ATE101181T1 - Anti-krebs-verbindungen. - Google Patents

Anti-krebs-verbindungen.

Info

Publication number
ATE101181T1
ATE101181T1 AT90915322T AT90915322T ATE101181T1 AT E101181 T1 ATE101181 T1 AT E101181T1 AT 90915322 T AT90915322 T AT 90915322T AT 90915322 T AT90915322 T AT 90915322T AT E101181 T1 ATE101181 T1 AT E101181T1
Authority
AT
Austria
Prior art keywords
group
pct
hydroxy
nhr
sec
Prior art date
Application number
AT90915322T
Other languages
English (en)
Inventor
Laurence Hylton Patterson
Original Assignee
British Tech Group
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Tech Group filed Critical British Tech Group
Application granted granted Critical
Publication of ATE101181T1 publication Critical patent/ATE101181T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
    • C09B1/50—Amino-hydroxy-anthraquinones; Ethers and esters thereof
    • C09B1/51—N-substituted amino-hydroxy anthraquinone
    • C09B1/515—N-alkyl, N-aralkyl or N-cycloalkyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT90915322T 1989-10-13 1990-10-12 Anti-krebs-verbindungen. ATE101181T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898923075A GB8923075D0 (en) 1989-10-13 1989-10-13 Anti-cancer compounds
PCT/GB1990/001574 WO1991005824A1 (en) 1989-10-13 1990-10-12 Anti-cancer compounds

Publications (1)

Publication Number Publication Date
ATE101181T1 true ATE101181T1 (de) 1994-02-15

Family

ID=10664506

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90915322T ATE101181T1 (de) 1989-10-13 1990-10-12 Anti-krebs-verbindungen.

Country Status (14)

Country Link
US (1) US5132327A (de)
EP (1) EP0450021B1 (de)
JP (1) JP2854971B2 (de)
AT (1) ATE101181T1 (de)
AU (1) AU634125B2 (de)
CA (1) CA2038934C (de)
DE (1) DE69006482T2 (de)
DK (1) DK0450021T3 (de)
ES (1) ES2062558T3 (de)
GB (2) GB8923075D0 (de)
NZ (1) NZ235658A (de)
PT (1) PT95584B (de)
WO (1) WO1991005824A1 (de)
ZA (1) ZA908178B (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5141957A (en) * 1990-11-02 1992-08-25 Sphinx Pharmaceuticals Corporation 1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
GB9107843D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
GB9107852D0 (en) * 1991-04-12 1991-05-29 Patterson Laurence H Anti-cancer compounds
GB9813062D0 (en) 1998-06-18 1998-08-19 Univ Wales Medicine An anthraquinone and its derivatives
GB9815910D0 (en) 1998-07-21 1998-09-23 Btg Int Ltd Synthetic method
FR2786484B1 (fr) 1998-11-30 2001-01-05 Oreal Aminoanthraquinones cationiques, leur utilisation pour la teinture des fibres keratiniques, compositions tinctoriales les renfermant et procedes de teinture
GB9828670D0 (en) * 1998-12-24 1999-02-17 Univ Montfort Anthraquinone anticancer drugs
GB0112868D0 (en) * 2001-05-25 2001-07-18 Secr Defence Detection system
US7074835B2 (en) 2002-03-15 2006-07-11 Btg International Limited Formulations of anthraquinone derivatives
GB0223563D0 (en) * 2002-10-10 2002-11-20 Secr Defence Detection system
US6949557B2 (en) * 2003-04-29 2005-09-27 Dabur Research Foundation Hydroanthracene based compounds as anticancer agents
US20050009924A1 (en) * 2003-07-08 2005-01-13 Hsu-Shan Huang Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives
EP1663147A1 (de) * 2003-09-17 2006-06-07 Btg International Limited Formulierungen von anthrachinon-derivaten
EP1701939B1 (de) * 2003-12-23 2009-02-25 Somanta Limited Anthraquinonderivate als mittel gegen krebs
CN1930117A (zh) * 2004-02-13 2007-03-14 库多斯药物有限公司 Aq4n的制备方法
WO2005097128A1 (en) * 2004-03-30 2005-10-20 Novacea, Inc. 1,4-bis-n-oxide azaanthracenediones and the use thereof
AU2006220886A1 (en) * 2005-03-04 2006-09-14 Novacea, Inc. Treatment of hyperproliferative diseases with anthraquinones
US20070117784A1 (en) * 2005-03-04 2007-05-24 Novacea, Inc. Treatment of hyperproliferative diseases with anthraquinones
WO2008103320A1 (en) * 2007-02-16 2008-08-28 Novacea, Inc. Methods of treating ophthalmic disorders with anthraquinones
US8999965B2 (en) 2008-10-27 2015-04-07 Life Technologies Corporation Anthraquinone based near IR emitting compounds and uses thereof
GB201005939D0 (en) 2010-04-09 2010-05-26 Biostatus Ltd Method of analysing a cell or other biological material containing nucleic acid
GB201214169D0 (en) 2012-08-08 2012-09-19 Biostatus Ltd New compounds and uses thereof
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US9272981B1 (en) * 2015-06-23 2016-03-01 Amazon Technologies, Inc. Method of preparing a compound
US11292803B2 (en) 2018-08-21 2022-04-05 The Board Of Trustees Of The University Of Illinois Bioreducible N-oxide-based probes for imaging of hypoxia
CN119118908B (zh) * 2024-08-13 2025-09-19 甘肃中医药大学 一种大黄酸氮氧自由基衍生物及其合成方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE194218C (de) *
US3174994A (en) * 1962-01-30 1965-03-23 Smith Kline French Lab Hypocholesterolemic n-oxide compositions
ZA774443B (en) * 1977-07-22 1978-06-28 Allied Chem Anthrquinone compounds as anti-cancer agents
US4138415A (en) * 1978-05-05 1979-02-06 American Cyanamid Company 1,4-Bis(aminoalkylamino)-anthraquinones and leuco derivatives thereof
US4820738A (en) * 1977-08-15 1989-04-11 American Cyanamid Company 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4540519A (en) * 1977-08-15 1985-09-10 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4278689A (en) * 1978-07-11 1981-07-14 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4197249A (en) * 1977-08-15 1980-04-08 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4430501A (en) * 1979-08-02 1984-02-07 American Cyanamid Company 1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4526989A (en) * 1978-07-11 1985-07-02 American Cyanamid Company 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4614618A (en) * 1979-08-02 1986-09-30 American Cyanamid Company 1,4-bis(substituted-amino)-5,8-dihydroxy anthraquinones and leuco bases thereof
US4275010A (en) * 1979-10-24 1981-06-23 American Cyanamid Company 5,8-Dihydroxy-1,4-bis(guanidinylamino)anthraquinones
US4278605A (en) * 1980-06-30 1981-07-14 American Cyanamid Company Heteroalkylenebisanthraquinones
US4555572A (en) * 1983-07-19 1985-11-26 Warner-Lambert Company Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use
US4626540A (en) * 1983-11-08 1986-12-02 Warner-Lambert Company Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
US4686218A (en) * 1985-01-30 1987-08-11 Smithkline Beckman Corporation Use of 6-chloro-3-methyl-1H-2,3,4,5-tetrahydro-3-benzazepine-n-oxide, as a prodrug
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides

Also Published As

Publication number Publication date
JPH04502166A (ja) 1992-04-16
GB2237283B (en) 1993-01-27
ES2062558T3 (es) 1994-12-16
NZ235658A (en) 1992-12-23
CA2038934C (en) 2002-11-19
AU634125B2 (en) 1993-02-11
EP0450021A1 (de) 1991-10-09
ZA908178B (en) 1992-06-24
EP0450021B1 (de) 1994-02-02
DE69006482D1 (de) 1994-03-17
CA2038934A1 (en) 1991-04-14
GB9022217D0 (en) 1990-11-28
GB8923075D0 (en) 1989-11-29
WO1991005824A1 (en) 1991-05-02
GB2237283A (en) 1991-05-01
DK0450021T3 (da) 1994-03-07
PT95584A (pt) 1991-09-13
JP2854971B2 (ja) 1999-02-10
DE69006482T2 (de) 1994-05-11
AU6539590A (en) 1991-05-16
PT95584B (pt) 1997-08-29
US5132327A (en) 1992-07-21

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee