ATE88352T1 - Humanes relaxinpraeparat. - Google Patents
Humanes relaxinpraeparat.Info
- Publication number
- ATE88352T1 ATE88352T1 AT89902688T AT89902688T ATE88352T1 AT E88352 T1 ATE88352 T1 AT E88352T1 AT 89902688 T AT89902688 T AT 89902688T AT 89902688 T AT89902688 T AT 89902688T AT E88352 T1 ATE88352 T1 AT E88352T1
- Authority
- AT
- Austria
- Prior art keywords
- human relaxin
- composition
- preparative
- formulated
- agent
- Prior art date
Links
- BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 206010036595 Premature delivery Diseases 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000000872 buffer Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000007979 citrate buffer Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000032696 parturition Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Electrotherapy Devices (AREA)
- Materials For Medical Uses (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16079788A | 1988-02-26 | 1988-02-26 | |
| US30377989A | 1989-01-27 | 1989-01-27 | |
| PCT/US1989/000502 WO1989007945A1 (en) | 1988-02-26 | 1989-02-08 | Human relaxin formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE88352T1 true ATE88352T1 (de) | 1993-05-15 |
Family
ID=26857232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89902688T ATE88352T1 (de) | 1988-02-26 | 1989-02-08 | Humanes relaxinpraeparat. |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5451572A (de) |
| EP (1) | EP0407401B1 (de) |
| JP (1) | JP2815649B2 (de) |
| CN (1) | CN1052655C (de) |
| AT (1) | ATE88352T1 (de) |
| AU (1) | AU626840B2 (de) |
| CA (1) | CA1336403C (de) |
| DE (1) | DE68906153T2 (de) |
| ES (1) | ES2013394A6 (de) |
| IE (1) | IE63208B1 (de) |
| IL (1) | IL89276A (de) |
| NZ (1) | NZ228012A (de) |
| PT (1) | PT89835B (de) |
| WO (1) | WO1989007945A1 (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
| US5478807A (en) * | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
| AU3123393A (en) * | 1991-10-28 | 1993-06-07 | Board Of Regents, The University Of Texas System | A method for detecting a differentiation marker in normal and carcinoma cells and in biological samples and body fluid |
| US5192743A (en) * | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
| US5830848A (en) * | 1992-10-09 | 1998-11-03 | The Regents Of The University Of California | Method and agents for inducement of endogenous nitric oxide synthase for control and management of labor during pregnancy |
| EP0782850A4 (de) * | 1994-10-13 | 1998-03-04 | Wakamoto Pharma Co Ltd | Lyophilisierte zubereitung zur herstellung eines reversibel thermogelierenden arzniemittels auf wasserbasis |
| US5811395A (en) * | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
| ES2187667T3 (es) | 1995-08-15 | 2003-06-16 | Connetics Corp | Uso de relaxina para estimular angiogenesis. |
| US5612051A (en) * | 1995-11-17 | 1997-03-18 | Yue; Samuel K. | Method of treating involuntary muscle dysfunction with relaxin hormone |
| EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| US5994148A (en) * | 1997-06-23 | 1999-11-30 | The Regents Of University Of California | Method of predicting and enhancing success of IVF/ET pregnancy |
| US6251863B1 (en) | 1998-09-08 | 2001-06-26 | Samuel K. Yue | Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin |
| EP1140001B1 (de) * | 1998-12-18 | 2005-05-04 | Palladin HealthCare International Ltd | Zusammensetzung zur behandlung von verbrennungen |
| ATE362770T1 (de) * | 2000-02-09 | 2007-06-15 | Bas Medical Inc | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
| US20050032683A1 (en) | 2000-10-04 | 2005-02-10 | Amento Edward P. | Methods of modulating apoptosis by administration of relaxin agonists or antagonists |
| EP1391209A4 (de) * | 2001-05-30 | 2009-12-16 | Chugai Pharmaceutical Co Ltd | Proteinzubereitung |
| US7660678B2 (en) * | 2004-02-05 | 2010-02-09 | Medpro Holdings, Llc | On-site method of providing analysis of potency and purity of pharmaceutical compounds |
| US20100134794A1 (en) * | 2004-02-05 | 2010-06-03 | Medpro Holdings, Llc | Analyzer for determining the concentration, potency and purity of pharmaceutical compounds |
| US7878978B2 (en) | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| WO2005115435A2 (en) * | 2004-04-30 | 2005-12-08 | Bas Medical, Inc. | Methods and compositions for control of fetal growth via modulation of relaxin |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| MX2007001589A (es) * | 2004-08-09 | 2007-08-02 | Alios Biopharma Inc | Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas. |
| US20060052304A1 (en) * | 2004-09-02 | 2006-03-09 | Bas Medical, Inc. | Method for remodeling bone and related sutures |
| US20080241260A1 (en) * | 2005-09-28 | 2008-10-02 | Padma Venkitachalam Devarajan | Compositions for Enhanced Absorption of Biologically Active Agents |
| CN102026650A (zh) * | 2008-05-16 | 2011-04-20 | 科尔泰拉公司 | 预防早产的方法 |
| AU2009246333B2 (en) * | 2008-05-16 | 2013-05-09 | Corthera, Inc. | Method of promoting wound healing |
| WO2010105081A1 (en) | 2009-03-13 | 2010-09-16 | Medtronic, Inc. | Method of treating heart failure |
| KR101800040B1 (ko) | 2010-03-10 | 2017-11-21 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 릴랙신을 사용한 아쿠아포린의 조절 |
| PE20140160A1 (es) | 2010-08-17 | 2014-02-08 | Ambrx Inc | Polipeptidos de relaxina modificados y sus usos |
| CN102133200B (zh) * | 2011-03-16 | 2012-07-25 | 济南环肽医药科技有限公司 | 一种人类松弛素-2 Relaxin的注射用冻干粉制剂 |
| US9393288B2 (en) | 2012-05-29 | 2016-07-19 | The University Of Vermont And State Agricultural College | Methods of treating diseases associated with PPARγ |
| CN103768584A (zh) * | 2014-02-10 | 2014-05-07 | 济南环肽医药科技有限公司 | 一种松弛肽注射液 |
| CN104922661B (zh) * | 2014-03-20 | 2018-08-24 | 深圳翰宇药业股份有限公司 | 一种含有serelaxin的药物组合物及其制备方法 |
| WO2016059593A1 (en) * | 2014-10-16 | 2016-04-21 | Piramal Enterprises Limited | Stable injectable composition of protein drugs and process for its preparation |
| CN107007822A (zh) * | 2016-01-27 | 2017-08-04 | 江苏恒瑞医药股份有限公司 | 一种含有重组人松弛素‑2类似物的药物组合物及其制备方法 |
| SG10201912034UA (en) | 2017-02-08 | 2020-02-27 | Bristol Myers Squibb Co | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
| CN110582264B (zh) * | 2017-03-26 | 2022-11-11 | V·R·斯塔福德 | 眼睑皮肤状况的处理方法 |
| EP4791358A1 (de) * | 2023-09-15 | 2026-08-19 | Relaxera Pharmazeutische Gesellschaft mbH & Co. KG | Relaxin-arzneimittel |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2964448A (en) * | 1959-01-27 | 1960-12-13 | Anschel Joachim | Relaxin composition and process for preparing same |
| US3003117A (en) * | 1959-09-29 | 1961-10-03 | Gen Frecision Inc | Coincident frequency tracker |
| US3962416A (en) * | 1971-01-25 | 1976-06-08 | Sol Katzen | Preserved nutrients and products |
| EP0018609B1 (de) * | 1979-04-30 | 1983-09-21 | Hoechst Aktiengesellschaft | Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US4267101A (en) * | 1980-02-01 | 1981-05-12 | Serono Laboratories Inc. | Process for obtaining human relaxin from fetal membranes |
| EP0080879B1 (de) * | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Stabilisiertes Interferon enthaltende pharmazeutische Zusammensetzung |
| EP0101309B1 (de) * | 1982-08-12 | 1991-01-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz |
| DE3236264A1 (de) | 1982-09-30 | 1984-04-05 | Serono Pharmazeutische Präparate GmbH, 7800 Freiburg | Verfahren zur gewinnung von relaxin |
| DE3236267A1 (de) * | 1982-09-30 | 1984-04-05 | Serono Pharmazeutische Präparate GmbH, 7800 Freiburg | Verfahren zur herstellung von relaxin und verfahren zur hochreinigung von relaxin |
| IL70414A (en) * | 1982-12-13 | 1991-06-10 | Florey Howard Inst | Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors |
| CH661662A5 (en) * | 1984-04-16 | 1987-08-14 | Georg L Prof Dr Floersheim | Product for the treatment of the skin and of the connective tissue |
| US4605555A (en) * | 1984-09-20 | 1986-08-12 | Sun Star Kabushiki Kaisha | Composition and method for treating keratosic disorder of skin and mucosa |
| US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
| EP0260149A1 (de) * | 1986-09-12 | 1988-03-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Menschliches Prorelaxin für therapeutische Anwendung |
| US4717717A (en) * | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
-
1989
- 1989-02-08 WO PCT/US1989/000502 patent/WO1989007945A1/en not_active Ceased
- 1989-02-08 EP EP89902688A patent/EP0407401B1/de not_active Expired - Lifetime
- 1989-02-08 JP JP1502501A patent/JP2815649B2/ja not_active Expired - Fee Related
- 1989-02-08 DE DE89902688T patent/DE68906153T2/de not_active Expired - Fee Related
- 1989-02-08 AT AT89902688T patent/ATE88352T1/de not_active IP Right Cessation
- 1989-02-08 AU AU31833/89A patent/AU626840B2/en not_active Ceased
- 1989-02-13 IE IE45289A patent/IE63208B1/en not_active IP Right Cessation
- 1989-02-14 IL IL8927689A patent/IL89276A/en unknown
- 1989-02-16 NZ NZ228012A patent/NZ228012A/en unknown
- 1989-02-23 CA CA000591933A patent/CA1336403C/en not_active Expired - Lifetime
- 1989-02-24 PT PT89835A patent/PT89835B/pt not_active IP Right Cessation
- 1989-02-24 ES ES8900688A patent/ES2013394A6/es not_active Expired - Lifetime
- 1989-02-25 CN CN89100947A patent/CN1052655C/zh not_active Expired - Fee Related
-
1993
- 1993-04-20 US US08/050,745 patent/US5451572A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/471,920 patent/US5945402A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1035619A (zh) | 1989-09-20 |
| AU626840B2 (en) | 1992-08-13 |
| PT89835B (pt) | 1994-01-31 |
| US5451572A (en) | 1995-09-19 |
| WO1989007945A1 (en) | 1989-09-08 |
| JP2815649B2 (ja) | 1998-10-27 |
| DE68906153T2 (de) | 1993-10-28 |
| EP0407401B1 (de) | 1993-04-21 |
| JPH03502794A (ja) | 1991-06-27 |
| IE63208B1 (en) | 1995-04-05 |
| US5945402A (en) | 1999-08-31 |
| EP0407401A1 (de) | 1991-01-16 |
| CA1336403C (en) | 1995-07-25 |
| IL89276A0 (en) | 1989-09-10 |
| IL89276A (en) | 1994-06-24 |
| IE890452L (en) | 1989-08-26 |
| CN1052655C (zh) | 2000-05-24 |
| PT89835A (pt) | 1989-10-04 |
| DE68906153D1 (de) | 1993-05-27 |
| NZ228012A (en) | 1991-07-26 |
| ES2013394A6 (es) | 1990-05-01 |
| AU3183389A (en) | 1989-09-22 |
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