ZA966665B - Aza-anthracyclinone derivatives - Google Patents

Aza-anthracyclinone derivatives

Info

Publication number
ZA966665B
ZA966665B ZA966665A ZA966665A ZA966665B ZA 966665 B ZA966665 B ZA 966665B ZA 966665 A ZA966665 A ZA 966665A ZA 966665 A ZA966665 A ZA 966665A ZA 966665 B ZA966665 B ZA 966665B
Authority
ZA
South Africa
Prior art keywords
aza
anthracyclinone derivatives
anthracyclinone
derivatives
Prior art date
Application number
ZA966665A
Inventor
Michele Caruso
Daniela Faiardi
Tiziano Bandiera
Jacqueline Lansen
Antonino Suarato
Original Assignee
Pharmacia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Spa filed Critical Pharmacia Spa
Publication of ZA966665B publication Critical patent/ZA966665B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
ZA966665A 1995-08-09 1996-08-06 Aza-anthracyclinone derivatives ZA966665B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9516349.9A GB9516349D0 (en) 1995-08-09 1995-08-09 Aza-anthracyclinone derivatives

Publications (1)

Publication Number Publication Date
ZA966665B true ZA966665B (en) 1997-05-12

Family

ID=10779013

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA966665A ZA966665B (en) 1995-08-09 1996-08-06 Aza-anthracyclinone derivatives

Country Status (22)

Country Link
US (1) US5985887A (en)
EP (1) EP0843675B1 (en)
JP (1) JPH11510500A (en)
KR (1) KR100449580B1 (en)
CN (1) CN1063178C (en)
AR (1) AR010200A1 (en)
AT (1) ATE225347T1 (en)
CA (1) CA2227984C (en)
DE (1) DE69624122T2 (en)
DK (1) DK0843675T3 (en)
ES (1) ES2184885T3 (en)
GB (1) GB9516349D0 (en)
IL (1) IL123000A (en)
NO (1) NO317825B1 (en)
NZ (1) NZ315609A (en)
PL (1) PL185305B1 (en)
PT (1) PT843675E (en)
RU (1) RU2159245C2 (en)
TW (1) TW327170B (en)
UA (1) UA48983C2 (en)
WO (1) WO1997006165A1 (en)
ZA (1) ZA966665B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9701628D0 (en) * 1997-01-27 1997-03-19 Pharmacia & Upjohn Spa Imino-aza-anthracyclinone derivatives
GB9805082D0 (en) 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Heterocyclyl anthracyclinone derivatives
GB9805080D0 (en) 1998-03-10 1998-05-06 Pharmacia & Upjohn Spa Amino anthracyclinone derivatives
US7053191B2 (en) * 2003-05-21 2006-05-30 Solux Corporation Method of preparing 4-R-substituted 4-demethoxydaunorubicin
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
US8846882B2 (en) 2011-04-29 2014-09-30 Synbias Pharma Ag Method of producing 4-demethoxydaunorubicin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110289A (en) * 1993-08-06 1998-01-04 Policlinico San Matteo Istitut Pharmaceutical compositions comprising 4(-iodo-4(-deoxydoxorubicin for treating amyloidosis
GB9416007D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Anthracyclinone derivatives
GB9418260D0 (en) * 1994-09-09 1994-10-26 Erba Carlo Spa Anthracycline derivatives

Also Published As

Publication number Publication date
NO317825B1 (en) 2004-12-13
CA2227984C (en) 2006-07-11
IL123000A0 (en) 1998-08-16
ATE225347T1 (en) 2002-10-15
DE69624122T2 (en) 2003-03-20
MX9801045A (en) 1998-10-31
KR19990036275A (en) 1999-05-25
JPH11510500A (en) 1999-09-14
AR010200A1 (en) 2000-06-07
PL324892A1 (en) 1998-06-22
RU2159245C2 (en) 2000-11-20
EP0843675A1 (en) 1998-05-27
AU6735996A (en) 1997-03-05
EP0843675B1 (en) 2002-10-02
PT843675E (en) 2002-12-31
UA48983C2 (en) 2002-09-16
ES2184885T3 (en) 2003-04-16
NZ315609A (en) 1999-11-29
CN1194646A (en) 1998-09-30
KR100449580B1 (en) 2004-12-03
CN1063178C (en) 2001-03-14
NO980518D0 (en) 1998-02-06
GB9516349D0 (en) 1995-10-11
IL123000A (en) 2000-10-31
AU712411B2 (en) 1999-11-04
NO980518L (en) 1998-03-31
WO1997006165A1 (en) 1997-02-20
DE69624122D1 (en) 2002-11-07
TW327170B (en) 1998-02-21
DK0843675T3 (en) 2003-02-10
US5985887A (en) 1999-11-16
PL185305B1 (en) 2003-04-30
CA2227984A1 (en) 1997-02-20

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