HUP0003029A2 - Ancrod specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and use of the same - Google Patents

Ancrod specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and use of the same

Info

Publication number
HUP0003029A2
HUP0003029A2 HU0003029A HUP0003029A HUP0003029A2 HU P0003029 A2 HUP0003029 A2 HU P0003029A2 HU 0003029 A HU0003029 A HU 0003029A HU P0003029 A HUP0003029 A HU P0003029A HU P0003029 A2 HUP0003029 A2 HU P0003029A2
Authority
HU
Hungary
Prior art keywords
ancrod
derivatives
monoclonal antibodies
mixtures
same
Prior art date
Application number
HU0003029A
Other languages
Hungarian (hu)
Inventor
Wilfried Hornberger
Thomas Subkowski
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19729544A external-priority patent/DE19729544A1/en
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of HUP0003029A2 publication Critical patent/HUP0003029A2/en
Publication of HUP0003029A3 publication Critical patent/HUP0003029A3/en
Publication of HU225784B1 publication Critical patent/HU225784B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)

Abstract

Monoclonal antibodies (mAb), their fragments and/or derivatives are capable of binding and inhibiting the activity of ancrod. mAb have a binding affinity of 1X10-7-1X10-12 and they have an improved binding and neutralising effect of 100% compared to polyclonal goat-derived antibodies.
HU0003029A 1997-07-10 1998-06-23 Ancrod specific monoclonal antibodies, antibody fragments and mixtures thereof, pharmaceutical preparations containing them and use of the same HU225784B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19729544A DE19729544A1 (en) 1997-07-10 1997-07-10 Ancrod specific monoclonal antibodies, antibody fragments, their mixture or derivatives and their use
PCT/EP1998/003834 WO1999002564A2 (en) 1997-07-10 1998-06-23 Ancrod specific monoclonal antibodies, antibody fragments, mixtures or derivatives thereof and use of the same

Publications (3)

Publication Number Publication Date
HUP0003029A2 true HUP0003029A2 (en) 2000-12-28
HUP0003029A3 HUP0003029A3 (en) 2003-01-28
HU225784B1 HU225784B1 (en) 2007-09-28

Family

ID=38527893

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003029A HU225784B1 (en) 1997-07-10 1998-06-23 Ancrod specific monoclonal antibodies, antibody fragments and mixtures thereof, pharmaceutical preparations containing them and use of the same

Country Status (1)

Country Link
HU (1) HU225784B1 (en)

Also Published As

Publication number Publication date
HU225784B1 (en) 2007-09-28
HUP0003029A3 (en) 2003-01-28

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Legal Events

Date Code Title Description
TH4A Erratum
MM4A Lapse of definitive patent protection due to non-payment of fees