NO972522L - Monoclonal antibodies with immunosuppressive activity - Google Patents
Monoclonal antibodies with immunosuppressive activityInfo
- Publication number
- NO972522L NO972522L NO972522A NO972522A NO972522L NO 972522 L NO972522 L NO 972522L NO 972522 A NO972522 A NO 972522A NO 972522 A NO972522 A NO 972522A NO 972522 L NO972522 L NO 972522L
- Authority
- NO
- Norway
- Prior art keywords
- fragments
- mab
- monoclonal antibodies
- fab
- immunosuppressive activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Oppfinnelsen omfatter enverdige mAb-fragmenter (Fab) av mAb, som har evnen til å nedregulere HLA-DR-ekspresjonen på antigenpresenterende celler. Fab-frag- mentene kan nedregulere denne HLA-DR-ekspreejon uten å utøve cytotoksisiteten som observeres hos stam- mAb'et eller av de toverdige fragmenter (F(ab)'2) av det monoklonale antistoff. Fab-fragmentene ifølge oppfinnelsen er derfor sterke MHC-klasse Il-spesifik- ke immunosuppressive forbindelser uten cytotoksiske bivirkninger.The invention comprises monovalent mAb fragments (Fab) of mAb, which have the ability to down-regulate HLA-DR expression on antigen presenting cells. The Fab fragments can down-regulate this HLA-DR expression without exerting the cytotoxicity observed in the stem mAb or of the bivalent fragments (F (ab) '2) of the monoclonal antibody. The Fab fragments of the invention are therefore strong MHC class II specific immunosuppressive compounds without cytotoxic side effects.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35091594A | 1994-12-07 | 1994-12-07 | |
PCT/EP1995/004648 WO1996017874A1 (en) | 1994-12-07 | 1995-11-25 | Monoclonal antibody fragments having immunosuppressant activity |
Publications (2)
Publication Number | Publication Date |
---|---|
NO972522D0 NO972522D0 (en) | 1997-06-03 |
NO972522L true NO972522L (en) | 1997-08-06 |
Family
ID=23378740
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO972522A NO972522L (en) | 1994-12-07 | 1997-06-03 | Monoclonal antibodies with immunosuppressive activity |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0787151A1 (en) |
JP (1) | JP2001506122A (en) |
CN (1) | CN1168679A (en) |
AR (1) | AR002005A1 (en) |
AU (1) | AU4256096A (en) |
BR (1) | BR9509902A (en) |
CA (1) | CA2206471A1 (en) |
CO (1) | CO4480041A1 (en) |
CZ (1) | CZ172497A3 (en) |
FI (1) | FI972430A0 (en) |
HU (1) | HUT77342A (en) |
IL (1) | IL116228A0 (en) |
MA (1) | MA23739A1 (en) |
NO (1) | NO972522L (en) |
PE (1) | PE52996A1 (en) |
PL (1) | PL320610A1 (en) |
TR (1) | TR199501542A2 (en) |
WO (1) | WO1996017874A1 (en) |
ZA (1) | ZA9510195B (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0893507A1 (en) * | 1997-07-25 | 1999-01-27 | Institut Gustave Roussy | Use of MHC class II ligands (CD4 and LAG-3) as adjuvant for vaccination and of LAG-3 in cancer treatment |
AU5588099A (en) | 1998-08-28 | 2000-03-21 | Dendreon Corporation | Selective apoptosis of neoplastic cells by an hla-dr specific monoclonal antibody |
EP1156060B1 (en) * | 2000-05-12 | 2007-06-27 | GPC Biotech AG | Human peptides/proteins causing or leading to the killing of cells including lymphoid tumor cells |
US7521047B2 (en) | 2000-05-12 | 2009-04-21 | Gpc Biotech Ag | Human polypeptides causing or leading to the killing of cells including lymphoid tumor cells |
EP1156062A1 (en) * | 2000-05-12 | 2001-11-21 | GPC Biotech AG | Immunomodulatory human MHC class II antigen-binding peptides/proteins |
US20030086929A1 (en) | 2001-10-11 | 2003-05-08 | Tso J. Yun | Treatment of prostate cancer by inhibitors of ATP synthase |
JP3665324B2 (en) | 2001-10-15 | 2005-06-29 | 麒麟麦酒株式会社 | Anti-HLA-DR antibody |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
AU2011235328A1 (en) * | 2010-04-01 | 2012-09-27 | Immunomedics, Inc. | Antibody-based depletion of antigen-presenting cells and dendritic cells |
KR102647825B1 (en) * | 2021-07-22 | 2024-03-14 | 서울대학교산학협력단 | Anti-HLA-DP monoclonal antibody and use thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0068790B1 (en) * | 1981-06-25 | 1986-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Allele specific immunotherapeutic method and dosage form |
ATE143377T1 (en) * | 1989-12-27 | 1996-10-15 | Centocor Inc | CHIMERIC IMMUNOGLOBULINS FOR CD4 RECEPTORS |
EP1266965B1 (en) * | 1991-07-25 | 2006-05-24 | Biogen Idec Inc. | Recombinant antibodies for human therapy |
-
1995
- 1995-11-25 JP JP51728896A patent/JP2001506122A/en active Pending
- 1995-11-25 CZ CZ971724A patent/CZ172497A3/en unknown
- 1995-11-25 HU HU9702311A patent/HUT77342A/en unknown
- 1995-11-25 CA CA002206471A patent/CA2206471A1/en not_active Abandoned
- 1995-11-25 CN CN95196662A patent/CN1168679A/en active Pending
- 1995-11-25 WO PCT/EP1995/004648 patent/WO1996017874A1/en not_active Application Discontinuation
- 1995-11-25 AU AU42560/96A patent/AU4256096A/en not_active Abandoned
- 1995-11-25 EP EP95941017A patent/EP0787151A1/en not_active Withdrawn
- 1995-11-25 BR BR9509902A patent/BR9509902A/en not_active Application Discontinuation
- 1995-11-25 PL PL95320610A patent/PL320610A1/en unknown
- 1995-11-30 ZA ZA9510195A patent/ZA9510195B/en unknown
- 1995-12-01 IL IL11622895A patent/IL116228A0/en unknown
- 1995-12-04 PE PE1995286338A patent/PE52996A1/en not_active Application Discontinuation
- 1995-12-05 AR ARP950100448A patent/AR002005A1/en unknown
- 1995-12-05 CO CO95057748A patent/CO4480041A1/en unknown
- 1995-12-07 TR TR95/01542A patent/TR199501542A2/en unknown
- 1995-12-07 MA MA24090A patent/MA23739A1/en unknown
-
1997
- 1997-06-03 NO NO972522A patent/NO972522L/en unknown
- 1997-06-06 FI FI972430A patent/FI972430A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR002005A1 (en) | 1998-01-07 |
ZA9510195B (en) | 1996-06-07 |
CN1168679A (en) | 1997-12-24 |
EP0787151A1 (en) | 1997-08-06 |
CA2206471A1 (en) | 1996-06-13 |
BR9509902A (en) | 1997-10-21 |
NO972522D0 (en) | 1997-06-03 |
TR199501542A2 (en) | 1996-07-21 |
CZ172497A3 (en) | 1997-10-15 |
FI972430A (en) | 1997-06-06 |
MX9704225A (en) | 1997-09-30 |
PE52996A1 (en) | 1996-12-12 |
AU4256096A (en) | 1996-06-26 |
FI972430A0 (en) | 1997-06-06 |
WO1996017874A1 (en) | 1996-06-13 |
IL116228A0 (en) | 1996-03-31 |
HUT77342A (en) | 1998-03-30 |
PL320610A1 (en) | 1997-10-13 |
MA23739A1 (en) | 1996-07-01 |
JP2001506122A (en) | 2001-05-15 |
CO4480041A1 (en) | 1997-07-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69429095T2 (en) | HUMANIZED ANTIBODIES | |
WO1998057994A3 (en) | Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria | |
GR3036906T3 (en) | Monoclonal antibody which specifically binds to tumor vascular endothelium and uses thereof. | |
ATE263189T1 (en) | ANTIBODIES TO HUMAN PROSTATE-SPECIFIC GLAND KALLIKREIN | |
BR9713521A (en) | ||
EP0677533A3 (en) | Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof | |
CA2093667A1 (en) | Mouse monoclonal antibodies and uses thereof | |
AU628948B2 (en) | Monoclonal antibodies (mabs) against tumor-associated antigens, the preparation and use thereof | |
DK0969873T3 (en) | Multiple carbohydrate-containing glycopeptide antigens, vaccine containing them, and use thereof | |
NO972522L (en) | Monoclonal antibodies with immunosuppressive activity | |
DK0845998T3 (en) | Immunotherapy drugs containing antibodies that specifically recognize the MHCII antigen in a patient to be treated | |
ES2127531T3 (en) | MEDICATION FOR PROLONGED IMMUNOSUPPRESSION AND ELIMINATION OF TUMOR CELLS. | |
CA2036814A1 (en) | Monoclonal antibodies against tumor-associated antigens, a process for the preparation thereof and the use thereof | |
ES2119992T3 (en) | SPECIFIC ANTIBODIES OF 6-O-METHYLGUANIN-DNA-METHYL TRANSFERASE (MGMT). | |
FI20095269A (en) | Human endothelial cell molecule affecting the binding of lymphocytes | |
PL314414A1 (en) | Antiidiotypic antibodies capable to induce an immunological response in respect to the receptor of epidermis growth factor | |
NO962827L (en) | Monoclonal antibodies to antigens expressed by hematopoietic facilitatory cells | |
BR9702101A (en) | Hybridoma and monoclonal antibody | |
AU1626492A (en) | Monoclonal antibodies against the plasmin-antiplasmin complex, a method for the preparation thereof and the use thereof | |
ECSP951605A (en) | FRAGMENTS OF MONOCLONAL ANTIBODIES THAT HAVE IMMUNOSUPPRESSIVE ACTIVITY, CASE RAN 4105/171 | |
EP0450573A3 (en) | Antibodies for the treatment and diagnosis of pseudomonas aeruginosa infections | |
刘亚霞 et al. | ISOLATION AND STUDY OF THE CD2 ANTIGEN PURIFIED BY AFFINITY CHROMATOGRAPHY WITH OKT11-LIKE MAB | |
CA2165672A1 (en) | Antibodies specific for human prostate glandular kallikrein | |
ES2088820A1 (en) | Antipneumolysin monoclonal antibodies | |
HUP0003029A2 (en) | Ancrod specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and use of the same |