KR840007002A - β-락탐 유도체의 제조방법 - Google Patents

β-락탐 유도체의 제조방법 Download PDF

Info

Publication number
KR840007002A
KR840007002A KR1019830005864A KR830005864A KR840007002A KR 840007002 A KR840007002 A KR 840007002A KR 1019830005864 A KR1019830005864 A KR 1019830005864A KR 830005864 A KR830005864 A KR 830005864A KR 840007002 A KR840007002 A KR 840007002A
Authority
KR
South Korea
Prior art keywords
group
general formula
formula
compound
substituted
Prior art date
Application number
KR1019830005864A
Other languages
English (en)
Other versions
KR870001363B1 (ko
Inventor
다께오(외 4) 요시오까
Original Assignee
스즈끼 시즈오
산라꾸오샨 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스즈끼 시즈오, 산라꾸오샨 가부시기가이샤 filed Critical 스즈끼 시즈오
Publication of KR840007002A publication Critical patent/KR840007002A/ko
Application granted granted Critical
Publication of KR870001363B1 publication Critical patent/KR870001363B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음

Description

β-락탐 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. (a) R2가 일반식 -CH2NO2의 기를 나타낼 경우에는 하기 일반식(Ⅱ)의 화합물을 니트로메탄과 염기존재하에 반응시키고, 또는
  2. (b) R2가 일반식 -CN→O의 기를 나타낼 경우에는 하기 일반식(Ⅰ-1)의 화합물을 탈수시키고, 또는
  3. (c) R2가 일반식의 기를 나타낼 경우에는 하기 일반식(Ⅰ-2)의 화합물을 일반식(Ⅲ), (Ⅳ), (Ⅴ) 및 (Ⅵ)로 표시되는 화합물과 반응시킴으로써 제조되고, R3가 치환 또는 불치환 탄화수소기인 일반식(Ⅰ)의 화합물을 R3가 수소원자인 일반식(Ⅰ)의 화합물을 그의 염으로 전환시킴을 특징으로 하는 일반식(Ⅰ)의 화합물의 제조방법.
  6. 상기식중 R1은 수소원자 또는 히드록실기를 나타내고, R2는 일반식-CH2NO2 ,
  7. -CN→O 또는- (여기서 A는 일반식또는을 나타내며 이때 R4는 수소원자 또는 알콕시카르보닐기를 나타내고, R5는 페닐, 알콕시카르보닐 또는 알카노일옥시메틸기를 나타내고, R6는 알킬기를 나타내며 R7는 페닐, 나프틸, 피리딜, 푸릴 또는 티에닐기를 나타낸다.)를 나타내고, R3는 수소원자 또는 치환 또는 불치환 탄화수소기를 나타내고, R31은 치환 또는 불치환탄화수소기를 나타내고 Z는 일반식 -CH2CH2NHCOCH3의 기 또는 하기 일반식의 기를 나타낸다.
  9. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005864A 1982-12-10 1983-12-10 β-락탐 유도체의 제조방법 KR870001363B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP215539 1982-12-10
JP57215539A JPS59106489A (ja) 1982-12-10 1982-12-10 新規β−ラクタム誘導体及びその製造方法
JP215,539 1982-12-10

Publications (2)

Publication Number Publication Date
KR840007002A true KR840007002A (ko) 1984-12-04
KR870001363B1 KR870001363B1 (ko) 1987-07-20

Family

ID=16674099

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830005864A KR870001363B1 (ko) 1982-12-10 1983-12-10 β-락탐 유도체의 제조방법

Country Status (7)

Country Link
US (1) US4517127A (ko)
EP (1) EP0111286B1 (ko)
JP (1) JPS59106489A (ko)
KR (1) KR870001363B1 (ko)
AT (1) ATE32722T1 (ko)
CA (1) CA1244439A (ko)
DE (1) DE3375786D1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3779856T2 (de) * 1986-10-16 1993-03-25 Merck & Co Inc Antibakterielle, 2-substituierte alkyl-carbapeneme.
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
GB9022309D0 (en) * 1990-10-15 1990-11-28 Fujisawa Pharmaceutical Co 1-azabicyclo(3.2.0.)hept-2-ene-2-carboxylic acid compounds
US5286721A (en) * 1990-10-15 1994-02-15 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
JP3233434B2 (ja) * 1992-04-01 2001-11-26 塩野義製薬株式会社 カルバペネム誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4424230A (en) * 1977-10-19 1984-01-03 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-3-substituted amino-1-azabicyclo- 3.2.0!hept-2-en-7-one-2-carboxylic acid
JPS55147284A (en) * 1979-04-17 1980-11-17 Sanraku Inc Novel beta-lactam derivative and its preparation
ATE9584T1 (de) * 1980-02-14 1984-10-15 Beecham Group Plc Antibakterielle beta-lactam-verbindungen, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
US4321197A (en) * 1980-12-24 1982-03-23 Merck & Co., Inc. 1-Carba-6-(1-hydroxyethyl)-2-carbonyl-penem-3-carboxylic acid and preparation thereof

Also Published As

Publication number Publication date
EP0111286B1 (en) 1988-03-02
US4517127A (en) 1985-05-14
EP0111286A1 (en) 1984-06-20
CA1244439A (en) 1988-11-08
JPH0247996B2 (ko) 1990-10-23
DE3375786D1 (en) 1988-04-07
JPS59106489A (ja) 1984-06-20
ATE32722T1 (de) 1988-03-15
KR870001363B1 (ko) 1987-07-20

Similar Documents

Publication Publication Date Title
KR860001104A (ko) 테트라히드로프탈이미드의 제조방법
KR890005084A (ko) 퀴놀린 유도체
KR840008001A (ko) 티아졸리딘 유도체의 제조방법
KR830007686A (ko) 세팔로 스포린 유도체의 제조방법
KR850004754A (ko) 3-인돌 카르복사미드 화합물류의 제조방법
KR840006324A (ko) 2-니트로-1,1-에렌디아민의 제조방법
KR840007002A (ko) β-락탐 유도체의 제조방법
KR830006302A (ko) 신규 피리미딘 유도체의 제조방법
KR840006234A (ko) 1,3-디티안류의 제조방법
KR840005723A (ko) 티아졸유도체의 제조방법
KR830005191A (ko) 푸란유도체의 제조방법
KR840002821A (ko) N-(2,3-에폭시프로필렌)-n-아르알킬술폰아미드 유도체의 제조방법
KR840004105A (ko) N,n- 치환된 아졸 카복스 아미드 유도체의 제조방법
KR880005095A (ko) 2,4-디아미노-3-옥시-피리미딘 유도체의 제조방법
KR850005411A (ko) α-메틸-(6-펜옥시)-2- 피콜릴 사이클로프로판 카복실 레이트의 제조방법
KR830009044A (ko) 3,5-디-3급부틸-4-하이드록시페닐-치환 복소환 화합물의 제조방법
KR850007247A (ko) 바이페닐릴설포닐 우레아의 제조방법
KR850007800A (ko) 세팔로스포린 유도체의 에스테르 제조방법
KR840004075A (ko) 피리드-2-온 유도체의 제조방법
KR840004759A (ko) 페니실린과 세팔로스포린 화합물의 제조방법 및 이들의 제조에 사용한 새로운 중간체의 제조방법
KR860001817A (ko) 페니실린 유도체의 제조방법
KR840002848A (ko) 유기인산염의 제조방법
KR830002783A (ko) 3-비닐-세팔로스포린 유도체 제조방법
KR830004269A (ko) Δ²-1,2,4-트리아졸린-5-온류의 제법
KR870011124A (ko) 푸란 유도체의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 19910627

Year of fee payment: 5

LAPS Lapse due to unpaid annual fee