기를 각각 뜻한다.]로 나타내는 아민 화합물을 반응시키든지 또는 일반식(Ⅳ)(식중, R3, R4 a및 R5은 전기와 같은 뜻임)로 나타내는 화합물에 일반식(Ⅴ)(식중, R1 a및 R2은 전기와 같은 뜻임)로 나타내는 아민화합물을 반응시켜서 일반식(Ⅵ)(식중, R1 a,R2,R3,R4 a및 R5은 전기와 같은 뜻임)로 나타내는 화합물을 제조하는 방법,(나) 일반식(Ⅵ)(식중, R1 a,R2,R3,R4 a및 R5은 전기와 같은 뜻임)로 나타내는 화합물을 가수분해하여 일반식(Ⅶ)(식중, R1 b은 포밀기 또는 포밀알킬기를, R4 b은 알킬기, 포밀기 또는 포밀알킬기를, R2,R3및 R5은 각각 전기와 같은 뜻임)로 나타내는 화합물을 제조하는 방법,(다) 일반식(Ⅶ)(식중, R1 b,R2,R3,R4 b및 R5은 전기와 같은 뜻임)로 나타내는 화합물로 환원하여 일반식(Ⅷ)(식중, R1 c은 히드록시알킬기를, R4 c은 알킬기 또는 히드록시알킬기를, R2,R3및 R5은 각각 전기와 같은 뜻임)로 나타내는 화합물을 제조하는 방법 및(라) 일반식(Ⅸ)(식중, R1은 디알콕시알킬기, 포밀기, 포밀알킬기 또는 히드록시알킬기를, R3 a은 할로알킬기를, R4 d은 알킬기를, R2및 R5은 각각 전기와 같은 뜻임)로 나타내는 화합물에 일반식(Ⅹ)(식중, R′과 R″은 동일 또는 다른 알킬기, 아랄킬기 또는 아릴기를 뜻함)로 나타내는 아민화합물을 반응시켜서 일반식(XI)(식중, R3 b은 N,N-디치환아미노알킬기(치환기로서는 동일 또는 다른 알킬기, 아랄킬기 또는 아릴기를 뜻함)을, R1,R2,R4 d및 R5은 각각 전기와 같은 뜻임)로 나타내는 화합물을 제조하는 방법으로써 되는 일반식(Ⅰ)(식중, R1,R2,R3및 R5은 전기와 같은 뜻이며, R4은 알킬기, 디알콕시알킬기, 포밀기, 포밀알킬기 또는 히드록시알킬기를 뜻함)로 나타내는 1,4-디히드로피리딘 유도체의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56057855A JPS57175164A (en) | 1981-04-18 | 1981-04-18 | 1,4-dihydropyridine derivative and its preparation |
JP57855/1981 | 1981-04-18 | ||
JP?56-57855 | 1981-04-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830010073A true KR830010073A (ko) | 1983-12-26 |
KR900004923B1 KR900004923B1 (ko) | 1990-07-12 |
Family
ID=13067598
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR8201696A KR900004923B1 (ko) | 1981-04-18 | 1982-04-17 | 1,4-디히드로피리딘 유도체의 제조방법 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0063359B1 (ko) |
JP (1) | JPS57175164A (ko) |
KR (1) | KR900004923B1 (ko) |
CA (1) | CA1176255A (ko) |
DE (1) | DE3267874D1 (ko) |
HU (1) | HU186494B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0125803A3 (en) * | 1983-04-27 | 1987-01-21 | FISONS plc | Pharmaceutically active dihydropyridines |
US4686217A (en) * | 1983-04-27 | 1987-08-11 | Fisons Plc | Calcium antagonist 2-fluoroalkyl-1,4-dihydropyridines |
JPS60120861A (ja) * | 1983-12-02 | 1985-06-28 | Otsuka Pharmaceut Co Ltd | ジヒドロピリジン誘導体 |
JPS60156671A (ja) * | 1984-01-25 | 1985-08-16 | Yamanouchi Pharmaceut Co Ltd | ジヒドロピリジン誘導体およびその製造法 |
US4672068A (en) * | 1984-05-04 | 1987-06-09 | Fujirebio Kabushiki Kaisha | Antihypertensive 1,4-dihydropyridines having a conjugated ester |
US6265127B1 (en) * | 1999-12-15 | 2001-07-24 | Eastman Kodak Company | 1, 4-dihydrophyridine charge control agents for electrostatographic toners and developers |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5084577A (ko) * | 1973-11-29 | 1975-07-08 | ||
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
GB1591089A (en) * | 1976-12-17 | 1981-06-10 | Fujisawa Pharmaceutical Co | 1,4-dihydropyridine derivatives and process for preparation thereof |
DE2650013C3 (de) * | 1976-10-30 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel |
US4307103A (en) * | 1978-09-08 | 1981-12-22 | Fujisawa Pharmaceutical Co., Ltd. | Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same |
CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
-
1981
- 1981-04-18 JP JP56057855A patent/JPS57175164A/ja active Granted
-
1982
- 1982-04-14 DE DE8282103145T patent/DE3267874D1/de not_active Expired
- 1982-04-14 EP EP82103145A patent/EP0063359B1/en not_active Expired
- 1982-04-15 HU HU821144A patent/HU186494B/hu not_active IP Right Cessation
- 1982-04-16 CA CA000401133A patent/CA1176255A/en not_active Expired
- 1982-04-17 KR KR8201696A patent/KR900004923B1/ko active
Also Published As
Publication number | Publication date |
---|---|
EP0063359A1 (en) | 1982-10-27 |
HU186494B (en) | 1985-08-28 |
DE3267874D1 (en) | 1986-01-23 |
JPS57175164A (en) | 1982-10-28 |
KR900004923B1 (ko) | 1990-07-12 |
CA1176255A (en) | 1984-10-16 |
JPH036140B2 (ko) | 1991-01-29 |
EP0063359B1 (en) | 1985-12-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR850005826A (ko) | 1,4-디히드로-2,6-디메틸피리딘-3,5-디카르복실산의 비대칭 디에스테르의 제조방법 | |
KR830007607A (ko) | 카보스티릴 화합물의 제조방법 | |
KR830010104A (ko) | 아릴페닐 에테르 유도체의 제조방법 | |
ATE89559T1 (de) | Camptothecin-derivate und verfahren zu ihrer herstellung. | |
KR830007685A (ko) | 세팔로스포린 유도체의 제조방법 | |
KR880002823A (ko) | 약제학적 화합물 | |
KR840008001A (ko) | 티아졸리딘 유도체의 제조방법 | |
KR860002496A (ko) | 카보닐 화합물의 제조방법 | |
KR850002964A (ko) | 심장병 치료제의 제조방법 | |
KR870003100A (ko) | 벤즈이미다졸 유도체 | |
KR850004492A (ko) | 옥시캄의 엔올 에테르 유도체의 제조방법 | |
KR840000534A (ko) | 디히드로피리딘 화합물류의 제조방법 | |
KR830010073A (ko) | 1,4-디하이드로피리딘 유도체의 제조방법 | |
KR890011829A (ko) | 디우레아 유도체 및 이의 제조방법 | |
KR840006482A (ko) | 디히드로피라졸로 [3,4-b]피리딘 유도체의 제조방법 | |
KR830010110A (ko) | 티에닐옥시프로판올 아민의 치환된 트립트아민 유도체의 제조방법 | |
KR860002450A (ko) | 아미노-알콜유도체의 제조방법 | |
KR840000521A (ko) | 3-메틸플라본-8-카르복실산 에스테르류의 제조방법 | |
KR840005723A (ko) | 티아졸유도체의 제조방법 | |
KR860006453A (ko) | 트리아지닐을 함유하는 스틸벤 유도체의 제조방법 | |
KR850007256A (ko) | 트리사이클릭 이미다졸 유도체의 제조방법 | |
KR860004051A (ko) | 치환된 페닐피페라진 유도체의 제조방법 | |
KR840001154A (ko) | 1,2-디티올-3-일리덴 암모늄 유도체의 제조방법 | |
KR860003224A (ko) | N-벤조일 페닐 우레아의 제조방법 | |
KR830006293A (ko) | 신규 폴리아자 헤테로고리 화합물의 제조방법 |