NO972522L - Monoklonale antistoffer med immunoundertrykkende aktivitet - Google Patents
Monoklonale antistoffer med immunoundertrykkende aktivitetInfo
- Publication number
- NO972522L NO972522L NO972522A NO972522A NO972522L NO 972522 L NO972522 L NO 972522L NO 972522 A NO972522 A NO 972522A NO 972522 A NO972522 A NO 972522A NO 972522 L NO972522 L NO 972522L
- Authority
- NO
- Norway
- Prior art keywords
- fragments
- mab
- monoclonal antibodies
- fab
- immunosuppressive activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Oppfinnelsen omfatter enverdige mAb-fragmenter (Fab) av mAb, som har evnen til å nedregulere HLA-DR-ekspresjonen på antigenpresenterende celler. Fab-frag- mentene kan nedregulere denne HLA-DR-ekspreejon uten å utøve cytotoksisiteten som observeres hos stam- mAb'et eller av de toverdige fragmenter (F(ab)'2) av det monoklonale antistoff. Fab-fragmentene ifølge oppfinnelsen er derfor sterke MHC-klasse Il-spesifik- ke immunosuppressive forbindelser uten cytotoksiske bivirkninger.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35091594A | 1994-12-07 | 1994-12-07 | |
PCT/EP1995/004648 WO1996017874A1 (en) | 1994-12-07 | 1995-11-25 | Monoclonal antibody fragments having immunosuppressant activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO972522D0 NO972522D0 (no) | 1997-06-03 |
NO972522L true NO972522L (no) | 1997-08-06 |
Family
ID=23378740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972522A NO972522L (no) | 1994-12-07 | 1997-06-03 | Monoklonale antistoffer med immunoundertrykkende aktivitet |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0787151A1 (no) |
JP (1) | JP2001506122A (no) |
CN (1) | CN1168679A (no) |
AR (1) | AR002005A1 (no) |
AU (1) | AU4256096A (no) |
BR (1) | BR9509902A (no) |
CA (1) | CA2206471A1 (no) |
CO (1) | CO4480041A1 (no) |
CZ (1) | CZ172497A3 (no) |
FI (1) | FI972430A0 (no) |
HU (1) | HUT77342A (no) |
IL (1) | IL116228A0 (no) |
MA (1) | MA23739A1 (no) |
NO (1) | NO972522L (no) |
PE (1) | PE52996A1 (no) |
PL (1) | PL320610A1 (no) |
TR (1) | TR199501542A2 (no) |
WO (1) | WO1996017874A1 (no) |
ZA (1) | ZA9510195B (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0893507A1 (en) * | 1997-07-25 | 1999-01-27 | Institut Gustave Roussy | Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment |
AU5588099A (en) * | 1998-08-28 | 2000-03-21 | Dendreon Corporation | Selective apoptosis of neoplastic cells by an hla-dr specific monoclonal antibody |
EP1156062A1 (en) * | 2000-05-12 | 2001-11-21 | GPC Biotech AG | Immunomodulatory human MHC class II antigen-binding peptides/proteins |
DE60035337T2 (de) * | 2000-05-12 | 2008-02-28 | Gpc Biotech Ag | Humane Peptide/Proteine, die das Töten von Zellen, einschliesslich lymphoider Tumorzellen, herbeiführen oder bewirken |
US7521047B2 (en) | 2000-05-12 | 2009-04-21 | Gpc Biotech Ag | Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells |
WO2003030831A2 (en) | 2001-10-11 | 2003-04-17 | Protein Design Labs, Inc. | Treatment of prostate cancer by inhibitors of atp synthase |
CN1571797A (zh) | 2001-10-15 | 2005-01-26 | 麒麟麦酒株式会社 | 抗hla-dr抗体 |
WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
EP2552483A4 (en) * | 2010-04-01 | 2013-09-25 | Immunomedics Inc | USE OF ANTIBODIES TO REDUCE THE NUMBER OF CELLS CONTAINING ANTIGENS AND DENDRITIC CELLS |
KR102647825B1 (ko) * | 2021-07-22 | 2024-03-14 | 서울대학교산학협력단 | 항-hla-dp 단클론 항체 및 이의 용도 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0068790B1 (en) * | 1981-06-25 | 1986-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Allele specific immunotherapeutic method and dosage form |
DE69028713T3 (de) * | 1989-12-27 | 2004-05-13 | Centocor, Inc. | Schimäre immunoglobuline für cd4-rezeptoren |
DK1266965T3 (da) * | 1991-07-25 | 2006-09-25 | Biogen Idec Inc | Rekombinante antistoffer til human terapi |
-
1995
- 1995-11-25 JP JP51728896A patent/JP2001506122A/ja active Pending
- 1995-11-25 AU AU42560/96A patent/AU4256096A/en not_active Abandoned
- 1995-11-25 CA CA002206471A patent/CA2206471A1/en not_active Abandoned
- 1995-11-25 HU HU9702311A patent/HUT77342A/hu unknown
- 1995-11-25 WO PCT/EP1995/004648 patent/WO1996017874A1/en not_active Application Discontinuation
- 1995-11-25 EP EP95941017A patent/EP0787151A1/en not_active Withdrawn
- 1995-11-25 CZ CZ971724A patent/CZ172497A3/cs unknown
- 1995-11-25 CN CN95196662A patent/CN1168679A/zh active Pending
- 1995-11-25 PL PL95320610A patent/PL320610A1/xx unknown
- 1995-11-25 BR BR9509902A patent/BR9509902A/pt not_active Application Discontinuation
- 1995-11-30 ZA ZA9510195A patent/ZA9510195B/xx unknown
- 1995-12-01 IL IL11622895A patent/IL116228A0/xx unknown
- 1995-12-04 PE PE1995286338A patent/PE52996A1/es not_active Application Discontinuation
- 1995-12-05 AR ARP950100448A patent/AR002005A1/es unknown
- 1995-12-05 CO CO95057748A patent/CO4480041A1/es unknown
- 1995-12-07 MA MA24090A patent/MA23739A1/fr unknown
- 1995-12-07 TR TR95/01542A patent/TR199501542A2/xx unknown
-
1997
- 1997-06-03 NO NO972522A patent/NO972522L/no unknown
- 1997-06-06 FI FI972430A patent/FI972430A0/fi unknown
Also Published As
Publication number | Publication date |
---|---|
MA23739A1 (fr) | 1996-07-01 |
HUT77342A (hu) | 1998-03-30 |
BR9509902A (pt) | 1997-10-21 |
TR199501542A2 (tr) | 1996-07-21 |
EP0787151A1 (en) | 1997-08-06 |
MX9704225A (es) | 1997-09-30 |
WO1996017874A1 (en) | 1996-06-13 |
NO972522D0 (no) | 1997-06-03 |
CO4480041A1 (es) | 1997-07-09 |
JP2001506122A (ja) | 2001-05-15 |
CN1168679A (zh) | 1997-12-24 |
AR002005A1 (es) | 1998-01-07 |
FI972430A (fi) | 1997-06-06 |
CA2206471A1 (en) | 1996-06-13 |
CZ172497A3 (en) | 1997-10-15 |
ZA9510195B (en) | 1996-06-07 |
AU4256096A (en) | 1996-06-26 |
PE52996A1 (es) | 1996-12-12 |
IL116228A0 (en) | 1996-03-31 |
FI972430A0 (fi) | 1997-06-06 |
PL320610A1 (en) | 1997-10-13 |
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