ATE88352T1 - Humanes relaxinpraeparat. - Google Patents
Humanes relaxinpraeparat.Info
- Publication number
- ATE88352T1 ATE88352T1 AT89902688T AT89902688T ATE88352T1 AT E88352 T1 ATE88352 T1 AT E88352T1 AT 89902688 T AT89902688 T AT 89902688T AT 89902688 T AT89902688 T AT 89902688T AT E88352 T1 ATE88352 T1 AT E88352T1
- Authority
- AT
- Austria
- Prior art keywords
- human relaxin
- composition
- preparative
- formulated
- agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16079788A | 1988-02-26 | 1988-02-26 | |
US30377989A | 1989-01-27 | 1989-01-27 | |
PCT/US1989/000502 WO1989007945A1 (en) | 1988-02-26 | 1989-02-08 | Human relaxin formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE88352T1 true ATE88352T1 (de) | 1993-05-15 |
Family
ID=26857232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT89902688T ATE88352T1 (de) | 1988-02-26 | 1989-02-08 | Humanes relaxinpraeparat. |
Country Status (14)
Country | Link |
---|---|
US (2) | US5451572A (de) |
EP (1) | EP0407401B1 (de) |
JP (1) | JP2815649B2 (de) |
CN (1) | CN1052655C (de) |
AT (1) | ATE88352T1 (de) |
AU (1) | AU626840B2 (de) |
CA (1) | CA1336403C (de) |
DE (1) | DE68906153T2 (de) |
ES (1) | ES2013394A6 (de) |
IE (1) | IE63208B1 (de) |
IL (1) | IL89276A (de) |
NZ (1) | NZ228012A (de) |
PT (1) | PT89835B (de) |
WO (1) | WO1989007945A1 (de) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5166191A (en) * | 1991-08-19 | 1992-11-24 | Genentech, Inc. | Use of relaxin in cardiovascular therapy |
US5478807A (en) * | 1991-08-19 | 1995-12-26 | Genentech, Inc. | Use of relaxin in the treatment of bradycardia |
JPH07508341A (ja) * | 1991-10-28 | 1995-09-14 | ボード・オヴ・リージェンツ,ザ・ユニヴァーシティ・オヴ・テキサス・システム | 生物サンプルおよび体液中の正常細胞と悪性腫瘍細胞とにおける分化マーカーの検出方法 |
US5192743A (en) * | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
US5830848A (en) * | 1992-10-09 | 1998-11-03 | The Regents Of The University Of California | Method and agents for inducement of endogenous nitric oxide synthase for control and management of labor during pregnancy |
WO1996011672A1 (fr) * | 1994-10-13 | 1996-04-25 | Wakamoto Pharmaceutical Co., Ltd. | Preparation lyophilisee permettant d'obtenir une composition pharmaceutique a base d'eau se transformant de maniere reversible en gel sous l'effet de la chaleur |
US5811395A (en) * | 1995-06-07 | 1998-09-22 | Medical University Of South Carolina | Relaxin analogs and derivatives methods and uses thereof |
AU6777196A (en) | 1995-08-15 | 1997-03-12 | Connective Therapeutics Inc. | Method of promoting angiogenesis |
US5612051A (en) * | 1995-11-17 | 1997-03-18 | Yue; Samuel K. | Method of treating involuntary muscle dysfunction with relaxin hormone |
EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
US5994148A (en) * | 1997-06-23 | 1999-11-30 | The Regents Of University Of California | Method of predicting and enhancing success of IVF/ET pregnancy |
US6251863B1 (en) | 1998-09-08 | 2001-06-26 | Samuel K. Yue | Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin |
AU781537B2 (en) * | 1998-12-18 | 2005-05-26 | Palladin Healthcare International, Ltd. | Composition for treatment of burns |
EP1253929B1 (de) * | 2000-02-09 | 2007-05-23 | BAS Medical, Inc. | Verwendung von relaxin zur behandlung von durch gefässverengung bedingten erkrankungen |
US20050032683A1 (en) | 2000-10-04 | 2005-02-10 | Amento Edward P. | Methods of modulating apoptosis by administration of relaxin agonists or antagonists |
US20040156835A1 (en) * | 2001-05-30 | 2004-08-12 | Taiji Imoto | Protein preparation |
US20100134794A1 (en) * | 2004-02-05 | 2010-06-03 | Medpro Holdings, Llc | Analyzer for determining the concentration, potency and purity of pharmaceutical compounds |
US7660678B2 (en) * | 2004-02-05 | 2010-02-09 | Medpro Holdings, Llc | On-site method of providing analysis of potency and purity of pharmaceutical compounds |
US7878978B2 (en) | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
JP4836942B2 (ja) * | 2004-04-30 | 2011-12-14 | コーセラ, インコーポレイテッド | リラキシンの調節による胎仔の発育の制御のための方法および組成物 |
WO2006020580A2 (en) * | 2004-08-09 | 2006-02-23 | Alios Biopharma Inc. | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
US20060052304A1 (en) * | 2004-09-02 | 2006-03-09 | Bas Medical, Inc. | Method for remodeling bone and related sutures |
US20080241260A1 (en) * | 2005-09-28 | 2008-10-02 | Padma Venkitachalam Devarajan | Compositions for Enhanced Absorption of Biologically Active Agents |
EP2288367B1 (de) * | 2008-05-16 | 2015-10-07 | Corthera, Inc. | H2-Relaxin zur Verwendung bei der Behandlung von vorzeitiger Zervixdilatation |
EP2278993A4 (de) * | 2008-05-16 | 2012-09-12 | Corthera Inc | Verfahren zur förderung von wundheilung |
EP2405933A1 (de) * | 2009-03-13 | 2012-01-18 | Medtronic, Inc | Verfahren zur behandlung von herzinsuffizienz |
WO2011112791A1 (en) * | 2010-03-10 | 2011-09-15 | Corthera, Inc | Modulating aquaporins with relaxin |
HUE045845T2 (hu) | 2010-08-17 | 2021-12-28 | Ambrx Inc | Módosított relaxin polipeptidek és felhasználásuk |
CN102133200B (zh) * | 2011-03-16 | 2012-07-25 | 济南环肽医药科技有限公司 | 一种人类松弛素-2 Relaxin的注射用冻干粉制剂 |
US9393288B2 (en) | 2012-05-29 | 2016-07-19 | The University Of Vermont And State Agricultural College | Methods of treating diseases associated with PPARγ |
CN103768584A (zh) * | 2014-02-10 | 2014-05-07 | 济南环肽医药科技有限公司 | 一种松弛肽注射液 |
CN104922661B (zh) * | 2014-03-20 | 2018-08-24 | 深圳翰宇药业股份有限公司 | 一种含有serelaxin的药物组合物及其制备方法 |
WO2016059593A1 (en) * | 2014-10-16 | 2016-04-21 | Piramal Enterprises Limited | Stable injectable composition of protein drugs and process for its preparation |
CN107007822A (zh) * | 2016-01-27 | 2017-08-04 | 江苏恒瑞医药股份有限公司 | 一种含有重组人松弛素‑2类似物的药物组合物及其制备方法 |
CA3052639A1 (en) | 2017-02-08 | 2018-08-16 | Bristol-Myers Squibb Company | Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof |
WO2018182562A1 (en) * | 2017-03-26 | 2018-10-04 | Stafford Vivi Robyn | Method of treatment of skin conditions of eye lids |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2964448A (en) * | 1959-01-27 | 1960-12-13 | Anschel Joachim | Relaxin composition and process for preparing same |
US3003117A (en) * | 1959-09-29 | 1961-10-03 | Gen Frecision Inc | Coincident frequency tracker |
US3962416A (en) * | 1971-01-25 | 1976-06-08 | Sol Katzen | Preserved nutrients and products |
EP0018609B1 (de) * | 1979-04-30 | 1983-09-21 | Hoechst Aktiengesellschaft | Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
US4267101A (en) * | 1980-02-01 | 1981-05-12 | Serono Laboratories Inc. | Process for obtaining human relaxin from fetal membranes |
EP0080879B1 (de) * | 1981-11-28 | 1986-10-01 | Sunstar Kabushiki Kaisha | Stabilisiertes Interferon enthaltende pharmazeutische Zusammensetzung |
EP0101309B1 (de) * | 1982-08-12 | 1991-01-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Molekulare Klonierung und Charakterisierung der das menschliche Relaxin kodierenden Gen-Sequenz |
DE3236264A1 (de) * | 1982-09-30 | 1984-04-05 | Serono Pharmazeutische Präparate GmbH, 7800 Freiburg | Verfahren zur gewinnung von relaxin |
DE3236267A1 (de) * | 1982-09-30 | 1984-04-05 | Serono Pharmazeutische Präparate GmbH, 7800 Freiburg | Verfahren zur herstellung von relaxin und verfahren zur hochreinigung von relaxin |
IL70414A (en) * | 1982-12-13 | 1991-06-10 | Florey Howard Inst | Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors |
CH661662A5 (en) * | 1984-04-16 | 1987-08-14 | Georg L Prof Dr Floersheim | Product for the treatment of the skin and of the connective tissue |
US4605555A (en) * | 1984-09-20 | 1986-08-12 | Sun Star Kabushiki Kaisha | Composition and method for treating keratosic disorder of skin and mucosa |
US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
NZ221789A (en) * | 1986-09-12 | 1991-05-28 | Genentech Inc | Recombinant prorelaxin, its preparation and pharmaceutical compositions comprising it |
US4717717A (en) * | 1986-11-05 | 1988-01-05 | Ethicon, Inc. | Stabilized compositions containing epidermal growth factor |
-
1989
- 1989-02-08 AT AT89902688T patent/ATE88352T1/de not_active IP Right Cessation
- 1989-02-08 JP JP1502501A patent/JP2815649B2/ja not_active Expired - Fee Related
- 1989-02-08 EP EP89902688A patent/EP0407401B1/de not_active Expired - Lifetime
- 1989-02-08 WO PCT/US1989/000502 patent/WO1989007945A1/en active IP Right Grant
- 1989-02-08 AU AU31833/89A patent/AU626840B2/en not_active Ceased
- 1989-02-08 DE DE89902688T patent/DE68906153T2/de not_active Expired - Fee Related
- 1989-02-13 IE IE45289A patent/IE63208B1/en not_active IP Right Cessation
- 1989-02-14 IL IL8927689A patent/IL89276A/en unknown
- 1989-02-16 NZ NZ228012A patent/NZ228012A/en unknown
- 1989-02-23 CA CA000591933A patent/CA1336403C/en not_active Expired - Lifetime
- 1989-02-24 ES ES8900688A patent/ES2013394A6/es not_active Expired - Lifetime
- 1989-02-24 PT PT89835A patent/PT89835B/pt not_active IP Right Cessation
- 1989-02-25 CN CN89100947A patent/CN1052655C/zh not_active Expired - Fee Related
-
1993
- 1993-04-20 US US08/050,745 patent/US5451572A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 US US08/471,920 patent/US5945402A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IL89276A (en) | 1994-06-24 |
US5451572A (en) | 1995-09-19 |
PT89835A (pt) | 1989-10-04 |
US5945402A (en) | 1999-08-31 |
JP2815649B2 (ja) | 1998-10-27 |
AU3183389A (en) | 1989-09-22 |
NZ228012A (en) | 1991-07-26 |
IE63208B1 (en) | 1995-04-05 |
EP0407401B1 (de) | 1993-04-21 |
EP0407401A1 (de) | 1991-01-16 |
WO1989007945A1 (en) | 1989-09-08 |
AU626840B2 (en) | 1992-08-13 |
PT89835B (pt) | 1994-01-31 |
JPH03502794A (ja) | 1991-06-27 |
CN1035619A (zh) | 1989-09-20 |
CN1052655C (zh) | 2000-05-24 |
IE890452L (en) | 1989-08-26 |
DE68906153T2 (de) | 1993-10-28 |
CA1336403C (en) | 1995-07-25 |
ES2013394A6 (es) | 1990-05-01 |
DE68906153D1 (de) | 1993-05-27 |
IL89276A0 (en) | 1989-09-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |