BR9713294A - "anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano" - Google Patents

"anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano"

Info

Publication number
BR9713294A
BR9713294A BR9713294-2A BR9713294A BR9713294A BR 9713294 A BR9713294 A BR 9713294A BR 9713294 A BR9713294 A BR 9713294A BR 9713294 A BR9713294 A BR 9713294A
Authority
BR
Brazil
Prior art keywords
antibodies against
human parathyroid
parathyroid hormone
protein related
against protein
Prior art date
Application number
BR9713294-2A
Other languages
English (en)
Inventor
Koh Sato
Yuji Wakahara
Naohiro Yabuta
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of BR9713294A publication Critical patent/BR9713294A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Patente de Invenção: <B>''ANTICORPOS CONTRA PROTEìNA RELACIONADA A HORMÈNIO DE PARATIRóIDE HUMANO"<D>. São divulgados um anticorpo contra uma proteína relacionada a hormónio de paratiróide humano, um DNA que codifica para o anticorpo, um vetor recombinante que contém o DNA, um transformante transformado com o vetor recombinante, um processo para preparação do anticorpo e usos do anticorpo.
BR9713294-2A 1996-09-26 1997-09-24 "anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano" BR9713294A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25519696 1996-09-26
JP21416897 1997-07-24
PCT/JP1997/003382 WO1998013388A1 (fr) 1996-09-26 1997-09-24 Anticorps contre les peptides lies a la parathormone humaine

Publications (1)

Publication Number Publication Date
BR9713294A true BR9713294A (pt) 2000-10-17

Family

ID=26520176

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713294-2A BR9713294A (pt) 1996-09-26 1997-09-24 "anticorpos contra proteìna relacionada a hormÈnio de paratiróide humano"

Country Status (17)

Country Link
US (3) US6903194B1 (pt)
EP (1) EP0962467A4 (pt)
KR (1) KR100847441B1 (pt)
CN (1) CN100335501C (pt)
AU (1) AU744146B2 (pt)
BR (1) BR9713294A (pt)
CA (1) CA2266332C (pt)
CZ (1) CZ106299A3 (pt)
HK (1) HK1096974A1 (pt)
HU (1) HUP9904177A3 (pt)
IL (1) IL129164A (pt)
NO (1) NO991449L (pt)
RU (1) RU2198220C2 (pt)
SK (1) SK40599A3 (pt)
TR (1) TR199900666T2 (pt)
TW (1) TW509697B (pt)
WO (1) WO1998013388A1 (pt)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU744146B2 (en) 1996-09-26 2002-02-14 Chugai Seiyaku Kabushiki Kaisha Antibody against human parathormone related peptides
TR199902800T2 (xx) 1997-05-15 2000-04-21 Chugai Seiyaku Kabushiki Kaisha Ka�eksiyi tedavi edici madde.
BR9912223A (pt) * 1998-06-26 2001-04-24 Chugai Pharmaceutical Co Ltd Agente terapêutico para crise hipercalcêmica
DE60021373T2 (de) * 1999-05-10 2006-04-27 Chugai Seiyaku K.K. Verfahren der zellkultivierung
TWI255718B (en) 1999-07-02 2006-06-01 Chugai Pharmaceutical Co Ltd Ameliorative agent for low vasopressin concentration
AU5708500A (en) * 1999-07-02 2001-01-22 Chugai Seiyaku Kabushiki Kaisha Remedies for diseases caused by pth or pthrp
EP1195164A4 (en) * 1999-07-06 2005-09-28 Chugai Pharmaceutical Co Ltd MEDICINAL PRODUCTS FOR THERAPY-BASED HYPERCALCEMENTS
BR0014667A (pt) 1999-10-01 2002-07-02 Chugai Pharmaceutical Co Ltd Prevenção e tratamento de doenças relacionadas à coagulação sanguìnea
EP1254666A4 (en) * 1999-12-28 2004-12-22 Chugai Pharmaceutical Co Ltd STABLE ANTIBODY COMPOSITIONS AND INJECTION FORMULATIONS
US20030049211A1 (en) * 2000-01-25 2003-03-13 Atsuhiko Kato Remedies and preventives for dental diseases
WO2001064249A1 (en) * 2000-02-28 2001-09-07 Chugai Seiyaku Kabushiki Kaisha Tissue decomposition inhibitor
EP1987842A1 (en) * 2000-04-28 2008-11-05 Chugai Seiyaku Kabushiki Kaisha Cell proliferation inhibitor
US8632778B2 (en) 2000-08-11 2014-01-21 Chugai Seiyaku Kabushiki Kaisha Stabilized anti-interleukin-6 antibody-containing preparations
US20040067231A1 (en) * 2000-08-16 2004-04-08 Hideki Yoshikawa Agents for ameliorating symtoms caused by joint diseases
US20060063152A1 (en) 2000-12-22 2006-03-23 Osamu Ohara Novel gene and protein encoded by the gene
EP1380589A4 (en) * 2001-03-09 2004-09-01 Chugai Pharmaceutical Co Ltd PROTEIN CLEANING METHOD
US20040213788A1 (en) * 2001-05-18 2004-10-28 Sweet Raymond W. Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders
WO2003040966A2 (en) 2001-11-02 2003-05-15 Siemens Medical Solutions Usa, Inc. Patient data mining for automated compliance
US8949082B2 (en) 2001-11-02 2015-02-03 Siemens Medical Solutions Usa, Inc. Healthcare information technology system for predicting or preventing readmissions
US7457731B2 (en) 2001-12-14 2008-11-25 Siemens Medical Solutions Usa, Inc. Early detection of disease outbreak using electronic patient data to reduce public health threat from bio-terrorism
DK1475101T3 (da) 2002-02-14 2011-01-10 Chugai Pharmaceutical Co Ltd Antistof-holdige farmaceutiske opløsninger
FR2841788B1 (fr) * 2002-07-05 2006-01-27 Univ Pasteur Utilisation d'antagonistes de la pthrp pour traiter le carcinome a cellules renales
AU2003257536A1 (en) 2002-08-27 2004-03-19 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein solution preparation
WO2004022595A1 (ja) 2002-09-04 2004-03-18 Chugai Seiyaku Kabushiki Kaisha MRL/lprマウスを用いた抗体の作製
US7680086B2 (en) * 2002-09-09 2010-03-16 Siemens Canada Limited Wireless local area network with clients having extended freedom of movement
SI1561756T1 (sl) 2002-09-11 2016-02-29 Chugai Seiyaku Kabushiki Kaisha Postopek čiščenja proteinov
WO2004043405A2 (en) * 2002-11-12 2004-05-27 The Brigham And Women's Hospital, Inc. Polysaccharide vaccine for staphylococcal infections
US7794711B2 (en) * 2002-11-18 2010-09-14 Chugai Seiyaku Kabushiki Kaisha Agent for treating chondroma and chondrosarcoma
US20080153104A1 (en) 2003-08-08 2008-06-26 Hiroyuki Aburantai Gene Overexpressed in Cancer
EP2468769A1 (en) * 2004-04-21 2012-06-27 The Brigham and Women's Hospital, Inc. Poly-N-acetyl glucosamine (PNAG/DPNAG)-binding peptides and methods of use thereof
CN111925445A (zh) 2004-07-09 2020-11-13 中外制药株式会社 抗-磷脂酰肌醇蛋白聚糖3抗体
JP5620626B2 (ja) 2005-03-31 2014-11-05 中外製薬株式会社 会合制御によるポリペプチド製造方法
US20080275731A1 (en) * 2005-05-18 2008-11-06 Rao R Bharat Patient data mining improvements
JP5224580B2 (ja) 2005-06-10 2013-07-03 中外製薬株式会社 ｓｃ（Ｆｖ）２部位特異的変異体
AU2006256041B2 (en) * 2005-06-10 2012-03-29 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
US9241994B2 (en) * 2005-06-10 2016-01-26 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical compositions containing sc(Fv)2
JP2008546716A (ja) * 2005-06-17 2008-12-25 バイオジェン・アイデック・エムエイ・インコーポレイテッド 抗ＧＦＲα３抗体
KR101323563B1 (ko) 2005-10-18 2013-10-29 니토 보세키 가부시기가이샤 항체를 생산하는 트랜스제닉 누에와 그의 제조방법
DOP2006000277A (es) 2005-12-12 2007-08-31 Bayer Pharmaceuticals Corp Anticuerpos anti mn y métodos para su utilización
WO2007074880A1 (ja) 2005-12-28 2007-07-05 Chugai Seiyaku Kabushiki Kaisha 抗体含有安定化製剤
EP4342995A3 (en) 2006-03-31 2024-05-15 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
EP2011513B1 (en) 2006-04-25 2016-10-19 The University of Tokyo Therapeutic agents for alzheimer's disease and cancer
KR20090021217A (ko) 2006-06-14 2009-02-27 추가이 세이야쿠 가부시키가이샤 조혈 줄기세포 증가 촉진제
US9023993B2 (en) 2006-10-20 2015-05-05 Chugai Seiyaku Kabushiki Kaisha Anti-cancer agent comprising anti-HB-EGF antibody as active ingredient
WO2008047925A1 (fr) 2006-10-20 2008-04-24 Forerunner Pharma Research Co., Ltd. Composition pharmaceutique comprenant un anticorps anti-hb-egf comme ingrédient actif
ATE504647T1 (de) 2007-01-30 2011-04-15 Forerunner Pharma Res Co Ltd Chimärer fc gamma rezeptor und verfahren zur bestimmung von adcc-aktivität unter verwendung des rezeptors
US8501929B2 (en) * 2007-08-17 2013-08-06 Biochrom Pharma Inc. PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
US7897139B2 (en) * 2007-08-17 2011-03-01 Biochrom Pharma, Inc. PTHrP, its isoforms and antagonist thereto in the diagnosis and treatment of disease
DK2202245T3 (en) 2007-09-26 2016-11-21 Chugai Pharmaceutical Co Ltd A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR
AR066172A1 (es) 2007-09-28 2009-07-29 Chugai Pharmaceutical Co Ltd Metodo para la preparacion de un anticuerpo antiglipicano 3 con modulada cinetica plasmatica mediante variacion de la semivida plasmatica.
KR101840994B1 (ko) 2007-12-05 2018-03-21 추가이 세이야쿠 가부시키가이샤 항ｎｒ１０ 항체 및 그의 이용
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
EP3056513A1 (en) 2008-04-11 2016-08-17 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
KR20110031393A (ko) 2008-07-21 2011-03-25 더 브리검 앤드 우먼즈 하스피털, 인크. 합성 베타-1,6 글루코사민 올리고당에 관한 방법 및 조성물
WO2010055950A1 (ja) 2008-11-17 2010-05-20 財団法人ヒューマンサイエンス振興財団 癌間質の構成因子に対して特異的結合能を有する物質と抗腫瘍性化合物との複合体による新規の癌ターゲティング治療
JP2010210772A (ja) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd 液晶表示装置の製造方法
US9340615B2 (en) 2009-05-15 2016-05-17 Chugai Seiyaku Kabushiki Kaisha Anti-AXL antibody
WO2011021381A1 (ja) 2009-08-17 2011-02-24 株式会社未来創薬研究所 抗hb-egf抗体を有効成分として含む医薬組成物
US8751495B2 (en) * 2009-09-29 2014-06-10 Siemens Medical Solutions Usa, Inc. Automated patient/document identification and categorization for medical data
TWI505838B (zh) 2010-01-20 2015-11-01 Chugai Pharmaceutical Co Ltd Stabilized antibody solution containing
US20110184761A1 (en) * 2010-01-25 2011-07-28 Siemens Medical Solutions Usa, Inc. Method and Apparatus for Estimating Patient Populations
TWI667346B (zh) 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的FcRn親和力之抗體
US10943676B2 (en) 2010-06-08 2021-03-09 Cerner Innovation, Inc. Healthcare information technology system for predicting or preventing readmissions
ES2899186T3 (es) 2010-12-31 2022-03-10 Bioatla Inc Humanización rápida de anticuerpos
EP2663333B8 (en) 2011-01-10 2020-06-17 The Regents Of The University Of Michigan Stem cell factor inhibitor
US20150018408A1 (en) * 2013-07-10 2015-01-15 The Regents Of The University Of Michigan Therapeutic antibodies and uses thereof
WO2013012022A1 (ja) 2011-07-19 2013-01-24 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
MY182178A (en) 2011-09-01 2021-01-18 Chugai Pharmaceutical Co Ltd Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
JP6077997B2 (ja) 2011-09-07 2017-02-08 中外製薬株式会社 癌幹細胞の分離
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TW201817744A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
WO2013062083A1 (ja) 2011-10-28 2013-05-02 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞特異的分子
WO2013065708A1 (ja) 2011-10-31 2013-05-10 中外製薬株式会社 重鎖と軽鎖の会合が制御された抗原結合分子
WO2013161814A1 (ja) 2012-04-23 2013-10-31 ジーンフロンティア株式会社 抗ヒトｃｄ６９抗体、及びその医薬用途
EP2902489B9 (en) 2012-09-27 2018-02-07 Chugai Seiyaku Kabushiki Kaisha Fgfr3 fusion gene and pharmaceutical drug targeting same
US10565315B2 (en) 2012-09-28 2020-02-18 Cerner Innovation, Inc. Automated mapping of service codes in healthcare systems
US10318635B2 (en) 2012-09-28 2019-06-11 Cerner Innovation, Inc. Automated mapping of service codes in healthcare systems
US10403391B2 (en) 2012-09-28 2019-09-03 Cerner Health Services, Inc. Automated mapping of service codes in healthcare systems
EP2918678B1 (en) 2012-11-09 2019-01-30 GeneFrontier Corporation Anti-adam28 antibody for treating cancer
US10540448B2 (en) 2013-07-15 2020-01-21 Cerner Innovation, Inc. Gap in care determination using a generic repository for healthcare
JP6534615B2 (ja) 2013-09-27 2019-06-26 中外製薬株式会社 ポリペプチド異種多量体の製造方法
EP3057992B1 (en) 2013-10-15 2024-04-17 GeneFrontier Corporation Human antibody against aggrecanase-type adamts species for therapeutics of aggrecanase-related diseases
EP3581179A1 (en) 2013-12-27 2019-12-18 Chugai Seiyaku Kabushiki Kaisha Fgfr gatekeeper mutant gene and drug targeting same
CN106029682B (zh) 2013-12-27 2021-04-13 中外制药株式会社 等电点低的抗体的纯化方法
US10703798B2 (en) 2014-03-31 2020-07-07 Debiopharm International Sa Methods of cancer therapy by inhibiting fusion polypeptides comprising fibroblast growth factor receptor 2 (FGFR2) and vinculin (VCL)
JP6858559B2 (ja) 2014-08-20 2021-04-14 中外製薬株式会社 蛋白質溶液の粘度測定方法
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
EP3816179A3 (en) 2015-02-05 2021-08-04 Chugai Seiyaku Kabushiki Kaisha Fc region variant comprising a modified fcrn-binding domain
TW202342532A (zh) 2015-09-18 2023-11-01 日商中外製藥股份有限公司 Il-8結合抗體及其用途
KR20180069839A (ko) 2015-10-08 2018-06-25 자임워크스 인코포레이티드 카파 및 람다 경사슬을 포함하는 항원-결합 폴리펩티드 구조체 및 이의 용도
EP3694883A1 (en) 2017-10-12 2020-08-19 Keio University Anti aqp3 monoclonal antibody specifically binding to extracellular domain of aquaporin 3 (aqp3) and use thereof
KR20210010996A (ko) 2018-05-21 2021-01-29 추가이 세이야쿠 가부시키가이샤 유리 용기에 봉입된 동결건조 제제
CN115649558A (zh) 2018-05-28 2023-01-31 中外制药株式会社 填充喷嘴
CA3102060A1 (en) 2018-05-31 2019-12-05 Shionogi & Co., Ltd. Nav1.7 monoclonal antibody
JP6894086B2 (ja) 2018-12-27 2021-06-23 塩野義製薬株式会社 新規抗ｃｃｒ８抗体
WO2020213084A1 (en) 2019-04-17 2020-10-22 Keio University Anti aqp3 monoclonal antibody specifically binding to extracellular domain of aquaporin 3 (aqp3) and use thereof
WO2022004760A1 (ja) 2020-06-30 2022-01-06 塩野義製薬株式会社 抗ｃｃｒ８抗体と化学療法剤の併用
TW202323810A (zh) 2021-10-08 2023-06-16 日商中外製藥股份有限公司 預填充式注射器製劑的調製方法
IL311683A (en) 2021-11-01 2024-05-01 Shionogi & Co A new Nav1.7 monoclonal antibody
CN115109161B (zh) * 2022-06-28 2023-08-11 广东赛尔生物科技有限公司 含有间充质干细胞的减肥药物组合物

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5618920A (en) * 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5001223A (en) 1987-05-26 1991-03-19 Merck & Co., Inc. Parathyroid hormone antagonists with enhanced metabolic properties
US4771124A (en) 1987-05-26 1988-09-13 Merck & Co., Inc. Parathyroid hormone antagonists with simplified synthetic methodology
EP0293130A3 (en) 1987-05-26 1990-06-13 Merck & Co. Inc. Dimers of parathyroid hormone antagonists
EP0293158A3 (en) 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroid hormone antagonists
EP0417193B1 (en) 1988-05-27 1993-08-04 Centocor, Inc. Freeze-dried formulation for antibody products
EP0417191B1 (en) 1988-05-27 1993-03-10 Centocor, Inc. Formulation for antibody reagents
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5217896A (en) 1988-12-30 1993-06-08 Oncogene Science, Inc. Monoclonal antibodies recognizing parathyroid hormone-like protein
JPH02207099A (ja) 1989-02-07 1990-08-16 Tonen Corp ＰＴＨｒＰ関連ペプチド、その製造法及び用途
CA2035179C (en) 1990-01-31 2001-08-14 Gerald S. Brenner Pharmaceutical compositions containing insoluble salts of bisphosphonic acids
GB9009548D0 (en) 1990-04-27 1990-06-20 Celltech Ltd Chimeric antibody and method
JPH04228089A (ja) 1990-05-15 1992-08-18 Kanegafuchi Chem Ind Co Ltd 高カルシウム血症治療・予防剤
EP0539491A1 (en) 1990-07-13 1993-05-05 The Regents Of The University Of California PARATHYROID HORMONE ANALOGUES MODIFIED AT POSITIONS 3, 6 or 9
DE4034612A1 (de) * 1990-10-31 1992-05-07 Huels Chemische Werke Ag Verfahren zur herstellung von methacryloxy- oder acryloxygruppen enthaltenden organosilanen
CA2107569C (en) 1991-04-05 2011-08-02 Gino V. Segre Parathyroid hormone receptor and dna encoding same
US5795965A (en) 1991-04-25 1998-08-18 Chugai Seiyaku Kabushiki Kaisha Reshaped human to human interleukin-6 receptor
DE4137744C2 (de) * 1991-11-15 1996-10-31 Kuesters Eduard Maschf Verfahren zum Herstellen eines Schichtwerkstoffs unter Wiederverwendung von Kunststoffabfällen und eigensteifer, Kunstsoffabfälle enthaltender Schichtwerkstoff
AU3095892A (en) * 1991-12-20 1993-07-28 Protein Design Labs, Inc. Human type antibody reactive with GPIIb/IIIa
US5993617A (en) 1991-12-26 1999-11-30 Asahi Glass Company Ltd. Functional product
US5648267A (en) 1992-11-13 1997-07-15 Idec Pharmaceuticals Corporation Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same
US5849695A (en) 1993-01-13 1998-12-15 The Regents Of The University Of California Parathyroid hormone analogues useful for treatment of osteoporosis and disorders of calcium meatabolism in mammals
JP3504697B2 (ja) 1993-09-30 2004-03-08 株式会社先端生命科学研究所 ＰＴＨｒＰアンタゴニスト活性を有するポリペプチド及びそれを含むカルシウム代謝治療薬
JPH07316195A (ja) 1994-05-25 1995-12-05 Nippon Kayaku Co Ltd 新規なＰＴＨｒＰ関連ペプチド及びその用途
CO4410206A1 (es) 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN
US5626845A (en) 1995-01-23 1997-05-06 Xenotech Incorporated Method to ameliorate osteolysis and metastasis
US5993817A (en) 1995-01-23 1999-11-30 Xenotech Method to ameliorate osteolysis and metastasis
JP4231106B2 (ja) * 1995-01-23 2009-02-25 ゼノテック インコーポレイティッド 骨溶解および転移を改善する方法
DK0811383T3 (da) 1995-02-20 2007-06-25 Yukio Kato Lægemidler til arthrosis deformans og inflammatoriske ledsygdomme
CA2214341A1 (en) 1995-03-01 1996-09-06 Creative Biomolecules, Inc. Morphogen-induced dentine regeneration
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
US5660826A (en) 1995-06-06 1997-08-26 The Regents Of The University Of California Therapeutic sepsis treatment using antagonists to PTHrP
JP2000513201A (ja) 1995-07-20 2000-10-10 アイ・シー・エヌ・フアーマシユーテイカルズ 上皮小体ホルモン様たんぱく質に関連する化合物および方法
ATE219374T1 (de) 1996-02-01 2002-07-15 Chugai Pharmaceutical Co Ltd Medikamente für die behandlung oder vorbeugung von thrombocytopenie
CA2265915C (en) 1996-09-10 2012-11-20 Theodor-Kocher Institute Cxcr3 chemokine receptor, antibodies, nucleic acids, and methods of use
AU744146B2 (en) 1996-09-26 2002-02-14 Chugai Seiyaku Kabushiki Kaisha Antibody against human parathormone related peptides
JP4228089B2 (ja) 1997-03-11 2009-02-25 株式会社ニコン 過電流検知機構およびそれを用いた電子閃光装置
TR199902800T2 (xx) 1997-05-15 2000-04-21 Chugai Seiyaku Kabushiki Kaisha Ka�eksiyi tedavi edici madde.
JP4372240B2 (ja) 1997-05-15 2009-11-25 中外製薬株式会社 悪液質治療剤
JP3791863B2 (ja) 1997-07-04 2006-06-28 株式会社フジタ 鉄筋コンクリート系建物の制震構造
JP4414494B2 (ja) 1998-02-03 2010-02-10 旭化成ファーマ株式会社 白血球減少症の予防剤および治療剤
HUP0300891A2 (hu) 1998-05-05 2003-07-28 Beth Israel Deaconess Medical Center, Inc. PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására
JP2000080100A (ja) 1998-06-17 2000-03-21 Japan Tobacco Inc 副甲状腺ホルモン関連タンパクに対するヒトモノクローナル抗体
BR9912223A (pt) 1998-06-26 2001-04-24 Chugai Pharmaceutical Co Ltd Agente terapêutico para crise hipercalcêmica

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EP0962467A1 (en) 1999-12-08
HUP9904177A2 (hu) 2000-03-28
AU744146B2 (en) 2002-02-14
US7842790B2 (en) 2010-11-30
CZ106299A3 (cs) 1999-08-11
CA2266332C (en) 2012-01-03
US6903194B1 (en) 2005-06-07
EP0962467A4 (en) 2002-10-30
IL129164A0 (en) 2000-02-17
US7358355B2 (en) 2008-04-15
TR199900666T2 (xx) 1999-06-21
WO1998013388A1 (fr) 1998-04-02
HUP9904177A3 (en) 2001-10-29
HK1096974A1 (en) 2007-06-15
NO991449D0 (no) 1999-03-25
AU4397297A (en) 1998-04-17
SK40599A3 (en) 2000-06-12
US20050136057A1 (en) 2005-06-23
KR20060006981A (ko) 2006-01-20
NO991449L (no) 1999-05-25
RU2198220C2 (ru) 2003-02-10
KR100847441B1 (ko) 2008-07-21
CN100335501C (zh) 2007-09-05
CN1237983A (zh) 1999-12-08
US20080095772A1 (en) 2008-04-24
CA2266332A1 (en) 1998-04-02

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