ZA9710409B - Stable lyophilised pharmaceutical preparations comprising mono- or polyclonal antibodies - Google Patents
Stable lyophilised pharmaceutical preparations comprising mono- or polyclonal antibodiesInfo
- Publication number
- ZA9710409B ZA9710409B ZA9710409A ZA9710409A ZA9710409B ZA 9710409 B ZA9710409 B ZA 9710409B ZA 9710409 A ZA9710409 A ZA 9710409A ZA 9710409 A ZA9710409 A ZA 9710409A ZA 9710409 B ZA9710409 B ZA 9710409B
- Authority
- ZA
- South Africa
- Prior art keywords
- mono
- polyclonal antibodies
- pharmaceutical preparations
- lyophilised pharmaceutical
- stable lyophilised
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96118489A EP0852951A1 (de) | 1996-11-19 | 1996-11-19 | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA9710409B true ZA9710409B (en) | 1999-05-19 |
Family
ID=8223412
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA9710409A ZA9710409B (en) | 1996-11-19 | 1997-11-19 | Stable lyophilised pharmaceutical preparations comprising mono- or polyclonal antibodies |
Country Status (19)
Country | Link |
---|---|
US (2) | US8758747B2 (xx) |
EP (2) | EP0852951A1 (xx) |
JP (2) | JP4536829B2 (xx) |
KR (1) | KR100514207B1 (xx) |
CN (1) | CN1155408C (xx) |
AR (2) | AR012540A1 (xx) |
AT (1) | ATE276762T1 (xx) |
AU (2) | AU735411C (xx) |
BR (1) | BR9713521A (xx) |
CA (1) | CA2272245C (xx) |
DE (1) | DE59711959D1 (xx) |
DK (1) | DK0941121T3 (xx) |
ES (1) | ES2227727T3 (xx) |
ID (1) | ID19029A (xx) |
PT (1) | PT941121E (xx) |
TR (1) | TR199901696T2 (xx) |
TW (1) | TW520291B (xx) |
WO (1) | WO1998022136A2 (xx) |
ZA (1) | ZA9710409B (xx) |
Families Citing this family (121)
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ATE220558T1 (de) * | 1997-11-22 | 2002-08-15 | Roche Diagnostics Gmbh | Verbessertes verfahren zur stabilisierung von proteinen |
EP1174148A4 (en) * | 1999-04-28 | 2005-05-04 | Yamanouchi Pharma Co Ltd | PARENTAL MEDICAL COMPOSITIONS CONTAINING FRAGMENTS OF HUMANIZED MONOCLONAL ANTIBODIES AND METHOD FOR STABILIZING THE SAME |
AU2001277781A1 (en) * | 2000-08-11 | 2002-02-25 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing preparations |
US7138262B1 (en) | 2000-08-18 | 2006-11-21 | Shire Human Genetic Therapies, Inc. | High mannose proteins and methods of making high mannose proteins |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
TWI232102B (en) * | 2001-07-17 | 2005-05-11 | Shionogi & Co | A pharmaceutical formulation for injection |
EP1428537B1 (en) * | 2001-08-29 | 2008-11-19 | Chugai Seiyaku Kabushiki Kaisha | Stabilized preparations containing antibody |
JP5290489B2 (ja) * | 2001-11-08 | 2013-09-18 | アッヴィ・バイオセラピューティクス・インコーポレイテッド | Igg抗体の安定な液体医薬製剤 |
DE10163459A1 (de) * | 2001-12-21 | 2003-07-03 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Antikörper gegen EGF-Rezeptor |
DE10204792A1 (de) * | 2002-02-06 | 2003-08-14 | Merck Patent Gmbh | Lyophilisierte Zubereitung enthaltend Immuncytokine |
EP2311489A3 (en) | 2002-02-14 | 2013-08-21 | Chugai Seiyaku Kabushiki Kaisha | Formulation of antibody-containing solutions comprising a sugar as a stabilizer |
MXPA04008215A (es) | 2002-02-27 | 2004-11-26 | Immunex Corp | Formulacion polipeptidica. |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
WO2004028557A1 (ja) * | 2002-09-26 | 2004-04-08 | Shionogi & Co., Ltd. | 安定化されたタンパク組成物 |
EP1561759B9 (en) | 2002-10-11 | 2009-08-26 | Chugai Seiyaku Kabushiki Kaisha | Cell death-inducing agent |
EP3777880A1 (en) | 2003-02-10 | 2021-02-17 | Biogen MA Inc. | Immunoglobulin formulation and method of preparation thereof |
KR101235507B1 (ko) * | 2003-02-28 | 2013-02-20 | 추가이 세이야쿠 가부시키가이샤 | 단백질을 함유하는 안정화 제제 |
CN1798575A (zh) | 2003-04-04 | 2006-07-05 | 健泰科生物技术公司 | 高浓度抗体和蛋白制剂 |
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-
1996
- 1996-11-19 EP EP96118489A patent/EP0852951A1/de not_active Withdrawn
-
1997
- 1997-11-19 ID IDP973713A patent/ID19029A/id unknown
- 1997-11-19 CN CNB971814163A patent/CN1155408C/zh not_active Ceased
- 1997-11-19 JP JP52321098A patent/JP4536829B2/ja not_active Expired - Lifetime
- 1997-11-19 KR KR10-1999-7004336A patent/KR100514207B1/ko not_active IP Right Cessation
- 1997-11-19 DE DE59711959T patent/DE59711959D1/de not_active Expired - Lifetime
- 1997-11-19 BR BR9713521A patent/BR9713521A/pt not_active Application Discontinuation
- 1997-11-19 DK DK97951238T patent/DK0941121T3/da active
- 1997-11-19 PT PT97951238T patent/PT941121E/pt unknown
- 1997-11-19 ES ES97951238T patent/ES2227727T3/es not_active Expired - Lifetime
- 1997-11-19 TR TR1999/01696T patent/TR199901696T2/xx unknown
- 1997-11-19 EP EP97951238A patent/EP0941121B1/de not_active Revoked
- 1997-11-19 CA CA2272245A patent/CA2272245C/en not_active Expired - Lifetime
- 1997-11-19 AT AT97951238T patent/ATE276762T1/de active
- 1997-11-19 WO PCT/EP1997/006452 patent/WO1998022136A2/de active IP Right Grant
- 1997-11-19 AU AU54841/98A patent/AU735411C/en not_active Expired
- 1997-11-19 ZA ZA9710409A patent/ZA9710409B/xx unknown
- 1997-11-19 AR ARP970105404A patent/AR012540A1/es active IP Right Grant
- 1997-11-19 TW TW086117416A patent/TW520291B/zh active
-
2001
- 2001-10-05 AU AU78242/01A patent/AU772940B2/en not_active Expired
-
2008
- 2008-07-28 US US12/180,794 patent/US8758747B2/en not_active Expired - Fee Related
- 2008-09-11 JP JP2008233138A patent/JP5153532B2/ja not_active Expired - Lifetime
-
2009
- 2009-12-30 AR ARP090105181A patent/AR074958A2/es not_active Application Discontinuation
-
2014
- 2014-05-12 US US14/275,140 patent/US20140248274A1/en not_active Abandoned
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CN1244805A (zh) | 2000-02-16 |
WO1998022136A2 (de) | 1998-05-28 |
EP0941121A2 (de) | 1999-09-15 |
AU772940B2 (en) | 2004-05-13 |
AU7824201A (en) | 2001-11-22 |
US20080286280A1 (en) | 2008-11-20 |
EP0852951A1 (de) | 1998-07-15 |
JP2001503781A (ja) | 2001-03-21 |
WO1998022136A3 (de) | 1998-08-20 |
EP0941121B1 (de) | 2004-09-22 |
CA2272245A1 (en) | 1998-05-28 |
BR9713521A (xx) | 2000-03-21 |
ATE276762T1 (de) | 2004-10-15 |
DK0941121T3 (da) | 2005-01-31 |
JP4536829B2 (ja) | 2010-09-01 |
AR012540A1 (es) | 2000-11-08 |
TW520291B (en) | 2003-02-11 |
KR100514207B1 (ko) | 2005-09-13 |
AU5484198A (en) | 1998-06-10 |
AR074958A2 (es) | 2011-02-23 |
KR20000053328A (ko) | 2000-08-25 |
US8758747B2 (en) | 2014-06-24 |
AU735411C (en) | 2004-08-05 |
CA2272245C (en) | 2013-09-10 |
ES2227727T3 (es) | 2005-04-01 |
PT941121E (pt) | 2005-01-31 |
TR199901696T2 (xx) | 1999-09-21 |
JP2009046494A (ja) | 2009-03-05 |
DE59711959D1 (de) | 2004-10-28 |
JP5153532B2 (ja) | 2013-02-27 |
US20140248274A1 (en) | 2014-09-04 |
ID19029A (id) | 1998-06-04 |
CN1155408C (zh) | 2004-06-30 |
AU735411B2 (en) | 2001-07-05 |
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