BR9713521A - - Google Patents
Info
- Publication number
- BR9713521A BR9713521A BR9713521A BR9713521A BR9713521A BR 9713521 A BR9713521 A BR 9713521A BR 9713521 A BR9713521 A BR 9713521A BR 9713521 A BR9713521 A BR 9713521A BR 9713521 A BR9713521 A BR 9713521A
- Authority
- BR
- Brazil
- Prior art keywords
- sugar
- antibodies
- amino
- polyclonals
- monoclonal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
POLICLONAIS"<D>. A invenção se refere a preparações farmacêuticas liofilizadas de anticorpos monoclonais ou policlonais, que contêm um açúcar ou um am processo para a produção desses liofilizados estáveis, bem como o uso de um açúcar ou amino-açúcar, um aminoácido e um tensoativo como estabilizadoro anticorpos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96118489A EP0852951A1 (de) | 1996-11-19 | 1996-11-19 | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
PCT/EP1997/006452 WO1998022136A2 (de) | 1996-11-19 | 1997-11-19 | Stabile lyophilisierte pharmazeutische zubereitungen von mono- oder polyklonalen antikörpern |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9713521A true BR9713521A (pt) | 2000-03-21 |
Family
ID=8223412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9713521A BR9713521A (pt) | 1996-11-19 | 1997-11-19 |
Country Status (19)
Country | Link |
---|---|
US (2) | US8758747B2 (pt) |
EP (2) | EP0852951A1 (pt) |
JP (2) | JP4536829B2 (pt) |
KR (1) | KR100514207B1 (pt) |
CN (1) | CN1155408C (pt) |
AR (2) | AR012540A1 (pt) |
AT (1) | ATE276762T1 (pt) |
AU (2) | AU735411C (pt) |
BR (1) | BR9713521A (pt) |
CA (1) | CA2272245C (pt) |
DE (1) | DE59711959D1 (pt) |
DK (1) | DK0941121T3 (pt) |
ES (1) | ES2227727T3 (pt) |
ID (1) | ID19029A (pt) |
PT (1) | PT941121E (pt) |
TR (1) | TR199901696T2 (pt) |
TW (1) | TW520291B (pt) |
WO (1) | WO1998022136A2 (pt) |
ZA (1) | ZA9710409B (pt) |
Families Citing this family (121)
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US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
PT917879E (pt) * | 1997-11-22 | 2002-12-31 | Roche Diagnostics Gmbh | Processo melhorado para estabilizacao de proteinas |
WO2000066160A1 (fr) * | 1999-04-28 | 2000-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Composition medicamenteuse parenterale a fragment d'anticorps monoclonal humanise et procede de stabilisation |
WO2002013860A1 (fr) * | 2000-08-11 | 2002-02-21 | Chugai Seiyaku Kabushiki Kaisha | Preparations stabilisees contenant un anticorps |
US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
TWI232102B (en) * | 2001-07-17 | 2005-05-11 | Shionogi & Co | A pharmaceutical formulation for injection |
ATE414537T1 (de) | 2001-08-29 | 2008-12-15 | Chugai Pharmaceutical Co Ltd | Antikörper enthaltende stabilisierte zubereitungen |
EP1441589B1 (en) * | 2001-11-08 | 2012-05-09 | Abbott Biotherapeutics Corp. | Stable liquid pharmaceutical formulation of igg antibodies |
DE10163459A1 (de) * | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
DE10204792A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
JP4364645B2 (ja) * | 2002-02-14 | 2009-11-18 | 中外製薬株式会社 | 抗体含有溶液製剤 |
SI1478394T1 (sl) | 2002-02-27 | 2008-12-31 | Immunex Corp | STABILIZIRAN TNFR-Fc SESTAVEK Z ARGININOM |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
WO2004028557A1 (ja) * | 2002-09-26 | 2004-04-08 | Shionogi & Co., Ltd. | 安定化されたタンパク組成物 |
EP1561759B9 (en) | 2002-10-11 | 2009-08-26 | Chugai Seiyaku Kabushiki Kaisha | Cell death-inducing agent |
MXPA05008409A (es) | 2003-02-10 | 2005-10-05 | Elan Pharm Inc | Formulacion de inmunoglobulina y metodo para la preparacion de la misma. |
US8765124B2 (en) | 2003-02-28 | 2014-07-01 | Chugai Seiyaku Kabushiki Kaisha | Stabilized preparation containing protein |
ZA200507757B (en) | 2003-04-04 | 2007-01-31 | Genentech Inc | High concentration antibody and protein formulations |
EP1684719B1 (en) * | 2003-11-14 | 2011-10-26 | Baxter International Inc. | Alpha 1-antitrypsin compositions and treatment methods using such compositions |
EP1532983A1 (en) | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
DE10355251A1 (de) * | 2003-11-26 | 2005-06-23 | Merck Patent Gmbh | Pharmazeutische Zubereitung enthaltend einen Antikörper gegen den EGF-Rezeptor |
DE10355904A1 (de) | 2003-11-29 | 2005-06-30 | Merck Patent Gmbh | Feste Formen von anti-EGFR-Antikörpern |
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TW200530269A (en) | 2003-12-12 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Anti-Mpl antibodies |
WO2005056602A1 (ja) * | 2003-12-12 | 2005-06-23 | Chugai Seiyaku Kabushiki Kaisha | アゴニスト活性を有する改変抗体のスクリーニング方法 |
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-
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- 1996-11-19 EP EP96118489A patent/EP0852951A1/de not_active Withdrawn
-
1997
- 1997-11-19 TW TW086117416A patent/TW520291B/zh active
- 1997-11-19 ES ES97951238T patent/ES2227727T3/es not_active Expired - Lifetime
- 1997-11-19 WO PCT/EP1997/006452 patent/WO1998022136A2/de active IP Right Grant
- 1997-11-19 BR BR9713521A patent/BR9713521A/pt not_active Application Discontinuation
- 1997-11-19 EP EP97951238A patent/EP0941121B1/de not_active Revoked
- 1997-11-19 KR KR10-1999-7004336A patent/KR100514207B1/ko not_active IP Right Cessation
- 1997-11-19 PT PT97951238T patent/PT941121E/pt unknown
- 1997-11-19 AU AU54841/98A patent/AU735411C/en not_active Expired
- 1997-11-19 ID IDP973713A patent/ID19029A/id unknown
- 1997-11-19 CA CA2272245A patent/CA2272245C/en not_active Expired - Lifetime
- 1997-11-19 DK DK97951238T patent/DK0941121T3/da active
- 1997-11-19 JP JP52321098A patent/JP4536829B2/ja not_active Expired - Lifetime
- 1997-11-19 ZA ZA9710409A patent/ZA9710409B/xx unknown
- 1997-11-19 AT AT97951238T patent/ATE276762T1/de active
- 1997-11-19 TR TR1999/01696T patent/TR199901696T2/xx unknown
- 1997-11-19 AR ARP970105404A patent/AR012540A1/es active IP Right Grant
- 1997-11-19 CN CNB971814163A patent/CN1155408C/zh not_active Ceased
- 1997-11-19 DE DE59711959T patent/DE59711959D1/de not_active Expired - Lifetime
-
2001
- 2001-10-05 AU AU78242/01A patent/AU772940B2/en not_active Expired
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2008
- 2008-07-28 US US12/180,794 patent/US8758747B2/en not_active Expired - Fee Related
- 2008-09-11 JP JP2008233138A patent/JP5153532B2/ja not_active Expired - Lifetime
-
2009
- 2009-12-30 AR ARP090105181A patent/AR074958A2/es not_active Application Discontinuation
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- 2014-05-12 US US14/275,140 patent/US20140248274A1/en not_active Abandoned
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JP2001503781A (ja) | 2001-03-21 |
AU772940B2 (en) | 2004-05-13 |
KR100514207B1 (ko) | 2005-09-13 |
CN1244805A (zh) | 2000-02-16 |
DK0941121T3 (da) | 2005-01-31 |
ZA9710409B (en) | 1999-05-19 |
US8758747B2 (en) | 2014-06-24 |
AU7824201A (en) | 2001-11-22 |
DE59711959D1 (de) | 2004-10-28 |
PT941121E (pt) | 2005-01-31 |
CA2272245C (en) | 2013-09-10 |
JP2009046494A (ja) | 2009-03-05 |
JP4536829B2 (ja) | 2010-09-01 |
EP0941121B1 (de) | 2004-09-22 |
AR074958A2 (es) | 2011-02-23 |
CN1155408C (zh) | 2004-06-30 |
JP5153532B2 (ja) | 2013-02-27 |
EP0852951A1 (de) | 1998-07-15 |
WO1998022136A2 (de) | 1998-05-28 |
AU5484198A (en) | 1998-06-10 |
CA2272245A1 (en) | 1998-05-28 |
TR199901696T2 (xx) | 1999-09-21 |
US20080286280A1 (en) | 2008-11-20 |
WO1998022136A3 (de) | 1998-08-20 |
AU735411C (en) | 2004-08-05 |
ID19029A (id) | 1998-06-04 |
ATE276762T1 (de) | 2004-10-15 |
US20140248274A1 (en) | 2014-09-04 |
TW520291B (en) | 2003-02-11 |
AU735411B2 (en) | 2001-07-05 |
ES2227727T3 (es) | 2005-04-01 |
KR20000053328A (ko) | 2000-08-25 |
AR012540A1 (es) | 2000-11-08 |
EP0941121A2 (de) | 1999-09-15 |
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