HUP0300891A2 - PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására - Google Patents

PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására

Info

Publication number
HUP0300891A2
HUP0300891A2 HU0300891A HUP0300891A HUP0300891A2 HU P0300891 A2 HUP0300891 A2 HU P0300891A2 HU 0300891 A HU0300891 A HU 0300891A HU P0300891 A HUP0300891 A HU P0300891A HU P0300891 A2 HUP0300891 A2 HU P0300891A2
Authority
HU
Hungary
Prior art keywords
abnormal
preparation
pharmaceutical compositions
selective compounds
receptor selective
Prior art date
Application number
HU0300891A
Other languages
English (en)
Inventor
Michael Chorev
Zheng Xin Dong
Michael Rosenblatt
Original Assignee
Beth Israel Deaconess Medical Center, Inc.
Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beth Israel Deaconess Medical Center, Inc., Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S filed Critical Beth Israel Deaconess Medical Center, Inc.
Publication of HUP0300891A2 publication Critical patent/HUP0300891A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány PTH és PThRP analógok sorozatára vonatkozik, amelyekszelektíven kötődnek a PTH2 receptorokhoz, és így jól alkalmazhatókrendellenes CNS funkciók, rendellenes hasnyálmirigy funkciók,normálistól eltérő ásványi metabolizmus és homeosztázis, férfimeddőségés hipotalamuszbetegségek kezelésére, valamint rendellenes vérnyomásszabályzására alkalmas gyógyszerkészítmények előállítására. Ó
HU0300891A 1998-05-05 1999-05-03 PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására HUP0300891A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7295698A 1998-05-05 1998-05-05
PCT/US1999/009521 WO1999057139A2 (en) 1998-05-05 1999-05-03 Pth2 receptor selective compounds

Publications (1)

Publication Number Publication Date
HUP0300891A2 true HUP0300891A2 (hu) 2003-07-28

Family

ID=22110801

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300891A HUP0300891A2 (hu) 1998-05-05 1999-05-03 PTH2 receptor szelektív vegyületek és alkalmazásuk gyógyszerkészítmények előállÍtására

Country Status (12)

Country Link
US (2) US7531621B1 (hu)
EP (1) EP1075491B1 (hu)
JP (1) JP4460157B2 (hu)
AT (1) ATE392431T1 (hu)
AU (1) AU3673699A (hu)
CA (1) CA2327509A1 (hu)
DE (1) DE69938548T2 (hu)
ES (1) ES2302374T3 (hu)
HU (1) HUP0300891A2 (hu)
NO (1) NO20005556L (hu)
PL (1) PL344645A1 (hu)
WO (1) WO1999057139A2 (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903194B1 (en) 1996-09-26 2005-06-07 Chungai Seiyaku Kabushiki Kaisha Antibody against human parathormone related peptides
US20020165363A1 (en) 1997-05-15 2002-11-07 Koh Sato Cachexia remedy
TWI255718B (en) 1999-07-02 2006-06-01 Chugai Pharmaceutical Co Ltd Ameliorative agent for low vasopressin concentration
AU5708500A (en) * 1999-07-02 2001-01-22 Chugai Seiyaku Kabushiki Kaisha Remedies for diseases caused by pth or pthrp
WO2001082968A1 (fr) 2000-04-28 2001-11-08 Chugai Seiyaku Kabushiki Kaisha Inhibiteurs de proliferation cellulaire
AU2001292905A1 (en) * 2000-09-19 2002-04-02 Curagen Corporation Method of identifying osteoregenerative agents using differential gene expression
WO2004071396A2 (en) * 2003-02-17 2004-08-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with parathyroid hormone receptor 2 (pthr2)
WO2008048784A1 (en) 2006-10-13 2008-04-24 Eli Lilly And Company Pegylated pth as pth receptor modulators and uses thereof
US8568737B2 (en) * 2007-08-01 2013-10-29 The General Hospital Corporation Screening methods using G-protein coupled receptors and related compositions
JP5941040B2 (ja) 2010-05-13 2016-06-29 ザ ジェネラル ホスピタル コーポレイション 副甲状腺ホルモン類似体およびその使用

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001223A (en) * 1987-05-26 1991-03-19 Merck & Co., Inc. Parathyroid hormone antagonists with enhanced metabolic properties
EP0293158A3 (en) 1987-05-26 1990-05-09 Merck & Co. Inc. Parathyroid hormone antagonists
US5527772A (en) 1987-10-20 1996-06-18 Holick; Michael F. Regulation of cell proliferation and differentiation using peptides
US4968669A (en) 1988-05-09 1990-11-06 Merck & Co., Inc. Parathyroid hormone antagonists
EP0341962B1 (en) 1988-05-09 1995-03-15 Merck & Co. Inc. Humoral hypercalcemic factor antagonists
CA2040264A1 (en) 1990-04-12 1991-10-13 Tatsuhiko Kanmera Parathyroid hormone antagonists
US5093233A (en) 1990-04-25 1992-03-03 Merck & Co., Inc. Antagonists with position 13 modification
US5087562A (en) 1990-04-25 1992-02-11 Merck & Co., Inc. Humoral hypercalcemic factor antagonists with modification at position 13 . . .
US5149779A (en) 1990-07-26 1992-09-22 Merck & Co., Inc. Humoral hypercalcemic factor antagonists
JPH0532696A (ja) 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
AU9103791A (en) * 1990-12-21 1992-07-22 Allelix Biopharmaceuticals Inc. Oxidation resistant variants of parathyroid hormone
DE4203040A1 (de) 1992-02-04 1993-08-05 Boehringer Mannheim Gmbh Neue parathormonfragmente, deren herstellung und diese enthaltende arzneimittel
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
US5556940A (en) * 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US5747456A (en) * 1994-12-19 1998-05-05 Beth Israel Deaconess Medical Center Continuous low-dose administration of parathyroid hormone or its agonist
US5717062A (en) 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
US5955574A (en) * 1995-07-13 1999-09-21 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Analogs of parathyroid hormone
US5723577A (en) * 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
US5969095A (en) 1995-07-13 1999-10-19 Biomeasure, Inc. Analogs of parathyroid hormone
JP3259011B2 (ja) * 1995-08-02 2002-02-18 ミヤチテクノス株式会社 インバータ式抵抗溶接制御方法及び装置
ATE304020T1 (de) 1996-07-31 2005-09-15 Gen Hospital Corp Parathyroidhormon-verwandthe peptidanaloge

Also Published As

Publication number Publication date
JP2002513801A (ja) 2002-05-14
US7531621B1 (en) 2009-05-12
AU3673699A (en) 1999-11-23
EP1075491A2 (en) 2001-02-14
CA2327509A1 (en) 1999-11-11
NO20005556L (no) 2001-01-03
US20090226477A1 (en) 2009-09-10
PL344645A1 (en) 2001-11-19
WO1999057139A3 (en) 2000-02-03
WO1999057139A2 (en) 1999-11-11
NO20005556D0 (no) 2000-11-03
ES2302374T3 (es) 2008-07-01
JP4460157B2 (ja) 2010-05-12
ATE392431T1 (de) 2008-05-15
DE69938548T2 (de) 2009-06-18
DE69938548D1 (de) 2008-05-29
EP1075491B1 (en) 2008-04-16

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