ES2062558T3 - Compuestos contra el cancer. - Google Patents

Compuestos contra el cancer.

Info

Publication number
ES2062558T3
ES2062558T3 ES90915322T ES90915322T ES2062558T3 ES 2062558 T3 ES2062558 T3 ES 2062558T3 ES 90915322 T ES90915322 T ES 90915322T ES 90915322 T ES90915322 T ES 90915322T ES 2062558 T3 ES2062558 T3 ES 2062558T3
Authority
ES
Spain
Prior art keywords
group
pct
hydroxy
nhr
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90915322T
Other languages
English (en)
Inventor
Laurence Hylton Patterson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Application granted granted Critical
Publication of ES2062558T3 publication Critical patent/ES2062558T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
    • C09B1/50—Amino-hydroxy-anthraquinones; Ethers and esters thereof
    • C09B1/51—N-substituted amino-hydroxy anthraquinone
    • C09B1/515—N-alkyl, N-aralkyl or N-cycloalkyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA (I) EN LA QUE R SUB 1, R SUB 2, R SUB 3 Y R SUB 4 SE ELIGEN, CADA UNO POR SEPARADO, ENTRE HIDROGENO, X, NH-A-NHR Y NH-A-N(O)R''R" DONDE X ES HIDROXI, HALOGENO, AMINO, ALCOXI C SUB 1-4 O ALCANOILOXI C SUB 2-8, A ES UN GRUPO ALQUILENO C SUB 2-4 CON UNA LONGITUD DE CADENA ENTRE NH Y NHR O N(O)R''R" DE 2 ATOMOS DE CARBONO COMO MINIMO Y R, R'' Y R" SE ELIGEN, CADA UNO POR SEPARADO, ENTRE GRUPOS ALQUILO C SUB 1-4 E HIDROXIALQUILO C SUB 2-4 Y GRUPOS HIDROXIALQUILO C SUB 2-4 EN LOS QUE EL ATOMO DE CARBONO UNIDO AL ATOMO DE NITROGENO NO LLEVA UN GRUPO HIDROXI Y NO SE HA SUSTITUIDO NINGUN ATOMO DE CARBONO POR DOS GRUPOS HIDROXI, O R'' Y R" JUNTAS SON UN GRUPO ALQUILENO C SUB 2-6 CON EL QUE EL ATOMO DE NITROGENO, AL QUE SE HAN UNIDO R'' Y R", FORMA UN GRUPO HETEROCICLICO CON ENTRE 3 Y 7 ATOMOS EN EL ANILLO, PERO CON LA CONDICION DE QUE POR LO MENOS UNO DE R SUB 1 A R SUB 4 ES UN GRUPO NH-A-N(O)R''R", Y SUS SALES ACEPTABLES FISIOLOGICAMENTE SON VALIDOS PARA EL TRATAMIENTO DE CANCER.
ES90915322T 1989-10-13 1990-10-12 Compuestos contra el cancer. Expired - Lifetime ES2062558T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898923075A GB8923075D0 (en) 1989-10-13 1989-10-13 Anti-cancer compounds

Publications (1)

Publication Number Publication Date
ES2062558T3 true ES2062558T3 (es) 1994-12-16

Family

ID=10664506

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90915322T Expired - Lifetime ES2062558T3 (es) 1989-10-13 1990-10-12 Compuestos contra el cancer.

Country Status (14)

Country Link
US (1) US5132327A (es)
EP (1) EP0450021B1 (es)
JP (1) JP2854971B2 (es)
AT (1) ATE101181T1 (es)
AU (1) AU634125B2 (es)
CA (1) CA2038934C (es)
DE (1) DE69006482T2 (es)
DK (1) DK0450021T3 (es)
ES (1) ES2062558T3 (es)
GB (2) GB8923075D0 (es)
NZ (1) NZ235658A (es)
PT (1) PT95584B (es)
WO (1) WO1991005824A1 (es)
ZA (1) ZA908178B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141957A (en) * 1990-11-02 1992-08-25 Sphinx Pharmaceuticals Corporation 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
GB9107852D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
GB9107843D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
GB9813062D0 (en) * 1998-06-18 1998-08-19 Univ Wales Medicine An anthraquinone and its derivatives
GB9815910D0 (en) * 1998-07-21 1998-09-23 Btg Int Ltd Synthetic method
FR2786484B1 (fr) 1998-11-30 2001-01-05 Oreal Aminoanthraquinones cationiques, leur utilisation pour la teinture des fibres keratiniques, compositions tinctoriales les renfermant et procedes de teinture
GB9828670D0 (en) * 1998-12-24 1999-02-17 Univ Montfort Anthraquinone anticancer drugs
GB0112868D0 (en) * 2001-05-25 2001-07-18 Secr Defence Detection system
MXPA04008821A (es) * 2002-03-15 2004-11-26 Btg Int Ltd Formulaciones de derivados de antraquinona.
GB0223563D0 (en) * 2002-10-10 2002-11-20 Secr Defence Detection system
US6949557B2 (en) * 2003-04-29 2005-09-27 Dabur Research Foundation Hydroanthracene based compounds as anticancer agents
US20050009924A1 (en) * 2003-07-08 2005-01-13 Hsu-Shan Huang Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives
JP2007505876A (ja) * 2003-09-17 2007-03-15 ビーティージー・インターナショナル・リミテッド アントラキノン誘導体調合物
JP2007516270A (ja) * 2003-12-23 2007-06-21 ソマンタ リミテッド 抗ガン性化合物としてのアントラキノン化合物
EP1732881A2 (en) * 2004-02-13 2006-12-20 Kudos Pharmaceuticals Limited Process for the preparation of aq4n
WO2005097128A1 (en) * 2004-03-30 2005-10-20 Novacea, Inc. 1,4-bis-n-oxide azaanthracenediones and the use thereof
EP1853243A2 (en) * 2005-03-04 2007-11-14 Novacea, Inc. Treatment of hyperproliferative diseases with anthraquinones
US20070117784A1 (en) * 2005-03-04 2007-05-24 Novacea, Inc. Treatment of hyperproliferative diseases with anthraquinones
WO2008103320A1 (en) * 2007-02-16 2008-08-28 Novacea, Inc. Methods of treating ophthalmic disorders with anthraquinones
WO2010062499A2 (en) * 2008-10-27 2010-06-03 Life Technologies Corporation Anthraquinone based near ir emitting compounds and uses thereof
GB201005939D0 (en) 2010-04-09 2010-05-26 Biostatus Ltd Method of analysing a cell or other biological material containing nucleic acid
GB201214169D0 (en) 2012-08-08 2012-09-19 Biostatus Ltd New compounds and uses thereof
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US9272981B1 (en) * 2015-06-23 2016-03-01 Amazon Technologies, Inc. Method of preparing a compound
US11292803B2 (en) 2018-08-21 2022-04-05 The Board Of Trustees Of The University Of Illinois Bioreducible N-oxide-based probes for imaging of hypoxia

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE194218C (es) *
US3174994A (en) * 1962-01-30 1965-03-23 Smith Kline French Lab Hypocholesterolemic n-oxide compositions
SE7708452L (sv) * 1977-07-22 1979-01-23 Allied Chem Komposition innehallande en antrakinonforening
US4430501A (en) * 1979-08-02 1984-02-07 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4138415A (en) * 1978-05-05 1979-02-06 American Cyanamid Company 1,4-Bis(aminoalkylamino)-anthraquinones and leuco derivatives thereof
US4820738A (en) * 1977-08-15 1989-04-11 American Cyanamid Company 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4278689A (en) * 1978-07-11 1981-07-14 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4540519A (en) * 1977-08-15 1985-09-10 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4526989A (en) * 1978-07-11 1985-07-02 American Cyanamid Company 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4614618A (en) * 1979-08-02 1986-09-30 American Cyanamid Company 1,4-bis(substituted-amino)-5,8-dihydroxy anthraquinones and leuco bases thereof
US4275010A (en) * 1979-10-24 1981-06-23 American Cyanamid Company 5,8-Dihydroxy-1,4-bis(guanidinylamino)anthraquinones
US4278605A (en) * 1980-06-30 1981-07-14 American Cyanamid Company Heteroalkylenebisanthraquinones
US4555572A (en) * 1983-07-19 1985-11-26 Warner-Lambert Company Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use
US4626540A (en) * 1983-11-08 1986-12-02 Warner-Lambert Company Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
US4686218A (en) * 1985-01-30 1987-08-11 Smithkline Beckman Corporation Use of 6-chloro-3-methyl-1H-2,3,4,5-tetrahydro-3-benzazepine-n-oxide, as a prodrug
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides

Also Published As

Publication number Publication date
NZ235658A (en) 1992-12-23
DE69006482D1 (de) 1994-03-17
US5132327A (en) 1992-07-21
AU634125B2 (en) 1993-02-11
AU6539590A (en) 1991-05-16
EP0450021B1 (en) 1994-02-02
GB2237283A (en) 1991-05-01
JPH04502166A (ja) 1992-04-16
PT95584A (pt) 1991-09-13
CA2038934A1 (en) 1991-04-14
CA2038934C (en) 2002-11-19
DK0450021T3 (da) 1994-03-07
GB9022217D0 (en) 1990-11-28
ATE101181T1 (de) 1994-02-15
PT95584B (pt) 1997-08-29
EP0450021A1 (en) 1991-10-09
GB8923075D0 (en) 1989-11-29
GB2237283B (en) 1993-01-27
DE69006482T2 (de) 1994-05-11
WO1991005824A1 (en) 1991-05-02
ZA908178B (en) 1992-06-24
JP2854971B2 (ja) 1999-02-10

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