ES2104605T3 - Composiciones estables de acido ascorbico. - Google Patents

Composiciones estables de acido ascorbico.

Info

Publication number
ES2104605T3
ES2104605T3 ES90906651T ES90906651T ES2104605T3 ES 2104605 T3 ES2104605 T3 ES 2104605T3 ES 90906651 T ES90906651 T ES 90906651T ES 90906651 T ES90906651 T ES 90906651T ES 2104605 T3 ES2104605 T3 ES 2104605T3
Authority
ES
Spain
Prior art keywords
ascorbic acid
stable compositions
stable
compositions
maintaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90906651T
Other languages
English (en)
Inventor
Douglas Darr
Sheldon R Pinnell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23329228&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2104605(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Duke University filed Critical Duke University
Application granted granted Critical
Publication of ES2104605T3 publication Critical patent/ES2104605T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/731—Cellulose; Quaternized cellulose derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/51—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE DESCRIBE UNA COMPOSICION TOPICA ESTABLE CONSISTE ESENCIALMENTE DE AL MENOS UN 1% EN PESO APROXIMADAMENTE DE ACIDO ASCORBICO-L, PREFERENTEMENTE DEL 3 AL 20% EN PESO DE ACIDO ASCORBICO-L, Y MAS PREFERENTEMENTE DEL 5 AL 10% EN PESO APROXIMADAMENTE DE ACIDO ASCORBICO-L EN AGUA Y UN PORTADOR PARA APLICACION TOPICA. TAL COMPOSICION APARECE PARA PERMITIR UNA RAPIDA PENETRACION EN LA PIEL Y RETRASA EL DAÑO CAUSADO POR LA LUZ ULTRAVIOLETA. NO SE ESPERA QUE NINGUNA COMPOSICION CONTENIENDO AL MENOS UN 1% EN PESO APROXIMADAMENTE DE ACIDO ASCORBICO-L TENGA EFECTOS BENEFICIOSOS, ESTANDO LA CONCENTRACION DE ACIDO ASCORBICO-L PRINCIPALMENTE LIMITADA POR SU SOLUBILIDAD EN EL SISTEMA PORTADOR DE AGUA. LA RAZON DE AGUA A PORTADOR ES AL MENOS DE 1:1, Y MAS PREFERIBLEMENTE DE 2:1 A 10:1, Y EL PH DE LA COMPOSICION NO ES MAS DE 3.0 A 3.5 PREFERIBLEMENTE NO MAYOR DE APROXIMADAMENTE 2.5.
ES90906651T 1989-04-17 1990-04-16 Composiciones estables de acido ascorbico. Expired - Lifetime ES2104605T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/339,488 US5140043A (en) 1989-04-17 1989-04-17 Stable ascorbic acid compositions

Publications (1)

Publication Number Publication Date
ES2104605T3 true ES2104605T3 (es) 1997-10-16

Family

ID=23329228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90906651T Expired - Lifetime ES2104605T3 (es) 1989-04-17 1990-04-16 Composiciones estables de acido ascorbico.

Country Status (11)

Country Link
US (1) US5140043A (es)
EP (1) EP0486499B1 (es)
JP (1) JP3708540B2 (es)
AT (1) ATE156355T1 (es)
AU (1) AU647699B2 (es)
CA (1) CA2054189C (es)
DE (1) DE69031219T2 (es)
DK (1) DK0486499T3 (es)
ES (1) ES2104605T3 (es)
HK (1) HK1001834A1 (es)
WO (1) WO1990012572A1 (es)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622690A (en) * 1990-04-05 1997-04-22 Nurture, Inc. Seed-derived proteinaceous compositions for reduction of sunburn cell formation
WO1992010999A1 (en) * 1990-12-06 1992-07-09 Leslie Binshyang Soong Substance that can stop bleeding in surgical, medical and dental uses/substance powder 001 that can stop bleeding during surgery, after surgery, medicine, dentistry or any bleeding due to any causes
US5308621A (en) * 1991-02-18 1994-05-03 Commonwealth Scientific And Industrial Research Organisation Ascorbic acid composition and transdermal administration method
US5523077A (en) * 1992-02-06 1996-06-04 Yale University Composition and method for whitening skin
ATE196599T1 (de) * 1993-01-19 2000-10-15 Nicholas V Dr Perricone Mittel zur topischen anwendung auf der haut zur behandlung und/oder zur verhütung von, durch strahlen verursachten hautschäden
US5516793A (en) * 1993-04-26 1996-05-14 Avon Products, Inc. Use of ascorbic acid to reduce irritation of topically applied active ingredients
US5759548A (en) * 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
US5935584A (en) * 1994-01-13 1999-08-10 Elizabeth Arden Company Vitamin C delivery system
US5455035A (en) * 1994-01-13 1995-10-03 Elizabeth Arden Company, Division Of Conopco, Inc. Clear two-phase cosmetic composition
FR2718018B1 (fr) * 1994-04-05 1996-04-26 Oreal Composition cosmétique et/ou dermatologique à support hydrophile et vitamine C mélangeables extemporanément.
US5470874A (en) * 1994-10-14 1995-11-28 Lerner; Sheldon Ascorbic acid and proanthocyanidine composition for topical application to human skin
EP0729746A1 (en) * 1995-02-28 1996-09-04 Unilever Plc Vitamin C delivery system
FR2737122B1 (fr) * 1995-07-25 1997-09-12 Oreal Composition stable contenant de l'acide ascorbique
FR2737116B1 (fr) * 1995-07-25 1997-08-22 Oreal Composition stable contenant un actif cosmetique et/ou dermatologique sensible a l'eau
US5843411A (en) * 1997-02-06 1998-12-01 Topix Pharmaceuticals Inc. Stabilization of ascorbic acid, ascorbic acid derivatives and/or extracts containing ascorbic acid for topical use
JPH09309833A (ja) * 1996-05-22 1997-12-02 Toyo Hakko:Kk 活性酸素抑制組成物及びその製造方法並びに血圧抑制剤
US5853741A (en) * 1996-06-28 1998-12-29 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Vitamin C delivery system
EP0938548B1 (en) 1996-11-06 2008-08-06 The Regents of the University of California Isolated tumor necrosis factor receptor releasing enzyme, compositions comprising the enzyme and methods of the use thereof
US20050191661A1 (en) * 1996-11-06 2005-09-01 Tetsuya Gatanaga Treatment of inflammatory disease by cleaving TNF receptors
US6593456B1 (en) * 1996-11-06 2003-07-15 The Regents Of The University Of California Tumor necrosis factor receptor releasing enzyme
US5877209A (en) * 1996-11-07 1999-03-02 Yunis; Adel A. Hair follicle protective formulations
SE9604610D0 (sv) * 1996-12-16 1996-12-16 Noviscens Ab Medical composition
US5906918A (en) * 1997-02-07 1999-05-25 Health Research Inc. Compositions and methods for measurement of oxidative DNA damage
US6495532B1 (en) * 1997-03-19 2002-12-17 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US6037481A (en) * 1997-08-08 2000-03-14 Industria E Comercio De Cosmeticos Natura Ltda Process for stabilizing levogyre ascorbic acid (LAA), a stable aqueous LAA composition, a process for preparing a stable topical solution, an emulsion, a vitamin product, and a method for cosmetic, pharmaceutical or nutritional treatment
US6197317B1 (en) 1997-08-11 2001-03-06 Marvin E. Klein Composition and method for the treatment of skin
US5981578A (en) * 1997-09-15 1999-11-09 Alexandrides; Ariadne Increased solubilization and stable cosmetic preparations of ascorbic acid
US6132737A (en) * 1997-09-29 2000-10-17 Revlon Consumer Products Corporation Method for reducing sunburn cell formation with cosmetic compositions containing ascorbic acid
US6685965B1 (en) 1997-10-22 2004-02-03 Industria E Comercio De Cosmeticos Natura Ltda. Process for stabilizing levogyre ascorbic acid (laa), a stable aqueous laa composition, a process for preparing a stable topical solution, an emulsion, a vitamin product, and a method for cosmetic, pharmaceutical or nutritional treatment
US6194452B1 (en) 1997-11-07 2001-02-27 Howard Murad Stable pharmaceutical compositions including ascorbic acid and methods of using same
US6036946A (en) 1997-12-24 2000-03-14 Shaklee Corporation Methods for protecting skin from damaging effects of ultraviolet light
US5980925A (en) * 1997-12-30 1999-11-09 Ethicon, Inc. High glycerin containing anti-microbial cleansers
US6110966A (en) * 1998-02-20 2000-08-29 Medi-Cell Laboratories, Inc. Triple action complex
US6809075B1 (en) 2000-05-30 2004-10-26 Connective Tissue Imagineering Llc Elastin peptide analogs and uses of same incombination with skin enhancing agents
US6962904B1 (en) * 1998-03-13 2005-11-08 Connective Tissue Imagineering Elastin peptide analogs and uses thereof
US6949528B1 (en) 1998-03-18 2005-09-27 Goddard John G Compositions containing lysophosphatidic acids which inhibit apoptosis and uses thereof
US6703030B2 (en) 1998-06-16 2004-03-09 Marvin E. Klein Amino fruit acid composition and method for the treatment of skin
US6146664A (en) * 1998-07-10 2000-11-14 Shaklee Corporation Stable topical ascorbic acid compositions
US6103267A (en) * 1998-07-27 2000-08-15 Sunsmart, Inc. Stabilized ascorbic acid, composition, and method of use
US6207694B1 (en) 1998-07-27 2001-03-27 Howard Murad Pharmaceutical compositions and methods for managing scalp conditions
US6299889B1 (en) 1998-09-10 2001-10-09 Avon Products, Inc. Stable ascorbic acid preparation for topical use
US6110477A (en) * 1998-10-30 2000-08-29 Topix Pharmaceuticals Inc. Stabilization of ascorbic acid, ascorbic acid derivatives and/or extracts containing ascorbic acid for topical use
US6777389B1 (en) 1998-11-19 2004-08-17 Connective Tissue Imagineering Llc Cosmetic or dermatological use of 7-hydroxylated steroids in combination with elastin derived peptides
KR100297347B1 (ko) * 1998-12-09 2001-08-07 이현순 안정화된l-아스코르빈산을함유하는유중수형에멀젼화장료조성물및그의제조방법
US7816402B2 (en) * 1999-03-19 2010-10-19 Bioderm, Inc. Compositions and methods for the treatment of skin
US6217914B1 (en) 1999-03-19 2001-04-17 Bioderm, Inc. Ascorbic acid composition and method for treatment of aging or damaged skin
US6087393A (en) * 1999-06-10 2000-07-11 Igen, Inc. Stabilized vitamin C formulations
BRPI0003166B1 (pt) * 1999-07-16 2015-08-25 Natura Cosmeticos Sa Processo para estabilização de compostos antioxidantes, e composições aquosas
US20060063738A1 (en) * 2000-02-28 2006-03-23 Sky High, Llc Compositions containing lysophosphotidic acids which inhibit apoptosis and uses thereof
US7101563B1 (en) 2000-03-03 2006-09-05 Australian Importers, Ltd. Micronized vitamin C formulation
EP1688130A1 (en) * 2000-03-03 2006-08-09 Australian Importers, Ltd. Micronized vitamin C formulation
US20050003023A1 (en) * 2002-06-28 2005-01-06 Meisner Lorraine Faxon Topical composition for the treatment of psoriasis and related skin disorders
US6440465B1 (en) 2000-05-01 2002-08-27 Bioderm, Inc. Topical composition for the treatment of psoriasis and related skin disorders
CN1189159C (zh) * 2000-05-05 2005-02-16 欧莱雅 含水溶性美容活性组分水性核的微胶囊及含其的组合物
US6794362B1 (en) * 2000-05-30 2004-09-21 Connective Tissue Imagineering Llc Asparagine containing elastin peptide analogs
CA2396927C (en) * 2000-09-08 2004-07-20 Vivier Pharma Inc. Stabilized ascorbic acid solutions; use thereof; process for their obtention; and formulations comprising the same
US6576248B1 (en) 2000-09-11 2003-06-10 Avon Products, Inc. Pigmented vitamin C composition
US6583184B1 (en) 2000-11-27 2003-06-24 Avon Products, Inc. Compositions having comfrey and methods for reducing retinoid-induced skin irritation
KR100836032B1 (ko) * 2002-03-26 2008-06-09 (주)아모레퍼시픽 Ｌ-아스코빌산 함유 다중공 고분자 마이크로캡슐, 이의제조방법 및 이를 함유하는 화장료 조성물
US7241808B2 (en) * 2002-05-01 2007-07-10 Marvin Klein Composition for treatment of skin and method for stabilizing the composition
US7482116B2 (en) * 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
KR100879133B1 (ko) 2002-12-23 2009-01-19 주식회사 엘지생활건강 비수유화 미백 화장료 조성물 및 그의 제조방법
DE602005014765D1 (de) * 2004-01-13 2009-07-16 Oreal Usa Creative Inc Verfahren dafür
US7566693B2 (en) * 2005-02-22 2009-07-28 Human Matrix Sciences, Llc Elastin protective polyphenolics and methods of using the same
US8114829B2 (en) * 2005-02-22 2012-02-14 Human Matrix Sciences, Llc Elastin protective polyphenolics and methods of using the same
EP1859039A4 (en) * 2005-03-16 2009-06-03 Dna Genotek Inc COMPOSITIONS AND METHOD FOR STORING NUCLEIC ACID FROM BODY FLUIDS
US8642578B2 (en) 2005-03-29 2014-02-04 Human Matrix Sciences, Llc Elastin protective polyphenolics and methods of using the same
EP1940816A2 (en) * 2005-09-30 2008-07-09 OMP, Inc. Stable ascorbic acid compositions
TWI428119B (zh) * 2005-12-09 2014-03-01 Dna Genotek Inc 用於可釋放儲存一物質之容器系統及使一物質與一生物樣本組合之方法
US20070178058A1 (en) * 2006-02-02 2007-08-02 Ramirez Jose E Methods of using stable ascorbic acid compositions
US20070269534A1 (en) * 2006-02-02 2007-11-22 Ramirez Jose E Methods of treating skin to enhance therapeutic treatment thereof
US20070225360A1 (en) * 2006-03-22 2007-09-27 L'oreal Anti-aging composition containing phloretin
US20080057138A1 (en) * 2006-09-06 2008-03-06 Telford Holdings Ltd. Restorative skin cream
US8415389B2 (en) * 2007-01-31 2013-04-09 John E. Kulesza Polyphenol-based composition, and methods and systems for its preparation
US8491212B2 (en) * 2008-03-17 2013-07-23 Laboratoire Naturel Paris, Llc Multi-functional applicator
US8881894B2 (en) * 2008-08-21 2014-11-11 Sonovia Holdings Llc Multiple-compartment applicator
US8034363B2 (en) * 2008-12-11 2011-10-11 Advanced Technologies And Regenerative Medicine, Llc. Sustained release systems of ascorbic acid phosphate
WO2011085013A2 (en) * 2010-01-05 2011-07-14 Kaplan David L Vitamin c composition for use in the prevention and treatment of stretch marks, radiation dermatitis, and other skin conditions and methods of using the same
JP2012054306A (ja) * 2010-08-31 2012-03-15 Tokyo Electron Ltd 半導体装置の製造方法
US9068694B2 (en) 2010-09-22 2015-06-30 Philip J. Gordon Consultants, Inc. Method of controlling by-products of vitamin C degradation and improving package integrity shelf life
EP3928715A1 (en) 2011-06-19 2021-12-29 DNA Genotek, Inc. Devices, solutions and methods for sample collection
JP5955625B2 (ja) * 2012-04-27 2016-07-20 御木本製薬株式会社 皮膚外用剤
CA2890177A1 (en) * 2012-11-08 2014-05-15 Summa Health System Vitamin c, vitamin k, a polyphenol, and combinations thereof for wound healing
CN114788791A (zh) 2017-06-23 2022-07-26 宝洁公司 用于改善皮肤外观的组合物和方法
TW201944991A (zh) * 2018-03-30 2019-12-01 日商樂敦製藥股份有限公司 含有抗壞血酸以及/或是其鹽的外用組成物、以及防止外用組成物之著色以及/或是結晶之析出之方法
CN112437657A (zh) 2018-07-03 2021-03-02 宝洁公司 处理皮肤状况的方法
WO2020032107A1 (ja) * 2018-08-09 2020-02-13 不二製油グループ本社株式会社 油脂組成物
WO2020067132A1 (ja) * 2018-09-25 2020-04-02 ロート製薬株式会社 アスコルビン酸及び／又はその塩を含有する外用組成物
DE102018008512A1 (de) 2018-10-27 2020-04-30 Ilma biochem GmbH Herstellung, Zusammensetzung und Anwendung von Zubereitungen in einer Zweikammer-Auftragungsvorrichtung zur Neutralisierung und Inaktivierung von oxidierenden, ätzenden und reizenden Chemikalien auf der Haut
FR3090330B1 (fr) 2018-12-20 2020-12-04 Oreal Composition aqueuse comprenant des capsules à base d’huile gélifiée contenant un actif sensible à l’oxygène
US20220313588A1 (en) * 2019-09-11 2022-10-06 Amorepacific Corporation Additive composition for preventing vitamin c precipitation
FR3105735B1 (fr) 2019-12-26 2023-07-07 Oreal Composition comprenant de l’acide ascorbique
CA3177393A1 (en) 2020-04-16 2021-10-21 Baek Clinical Inc. High-potency vitamin c and sugar alcohol topical formulations
US10959933B1 (en) 2020-06-01 2021-03-30 The Procter & Gamble Company Low pH skin care composition and methods of using the same
EP4157206A1 (en) 2020-06-01 2023-04-05 The Procter & Gamble Company Method of improving penetration of a vitamin b3 compound into skin
FR3118874B1 (fr) 2021-01-21 2024-01-12 Oreal Composition cosmétique de séquestration des métaux
KR20230110554A (ko) 2020-12-17 2023-07-24 로레알 활성 함량이 높은 하이드로글리콜 화장료 조성물
FR3121357B1 (fr) 2021-03-31 2024-05-03 Oreal Composition cosmetique hydroglycolique avec une teneur elevee en principes actifs
WO2022130292A1 (en) 2020-12-17 2022-06-23 L'oreal Metal sequestering cosmetic composition
FR3117803B1 (fr) 2020-12-18 2022-12-09 Oreal Composition comprenant des gélifiants aqueux, un tensioactif et de l’acide ascorbique
FR3117847B1 (fr) 2020-12-18 2023-11-24 Oreal Composition comprenant des gélifiants aqueux, des tensioactifs et de l’acide ascorbique
WO2022149055A1 (en) 2021-01-05 2022-07-14 L'oreal Organic uva filter-stabilized antioxidant composition
FR3121043B1 (fr) 2021-03-29 2024-03-08 Oreal Composition antioxydante stabilisee par un filtre uva organique
FR3130603B1 (fr) * 2021-12-20 2024-10-04 Loreal Composition cosmétique aqueuse avec acide ascorbique et urée

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2161651A (en) * 1934-12-27 1939-06-06 Elliott J Roberts Manufacture of finely divided precipitates
US2249903A (en) * 1935-01-26 1941-07-22 Winthrop Chem Co Inc Stable aqueous solution of ascorbic acid
US2400171A (en) * 1935-09-26 1946-05-14 Frances R Ruskin Stabilized metal ascorbates
US2134246A (en) * 1936-07-09 1938-10-25 Hoffmann La Roche Stable solutions of ascorbic acid salts of histidine and process for the manufacture of same
US2140989A (en) * 1936-07-30 1938-12-20 Winthrop Chem Co Inc Molecular compounds and a process of preparing them
US2132662A (en) * 1937-04-08 1938-10-11 Abbott Lab Aliphatic amine salts of cevitamic acid
US2150140A (en) * 1937-04-24 1939-03-07 Hoffmann La Roche Derivatives of ascorbic acid having an antiscorbutic action and process for the manufacture of same
US2297212A (en) * 1938-02-10 1942-09-29 Gockel Heinrich Stable vitamin c and process for preparing the same
US2294937A (en) * 1938-02-26 1942-09-08 Simon L Ruskin Cevitamate compound
US2165184A (en) * 1938-08-31 1939-07-04 Pfizer Charles & Co Process for producing ascorbic acid
US2187467A (en) * 1939-02-11 1940-01-16 Lilly Co Eli Cevitamate solution
US2442461A (en) * 1944-03-09 1948-06-01 Hoffmann La Roche Stable solutions of calcium ascorbate
US2585580A (en) * 1947-06-12 1952-02-12 Opplt Jan Stabilizing ascorbic acid with thio-sugars
US2721161A (en) * 1951-10-23 1955-10-18 American Home Prod Ascorbic acid preparation
US4294852A (en) * 1973-11-01 1981-10-13 Johnson & Johnson Skin treating compositions
US4372874A (en) * 1976-09-13 1983-02-08 Modrovich Ivan Endre Stabilization of hydrolysis prone labile organic reagents in liquid media
US4199469A (en) * 1978-06-21 1980-04-22 Feldmann Chemie Composition and method for cleaning drinking water tanks
US4367157A (en) * 1979-05-10 1983-01-04 Sherman Laboratories, Inc. Soft contact lens ambient temperature disinfectant solution containing ascorbic acid or salt thereof
US4414202A (en) * 1980-02-19 1983-11-08 Silvetti Anthony N Composition for treatment of wounds
US4722936A (en) * 1983-05-05 1988-02-02 Joseph Jacob Deodorization vaginal products and catamenials
US4818521A (en) * 1985-04-18 1989-04-04 Sunstar Kabushiki Kaisha Emulsion cosmetic stably containing vitamin C
US4983382A (en) * 1987-01-27 1991-01-08 Avon Products, Inc. Cosmetic preparation incorporating stabilized ascorbic acid
NZ219636A (en) * 1987-03-16 1989-06-28 Donald Sinclair Hamilton Cream containing powdered ascorbate
US4847071A (en) * 1987-10-22 1989-07-11 The Procter & Gamble Company Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent
US4954332A (en) * 1987-10-22 1990-09-04 The Procter & Gamble Company Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent
US4946671A (en) * 1987-10-22 1990-08-07 The Procter & Gamble Company Photoprotection compositions comprising sorbohydroxamic acid and an anti-inflammatory agent
US4938969A (en) * 1988-11-14 1990-07-03 Milor Scientific, Ltd. Method for the treatment of aging or photo-damaged skin
JPH06337087A (ja) * 1993-05-27 1994-12-06 Takasago Thermal Eng Co Ltd 分岐管取付方法及びボンネットの取付方法

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DE69031219D1 (de) 1997-09-11
EP0486499A1 (en) 1992-05-27
CA2054189A1 (en) 1990-10-18
DE69031219T2 (de) 1998-01-22
ATE156355T1 (de) 1997-08-15
WO1990012572A1 (en) 1990-11-01
US5140043A (en) 1992-08-18
EP0486499A4 (en) 1993-06-16
JPH04507089A (ja) 1992-12-10
JP3708540B2 (ja) 2005-10-19
AU5523990A (en) 1990-11-16
DK0486499T3 (da) 1998-03-16
EP0486499B1 (en) 1997-08-06
HK1001834A1 (en) 1998-07-10
CA2054189C (en) 2000-11-21
AU647699B2 (en) 1994-03-24

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