AR010200A1 - Derivados de aza-antraciclinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de aza-antraciclinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
AR010200A1
AR010200A1 ARP960103903A AR10390396A AR010200A1 AR 010200 A1 AR010200 A1 AR 010200A1 AR P960103903 A ARP960103903 A AR P960103903A AR 10390396 A AR10390396 A AR 10390396A AR 010200 A1 AR010200 A1 AR 010200A1
Authority
AR
Argentina
Prior art keywords
procedure
preparation
pharmaceutical compositions
anthraciclinone
aza
Prior art date
Application number
ARP960103903A
Other languages
English (en)
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of AR010200A1 publication Critical patent/AR010200A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de formula I: en donde X1 y X2 son C=O, C=NH o CH2, X3 es CH2, CO, CHOH, (formula II), en donde n=2 o 3, y C=N(R9) en donde R9 es hidroxi oamino-arilo, y cada uno de R1, R2, R3, R4, R5, R6, R7 y R8 son hidrogeno, halogeno o unresi duo orgánico, son utiles en el tratamiento de la amiloidosis.También se describe un procedimiento para su preparacion y composiciones farmacéuticas que los contienen.
ARP960103903A 1995-08-09 1996-08-07 Derivados de aza-antraciclinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. AR010200A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9516349.9A GB9516349D0 (en) 1995-08-09 1995-08-09 Aza-anthracyclinone derivatives

Publications (1)

Publication Number Publication Date
AR010200A1 true AR010200A1 (es) 2000-06-07

Family

ID=10779013

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103903A AR010200A1 (es) 1995-08-09 1996-08-07 Derivados de aza-antraciclinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (22)

Country Link
US (1) US5985887A (es)
EP (1) EP0843675B1 (es)
JP (1) JPH11510500A (es)
KR (1) KR100449580B1 (es)
CN (1) CN1063178C (es)
AR (1) AR010200A1 (es)
AT (1) ATE225347T1 (es)
CA (1) CA2227984C (es)
DE (1) DE69624122T2 (es)
DK (1) DK0843675T3 (es)
ES (1) ES2184885T3 (es)
GB (1) GB9516349D0 (es)
IL (1) IL123000A (es)
NO (1) NO317825B1 (es)
NZ (1) NZ315609A (es)
PL (1) PL185305B1 (es)
PT (1) PT843675E (es)
RU (1) RU2159245C2 (es)
TW (1) TW327170B (es)
UA (1) UA48983C2 (es)
WO (1) WO1997006165A1 (es)
ZA (1) ZA966665B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9701628D0 (en) * 1997-01-27 1997-03-19 Pharmacia & Upjohn Spa Imino-aza-anthracyclinone derivatives
GB9805080D0 (en) 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Amino anthracyclinone derivatives
GB9805082D0 (en) * 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Heterocyclyl anthracyclinone derivatives
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110289A (en) * 1993-08-06 1998-01-04 Policlinico San Matteo Istitut Pharmaceutical preparations containing 4-iodo-4-deoxydoxorubicin for the treatment of amyloidosis
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives

Also Published As

Publication number Publication date
CA2227984C (en) 2006-07-11
EP0843675B1 (en) 2002-10-02
ATE225347T1 (de) 2002-10-15
IL123000A (en) 2000-10-31
ES2184885T3 (es) 2003-04-16
ZA966665B (en) 1997-05-12
CN1194646A (zh) 1998-09-30
NO317825B1 (no) 2004-12-13
EP0843675A1 (en) 1998-05-27
IL123000A0 (en) 1998-08-16
CN1063178C (zh) 2001-03-14
KR19990036275A (ko) 1999-05-25
UA48983C2 (uk) 2002-09-16
AU712411B2 (en) 1999-11-04
JPH11510500A (ja) 1999-09-14
GB9516349D0 (en) 1995-10-11
DE69624122T2 (de) 2003-03-20
NO980518L (no) 1998-03-31
DK0843675T3 (da) 2003-02-10
US5985887A (en) 1999-11-16
DE69624122D1 (de) 2002-11-07
PL324892A1 (en) 1998-06-22
WO1997006165A1 (en) 1997-02-20
CA2227984A1 (en) 1997-02-20
KR100449580B1 (ko) 2004-12-03
TW327170B (en) 1998-02-21
PT843675E (pt) 2002-12-31
NZ315609A (en) 1999-11-29
MX9801045A (es) 1998-10-31
PL185305B1 (pl) 2003-04-30
RU2159245C2 (ru) 2000-11-20
NO980518D0 (no) 1998-02-06
AU6735996A (en) 1997-03-05

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Legal Events

Date Code Title Description
FG Grant, registration