KR840008001A - 티아졸리딘 유도체의 제조방법 - Google Patents

티아졸리딘 유도체의 제조방법 Download PDF

Info

Publication number
KR840008001A
KR840008001A KR1019840001360A KR840001360A KR840008001A KR 840008001 A KR840008001 A KR 840008001A KR 1019840001360 A KR1019840001360 A KR 1019840001360A KR 840001360 A KR840001360 A KR 840001360A KR 840008001 A KR840008001 A KR 840008001A
Authority
KR
South Korea
Prior art keywords
formula
compound
group
preparing
nitrogen
Prior art date
Application number
KR1019840001360A
Other languages
English (en)
Inventor
엘레머에저, (외 8)
Original Assignee
이스트반 차보, 괸지베르페렌찌
리크터 게데온 베게스제티 기아르 알티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이스트반 차보, 괸지베르페렌찌, 리크터 게데온 베게스제티 기아르 알티 filed Critical 이스트반 차보, 괸지베르페렌찌
Publication of KR840008001A publication Critical patent/KR840008001A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/10—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/18—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Abstract

내용 없음.

Description

티아졸리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. a) 하기 일반식(Ⅲ)의 N-치환 1-아미노-2-티올유도체를 하기 일반식(Ⅳ)의 화합물과 반응 시키거나, b) 하기 일반식(Ⅴ)의 2-치환 티아졸리딘 유도체를 하기 일반식(Ⅵ)의 화합물로 N-알킬화하거나, c) 하기 일반식(Ⅶ)의 화합물을 브로모시아노겐과 반응시켜 Y가 질소, Z가 시아노 및 Ar이 하기에 정의한 바와 같은 일반식(I)의 화합물을 제조하거나, d) 일반식(I)의 화합물의 한 치환체를 공지의 방법에 의해 정의된 범위내의 다른 치환체로 전환 시킴을 특징으로 하는 하기 일반식(I)의 티아졸리딘 유도체의 제조방법.
    상기식중, Ar은 2-푸릴, 또는 하나 이상의 할로겐원자, 하나 이상의 C1-4알킬, C1-6알콕시, 할로겐-C1-4-알콕시, 디-또는 트할로메틸, 히드록실 및/또는 니트로기에 의해 또는 하기 일반식(Ⅱ)의 기
    에 의해 임의 치환된 페닐, 나프틸 또는 피리딜기이고, Y는 질소 또는 CH이며, Z는 Y변 질소라면 시아노 또는 카르바모일이고, Y가 CH이라면 니트로기를 나타내며, L는 이탈기이고, X는 할로겐 또는 반응성에스테르기이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001360A 1983-03-16 1984-03-16 티아졸리딘 유도체의 제조방법 KR840008001A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU888/83 1983-03-16
HU83888A HU188852B (en) 1983-03-16 1983-03-16 Process for producing thiazolidine derivatives active against gastric ulcer and intestinal ulcer

Publications (1)

Publication Number Publication Date
KR840008001A true KR840008001A (ko) 1984-12-12

Family

ID=10951891

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001360A KR840008001A (ko) 1983-03-16 1984-03-16 티아졸리딘 유도체의 제조방법

Country Status (32)

Country Link
US (1) US4616025A (ko)
JP (1) JPS59196877A (ko)
KR (1) KR840008001A (ko)
AT (1) AT383596B (ko)
AU (1) AU559753B2 (ko)
BE (1) BE899132A (ko)
CA (1) CA1273933A (ko)
CH (1) CH660592A5 (ko)
CS (1) CS241074B2 (ko)
DD (1) DD216929A5 (ko)
DE (1) DE3409801A1 (ko)
DK (1) DK143284A (ko)
ES (2) ES530738A0 (ko)
FI (1) FI79843C (ko)
FR (1) FR2542740B1 (ko)
GB (1) GB2140412B (ko)
GR (1) GR81883B (ko)
HU (1) HU188852B (ko)
IE (1) IE57101B1 (ko)
IL (1) IL71249A (ko)
IN (1) IN157738B (ko)
IT (1) IT1196048B (ko)
LU (1) LU85248A1 (ko)
NL (1) NL8400817A (ko)
NO (1) NO162858C (ko)
NZ (1) NZ207516A (ko)
PL (2) PL142909B1 (ko)
PT (1) PT78260B (ko)
SE (1) SE455945B (ko)
SU (2) SU1240355A3 (ko)
YU (1) YU47384A (ko)
ZA (1) ZA841938B (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051184A (ja) * 1983-08-30 1985-03-22 Fujimoto Seiyaku Kk Ν−シアノイミノチアゾリジン誘導体およびその製造法
JPH0730070B2 (ja) * 1985-10-03 1995-04-05 日本バイエルアグロケム株式会社 新規複素環式化合物
JPH066585B2 (ja) * 1985-02-04 1994-01-26 日本バイエルアグロケム株式会社 ニトロメチレン誘導体、その製法及び殺虫剤
US5001138B1 (en) * 1985-02-04 1998-01-20 Bayer Agrochem Kk Heterocyclic compounds
US5204360A (en) * 1985-02-04 1993-04-20 Nihon Bayer Agrochem K.K. Heterocyclic compounds
JPH0649699B2 (ja) * 1985-02-04 1994-06-29 日本バイエルアグロケム株式会社 ニトロメチレン誘導体、その製法及び殺虫剤
ATE67493T1 (de) 1985-02-04 1991-10-15 Bayer Agrochem Kk Heterocyclische verbindungen.
JPH0717621B2 (ja) * 1986-03-07 1995-03-01 日本バイエルアグロケム株式会社 新規ヘテロ環式化合物
USRE39130E1 (en) 1986-03-07 2006-06-13 Bayer Cropscience K.K. Heterocyclic compounds
JP2607369B2 (ja) * 1987-02-20 1997-05-07 興和株式会社 新規な複素環化合物
US5122522A (en) * 1989-06-21 1992-06-16 The Trustees Of The University Of Pennsylvania Treatment and control of ocular development
DE69033246T2 (de) * 1989-06-21 1999-12-02 Univ Pennsylvania Behandlung und Regulierung der Augenentwicklung mit cholinergischen Agonisten
HU207047B (en) * 1989-11-07 1993-03-01 Richter Gedeon Vegyeszet Process for producing new pyridine derivatives and pharmaceutical copositions comprising same
CA2063865A1 (en) * 1992-03-24 1993-09-25 Karoly Lempert 2-(substituted imino)-thiazolidines and process for the preparation thereof
JP2721805B2 (ja) * 1994-07-22 1998-03-04 日本バイエルアグロケム株式会社 新規ヘテロ環式化合物
DE4427539A1 (de) * 1994-08-04 1996-02-08 Sueddeutsche Kalkstickstoff Verfahren zur Herstellung von 2-Cyaniminothiazolidin
DE4427569A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Verfahren zur Herstellung von Cyanimino-1,3-thiazolidin
DE19904310A1 (de) * 1999-01-28 2000-08-03 Bayer Ag Verfahren zur Herstellung heterocyclischer Verbindungen
CN1198803C (zh) * 1999-03-05 2005-04-27 第一三得利制药株式会社 具有激活烟碱性乙酰胆碱α4β2受体作用的杂环化合物
KR20040018380A (ko) * 2001-05-25 2004-03-03 밸리 포지 파마슈티컬즈, 인크. 피렌제핀 안약 겔제
SI1567112T1 (sl) * 2002-11-22 2009-02-28 Smithkline Beecham Corp Thiazolidin-4-oni za inhibiranje proteinov hyak3
JP4847314B2 (ja) * 2003-04-07 2011-12-28 コーティカル・ピーティーワイ・リミテッド 炎症性疾患を治療するための新規な方法
EP2305658B9 (en) * 2008-07-01 2015-04-29 Meiji Seika Pharma Co., Ltd. Novel imino derivative, process for production of the same, and pesticide comprising the same
ES2556470T3 (es) * 2011-09-02 2016-01-18 Bayer Intellectual Property Gmbh Procedimiento para preparar [3-[(6-cloro-3-piridinil)metil]-2-tiazolidiniliden]cianamida

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3264316A (en) * 1963-09-18 1966-08-02 Res Lab Dr C Janssen N V Certain 2-acylimino-3-substitutedthiazoline-4 compounds
DE2205745A1 (de) * 1972-02-08 1973-08-23 Thomae Gmbh Dr K Neue durch den n-cyaniminorest substituierten heterocyclen und verfahren zu ihrer herstellung
US4006156A (en) * 1975-06-27 1977-02-01 Shell Oil Company 3-Alkyl-2-(nitromethylene) thiazolidine
DK173777A (da) * 1976-05-03 1977-11-04 Merck & Co Inc Fremgangsmade til fremstilling af derivater af 2-iminothiazolidiner og thiazoliner
JPS57171986A (en) * 1981-04-14 1982-10-22 Taiho Yakuhin Kogyo Kk Heterocylic ring compound containing sulfur
JPS5823682A (ja) * 1981-08-03 1983-02-12 Santen Pharmaceut Co Ltd 複素五員環化合物
DE3133918A1 (de) * 1981-08-27 1983-03-17 Bayer Ag, 5090 Leverkusen 2-arylhydrazino-2-thiazoline, acylderivate derselben, 2-arylazo-2-thiazoline, herstellungsverfahren und ihre verwendung zur bekaempfung von ekto- und endoparasiten
JPS58222886A (ja) * 1982-06-19 1983-12-24 Ricoh Co Ltd 感熱記録シ−ト
JPS5933267A (ja) * 1982-08-19 1984-02-23 Fujimoto Seiyaku Kk グアニジン誘導体およびその製造法

Also Published As

Publication number Publication date
PT78260B (en) 1986-04-30
CA1273933A (en) 1990-09-11
GB2140412A (en) 1984-11-28
DD216929A5 (de) 1985-01-02
NZ207516A (en) 1986-06-11
PL252129A1 (en) 1985-11-19
CH660592A5 (de) 1987-05-15
CS188584A2 (en) 1985-06-13
FI841066A0 (fi) 1984-03-16
ES8604179A1 (es) 1986-01-16
NO162858C (no) 1990-02-28
SE455945B (sv) 1988-08-22
IN157738B (ko) 1986-05-31
NL8400817A (nl) 1984-10-16
GB8406790D0 (en) 1984-04-18
ZA841938B (en) 1985-05-29
NO841002L (no) 1984-09-17
IT8420057A0 (it) 1984-03-15
ES544286A0 (es) 1986-01-16
ATA88284A (de) 1986-12-15
DK143284A (da) 1984-09-17
AU559753B2 (en) 1987-03-19
PL142749B1 (en) 1987-11-30
SE8401463D0 (sv) 1984-03-15
HU188852B (en) 1986-05-28
FI79843B (fi) 1989-11-30
FI79843C (fi) 1990-03-12
PT78260A (en) 1984-04-01
ES8601170A1 (es) 1985-11-01
IE840655L (en) 1984-09-16
ES530738A0 (es) 1985-11-01
DK143284D0 (da) 1984-02-29
PL246683A1 (en) 1985-07-16
FI841066A (fi) 1984-09-17
BE899132A (fr) 1984-09-12
IE57101B1 (en) 1992-04-22
LU85248A1 (fr) 1985-10-14
SU1240355A3 (ru) 1986-06-23
GB2140412B (en) 1987-02-11
AT383596B (de) 1987-07-27
SU1240356A3 (ru) 1986-06-23
DE3409801A1 (de) 1984-09-20
US4616025A (en) 1986-10-07
SE8401463L (sv) 1984-09-17
IL71249A (en) 1987-02-27
FR2542740B1 (fr) 1987-02-20
GR81883B (ko) 1984-12-12
CS241074B2 (en) 1986-03-13
AU2583384A (en) 1984-09-20
IT1196048B (it) 1988-11-10
FR2542740A1 (fr) 1984-09-21
NO162858B (no) 1989-11-20
PL142909B1 (en) 1987-12-31
IL71249A0 (en) 1984-06-29
YU47384A (ko) 1986-10-31
JPS59196877A (ja) 1984-11-08

Similar Documents

Publication Publication Date Title
KR840008001A (ko) 티아졸리딘 유도체의 제조방법
GB1455200A (en) 2-hydroxyliminoalkyl-2-cyclohexene-1-one derivatives
KR850002015A (ko) 퀴나졸린 유도체의 제조방법
KR890005084A (ko) 퀴놀린 유도체
KR860002496A (ko) 카보닐 화합물의 제조방법
KR830007686A (ko) 세팔로 스포린 유도체의 제조방법
ES8506629A1 (es) Un procedimiento para preparar derivados de piridina
KR840005100A (ko) 4-퀴놀론 유도체의 제법
KR870001214A (ko) 4,7-디히드로티에노[2,3-b]피리딘 유도체의 제조방법
KR880700798A (ko) 신규한 인데노티아졸유도체 및 그 제조법
KR830006302A (ko) 신규 피리미딘 유도체의 제조방법
IE841653L (en) Rooperol and its derivatives
EP0315434A3 (en) Pyridoxal hydrazone derivatives their production and use and pharmaceutical compositions containing the same
KR830006243A (ko) 헤테로고리화합물 유도체의 제조방법
KR860001789A (ko) 디히드로피리딘 유도체의 제조방법
KR840005723A (ko) 티아졸유도체의 제조방법
KR870004038A (ko) 제초제 화합물의 제조방법
KR830006293A (ko) 신규 폴리아자 헤테로고리 화합물의 제조방법
KR840007002A (ko) β-락탐 유도체의 제조방법
KR850000415A (ko) 퀴나졸리논 유도체의 제조방법
KR840001154A (ko) 1,2-디티올-3-일리덴 암모늄 유도체의 제조방법
KR830005176A (ko) 티아졸 유도체의 제조방법
KR840000516A (ko) 아미도벤즈아미드류의 제법
KR900003178A (ko) 세펨 화합물의 제조방법
KR860007222A (ko) 벤조[a]페나진 유도체의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application