US1073811A
(en)
|
1913-04-24 |
1913-09-23 |
Carl G Miller |
Fly-trap.
|
JPS5144499B1
(it)
|
1970-08-29 |
1976-11-29 |
|
|
JPS5334319B2
(it)
|
1971-12-28 |
1978-09-20 |
|
|
JPS5717624B2
(it)
|
1974-04-17 |
1982-04-12 |
|
|
US4208479A
(en)
|
1977-07-14 |
1980-06-17 |
Syva Company |
Label modified immunoassays
|
US4474893A
(en)
|
1981-07-01 |
1984-10-02 |
The University of Texas System Cancer Center |
Recombinant monoclonal antibodies
|
US4444878A
(en)
|
1981-12-21 |
1984-04-24 |
Boston Biomedical Research Institute, Inc. |
Bispecific antibody determinants
|
JPS58201994A
(ja)
|
1982-05-21 |
1983-11-25 |
Hideaki Hagiwara |
抗原特異的ヒト免疫グロブリンの生産方法
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
JPH0234615Y2
(it)
|
1986-08-08 |
1990-09-18 |
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
JPS63149900A
(ja)
|
1986-12-15 |
1988-06-22 |
Toshiba Corp |
半導体メモリ
|
US4851341A
(en)
|
1986-12-19 |
1989-07-25 |
Immunex Corporation |
Immunoaffinity purification system
|
US5004697A
(en)
|
1987-08-17 |
1991-04-02 |
Univ. Of Ca |
Cationized antibodies for delivery through the blood-brain barrier
|
JPH01144991A
(ja)
|
1987-12-02 |
1989-06-07 |
Kagaku Oyobi Ketsusei Riyouhou Kenkyusho |
血液凝固第8因子の精製方法
|
US5670373A
(en)
|
1988-01-22 |
1997-09-23 |
Kishimoto; Tadamitsu |
Antibody to human interleukin-6 receptor
|
US5322678A
(en)
|
1988-02-17 |
1994-06-21 |
Neorx Corporation |
Alteration of pharmacokinetics of proteins by charge modification
|
US6010902A
(en)
|
1988-04-04 |
2000-01-04 |
Bristol-Meyers Squibb Company |
Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity
|
JPH0250497A
(ja)
|
1988-08-12 |
1990-02-20 |
Tokin Corp |
電波吸収体とその製造方法
|
IL91778A
(en)
|
1988-09-28 |
1994-10-07 |
Lilly Co Eli |
A method for reducing the heterogeneity of monoclonal antibodies
|
US5126250A
(en)
|
1988-09-28 |
1992-06-30 |
Eli Lilly And Company |
Method for the reduction of heterogeneity of monoclonal antibodies
|
IL89491A0
(en)
|
1988-11-17 |
1989-09-10 |
Hybritech Inc |
Bifunctional chimeric antibodies
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
GB8916400D0
(en)
|
1989-07-18 |
1989-09-06 |
Dynal As |
Modified igg3
|
JPH0636741B2
(ja)
|
1989-11-08 |
1994-05-18 |
帝人株式会社 |
ヒト・プロテインcの分離方法
|
EP0505357B1
(en)
|
1989-12-11 |
1999-03-10 |
Immunomedics, Inc. |
Method for antibody targeting of diagnostic or therapeutic agents
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
US5130129A
(en)
|
1990-03-06 |
1992-07-14 |
The Regents Of The University Of California |
Method for enhancing antibody transport through capillary barriers
|
TW212184B
(it)
|
1990-04-02 |
1993-09-01 |
Takeda Pharm Industry Co Ltd |
|
JPH05184383A
(ja)
|
1990-06-19 |
1993-07-27 |
Dainabotsuto Kk |
二重特異性抗体
|
CA2109602C
(en)
|
1990-07-10 |
2002-10-01 |
Gregory P. Winter |
Methods for producing members of specific binding pairs
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
JPH05199894A
(ja)
|
1990-08-20 |
1993-08-10 |
Takeda Chem Ind Ltd |
二重特異性抗体および抗体含有薬剤
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
EP0628639B1
(en)
|
1991-04-25 |
1999-06-23 |
Chugai Seiyaku Kabushiki Kaisha |
Reconstituted human antibody against human interleukin 6 receptor
|
JPH05304992A
(ja)
|
1991-06-20 |
1993-11-19 |
Takeda Chem Ind Ltd |
ハイブリッド・モノクローナル抗体および抗体含有薬剤
|
US5468634A
(en)
|
1991-06-24 |
1995-11-21 |
The University Of North Carolina At Chapel Hill |
Axl oncogene
|
US6136310A
(en)
|
1991-07-25 |
2000-10-24 |
Idec Pharmaceuticals Corporation |
Recombinant anti-CD4 antibodies for human therapy
|
WO1993006213A1
(en)
|
1991-09-23 |
1993-04-01 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
ATE207080T1
(de)
|
1991-11-25 |
2001-11-15 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
WO1993011236A1
(en)
|
1991-12-02 |
1993-06-10 |
Medical Research Council |
Production of anti-self antibodies from antibody segment repertoires and displayed on phage
|
EP0746609A4
(en)
|
1991-12-17 |
1997-12-17 |
Genpharm Int |
NON-HUMAN TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGOUS ANTIBODIES
|
US5667988A
(en)
|
1992-01-27 |
1997-09-16 |
The Scripps Research Institute |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
JPH05203652A
(ja)
|
1992-01-28 |
1993-08-10 |
Fuji Photo Film Co Ltd |
抗体酵素免疫分析法
|
JPH05213775A
(ja)
|
1992-02-05 |
1993-08-24 |
Otsuka Pharmaceut Co Ltd |
Bfa抗体
|
US6749853B1
(en)
|
1992-03-05 |
2004-06-15 |
Board Of Regents, The University Of Texas System |
Combined methods and compositions for coagulation and tumor treatment
|
EP0656941B1
(en)
|
1992-03-24 |
2005-06-01 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
US6129914A
(en)
|
1992-03-27 |
2000-10-10 |
Protein Design Labs, Inc. |
Bispecific antibody effective to treat B-cell lymphoma and cell line
|
US5744446A
(en)
|
1992-04-07 |
1998-04-28 |
Emory University |
Hybrid human/animal factor VIII
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
WO1994002602A1
(en)
|
1992-07-24 |
1994-02-03 |
Cell Genesys, Inc. |
Generation of xenogeneic antibodies
|
ZA936260B
(en)
|
1992-09-09 |
1994-03-18 |
Smithkline Beecham Corp |
Novel antibodies for conferring passive immunity against infection by a pathogen in man
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
BR9204244A
(pt)
|
1992-10-26 |
1994-05-03 |
Cofap |
Ferro fundido cinzento
|
KR100371784B1
(ko)
|
1992-12-01 |
2003-07-22 |
프로테인 디자인랩스, 인코포레이티드 |
L-셀렉틴과반응성인인체화된항체
|
JP3720353B2
(ja)
|
1992-12-04 |
2005-11-24 |
メディカル リサーチ カウンシル |
多価および多重特異性の結合タンパク質、それらの製造および使用
|
US7393682B1
(en)
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
DK0690873T3
(da)
|
1993-03-19 |
2003-09-29 |
Univ Johns Hopkins Med |
Vækstdifferentieringsfaktor-8
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
JPH08510555A
(ja)
|
1993-07-01 |
1996-11-05 |
デイド、インターナショナル、インコーポレイテッド |
第x因子除去血漿の調製のための方法
|
GB9314271D0
(en)
|
1993-07-09 |
1993-08-18 |
Inst Of Cancer The Research |
Cell growth factor receptors
|
UA40577C2
(uk)
|
1993-08-02 |
2001-08-15 |
Мерк Патент Гмбх |
Біспецифічна молекула, що використовується для лізису пухлинних клітин, спосіб її одержання, моноклональне антитіло (варіанти), фармацевтичний препарат, фармацевтичний набір (варіанти), спосіб видалення пухлинних клітин
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
JPH09506508A
(ja)
|
1993-12-03 |
1997-06-30 |
メディカル リサーチ カウンシル |
組換え結合タンパク質およびペプチド
|
CA2177988A1
(en)
|
1993-12-03 |
1995-06-08 |
Kazuo Higuchi |
Expression vector for preparing an anti-body-variable-region library
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
DE4419399C1
(de)
|
1994-06-03 |
1995-03-09 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von heterologen bispezifischen Antikörpern
|
US5945311A
(en)
|
1994-06-03 |
1999-08-31 |
GSF--Forschungszentrumfur Umweltund Gesundheit |
Method for producing heterologous bi-specific antibodies
|
US8017121B2
(en)
|
1994-06-30 |
2011-09-13 |
Chugai Seiyaku Kabushika Kaisha |
Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component
|
DE69519929T2
(de)
|
1994-07-11 |
2001-05-23 |
Univ Texas |
Verfahren und zusammensetzungen für die spezifische koagulation von tumorgefässen
|
CA2194907A1
(en)
|
1994-07-13 |
1996-02-01 |
Kouji Matsushima |
Reshaped human antibody against human interleukin-8
|
JP3865418B2
(ja)
|
1994-07-13 |
2007-01-10 |
中外製薬株式会社 |
ヒトインターロイキン−8に対する再構成ヒト抗体
|
US6048972A
(en)
|
1994-07-13 |
2000-04-11 |
Chugai Pharmaceutical Co., Ltd. |
Recombinant materials for producing humanized anti-IL-8 antibodies
|
TW416960B
(en)
|
1994-07-13 |
2001-01-01 |
Chugai Pharmaceutical Co Ltd |
Reshaped human antibody to human interleukin-8
|
US6309636B1
(en)
|
1995-09-14 |
2001-10-30 |
Cancer Research Institute Of Contra Costa |
Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
|
ATE552012T1
(de)
|
1994-10-07 |
2012-04-15 |
Chugai Pharmaceutical Co Ltd |
Hemmung des abnormalen wachstums von synovialzellen durch il-6-antagonisten als wirkstoff
|
EP0791359A4
(en)
|
1994-10-21 |
2002-09-11 |
Chugai Pharmaceutical Co Ltd |
MEDICINE AGAINST IL-6 PRODUCTION IN DISEASES
|
AU4289496A
(en)
|
1994-12-02 |
1996-06-19 |
Chiron Corporation |
Method of promoting an immune response with a bispecific antibody
|
US6485943B2
(en)
|
1995-01-17 |
2002-11-26 |
The University Of Chicago |
Method for altering antibody light chain interactions
|
US5876950A
(en)
|
1995-01-26 |
1999-03-02 |
Bristol-Myers Squibb Company |
Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy
|
CN1097438C
(zh)
|
1995-02-28 |
2003-01-01 |
普罗格特-甘布尔公司 |
微生物稳定的非充气饮料产品的制备
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
AU5632296A
(en)
|
1995-04-27 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
WO1996034096A1
(en)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US6018032A
(en)
|
1995-09-11 |
2000-01-25 |
Kyowa Hakko Kogyo Co., Ltd. |
Antibody against human interleukin-5-receptor α chain
|
MA24512A1
(fr)
|
1996-01-17 |
1998-12-31 |
Univ Vermont And State Agrienl |
Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose
|
DE69731289D1
(de)
|
1996-03-18 |
2004-11-25 |
Univ Texas |
Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
|
JP3032287U
(ja)
|
1996-06-10 |
1996-12-17 |
幸喜 高橋 |
人 形
|
US20020147326A1
(en)
|
1996-06-14 |
2002-10-10 |
Smithkline Beecham Corporation |
Hexameric fusion proteins and uses therefor
|
CZ399A3
(cs)
*
|
1996-07-19 |
1999-06-16 |
Amgen Inc. |
Polypeptidová analoga kationaktivních polypeptidů
|
CA2262405A1
(en)
|
1996-08-02 |
1998-02-12 |
Bristol-Myers Squibb Company |
A method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
US7247302B1
(en)
|
1996-08-02 |
2007-07-24 |
Bristol-Myers Squibb Company |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
BR9713294A
(pt)
|
1996-09-26 |
2000-10-17 |
Chugai Pharmaceutical Co Ltd |
"anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano"
|
JPH10165184A
(ja)
|
1996-12-16 |
1998-06-23 |
Tosoh Corp |
抗体、遺伝子及びキメラ抗体の製法
|
US5990286A
(en)
|
1996-12-18 |
1999-11-23 |
Techniclone, Inc. |
Antibodies with reduced net positive charge
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
CA2284271C
(en)
|
1997-03-21 |
2012-05-08 |
Chugai Seiyaku Kabushiki Kaisha |
A preventive or therapeutic agent for sensitized t cell-mediated diseases comprising il-6 antagonist as an active ingredient
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US7365166B2
(en)
|
1997-04-07 |
2008-04-29 |
Genentech, Inc. |
Anti-VEGF antibodies
|
FR2761994B1
(fr)
|
1997-04-11 |
1999-06-18 |
Centre Nat Rech Scient |
Preparation de recepteurs membranaires a partir de baculovirus extracellulaires
|
US20030207346A1
(en)
|
1997-05-02 |
2003-11-06 |
William R. Arathoon |
Method for making multispecific antibodies having heteromultimeric and common components
|
EP0979281B1
(en)
|
1997-05-02 |
2005-07-20 |
Genentech, Inc. |
A method for making multispecific antibodies having heteromultimeric and common components
|
US20020062010A1
(en)
|
1997-05-02 |
2002-05-23 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
DE19725586C2
(de)
|
1997-06-17 |
1999-06-24 |
Gsf Forschungszentrum Umwelt |
Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper
|
US5980893A
(en)
|
1997-07-17 |
1999-11-09 |
Beth Israel Deaconess Medical Center, Inc. |
Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
|
US6207805B1
(en)
|
1997-07-18 |
2001-03-27 |
University Of Iowa Research Foundation |
Prostate cell surface antigen-specific antibodies
|
DE69839517D1
(de)
|
1997-08-15 |
2008-07-03 |
Chugai Pharmaceutical Co Ltd |
Präventiva oder arzneien enthaltend neutralisierende anti-il6-rezeptor antikörper zur reduktion urinären proteins bei systemischen lupus erythematosus
|
US20020187150A1
(en)
|
1997-08-15 |
2002-12-12 |
Chugai Seiyaku Kabushiki Kaisha |
Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient
|
US6342220B1
(en)
|
1997-08-25 |
2002-01-29 |
Genentech, Inc. |
Agonist antibodies
|
KR100473836B1
(ko)
|
1997-10-03 |
2005-03-07 |
츄가이 세이야꾸 가부시키가이샤 |
천연 인간형화 항체
|
JP4124573B2
(ja)
|
1998-03-17 |
2008-07-23 |
中外製薬株式会社 |
Il−6アンタゴニストを有効成分として含有する炎症性腸疾患の予防又は治療剤
|
JP2002510481A
(ja)
|
1998-04-02 |
2002-04-09 |
ジェネンテック・インコーポレーテッド |
抗体変異体及びその断片
|
US6677436B1
(en)
|
1998-04-03 |
2004-01-13 |
Chugai Seiyaku Kabushiki Kaisha |
Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
WO2000009560A2
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
MXPA01005515A
(es)
|
1998-12-01 |
2003-07-14 |
Protein Design Labs Inc |
Anticuerpos humanizados para gamma-interferon.
|
CN1202128C
(zh)
|
1998-12-08 |
2005-05-18 |
拜奥威神有限公司 |
修饰蛋白的免疫原性
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
PL209786B1
(pl)
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
|
US6972125B2
(en)
*
|
1999-02-12 |
2005-12-06 |
Genetics Institute, Llc |
Humanized immunoglobulin reactive with B7-2 and methods of treatment therewith
|
WO2004009618A2
(en)
|
2002-07-18 |
2004-01-29 |
Crucell Holland B.V. |
Recombinant production of mixtures of antibodies
|
PT1188830E
(pt)
|
1999-06-02 |
2010-04-09 |
Chugai Pharmaceutical Co Ltd |
Nova proteína nr10 receptora da hemopoietina
|
SK782002A3
(en)
|
1999-07-21 |
2003-08-05 |
Lexigen Pharm Corp |
FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
|
AT411997B
(de)
|
1999-09-14 |
2004-08-26 |
Baxter Ag |
Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
|
SE9903895D0
(sv)
|
1999-10-28 |
1999-10-28 |
Active Biotech Ab |
Novel compounds
|
JP2004505609A
(ja)
|
2000-04-03 |
2004-02-26 |
オックスフォード グリコサイエンシズ(ユーケー) リミテッド |
核酸分子、ポリペプチド、ならびにアルツハイマー病の診断および処置を含むそれらの使用
|
DE60126483T2
(de)
|
2000-04-28 |
2007-12-06 |
Sangamo BioSciences, Inc., Richmond |
Gezielte Modifikation der Chromatinstruktur
|
EP1278512A2
(en)
*
|
2000-05-03 |
2003-01-29 |
MBT Munich Biotechnology AG |
Cationic diagnostic, imaging and therapeutic agents associated with activated vascular sites
|
EP1299419A2
(en)
|
2000-05-24 |
2003-04-09 |
Imclone Systems, Inc. |
Bispecific immunoglobulin-like antigen binding proteins and method of production
|
WO2002006838A1
(fr)
|
2000-07-17 |
2002-01-24 |
Chugai Seiyaku Kabushiki Kaisha |
Methode de criblage d'un ligand dote d'une activite biologique
|
AU2011244851A1
(en)
|
2000-07-27 |
2011-11-24 |
The John Hopkins University School Of Medicine |
Promyostatin peptides and methods of using same
|
US6534058B2
(en)
|
2000-10-10 |
2003-03-18 |
Tanox, Inc. |
Anti-C5 monoclonal antibodies
|
ES2332402T5
(es)
|
2000-10-12 |
2018-05-14 |
Genentech, Inc. |
Formulaciones de proteína concentradas de viscosidad reducida
|
WO2002033073A1
(fr)
|
2000-10-20 |
2002-04-25 |
Chugai Seiyaku Kabushiki Kaisha |
Anticorps agoniste degrade
|
EP1334731B1
(en)
|
2000-10-25 |
2008-02-27 |
Chugai Seiyaku Kabushiki Kaisha |
Preventives or remedies for psoriasis containing as the active ingredient il-6 antagonist
|
AU2000279625A1
(en)
|
2000-10-27 |
2002-05-15 |
Chugai Seiyaku Kabushiki Kaisha |
Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient
|
ES2649037T3
(es)
|
2000-12-12 |
2018-01-09 |
Medimmune, Llc |
Moléculas con semividas prolongadas, composiciones y usos de las mismas
|
AU2002248571B2
(en)
|
2001-03-07 |
2007-01-18 |
Merck Patent Gmbh |
Expression technology for proteins containing a hybrid isotype antibody moiety
|
UA80091C2
(en)
|
2001-04-02 |
2007-08-27 |
Chugai Pharmaceutical Co Ltd |
Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist
|
CZ303450B6
(cs)
|
2001-04-13 |
2012-09-19 |
Biogen Idec Ma Inc. |
Protilátky k VLA-1, kompozice je obsahující a nukleové kyseliny, které je kódují, zpusob stanovení hladiny VLA-1 a použití pri lécení imunologického onemocnení
|
JP4281869B2
(ja)
|
2001-06-22 |
2009-06-17 |
中外製薬株式会社 |
抗グリピカン3抗体を含む細胞増殖抑制剤
|
EP1425042B2
(en)
|
2001-08-17 |
2016-02-10 |
Genentech, Inc. |
Complement pathway inhibitors binding to c5 and c5a without preventing the formation of c5b
|
US20030049203A1
(en)
|
2001-08-31 |
2003-03-13 |
Elmaleh David R. |
Targeted nucleic acid constructs and uses related thereto
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
WO2003035835A2
(en)
|
2001-10-25 |
2003-05-01 |
Genentech, Inc. |
Glycoprotein compositions
|
US20030190705A1
(en)
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
DE10156482A1
(de)
|
2001-11-12 |
2003-05-28 |
Gundram Jung |
Bispezifisches Antikörper-Molekül
|
US7771951B2
(en)
|
2001-12-03 |
2010-08-10 |
Amgen Fremont Inc. |
Antibody categorization based on binding characteristics
|
JP4063769B2
(ja)
|
2001-12-28 |
2008-03-19 |
中外製薬株式会社 |
タンパク質安定化方法
|
ES2546797T3
(es)
|
2002-01-18 |
2015-09-28 |
Zymogenetics, Inc. |
Multímeros Zcytor17 receptores de citocinas
|
CA2473686C
(en)
|
2002-01-18 |
2011-09-20 |
Zymogenetics, Inc. |
Novel cytokine zcytor17 ligand
|
AU2003216250A1
(en)
|
2002-02-11 |
2003-09-04 |
Genentech, Inc. |
Antibody variants with faster antigen association rates
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
US20040110226A1
(en)
|
2002-03-01 |
2004-06-10 |
Xencor |
Antibody optimization
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
AU2003227504A1
(en)
|
2002-04-15 |
2003-10-27 |
Chugai Seiyaku Kabushiki Kaisha |
METHOD OF CONSTRUCTING scDb LIBRARY
|
JP4518941B2
(ja)
|
2002-04-26 |
2010-08-04 |
中外製薬株式会社 |
アゴニスト抗体のスクリーニング方法
|
WO2005056606A2
(en)
|
2003-12-03 |
2005-06-23 |
Xencor, Inc |
Optimized antibodies that target the epidermal growth factor receptor
|
WO2003102580A1
(en)
|
2002-05-31 |
2003-12-11 |
Biacore Ab |
Method of coupling binding agents to a substrate surface
|
JP2004086862A
(ja)
|
2002-05-31 |
2004-03-18 |
Celestar Lexico-Sciences Inc |
タンパク質相互作用情報処理装置、タンパク質相互作用情報処理方法、プログラム、および、記録媒体
|
US20050130224A1
(en)
|
2002-05-31 |
2005-06-16 |
Celestar Lexico- Sciences, Inc. |
Interaction predicting device
|
AU2003256266A1
(en)
|
2002-06-12 |
2003-12-31 |
Genencor International, Inc. |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
ITMI20021527A1
(it)
|
2002-07-11 |
2004-01-12 |
Consiglio Nazionale Ricerche |
Anticorpi anti componente c5 del complemento e loro uso
|
EP1382969A1
(en)
|
2002-07-17 |
2004-01-21 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Diagnosis and prevention of cancer cell invasion
|
TW200407335A
(en)
|
2002-07-22 |
2004-05-16 |
Chugai Pharmaceutical Co Ltd |
Non-neutralizing antibody to inhibit the inactivation of activated protein C
|
AU2003264009A1
(en)
|
2002-08-15 |
2004-03-03 |
Epitomics, Inc. |
Humanized rabbit antibodies
|
JP4547561B2
(ja)
|
2002-09-16 |
2010-09-22 |
ザ ジョンズ ホプキンス ユニバーシティー |
メタロプロテアーゼによるミオスタチンの活性化、およびミオスタチン活性の調節法
|
ATE541857T1
(de)
|
2002-09-27 |
2012-02-15 |
Xencor Inc |
Optimierte fc-varianten und herstellungsverfahren dafür
|
JP4768439B2
(ja)
|
2002-10-15 |
2011-09-07 |
アボット バイオセラピューティクス コーポレイション |
変異誘発による抗体のFcRn結合親和力又は血清半減期の改変
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
GB0224082D0
(en)
|
2002-10-16 |
2002-11-27 |
Celltech R&D Ltd |
Biological products
|
US7261893B2
(en)
|
2002-10-22 |
2007-08-28 |
Wyeth |
Neutralizing antibodies against GDF-8 and uses therefor
|
ATE527278T1
(de)
|
2002-12-16 |
2011-10-15 |
Genmab As |
Humane monoklonale antikörper gegen interleukin 8 (il-8)
|
CA2921578C
(en)
|
2002-12-24 |
2017-02-14 |
Rinat Neuroscience Corp. |
Anti-ngf antibodies and methods using same
|
AU2003303543A1
(en)
|
2002-12-26 |
2004-07-29 |
Chugai Seiyaku Kabushiki Kaisha |
Agonist antibody against heteroreceptor
|
EP1605058B1
(en)
|
2003-01-21 |
2009-05-13 |
Chugai Seiyaku Kabushiki Kaisha |
Method of screening light chain of antibody light chains
|
CA2515081A1
(en)
|
2003-02-07 |
2004-08-19 |
Protein Design Labs, Inc. |
Amphiregulin antibodies and their use to treat cancer and psoriasis
|
US20040223970A1
(en)
|
2003-02-28 |
2004-11-11 |
Daniel Afar |
Antibodies against SLC15A2 and uses thereof
|
US20040258705A1
(en)
|
2003-02-28 |
2004-12-23 |
Antigenics Inc. |
Use of lectins to promote oligomerization of glycoproteins and antigenic molecules
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
CA2517926A1
(en)
|
2003-03-04 |
2004-10-28 |
Alexion Pharmaceuticals, Inc. |
Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells
|
GB0306098D0
(en)
*
|
2003-03-18 |
2003-04-23 |
Platform Diagnostics Group Ltd |
Sample testing device
|
DE602004028347D1
(de)
|
2003-03-24 |
2010-09-09 |
Zymogenetics Inc |
Anti-il-22ra antikörper und bindungspartner und verwendungsmethoden bei entzündung
|
GB2400851B
(en)
|
2003-04-25 |
2004-12-15 |
Bioinvent Int Ab |
Identifying binding of a polypeptide to a polypeptide target
|
GB2401040A
(en)
|
2003-04-28 |
2004-11-03 |
Chugai Pharmaceutical Co Ltd |
Method for treating interleukin-6 related diseases
|
US9051373B2
(en)
|
2003-05-02 |
2015-06-09 |
Xencor, Inc. |
Optimized Fc variants
|
EP1639009B1
(en)
|
2003-05-30 |
2013-02-27 |
Merus B.V. |
Fab library for the preparation of a mixture of antibodies
|
KR20160114727A
(ko)
|
2003-05-30 |
2016-10-05 |
제넨테크, 인크. |
항-vegf 항체를 사용한 치료
|
EP1635870A2
(en)
|
2003-06-02 |
2006-03-22 |
Wyeth |
Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders
|
ES2538469T3
(es)
|
2003-06-05 |
2015-06-22 |
Genentech, Inc. |
Terapia de combinación para trastornos de células B
|
JP4794301B2
(ja)
|
2003-06-11 |
2011-10-19 |
中外製薬株式会社 |
抗体の製造方法
|
EP1636264A2
(en)
|
2003-06-24 |
2006-03-22 |
MERCK PATENT GmbH |
Tumour necrosis factor receptor molecules with reduced immunogenicity
|
WO2005005604A2
(en)
|
2003-06-30 |
2005-01-20 |
Centocor, Inc. |
Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses
|
WO2005023193A2
(en)
|
2003-09-04 |
2005-03-17 |
Interleukin Genetics, Inc. |
Methods of treating endometriosis
|
US7297336B2
(en)
|
2003-09-12 |
2007-11-20 |
Baxter International Inc. |
Factor IXa specific antibodies displaying factor VIIIa like activity
|
JP2005101105A
(ja)
|
2003-09-22 |
2005-04-14 |
Canon Inc |
位置決め装置、露光装置、デバイス製造方法
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
JP2005112514A
(ja)
|
2003-10-06 |
2005-04-28 |
Tadano Ltd |
伸縮ブーム
|
AU2003271174A1
(en)
|
2003-10-10 |
2005-04-27 |
Chugai Seiyaku Kabushiki Kaisha |
Double specific antibodies substituting for functional protein
|
EP1693448A4
(en)
|
2003-10-14 |
2008-03-05 |
Chugai Pharmaceutical Co Ltd |
DOUBLE SPECIFICITY ANTIBODY FOR FUNCTIONAL PROTEIN SUBSTITUTION
|
CA2545539A1
(en)
|
2003-10-15 |
2005-04-28 |
Pdl Biopharma, Inc. |
Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
|
DK1690550T3
(da)
|
2003-10-17 |
2012-11-05 |
Chugai Pharmaceutical Co Ltd |
Terapeutisk middel til mesothelioma
|
WO2005047327A2
(en)
*
|
2003-11-12 |
2005-05-26 |
Biogen Idec Ma Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
EP2221315A1
(en)
|
2003-12-04 |
2010-08-25 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
DK1691837T3
(da)
|
2003-12-10 |
2012-10-01 |
Medarex Inc |
IP-10-antistoffer og anvendelse heraf
|
CA2546054C
(en)
|
2003-12-10 |
2014-05-13 |
Medarex, Inc. |
Interferon alpha antibodies and their uses
|
AR048210A1
(es)
|
2003-12-19 |
2006-04-12 |
Chugai Pharmaceutical Co Ltd |
Un agente preventivo para la vasculitis.
|
US20050249723A1
(en)
|
2003-12-22 |
2005-11-10 |
Xencor, Inc. |
Fc polypeptides with novel Fc ligand binding sites
|
US20050136051A1
(en)
|
2003-12-22 |
2005-06-23 |
Bernard Scallon |
Methods for generating multimeric molecules
|
CA2551008C
(en)
|
2003-12-25 |
2013-10-01 |
Kirin Beer Kabushiki Kaisha |
Anti-cd40 antibody mutants
|
US20050266425A1
(en)
|
2003-12-31 |
2005-12-01 |
Vaccinex, Inc. |
Methods for producing and identifying multispecific antibodies
|
SG153874A1
(en)
|
2003-12-31 |
2009-07-29 |
Schering Plough Ltd |
Neutralizing epitope-based growth enhancing vaccine
|
ITMI20040003A1
(it)
|
2004-01-07 |
2004-04-07 |
Zambon Spa |
Processo per la preparazione di 6-fluoro-2-metil-1-indanone
|
CA2552523C
(en)
|
2004-01-09 |
2019-11-26 |
Pfizer Inc. |
Monoclonal antibodies to mucosal addressin cell adhesion molecule(madcam)
|
BRPI0506771A
(pt)
|
2004-01-12 |
2007-05-22 |
Applied Molecular Evolution |
anticorpo, e, composição farmacêutica
|
US20070116710A1
(en)
|
2004-02-03 |
2007-05-24 |
Leonard Bell |
Methods of treating hemolytic anemia
|
US20050169921A1
(en)
|
2004-02-03 |
2005-08-04 |
Leonard Bell |
Method of treating hemolytic disease
|
JP2008505054A
(ja)
|
2004-02-11 |
2008-02-21 |
ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー |
Il−6アンタゴニストで骨関節炎を治療する方法
|
CA2558805C
(en)
|
2004-03-23 |
2011-09-27 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
AU2005227326B2
(en)
|
2004-03-24 |
2009-12-03 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
KR20070035482A
(ko)
|
2004-03-24 |
2007-03-30 |
추가이 세이야쿠 가부시키가이샤 |
인터로킨-6 안타고니스트를 활성성분으로 함유하는내이장해 치료제
|
US8398980B2
(en)
|
2004-03-24 |
2013-03-19 |
Chugai Seiyaku Kabushiki Kaisha |
Subtypes of humanized antibody against interleuken-6 receptor
|
AR048335A1
(es)
|
2004-03-24 |
2006-04-19 |
Chugai Pharmaceutical Co Ltd |
Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
WO2005112564A2
(en)
|
2004-04-15 |
2005-12-01 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Germline and sequence variants of humanized antibodies and methods of making and using them
|
AU2005247301B2
(en)
|
2004-04-16 |
2011-08-18 |
Macrogenics, Inc. |
FCγRIIB-specific antibodies and methods of use thereof
|
KR100620554B1
(ko)
|
2004-06-05 |
2006-09-06 |
한국생명공학연구원 |
Tag-72에 대한 인간화 항체
|
AR049390A1
(es)
|
2004-06-09 |
2006-07-26 |
Wyeth Corp |
Anticuerpos contra la interleuquina-13 humana y usos de los mismos
|
JP2008504289A
(ja)
|
2004-06-25 |
2008-02-14 |
メディミューン,インコーポレーテッド |
部位特異的突然変異誘発による哺乳動物細胞における組換え抗体の産生の増加
|
BRPI0513155B1
(pt)
|
2004-07-06 |
2021-07-20 |
Bioren, Inc. |
Método de distinguir um ou mais resíduos de aminoácido funcionais dos resíduos de aminoácido não-funcionais em uma região definida dentro de um polipeptídeo, método de gerar uma biblioteca de análogos de polipeptídeo e método de identificar um subconjunto de análogos de polipeptídeo tendo uma propriedade desejada
|
EP2314317A3
(en)
|
2004-07-09 |
2011-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-glypican 3 antibody
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
EP3342782B1
(en)
|
2004-07-15 |
2022-08-17 |
Xencor, Inc. |
Optimized fc variants
|
EA012464B1
(ru)
|
2004-08-04 |
2009-10-30 |
Эпплайд Молекьюлар Эволюшн, Инк. |
Антитело против cd20 и его применение
|
JP2008510007A
(ja)
|
2004-08-16 |
2008-04-03 |
メディミューン,インコーポレーテッド |
抗体依存性細胞性細胞傷害活性が増強されたEph受容体Fc変異体
|
AU2005285347A1
(en)
|
2004-08-19 |
2006-03-23 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
AU2005282700A1
(en)
|
2004-09-02 |
2006-03-16 |
Genentech, Inc. |
Heteromultimeric molecules
|
US7572456B2
(en)
|
2004-09-13 |
2009-08-11 |
Macrogenics, Inc. |
Humanized antibodies against West Nile Virus and therapeutic and prophylactic uses thereof
|
US20060074225A1
(en)
|
2004-09-14 |
2006-04-06 |
Xencor, Inc. |
Monomeric immunoglobulin Fc domains
|
CA2580319A1
(en)
|
2004-09-14 |
2006-03-23 |
National Institute For Biological Standards And Control |
Vaccine
|
US7563443B2
(en)
|
2004-09-17 |
2009-07-21 |
Domantis Limited |
Monovalent anti-CD40L antibody polypeptides and compositions thereof
|
TWI309240B
(en)
|
2004-09-17 |
2009-05-01 |
Hoffmann La Roche |
Anti-ox40l antibodies
|
US8911726B2
(en)
|
2004-09-22 |
2014-12-16 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human Igg4 antibodies
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
CN101132811B
(zh)
|
2004-10-22 |
2012-05-30 |
米迪缪尼有限公司 |
抗hmgb1的高亲和力抗体及其用法
|
NZ554520A
(en)
|
2004-10-22 |
2010-03-26 |
Amgen Inc |
Methods for refolding of recombinant antibodies
|
EP1812068A4
(en)
|
2004-10-29 |
2010-06-09 |
Medimmune Inc |
METHODS FOR PREVENTING AND TREATING RSV INFECTIONS AND ASSOCIATED DISEASES
|
US7462697B2
(en)
|
2004-11-08 |
2008-12-09 |
Epitomics, Inc. |
Methods for antibody engineering
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
BRPI0517837A
(pt)
|
2004-11-12 |
2008-10-21 |
Xencor Inc |
variantes fc com ligação alterada a fcrn
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
CN101098890B
(zh)
|
2004-11-12 |
2012-07-18 |
赞科股份有限公司 |
对FcRn的结合被改变的Fc变体
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
JP5787461B2
(ja)
|
2004-12-14 |
2015-09-30 |
ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ |
免疫グロブリンの精製方法
|
US8329186B2
(en)
|
2004-12-20 |
2012-12-11 |
Isu Abxis Co., Ltd |
Treatment of inflammation using BST2 inhibitor
|
WO2006067847A1
(ja)
|
2004-12-22 |
2006-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法
|
US8728828B2
(en)
|
2004-12-22 |
2014-05-20 |
Ge Healthcare Bio-Sciences Ab |
Purification of immunoglobulins
|
US20090087478A1
(en)
|
2004-12-27 |
2009-04-02 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally Deliverable and Anti-Toxin Antibodies and Methods for Making and Using Them
|
DK1831258T4
(en)
|
2004-12-28 |
2023-08-28 |
Innate Pharma Sa |
Monoklonale antistoffer mod NKG2A
|
EP1858925A2
(en)
|
2005-01-12 |
2007-11-28 |
Xencor, Inc. |
Antibodies and fc fusion proteins with altered immunogenicity
|
US8716451B2
(en)
|
2005-01-12 |
2014-05-06 |
Kyowa Hakko Kirin Co., Ltd |
Stabilized human IgG2 and IgG3 antibodies
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
MX2007009718A
(es)
|
2005-02-14 |
2007-09-26 |
Zymogenetics Inc |
Metodos para tratar trastornos cutaneos utilizando un antagonista il-31ra.
|
WO2006102095A2
(en)
|
2005-03-18 |
2006-09-28 |
Medimmune, Inc. |
Framework-shuffling of antibodies
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
JP5057967B2
(ja)
|
2005-03-31 |
2012-10-24 |
中外製薬株式会社 |
sc(Fv)2構造異性体
|
AU2006230413B8
(en)
|
2005-03-31 |
2011-01-20 |
Xencor, Inc |
Fc variants with optimized properties
|
PL1876236T3
(pl)
|
2005-04-08 |
2015-01-30 |
Chugai Pharmaceutical Co Ltd |
Przeciwciała zastępujące czynność czynnika krzepnięcia VIII
|
ZA200710599B
(en)
|
2005-04-15 |
2009-08-26 |
Genentech Inc |
HGF Beta chain variants
|
CA2605964A1
(en)
|
2005-04-20 |
2006-10-26 |
Amgen Fremont Inc. |
High affinity fully human monoclonal antibodies to interleukin-8 and epitopes for such antibodies
|
PE20061395A1
(es)
|
2005-04-25 |
2007-01-15 |
Amgen Fremont Inc |
Anticuerpos contra miostatina
|
JP5255435B2
(ja)
|
2005-04-26 |
2013-08-07 |
メディミューン,エルエルシー |
ヒンジドメイン操作による抗体エフェクター機能の調節
|
PA8672101A1
(es)
|
2005-04-29 |
2006-12-07 |
Centocor Inc |
Anticuerpos anti-il-6, composiciones, métodos y usos
|
PE20061323A1
(es)
|
2005-04-29 |
2007-02-09 |
Rinat Neuroscience Corp |
Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos
|
US8003108B2
(en)
|
2005-05-03 |
2011-08-23 |
Amgen Inc. |
Sclerostin epitopes
|
EP2221316A1
(en)
|
2005-05-05 |
2010-08-25 |
Duke University |
Anti-CD19 antibody therapy for autoimmune disease
|
EP1896503B1
(en)
|
2005-05-31 |
2014-10-29 |
Board of Regents, The University of Texas System |
IgG1 ANTIBODIES WITH MUTATED Fc PORTION FOR INCREASED BINDING TO FcRn RECEPTOR AND USES TEHEREOF
|
KR101367544B1
(ko)
|
2005-06-10 |
2014-02-26 |
추가이 세이야쿠 가부시키가이샤 |
메글루민을 함유하는 단백질 제제의 안정화제, 및 그의이용
|
EP1900814A4
(en)
|
2005-06-10 |
2010-07-21 |
Chugai Pharmaceutical Co Ltd |
SCREED SC (FV) 2-MUTANTE
|
AU2006261920A1
(en)
|
2005-06-23 |
2007-01-04 |
Medimmune, Llc |
Antibody formulations having optimized aggregation and fragmentation profiles
|
AU2006268227A1
(en)
|
2005-07-08 |
2007-01-18 |
Xencor, Inc |
Optimized anti-Ep-CAM antibodies
|
EP1907002A2
(en)
|
2005-07-11 |
2008-04-09 |
Macrogenics, Inc. |
Methods of treating autoimmune disease using humanized anti-cd16a antibodies
|
SI2573114T1
(sl)
|
2005-08-10 |
2016-08-31 |
Macrogenics, Inc. |
Identifikacija in inženiring protiteles z variantnimi fc regijami in postopki za njih uporabo
|
AU2006283725B2
(en)
|
2005-08-19 |
2012-02-16 |
The Trustees Of The University Of Pennsylvania |
Antagonist antibodies against GDF-8 and uses in treatment of ALS and other GDF-8-associated disorders
|
WO2007032634A1
(en)
|
2005-09-12 |
2007-03-22 |
Industry Foundation Of Chonnam National University |
A method for production of mature natural killer cell
|
CA2622772A1
(en)
|
2005-09-29 |
2007-04-12 |
Viral Logic Systems Technology Corp. |
Immunomodulatory compositions and uses therefor
|
CA2624189A1
(en)
|
2005-10-03 |
2007-04-12 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
US7973136B2
(en)
|
2005-10-06 |
2011-07-05 |
Xencor, Inc. |
Optimized anti-CD30 antibodies
|
US7635760B2
(en)
|
2005-10-06 |
2009-12-22 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
EP1941907B1
(en)
|
2005-10-14 |
2016-03-23 |
Fukuoka University |
Inhibitor of transplanted islet dysfunction in islet transplantation
|
US8945558B2
(en)
|
2005-10-21 |
2015-02-03 |
Chugai Seiyaku Kabushiki Kaisha |
Methods for treating myocardial infarction comprising administering an IL-6 inhibitor
|
AR057582A1
(es)
|
2005-11-15 |
2007-12-05 |
Nat Hospital Organization |
Agentes para suprimir la induccion de linfocitos t citotoxicos
|
WO2007060411A1
(en)
|
2005-11-24 |
2007-05-31 |
Ucb Pharma S.A. |
Anti-tnf alpha antibodies which selectively inhibit tnf alpha signalling through the p55r
|
JPWO2007061029A1
(ja)
|
2005-11-25 |
2009-05-07 |
学校法人慶應義塾 |
前立腺癌治療剤
|
EP1959997A4
(en)
|
2005-11-28 |
2009-12-23 |
Medimmune Llc |
ANTAGONISTS OF HMGB1 AND / OR RAGE AND METHOD OF USE THEREOF
|
MY181173A
(en)
|
2005-12-12 |
2020-12-21 |
Ac Immune Sa |
Therapeutic vaccine
|
EP1977763A4
(en)
|
2005-12-28 |
2010-06-02 |
Chugai Pharmaceutical Co Ltd |
STABILIZER PREPARATION CONTAINING ANTIBODIES
|
EP2001906A2
(en)
|
2006-01-10 |
2008-12-17 |
Zymogenetics, Inc. |
Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists
|
KR20140091765A
(ko)
|
2006-01-12 |
2014-07-22 |
알렉시온 파마슈티칼스, 인코포레이티드 |
Ox-2/cd200에 대한 항체 및 이들의 용도
|
CA2637917C
(en)
|
2006-01-27 |
2015-11-24 |
Keio University |
Therapeutic agents for diseases involving choroidal neovascularization
|
EP1988922A4
(en)
|
2006-02-03 |
2010-06-02 |
Medimmune Llc |
PROTEIN FORMULATIONS
|
US20070190056A1
(en)
|
2006-02-07 |
2007-08-16 |
Ravi Kambadur |
Muscle regeneration compositions and uses therefor
|
JP5722524B2
(ja)
|
2006-03-02 |
2015-05-20 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
補体活性を抑制することによる同種移植片の生存の延長
|
KR101584468B1
(ko)
|
2006-03-08 |
2016-01-13 |
아케믹스 엘엘씨 |
안질환의 치료에 유용한 보체 결합 앱타머 및 항-c5 제제
|
KR20140057635A
(ko)
|
2006-03-15 |
2014-05-13 |
알렉시온 파마슈티칼스, 인코포레이티드 |
보체의 저해물질로 발작성 야간혈색뇨증 환자의 치료
|
NZ567888A
(en)
|
2006-03-23 |
2010-08-27 |
Bioarctic Neuroscience Ab |
Improved protofibril selective antibodies and the use thereof
|
CA2644663A1
(en)
|
2006-03-23 |
2007-09-27 |
Kirin Pharma Kabushiki Kaisha |
Agonist antibody to human thrombopoietin receptor
|
WO2007126876A2
(en)
|
2006-03-28 |
2007-11-08 |
Biogen Idec Ma Inc. |
Anti-igf-ir antibodies and uses thereof
|
EP4218801A3
(en)
|
2006-03-31 |
2023-08-23 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
WO2007114319A1
(ja)
|
2006-03-31 |
2007-10-11 |
Chugai Seiyaku Kabushiki Kaisha |
抗体の血中動態を制御する方法
|
JP5754875B2
(ja)
|
2006-04-07 |
2015-07-29 |
国立大学法人大阪大学 |
筋再生促進剤
|
TWI395754B
(zh)
|
2006-04-24 |
2013-05-11 |
Amgen Inc |
人類化之c-kit抗體
|
AU2007267213B2
(en)
|
2006-05-25 |
2012-03-29 |
Glaxo Group Limited |
Modified humanised anti-interleukin-18 antibodies
|
US8080248B2
(en)
|
2006-06-02 |
2011-12-20 |
Regeneron Pharmaceuticals, Inc. |
Method of treating rheumatoid arthritis with an IL-6R antibody
|
ATE537190T1
(de)
|
2006-06-02 |
2011-12-15 |
Regeneron Pharma |
Hochaffine antikörper gegen den humanen il-6- rezeptor
|
BRPI0712426B1
(pt)
|
2006-06-08 |
2021-10-26 |
Chugai Seiyaku Kabushiki Kaisha |
Usos de um anticorpo anti-nr10/il-31ra com atividade neutralizante de nr10/il-31ra, de um fragmento e/ou um fragmento quimicamente modificado do anticorpo e de um agente
|
EP2032602B1
(en)
|
2006-06-15 |
2013-03-27 |
The Board of Trustees of the University of Arkansas |
Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds
|
JP2009541275A
(ja)
|
2006-06-22 |
2009-11-26 |
ノボ・ノルデイスク・エー/エス |
二重特異性抗体の生産
|
PE20080943A1
(es)
|
2006-06-23 |
2008-09-27 |
Smithkline Beecham Corp |
Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8
|
EP2059536B1
(en)
|
2006-08-14 |
2014-01-08 |
Xencor, Inc. |
Optimized antibodies that target cd19
|
MX2009002470A
(es)
|
2006-09-05 |
2009-03-20 |
Lilly Co Eli |
Anticuerpos anti-miostatina.
|
PL2066349T3
(pl)
|
2006-09-08 |
2012-09-28 |
Medimmune Llc |
Humanizowane przeciwciała anty-CD19 i ich zastosowanie w leczeniu nowotworów, transplantacjach i leczeniu chorób autoimmunologicznych
|
AU2007299843B2
(en)
|
2006-09-18 |
2012-03-08 |
Xencor, Inc |
Optimized antibodies that target HM1.24
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
WO2008121160A2
(en)
|
2006-11-21 |
2008-10-09 |
Xencor, Inc. |
Optimized antibodies that target cd5
|
WO2008091798A2
(en)
|
2007-01-22 |
2008-07-31 |
Xencor, Inc. |
Optimized ca9 antibodies and methods of using the same
|
AU2008208321B2
(en)
|
2007-01-23 |
2013-03-21 |
Chugai Seiyaku Kabushiki Kaisha |
Chronic rejection inhibitor
|
CA2669412A1
(en)
|
2007-01-23 |
2008-07-31 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
US20110236374A1
(en)
|
2007-01-24 |
2011-09-29 |
Kyowa Hakko Kirin Co., Ltd. |
Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
WO2008098115A2
(en)
|
2007-02-07 |
2008-08-14 |
Xencor, Inc. |
Optimized igf-1r antibodies and methods of using the same
|
EP2069404B1
(en)
|
2007-02-14 |
2011-01-05 |
Vaccinex, Inc. |
Humanized anti-cd100 antibodies
|
NZ579158A
(en)
|
2007-02-23 |
2012-01-12 |
Schering Corp |
Engineered anti-il-23p19 antibodies
|
JPWO2008114733A1
(ja)
|
2007-03-16 |
2010-07-01 |
協和発酵キリン株式会社 |
抗Claudin−4抗体
|
BRPI0809105A2
(pt)
|
2007-03-22 |
2019-09-10 |
Novartis Ag |
antígenos c5 e uso destes
|
JP5779350B2
(ja)
|
2007-03-27 |
2015-09-16 |
シー レーン バイオテクノロジーズ, エルエルシー |
抗体代替軽鎖配列を含む構築物およびライブラリー
|
CN101802015B
(zh)
|
2007-03-29 |
2015-05-06 |
根马布股份公司 |
双特异性抗体及其制造方法
|
CL2008001071A1
(es)
|
2007-04-17 |
2009-05-22 |
Smithkline Beecham Corp |
Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
WO2008143954A2
(en)
|
2007-05-14 |
2008-11-27 |
Biogen Idec Ma Inc. |
Single-chain fc (scfc) regions, binding polypeptides comprising same, and methods related thereto
|
WO2008150494A1
(en)
|
2007-05-30 |
2008-12-11 |
Xencor, Inc. |
Methods and compositions for inhibiting cd32b expressing cells
|
CA2688275A1
(en)
|
2007-05-31 |
2008-12-04 |
Genmab A/S |
Stable igg4 antibodies
|
EP2155790A1
(en)
|
2007-05-31 |
2010-02-24 |
Genmab A/S |
Method for extending the half-life of exogenous or endogenous soluble molecules
|
EP2158315B1
(en)
|
2007-06-25 |
2016-03-23 |
ESBATech, an Alcon Biomedical Research Unit LLC |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
EP2164961B1
(en)
|
2007-06-25 |
2015-01-07 |
ESBATech, an Alcon Biomedical Research Unit LLC |
Sequence based engineering and optimization of single chain antibodies
|
ES2562790T3
(es)
|
2007-07-17 |
2016-03-08 |
E. R. Squibb & Sons, L.L.C. |
Anticuerpos monoclonales contra Glipicano-3
|
EP3246045A1
(en)
|
2007-07-26 |
2017-11-22 |
Osaka University |
Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient
|
WO2009026117A2
(en)
|
2007-08-16 |
2009-02-26 |
Glaxo Group Limited |
Novel compounds
|
WO2009032145A1
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Anti-igf-1r antibodies and uses thereof
|
KR20100052545A
(ko)
|
2007-08-28 |
2010-05-19 |
바이오겐 아이덱 엠에이 인코포레이티드 |
Igf―1r의 다중 에피토프에 결합하는 조성물
|
EP2031064A1
(de)
|
2007-08-29 |
2009-03-04 |
Boehringer Ingelheim Pharma GmbH & Co. KG |
Verfahren zur Steigerung von Proteintitern
|
EP2197911A2
(en)
|
2007-09-14 |
2010-06-23 |
Amgen Inc. |
Homogeneous antibody populations
|
TWI464262B
(zh)
|
2007-09-26 |
2014-12-11 |
中外製藥股份有限公司 |
抗體固定區的變異
|
AU2008304756B8
(en)
|
2007-09-26 |
2015-02-12 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-IL-6 receptor antibody
|
WO2009041734A1
(ja)
|
2007-09-26 |
2009-04-02 |
Kyowa Hakko Kirin Co., Ltd. |
ヒトトロンボポエチン受容体に対するアゴニスト抗体
|
JP5334319B2
(ja)
|
2007-09-26 |
2013-11-06 |
中外製薬株式会社 |
Cdrのアミノ酸置換により抗体の等電点を改変する方法
|
MY148637A
(en)
|
2007-09-28 |
2013-05-15 |
Chugai Pharmaceutical Co Ltd |
Anti-glypican-3 antibody having improved kinetics in plasma
|
RU2490025C2
(ru)
|
2007-10-02 |
2013-08-20 |
Чугаи Сейяку Кабусики Кайся |
Терапевтические средства, используемые против реакции трансплантат против хозяина, содержащие в качестве активного ингредиента ингибитор рецептора интерлейкина-6
|
JO3076B1
(ar)
|
2007-10-17 |
2017-03-15 |
Janssen Alzheimer Immunotherap |
نظم العلاج المناعي المعتمد على حالة apoe
|
WO2009053358A1
(en)
|
2007-10-22 |
2009-04-30 |
Merck Serono S.A. |
Method for purifying fc-fusion proteins
|
EP2203180B1
(en)
|
2007-10-22 |
2012-11-21 |
Merck Serono S.A. |
Single ifn-beta fused to a mutated igg fc fragment
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
TW200936160A
(en)
|
2007-11-15 |
2009-09-01 |
Chugai Pharmaceutical Co Ltd |
Monoclonal antibodies that bind to anexelekto and uses thereof
|
EP2236604B1
(en)
|
2007-12-05 |
2016-07-06 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-nr10 antibody and use thereof
|
EP2241332A4
(en)
|
2007-12-05 |
2011-01-26 |
Chugai Pharmaceutical Co Ltd |
THERAPEUTIC AGENT AGAINST PRITURE
|
WO2009079649A1
(en)
|
2007-12-18 |
2009-06-25 |
Bioalliance C.V. |
Antibodies recognizing a carbohydrate containing epitope on cd-43 and cea expressed on cancer cells and methods using same
|
EP4098661A1
(en)
|
2007-12-26 |
2022-12-07 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
PE20091174A1
(es)
|
2007-12-27 |
2009-08-03 |
Chugai Pharmaceutical Co Ltd |
Formulacion liquida con contenido de alta concentracion de anticuerpo
|
MX350962B
(es)
|
2008-01-07 |
2017-09-27 |
Amgen Inc |
Metodo para fabricar moleculas heterodimericas de fragmentos cristalizables de anticuerpo, utilizando efectos electrostaticos de direccion.
|
US8426141B2
(en)
|
2008-01-18 |
2013-04-23 |
Stichting Sanquin Bloedvoorziening |
Methods for increasing the therapeutic efficacy of immunoglobulin G class 3 (IgG3) antibodies
|
CN101932593B
(zh)
|
2008-01-29 |
2014-08-20 |
埃博灵克斯股份有限公司 |
稳定蛋白和多肽的方法
|
HUE028958T2
(en)
|
2008-02-08 |
2017-01-30 |
Medimmune Llc |
Anti-IFNAR1 antibodies with reduced Fc ligand affinity
|
PL2708558T3
(pl)
|
2008-04-11 |
2018-09-28 |
Chugai Seiyaku Kabushiki Kaisha |
Cząsteczka wiążąca antygen zdolna do wiązania dwóch lub więcej cząsteczek antygenu w sposób powtarzalny
|
AU2015227424A1
(en)
|
2008-04-11 |
2015-10-01 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
EP2294087B1
(en)
|
2008-05-01 |
2014-05-14 |
Amgen, Inc. |
Anti-hepcidin antibodies and methods of use
|
RU2519645C2
(ru)
|
2008-05-14 |
2014-06-20 |
Эгрикалчер Виктория Сервисиз Пти Лтд |
Применение ангиогенина или агонистов ангиогенина для лечения заболеваний и нарушений
|
CN104906581A
(zh)
|
2008-06-05 |
2015-09-16 |
国立研究开发法人国立癌症研究中心 |
神经浸润抑制剂
|
RS54113B1
(en)
|
2008-08-05 |
2015-12-31 |
Novartis Ag |
COMPOSITIONS AND PROCEDURES FOR ANTIBODIES ON THE C5 COMPLEMENTARY PROTEIN
|
SI2853545T1
(sl)
|
2008-09-17 |
2016-10-28 |
Xencor Inc., |
Protitelesa, specifična za IgE
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
JP5028372B2
(ja)
|
2008-09-26 |
2012-09-19 |
京セラドキュメントソリューションズ株式会社 |
画像処理装置、画像処理方法及び画像処理プログラム
|
WO2010042904A2
(en)
|
2008-10-10 |
2010-04-15 |
Trubion Pharmaceuticals, Inc. |
Tcr complex immunotherapeutics
|
KR102100066B1
(ko)
|
2008-10-14 |
2020-04-10 |
제넨테크, 인크. |
이뮤노글로불린 변이체 및 그의 용도
|
EP3101031A1
(en)
|
2008-11-10 |
2016-12-07 |
Alexion Pharmaceuticals, Inc. |
Methods and compositions for treating complement-associated disorders
|
WO2010058860A1
(ja)
|
2008-11-18 |
2010-05-27 |
株式会社シノテスト |
試料中のc反応性蛋白質の測定方法及び測定試薬
|
AU2009323002B2
(en)
|
2008-11-25 |
2016-01-28 |
Vitaeris Inc. |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
WO2010064090A1
(en)
|
2008-12-02 |
2010-06-10 |
Pierre Fabre Medicament |
Process for the modulation of the antagonistic activity of a monoclonal antibody
|
AR074438A1
(es)
|
2008-12-02 |
2011-01-19 |
Pf Medicament |
Proceso para la modulacion de la actividad antagonista de un anticuerpo monoclonal
|
KR20160062207A
(ko)
|
2008-12-05 |
2016-06-01 |
추가이 세이야쿠 가부시키가이샤 |
항nr10 항체 및 그의 이용
|
AR074777A1
(es)
|
2008-12-19 |
2011-02-09 |
Glaxo Group Ltd |
Proteinas de union a antigeno
|
EP3543256A1
(en)
|
2009-01-12 |
2019-09-25 |
Cytomx Therapeutics Inc. |
Modified antibody compositions, methods of making and using thereof
|
CN102369291A
(zh)
|
2009-01-23 |
2012-03-07 |
比奥根艾迪克Ma公司 |
效应子功能降低的稳定Fc多肽及使用方法
|
JP2010210772A
(ja)
|
2009-03-13 |
2010-09-24 |
Dainippon Screen Mfg Co Ltd |
液晶表示装置の製造方法
|
TWI682995B
(zh)
|
2009-03-19 |
2020-01-21 |
日商中外製藥股份有限公司 |
抗體恆定區域改變體
|
AR075908A1
(es)
|
2009-03-19 |
2011-05-04 |
Chugai Pharmaceutical Co Ltd |
Formulacion farmaceutica que contiene moleculas de anticuerpo mejoradas, polipeptidos. metodo para estabilizar solucion, anticuerpo.
|
JP5717624B2
(ja)
|
2009-03-19 |
2015-05-13 |
中外製薬株式会社 |
抗体定常領域改変体
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
CA2757931C
(en)
|
2009-04-07 |
2019-03-26 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
JP2010250827A
(ja)
|
2009-04-16 |
2010-11-04 |
Accenture Global Services Gmbh |
タッチポイントをカスタマイズするシステム
|
CA2759233C
(en)
|
2009-04-27 |
2019-07-16 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
PE20120562A1
(es)
|
2009-05-15 |
2012-06-06 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti-axl
|
US8609097B2
(en)
|
2009-06-10 |
2013-12-17 |
Hoffmann-La Roche Inc. |
Use of an anti-Tau pS422 antibody for the treatment of brain diseases
|
NZ597259A
(en)
|
2009-06-23 |
2014-04-30 |
Alexion Pharma Inc |
Bispecific antibodies that bind to complement proteins
|
US8945511B2
(en)
|
2009-06-25 |
2015-02-03 |
Paul Weinberger |
Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
|
KR102010827B1
(ko)
|
2009-06-26 |
2019-08-14 |
리제너론 파마슈티칼스 인코포레이티드 |
천연 면역글로불린 포맷을 가지는 용이하게 분리된 이중특이성 항체
|
GB0914691D0
(en)
|
2009-08-21 |
2009-09-30 |
Lonza Biologics Plc |
Immunoglobulin variants
|
KR20120089659A
(ko)
|
2009-08-29 |
2012-08-13 |
아보트 러보러터리즈 |
치료용 dll4 결합 단백질
|
CN102574924A
(zh)
|
2009-09-03 |
2012-07-11 |
先灵公司 |
抗-gitr抗体
|
JP5837821B2
(ja)
|
2009-09-24 |
2015-12-24 |
中外製薬株式会社 |
抗体定常領域改変体
|
US8568726B2
(en)
|
2009-10-06 |
2013-10-29 |
Medimmune Limited |
RSV specific binding molecule
|
ES2621458T3
(es)
|
2009-10-06 |
2017-07-04 |
Medimmune Limited |
Molécula de unión específica al RSV
|
DK2486141T3
(en)
|
2009-10-07 |
2018-04-23 |
Macrogenics Inc |
FC-REGION-CONTAINING POLYPEPTIDES THAT PROVIDE IMPROVED EFFECTOR FUNCTION BASED ON CHANGES OF THE SCOPE OF FUCOSYLATION AND PROCEDURES FOR THEIR USE
|
EP2493926B1
(en)
|
2009-10-27 |
2020-03-11 |
UCB Biopharma SRL |
Function modifying nav 1.7 antibodies
|
CN101875696B
(zh)
|
2009-11-11 |
2012-02-08 |
中国人民解放军军事医学科学院生物工程研究所 |
一种抗体及其制备方法与应用
|
JP6087054B2
(ja)
|
2009-12-25 |
2017-03-01 |
中外製薬株式会社 |
ポリペプチド多量体を精製するためのポリペプチドの改変方法
|
WO2011090762A1
(en)
|
2009-12-29 |
2011-07-28 |
Emergent Product Development Seattle, Llc |
Heterodimer binding proteins and uses thereof
|
AR080428A1
(es)
|
2010-01-20 |
2012-04-11 |
Chugai Pharmaceutical Co Ltd |
Formulaciones liquidas estabilizadas contentivas de anticuerpos
|
JP2013517330A
(ja)
|
2010-01-20 |
2013-05-16 |
トーラックス インコーポレイテッド |
抗ilt5抗体およびilt5結合抗体断片
|
EP2525822B1
(en)
|
2010-01-20 |
2017-05-10 |
Merck Sharp & Dohme Corp. |
Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments
|
EP2528948B1
(en)
|
2010-01-28 |
2018-09-19 |
AB Biosciences, Inc. |
Novel lowered affinity antibodies and methods of making the same
|
CA2789416A1
(en)
|
2010-02-09 |
2011-08-18 |
Glaxosmithkline Llc |
Novel uses
|
CN113372451A
(zh)
|
2010-02-19 |
2021-09-10 |
Xencor公司 |
新颖ctla4-ig免疫粘附素
|
CN102985106A
(zh)
|
2010-03-01 |
2013-03-20 |
阿雷克森制药公司 |
用于治疗德戈斯病的方法和组合物
|
EP2543727B1
(en)
|
2010-03-02 |
2016-08-31 |
Kyowa Hakko Kirin Co., Ltd. |
Modified antibody composition
|
EP2543730B1
(en)
|
2010-03-04 |
2018-10-31 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
TW201206466A
(en)
|
2010-03-11 |
2012-02-16 |
Rinat Neuroscience Corp |
Antibodies with pH dependent antigen binding
|
JP2011184418A
(ja)
|
2010-03-11 |
2011-09-22 |
Tokyo Institute Of Technology |
親和性可変抗体
|
CN105218674A
(zh)
|
2010-03-11 |
2016-01-06 |
瑞纳神经科学公司 |
呈pH依赖性抗原结合的抗体
|
TWI667257B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
WO2011125674A1
(ja)
|
2010-03-31 |
2011-10-13 |
Jsr株式会社 |
アフィニティークロマトグラフィー用充填剤
|
SG10201800757TA
(en)
|
2010-04-20 |
2018-02-27 |
Genmab As |
Heterodimeric antibody fc-containing proteins and methods for production thereof
|
TWI586806B
(zh)
|
2010-04-23 |
2017-06-11 |
建南德克公司 |
異多聚體蛋白質之製造
|
SG185107A1
(en)
|
2010-04-30 |
2012-12-28 |
Alexion Pharma Inc |
Antibodies having reduced immunogenicity in a human
|
CA2797981C
(en)
|
2010-05-14 |
2019-04-23 |
Rinat Neuroscience Corporation |
Heterodimeric proteins and methods for producing and purifying them
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
WO2011149046A1
(ja)
|
2010-05-28 |
2011-12-01 |
独立行政法人国立がん研究センター |
膵癌治療剤
|
TW201210612A
(en)
|
2010-06-03 |
2012-03-16 |
Glaxo Group Ltd |
Humanised antigen binding proteins
|
JP5953303B2
(ja)
|
2010-07-29 |
2016-07-20 |
ゼンコア インコーポレイテッド |
改変された等電点を有する抗体
|
JP2013537416A
(ja)
|
2010-08-13 |
2013-10-03 |
メディミューン リミテッド |
変異型Fc領域を含むモノマーポリペプチド及び使用方法
|
CN105440134A
(zh)
|
2010-08-16 |
2016-03-30 |
安姆根公司 |
结合肌肉生长抑制素的抗体、组合物和方法
|
EP2614086A1
(en)
|
2010-09-08 |
2013-07-17 |
Halozyme, Inc. |
Methods for assessing and identifying or evolving conditionally active therapeutic proteins
|
JP6173911B2
(ja)
|
2010-09-10 |
2017-08-09 |
メディミューン リミテド |
抗体誘導体
|
MX352929B
(es)
|
2010-11-05 |
2017-12-13 |
Zymeworks Inc |
DISEÑO DE ANTICUERPOS HETERODIMÉRICOS ESTABLES CON MUTACIONES EN EL DOMINIO Fc.
|
KR20220070586A
(ko)
|
2010-11-08 |
2022-05-31 |
제넨테크, 인크. |
피하 투여용 항―il―6 수용체 항체
|
ES2660151T3
(es)
|
2010-11-17 |
2018-03-21 |
Chugai Seiyaku Kabushiki Kaisha |
Molécula de unión a antígeno multiespecífica que tiene función alternativa a la función del factor VIII de coagulación sanguínea
|
KR102244173B1
(ko)
|
2010-11-30 |
2021-04-26 |
추가이 세이야쿠 가부시키가이샤 |
세포상해 유도 치료제
|
WO2012073992A1
(ja)
|
2010-11-30 |
2012-06-07 |
中外製薬株式会社 |
複数分子の抗原に繰り返し結合する抗原結合分子
|
WO2012088247A2
(en)
|
2010-12-22 |
2012-06-28 |
Medimmune, Llc |
Anti-c5/c5a/c5adesr antibodies and fragments
|
US20140080153A1
(en)
|
2011-01-07 |
2014-03-20 |
Chugai Seiyaku Kabushiki Kaisha |
Method for improving physical properties of antibody
|
CA2827923C
(en)
|
2011-02-25 |
2021-11-23 |
Chugai Seiyaku Kabushiki Kaisha |
Fc.gamma.riib-specific fc antibody
|
WO2012132067A1
(ja)
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
EP3825325A3
(en)
|
2011-03-30 |
2021-10-13 |
Chugai Seiyaku Kabushiki Kaisha |
Retention of antigen-binding molecules in blood plasma and method for modifying immunogenicity
|
EP2699263A4
(en)
|
2011-04-20 |
2014-12-24 |
Liquidating Trust |
METHOD FOR REDUCING AN UNWANTED IMMUNE RESPONSE TO A FOREIGN-LIKE IN A HUMAN PATIENT WITH ANTI-CD4 ANTIBODIES OR CD4-BINDING FRAGMENTS THEREOF OR CD4-BINDING MOLECULES
|
SG194701A1
(en)
|
2011-04-29 |
2013-12-30 |
Apexigen Inc |
Anti-cd40 antibodies and methods of use
|
EP2720708A4
(en)
|
2011-06-20 |
2015-10-14 |
Univ Saint Louis |
AIMING AT THE NEUROMUSCULAR END PLATE FOR TREATMENT PURPOSES
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
BR112014007353B1
(pt)
|
2011-09-30 |
2022-09-13 |
Chugai Seiyaku Kabushiki Kaisha |
Biblioteca de anticorpos dependentes de concentração de íon
|
CN110627902A
(zh)
|
2011-09-30 |
2019-12-31 |
中外制药株式会社 |
诱导针对靶抗原的免疫应答的抗原结合分子
|
EP3939996A1
(en)
|
2011-09-30 |
2022-01-19 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
EP2762166B1
(en)
|
2011-09-30 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecules for promoting elimination of antigens
|
AU2012328322A1
(en)
|
2011-10-27 |
2014-06-12 |
Genmab A/S |
Production of heterodimeric proteins
|
KR102168733B1
(ko)
|
2011-10-31 |
2020-10-23 |
추가이 세이야쿠 가부시키가이샤 |
중쇄와 경쇄의 회합이 제어된 항원 결합 분자
|
WO2013063702A1
(en)
|
2011-11-04 |
2013-05-10 |
Zymeworks Inc. |
Stable heterodimeric antibody design with mutations in the fc domain
|
JP6124800B2
(ja)
|
2011-11-30 |
2017-05-10 |
中外製薬株式会社 |
免疫複合体を形成する細胞内への運搬体(キャリア)を含む医薬
|
GB201203051D0
(en)
|
2012-02-22 |
2012-04-04 |
Ucb Pharma Sa |
Biological products
|
ES2795419T3
(es)
|
2012-02-24 |
2020-11-23 |
Chugai Pharmaceutical Co Ltd |
Molécula de unión al antígeno que promueve la desaparición del antígeno vía Fc RIIB
|
NZ626955A
(en)
|
2012-03-08 |
2016-01-29 |
Hoffmann La Roche |
Abeta antibody formulation
|
WO2013136186A2
(en)
|
2012-03-13 |
2013-09-19 |
Novimmune S.A. |
Readily isolated bispecific antibodies with native immunoglobulin format
|
PL2825037T4
(pl)
|
2012-03-16 |
2020-03-31 |
Regeneron Pharmaceuticals, Inc. |
Gryzonie eksprymujące sekwencje immunoglobuliny wrażliwej na pH
|
KR102228296B1
(ko)
|
2012-03-16 |
2021-03-17 |
리제너론 파마슈티칼스 인코포레이티드 |
히스티딘 공학처리된 경쇄 항체 및 그것을 생성하기 위한 유전자 변형된 비-사람 동물
|
JP6280031B2
(ja)
|
2012-03-29 |
2018-02-14 |
中外製薬株式会社 |
抗lamp5抗体およびその利用
|
AU2013237929B2
(en)
|
2012-03-29 |
2017-09-14 |
Novimmune S.A. |
Anti-TLR4 antibodies and uses thereof
|
TWI619729B
(zh)
|
2012-04-02 |
2018-04-01 |
再生元醫藥公司 |
抗-hla-b*27抗體及其用途
|
SG10201608307WA
(en)
|
2012-04-20 |
2016-11-29 |
Emergent Product Dev Seattle |
Cd3 binding polypeptides
|
LT2838918T
(lt)
|
2012-04-20 |
2019-09-10 |
Merus N.V. |
Būdai ir priemonės heterodimerinių ig-tipo molekulių gamybai
|
WO2013166099A1
(en)
|
2012-05-01 |
2013-11-07 |
Glaxosmithkline Llc |
Novel antibodies
|
US9255154B2
(en)
|
2012-05-08 |
2016-02-09 |
Alderbio Holdings, Llc |
Anti-PCSK9 antibodies and use thereof
|
CN107964042B
(zh)
|
2012-05-30 |
2022-04-19 |
中外制药株式会社 |
靶组织特异性抗原结合分子
|
ES2856272T3
(es)
|
2012-05-30 |
2021-09-27 |
Chugai Pharmaceutical Co Ltd |
Molécula de unión a antígenos para eliminar antígenos agregados
|
WO2013181543A1
(en)
|
2012-06-01 |
2013-12-05 |
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services |
High-affinity monoclonal antibodies to glypican-3 and use thereof
|
EP2861617A1
(en)
|
2012-06-15 |
2015-04-22 |
Pfizer Inc. |
Improved antagonist antibodies against gdf-8 and uses therefor
|
AU2013285355A1
(en)
|
2012-07-06 |
2015-01-29 |
Genmab B.V. |
Dimeric protein with triple mutations
|
EP2882778B1
(en)
|
2012-08-13 |
2018-04-11 |
Regeneron Pharmaceuticals, Inc. |
Anti-pcsk9 antibodies with ph-dependent binding characteristics
|
US9133269B2
(en)
|
2012-08-24 |
2015-09-15 |
Anaptysbio, Inc. |
Humanized antibodies directed against complement protein C5
|
DK2889377T3
(da)
|
2012-08-24 |
2020-03-30 |
Chugai Pharmaceutical Co Ltd |
Fc?RIIb-Specifik Fc-regionsvariant
|
TWI595007B
(zh)
|
2012-09-10 |
2017-08-11 |
Neotope Biosciences Ltd |
抗mcam抗體及相關使用方法
|
EA033536B1
(ru)
|
2012-09-13 |
2019-10-31 |
Bristol Myers Squibb Co |
Основанные на фибронектине каркасные доменные белки, которые связываются с миостатином
|
TW201418707A
(zh)
|
2012-09-21 |
2014-05-16 |
Alexion Pharma Inc |
補體組分c5拮抗劑之篩選分析
|
CA2889681C
(en)
|
2012-09-27 |
2023-04-11 |
Merus B.V. |
Bispecific igg antibodies as t cell engagers
|
JP6273205B2
(ja)
|
2012-10-05 |
2018-01-31 |
協和発酵キリン株式会社 |
ヘテロダイマータンパク質組成物
|
EP2914634B1
(en)
|
2012-11-02 |
2017-12-06 |
Zymeworks Inc. |
Crystal structures of heterodimeric fc domains
|
AU2013341353B2
(en)
|
2012-11-06 |
2017-03-16 |
Children's Medical Center Corporation |
Compositions and methods for modulating cell signaling
|
CN103833852A
(zh)
|
2012-11-23 |
2014-06-04 |
上海市肿瘤研究所 |
针对磷脂酰肌醇蛋白多糖-3和t细胞抗原的双特异性抗体
|
EP3689370A1
(en)
|
2012-12-21 |
2020-08-05 |
Aveo Pharmaceuticals Inc. |
Anti-gdf15 antibodies
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
RU2015130100A
(ru)
|
2013-01-24 |
2017-03-03 |
Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед |
TNF-альфа антиген-связывающие белки
|
RU2018125515A
(ru)
|
2013-01-31 |
2018-10-29 |
СЕУЛ НЭШНЛ ЮНИВЕРСИТИ Ар энд ДиБи ФАУНДЕЙШН |
Антитело против c5 и способ предупреждения и лечения обусловленных комплементом заболеваний
|
US9481725B2
(en)
|
2013-03-14 |
2016-11-01 |
Alderbio Holdings, Llc |
Antibodies to HGF and compositions containing
|
EP2970436B1
(en)
|
2013-03-15 |
2018-09-05 |
AbbVie Biotherapeutics Inc. |
Fc variants
|
EP2970508A4
(en)
|
2013-03-15 |
2016-12-14 |
Permeon Biologics Inc |
GENETICALLY MODIFIED LOADING ANTIBODIES OR ENHANCED ENHANCEMENT ENHANCEMENT TARGETING PROTEIN COMPOSITIONS AND METHODS OF USE
|
EP3587448B1
(en)
|
2013-03-15 |
2021-05-19 |
Xencor, Inc. |
Heterodimeric proteins
|
MX2015011430A
(es)
|
2013-03-15 |
2016-04-20 |
Amgen Inc |
Antagonismo de la miostatina en seres humanos.
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
WO2014160958A1
(en)
|
2013-03-29 |
2014-10-02 |
Alexion Pharmaceuticals, Inc. |
Compositions and methods for increasing the serum half-life of a therapeutic agent targeting complement c5
|
SG11201508170TA
(en)
|
2013-04-02 |
2015-11-27 |
Chugai Pharmaceutical Co Ltd |
Fc REGION VARIANT
|
AU2014262843B2
(en)
|
2013-05-06 |
2017-06-22 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
KR20160021125A
(ko)
|
2013-05-17 |
2016-02-24 |
쌩뜨레 나티오날 데 라 르세르쉬 생띠끄 (씨. 엔. 알. 에스) |
항-cxcl1, cxcl7 및 cxcl8 항체 및 이들의 용도
|
DK3004174T3
(da)
|
2013-05-31 |
2019-07-22 |
Zymeworks Inc |
Heteromultimerer med reduceret eller nedreguleret effektorfunktion
|
CN105722859B
(zh)
|
2013-07-25 |
2021-05-07 |
西托姆克斯治疗公司 |
多特异性抗体、多特异性可活化抗体及其使用方法
|
EP3033358A2
(en)
|
2013-08-14 |
2016-06-22 |
Novartis AG |
Methods of treating sporadic inclusion body myositis
|
JP2016531910A
(ja)
|
2013-08-16 |
2016-10-13 |
アレクシオン ファーマシューティカルズ, インコーポレイテッド |
移植前の臓器への補体阻害剤の投与による移植拒絶の処置
|
US11124576B2
(en)
|
2013-09-27 |
2021-09-21 |
Chungai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide heteromultimer
|
EP2853898B1
(en)
|
2013-09-27 |
2017-01-04 |
Medizinische Hochschule Hannover |
Analysis of myostatin in serum
|
US10501737B2
(en)
|
2013-09-30 |
2019-12-10 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing antigen-binding molecule using modified helper phage
|
EP3176185A1
(en)
|
2013-11-04 |
2017-06-07 |
Glenmark Pharmaceuticals S.A. |
Production of t cell retargeting hetero-dimeric immunoglobulins
|
WO2015111008A2
(en)
|
2014-01-27 |
2015-07-30 |
Novartis Ag |
Biomarkers predictive of muscle atrophy, method and use
|
AU2015218903B2
(en)
|
2014-02-20 |
2020-10-15 |
Allergan, Inc. |
Complement component C5 antibodies
|
NZ711451A
(en)
|
2014-03-07 |
2016-05-27 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
EP3130606B1
(en)
|
2014-04-07 |
2021-10-13 |
Chugai Seiyaku Kabushiki Kaisha |
Immunoactivating bispecific antibodies
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
US11505605B2
(en)
|
2014-05-13 |
2022-11-22 |
Chugai Seiyaku Kabushiki Kaisha |
T cell-redirected antigen-binding molecule for cells having immunosuppression function
|
TW201625299A
(zh)
|
2014-06-20 |
2016-07-16 |
Chugai Pharmaceutical Co Ltd |
用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
|
JP7037885B2
(ja)
|
2014-06-30 |
2022-03-17 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
pH依存性抗原結合を示す抗TNFa抗体
|
MA40764A
(fr)
|
2014-09-26 |
2017-08-01 |
Chugai Pharmaceutical Co Ltd |
Agent thérapeutique induisant une cytotoxicité
|
JP6630036B2
(ja)
|
2014-09-30 |
2020-01-15 |
Jsr株式会社 |
標的物の精製方法、及び、ミックスモード用担体
|
EP3215175A4
(en)
|
2014-11-06 |
2018-06-27 |
Scholar Rock, Inc. |
Anti-pro/latent-myostatin antibodies and uses thereof
|
WO2016073879A2
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Transforming growth factor-related antibodies and uses thereof
|
SG11201704094QA
(en)
|
2014-12-08 |
2017-06-29 |
Novartis Ag |
Myostatin or activin antagonists for the treatment of sarcopenia
|
SI3233921T1
(sl)
|
2014-12-19 |
2022-01-31 |
Chugai Seiyaku Kabushiki Kaisha |
Protitelesa proti C5 in postopki za uporabo
|
PE20221834A1
(es)
|
2014-12-19 |
2022-11-29 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos antimiostatina
|
EP3247723A1
(en)
|
2015-01-22 |
2017-11-29 |
Chugai Seiyaku Kabushiki Kaisha |
A combination of two or more anti-c5 antibodies and methods of use
|
CA2974547A1
(en)
|
2015-02-05 |
2016-08-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses thereof
|
US10774148B2
(en)
|
2015-02-27 |
2020-09-15 |
Chugai Seiyaku Kabushiki Kaisha |
Composition for treating IL-6-related diseases
|
EP3277715A2
(en)
|
2015-03-31 |
2018-02-07 |
Alexion Pharmaceuticals, Inc. |
Identifying and treating subpopulations of paroxysmal nocturnal hemoglobinuria (pnh) patients
|
US11142587B2
(en)
|
2015-04-01 |
2021-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
Method for producing polypeptide hetero-oligomer
|
EA201792298A1
(ru)
|
2015-04-15 |
2018-04-30 |
Регенерон Фармасьютикалз, Инк. |
Способы увеличения силы и функциональности с помощью ингибиторов gdf8
|
JP6698102B2
(ja)
|
2015-04-17 |
2020-05-27 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
凝固因子と多重特異的抗体を用いた併用療法
|
JP2018123055A
(ja)
|
2015-04-24 |
2018-08-09 |
公立大学法人奈良県立医科大学 |
血液凝固第viii因子(fviii)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第xi因子(fxi)異常症の予防および/または治療に用いられる医薬組成物
|
EP3288586A1
(en)
|
2015-05-01 |
2018-03-07 |
Alexion Pharmaceuticals, Inc. |
Efficacy of an anti-c5 antibody in the prevention of antibody mediated rejection in sensitized recipients of kindney thansplant
|
US20180142010A1
(en)
|
2015-06-26 |
2018-05-24 |
Alexion Pharmaceuticals, Inc. |
Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant
|
US10940126B2
(en)
|
2015-07-03 |
2021-03-09 |
Camilla Svensson |
Inhibition of IL-8 in the treatment of pain and/or bone loss
|
CA3036652A1
(en)
|
2015-09-15 |
2017-03-23 |
Scholar Rock, Inc. |
Anti-pro/latent-myostatin antibodies and uses thereof
|
WO2017046994A1
(en)
|
2015-09-18 |
2017-03-23 |
Chugai Seiyaku Kabushiki Kaisha |
Il-8-binding antibodies and uses thereof
|
TW201718014A
(zh)
|
2015-10-12 |
2017-06-01 |
諾華公司 |
C5抑制劑於移植相關微血管病之用途
|
BR112018011073A2
(pt)
|
2015-12-18 |
2018-11-21 |
Chugai Pharmaceutical Co Ltd |
anticorpos antimiostatina, polipeptídeos contendo regiões fc variantes e métodos de utilização
|
SG10201709415WA
(en)
|
2015-12-18 |
2017-12-28 |
Chugai Pharmaceutical Co Ltd |
Anti-c5 antibodies and methods of use
|
WO2017110981A1
(en)
|
2015-12-25 |
2017-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
US11649262B2
(en)
|
2015-12-28 |
2023-05-16 |
Chugai Seiyaku Kabushiki Kaisha |
Method for promoting efficiency of purification of Fc region-containing polypeptide
|
KR20180094110A
(ko)
|
2016-01-08 |
2018-08-22 |
스칼러 락, 인크. |
항-프로/잠재성 미오스타틴 항체 및 그의 사용 방법
|
US20190023775A1
(en)
|
2016-01-11 |
2019-01-24 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-c5 antibodies for treatment
|
JOP20170017B1
(ar)
|
2016-01-25 |
2021-08-17 |
Amgen Res Munich Gmbh |
تركيب صيدلي يتضمن تركيبات جسم مضاد ثنائي الاختصاص
|
JP6175590B1
(ja)
|
2016-03-14 |
2017-08-02 |
中外製薬株式会社 |
癌の治療に用いるための細胞傷害誘導治療剤
|
EP3431102A4
(en)
|
2016-03-14 |
2019-09-25 |
Chugai Seiyaku Kabushiki Kaisha |
THERAPEUTIC MEDICINE INDUCING CELLULAR INJURY FOR USE IN THE TREATMENT OF CANCER
|
TW202402326A
(zh)
|
2016-04-28 |
2024-01-16 |
日商中外製藥股份有限公司 |
含抗體製劑
|
JP6823167B2
(ja)
|
2016-06-13 |
2021-01-27 |
スカラー ロック インコーポレイテッドScholar Rock,Inc. |
ミオスタチン阻害剤の使用および併用療法
|
AU2017285764B2
(en)
|
2016-06-17 |
2024-05-02 |
Chugai Pharmaceutical Co Ltd |
Anti-myostatin antibodies and methods of use
|
EP3472316A4
(en)
|
2016-06-17 |
2020-01-08 |
Chugai Seiyaku Kabushiki Kaisha |
ANTI-C5 ANTIBODIES AND METHODS OF USE THEREOF
|
MX2019001448A
(es)
|
2016-08-05 |
2019-09-13 |
Chugai Pharmaceutical Co Ltd |
Composicion para profilaxis o tratamiento de enfermedades relacionadas con interleucina 8 (il-8).
|
BR112019015426A2
(pt)
|
2017-01-31 |
2020-05-26 |
Chugai Seiyaku Kabushiki Kaisha |
Composição farmacêutica para uso no tratamento ou prevenção de uma doença relacionada a c5 e um método para tratar ou prevenir uma doença rela-cionada a c5
|
CN110740749A
(zh)
|
2017-03-14 |
2020-01-31 |
戊瑞治疗有限公司 |
在酸性pH下与VISTA结合的抗体
|
CN110461358A
(zh)
|
2017-03-31 |
2019-11-15 |
公立大学法人奈良县立医科大学 |
可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物
|
AU2018354404A1
(en)
|
2017-10-26 |
2020-04-16 |
Alexion Pharmaceuticals, Inc. |
Dosage and administration of anti-C5 antibodies for treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH) and Atypical Hemolytic Uremic Syndrome (aHUS)
|
KR20200095485A
(ko)
|
2017-12-04 |
2020-08-10 |
라 파마슈티컬스 인코포레이티드 |
보체 활성의 조절인자
|
BR112021001655A2
(pt)
|
2018-08-01 |
2021-05-04 |
Chugai Seiyaku Kabushiki Kaisha |
composição farmacêutica para uso no tratamento ou prevenção de uma doença relacionada a c5 e método para tratar ou prevenir uma doença relacionada a c5
|