ATE110729T1 - Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel. - Google Patents
Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel.Info
- Publication number
- ATE110729T1 ATE110729T1 AT87109416T AT87109416T ATE110729T1 AT E110729 T1 ATE110729 T1 AT E110729T1 AT 87109416 T AT87109416 T AT 87109416T AT 87109416 T AT87109416 T AT 87109416T AT E110729 T1 ATE110729 T1 AT E110729T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- substituted
- processes
- preparation
- antibacterial agents
- Prior art date
Links
- -1 CEPHALOSPORIN COMPOUNDS Chemical class 0.000 title abstract 3
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000004149 thio group Chemical group *S* 0.000 abstract 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15270686 | 1986-07-01 | ||
| JP19159086 | 1986-08-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE110729T1 true ATE110729T1 (de) | 1994-09-15 |
Family
ID=26481559
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87109416T ATE110729T1 (de) | 1986-07-01 | 1987-06-30 | Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US4822786A (de) |
| EP (1) | EP0251299B1 (de) |
| KR (1) | KR930007418B1 (de) |
| CN (1) | CN1022036C (de) |
| AT (1) | ATE110729T1 (de) |
| AU (3) | AU597676B2 (de) |
| CA (1) | CA1283404C (de) |
| DE (1) | DE3750443T2 (de) |
| ES (1) | ES2062974T3 (de) |
| HU (3) | HU198500B (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5028601A (en) * | 1987-04-30 | 1991-07-02 | Meiji Saika Kaisha, Ltd. | Cephalosporin compounds and antibacterial agents |
| JPH0633281B2 (ja) * | 1987-11-11 | 1994-05-02 | 明治製菓株式会社 | 新規セファロスポリン化合物及び抗菌剤 |
| JPH0686463B2 (ja) * | 1988-07-01 | 1994-11-02 | 明治製菓株式会社 | 新規セフェム化合物、その製造法及び抗菌剤 |
| DE3826846A1 (de) * | 1988-08-06 | 1990-02-08 | Goedecke Ag | Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
| JPH0248580A (ja) * | 1988-08-10 | 1990-02-19 | Meiji Seika Kaisha Ltd | 新規セファロスポリン系化合物及び抗菌剤 |
| EP0400805A1 (de) * | 1989-04-25 | 1990-12-05 | Toshiyasu Ishimaru | Cephalosporinverbindungen und ihre Verwendung |
| JPH03176473A (ja) * | 1989-12-01 | 1991-07-31 | Kaken Pharmaceut Co Ltd | ピリジン―ｎ―オキシド誘導体及びその製法 |
| CA2100623A1 (en) * | 1992-07-17 | 1994-01-18 | Michiyuki Sendai | Cephem compounds, their production and use |
| JPH11124384A (ja) * | 1997-10-17 | 1999-05-11 | Otsuka Chem Co Ltd | ３−セフェム化合物の製造法 |
| US6352770B1 (en) | 1999-01-15 | 2002-03-05 | Bic Corporation | Correction tape having dye migration blocking properties |
| DK1965798T3 (da) | 2005-12-07 | 2011-11-28 | Basilea Pharmaceutica Ag | Nyttige monobactam-antibiotika |
| JP2010521517A (ja) | 2007-03-23 | 2010-06-24 | バジリア ファルマスーチカ アーゲー | 細菌感染症を処置するための組合せ薬 |
| JP6266978B2 (ja) | 2010-08-10 | 2018-01-24 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | 環状ボロン酸エステル誘導体およびその治療的使用 |
| WO2013033461A1 (en) | 2011-08-31 | 2013-03-07 | Rempex Pharmaceuticals, Inc. | Heterocyclic boronic acid ester derivatives and therapeutic uses thereof |
| US9156858B2 (en) | 2012-05-23 | 2015-10-13 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US10561675B2 (en) | 2012-06-06 | 2020-02-18 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| KR20150103269A (ko) | 2013-01-04 | 2015-09-09 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
| EA201591004A1 (ru) | 2013-01-04 | 2016-02-29 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| US9241947B2 (en) | 2013-01-04 | 2016-01-26 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| US9101638B2 (en) | 2013-01-04 | 2015-08-11 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| PL3604316T3 (pl) | 2014-05-05 | 2024-04-29 | Melinta Therapeutics, Inc. | Synteza soli boronianowych |
| US9687497B1 (en) | 2014-05-05 | 2017-06-27 | Rempex Pharmaceuticals, Inc. | Salts and polymorphs of cyclic boronic acid ester derivatives and therapeutic uses thereof |
| EP3145936B1 (de) | 2014-05-19 | 2020-09-30 | Qpex Biopharma, Inc. | Borsäurederivate und therapeutische verwendungen davon |
| JP6700203B2 (ja) | 2014-07-01 | 2020-05-27 | レンペックス・ファーマシューティカルズ・インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
| WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
| ES2761778T3 (es) | 2014-12-19 | 2020-05-21 | Rempex Pharmaceuticals Inc | Aparato y proceso de flujo continuo para la producción de derivados de ácido borónico |
| US20180051041A1 (en) | 2015-03-17 | 2018-02-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| JP7060245B2 (ja) | 2016-06-30 | 2022-04-26 | キューペックス バイオファーマ， インコーポレイテッド | ボロン酸誘導体およびその治療的使用 |
| CN107641119B (zh) | 2016-07-21 | 2019-11-08 | 中国科学院上海药物研究所 | 单环β-内酰胺-铁载体轭合物及其制备方法和用途 |
| BR112020007138B1 (pt) | 2017-10-11 | 2023-03-21 | Qpex Biopharma, Inc | Derivados de ácido borônico, métodos de síntese, composição farmacêutica e uso dos mesmos |
| CA3097127A1 (en) | 2018-04-20 | 2019-10-24 | Qpex Biopharma, Inc. | Boronic acid derivatives and therapeutic uses thereof |
| CN112409383A (zh) * | 2020-11-30 | 2021-02-26 | 上海交通大学医学院 | 一种氨噻肟哌啶酮头孢菌素的制备及应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
| ZA806977B (en) * | 1979-11-19 | 1981-10-28 | Fujisawa Pharmaceutical Co | 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| JPS5849382A (ja) * | 1981-09-18 | 1983-03-23 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
| US4616081A (en) * | 1982-07-07 | 1986-10-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Cephalosporin compounds |
| JPS59167576A (ja) * | 1983-03-15 | 1984-09-21 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
| JPS59219282A (ja) * | 1983-05-28 | 1984-12-10 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物およびその中間体 |
| GB8329043D0 (en) * | 1983-10-31 | 1983-11-30 | Hider R C | Pharmaceutical compositions |
| GB8410289D0 (en) * | 1984-04-19 | 1984-05-31 | Callingham B A | Pharmaceutical compositions |
| NZ215527A (en) * | 1985-04-01 | 1989-06-28 | Mochida Pharm Co Ltd | Cephalosporin derivatives and pharmaceutical compositions |
| DE3826846A1 (de) * | 1988-08-06 | 1990-02-08 | Goedecke Ag | Alkoxy-4(1h)-pyridon-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel |
-
1987
- 1987-06-17 US US07/063,077 patent/US4822786A/en not_active Expired - Fee Related
- 1987-06-17 CA CA000539868A patent/CA1283404C/en not_active Expired - Lifetime
- 1987-06-25 HU HU872882A patent/HU198500B/hu not_active IP Right Cessation
- 1987-06-25 HU HU892782A patent/HUT56099A/hu unknown
- 1987-06-25 HU HU908257A patent/HUT56071A/hu unknown
- 1987-06-29 AU AU74931/87A patent/AU597676B2/en not_active Ceased
- 1987-06-30 EP EP87109416A patent/EP0251299B1/de not_active Expired - Lifetime
- 1987-06-30 AT AT87109416T patent/ATE110729T1/de not_active IP Right Cessation
- 1987-06-30 ES ES87109416T patent/ES2062974T3/es not_active Expired - Lifetime
- 1987-06-30 CN CN87104590A patent/CN1022036C/zh not_active Expired - Fee Related
- 1987-06-30 DE DE3750443T patent/DE3750443T2/de not_active Expired - Fee Related
- 1987-07-01 KR KR1019870006897A patent/KR930007418B1/ko not_active Expired - Fee Related
-
1989
- 1989-01-13 US US07/296,765 patent/US4883879A/en not_active Expired - Fee Related
-
1990
- 1990-09-04 AU AU62143/90A patent/AU627067B2/en not_active Ceased
-
1992
- 1992-07-10 AU AU19628/92A patent/AU635174B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| HUT44259A (en) | 1988-02-29 |
| AU6214390A (en) | 1990-12-20 |
| AU635174B2 (en) | 1993-03-11 |
| AU627067B2 (en) | 1992-08-13 |
| EP0251299B1 (de) | 1994-08-31 |
| KR880001674A (ko) | 1988-04-26 |
| CN1022036C (zh) | 1993-09-08 |
| EP0251299A3 (en) | 1989-10-11 |
| US4822786A (en) | 1989-04-18 |
| HU198500B (en) | 1989-10-30 |
| DE3750443T2 (de) | 1995-04-20 |
| AU1962892A (en) | 1992-09-10 |
| EP0251299A2 (de) | 1988-01-07 |
| ES2062974T3 (es) | 1995-01-01 |
| CN87104590A (zh) | 1988-01-13 |
| KR930007418B1 (ko) | 1993-08-10 |
| HU908257D0 (en) | 1991-06-28 |
| HUT56071A (en) | 1991-07-29 |
| AU7493187A (en) | 1988-01-07 |
| CA1283404C (en) | 1991-04-23 |
| US4883879A (en) | 1989-11-28 |
| HUT56099A (en) | 1991-07-29 |
| DE3750443D1 (de) | 1994-10-06 |
| AU597676B2 (en) | 1990-06-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |