DE3026398A1 - Modifiziertes haemoglobin enthaltender blutersatz - Google Patents

Modifiziertes haemoglobin enthaltender blutersatz

Info

Publication number
DE3026398A1
DE3026398A1 DE19803026398 DE3026398A DE3026398A1 DE 3026398 A1 DE3026398 A1 DE 3026398A1 DE 19803026398 DE19803026398 DE 19803026398 DE 3026398 A DE3026398 A DE 3026398A DE 3026398 A1 DE3026398 A1 DE 3026398A1
Authority
DE
Germany
Prior art keywords
hemoglobin
polyethylene glycol
modified
carbon atoms
glycol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19803026398
Other languages
German (de)
English (en)
Other versions
DE3026398C2 (enExample
Inventor
Katsumi Yokohama Kanagawa Ajisaka
Yuji Kawasaki Kanagawa Iwashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of DE3026398A1 publication Critical patent/DE3026398A1/de
Application granted granted Critical
Publication of DE3026398C2 publication Critical patent/DE3026398C2/de
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
DE19803026398 1979-07-11 1980-07-11 Modifiziertes haemoglobin enthaltender blutersatz Granted DE3026398A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54087910A JPS6023084B2 (ja) 1979-07-11 1979-07-11 代用血液

Publications (2)

Publication Number Publication Date
DE3026398A1 true DE3026398A1 (de) 1981-03-26
DE3026398C2 DE3026398C2 (enExample) 1990-09-13

Family

ID=13928063

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19803026398 Granted DE3026398A1 (de) 1979-07-11 1980-07-11 Modifiziertes haemoglobin enthaltender blutersatz

Country Status (6)

Country Link
US (1) US4301144A (enExample)
JP (1) JPS6023084B2 (enExample)
CA (1) CA1146858A (enExample)
DE (1) DE3026398A1 (enExample)
FR (1) FR2460674A1 (enExample)
GB (1) GB2055868B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002000768A1 (de) 2000-06-29 2002-01-03 Sanguibio Tech Ag Mit blutplasma verträgliche, vernetzte und mit polyalkylenoxiden konjugierte säugetierhämoglobine als künstliche medizinische sauerstoffträger, ihre herstellung und ihre verwendung
US7005414B2 (en) 2000-06-29 2006-02-28 Sanguibiotech Gmbh Synthetic oxygen transport made from cross-linked modified human or porcine haemoglobin with improved properties, method for a preparation thereof from purified material and use thereof
US9493616B2 (en) 2010-02-25 2016-11-15 Sangart, Inc. Methods for preparing PEG-hemoglobin conjugates using reduced reactant ratios

Families Citing this family (901)

* Cited by examiner, † Cited by third party
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JPS59104323A (ja) * 1982-12-07 1984-06-16 Ajinomoto Co Inc 代用血液
DE3340592A1 (de) * 1983-11-10 1985-05-23 B. Braun Melsungen Ag, 3508 Melsungen Konjugate makromolekularer verbindungen an haemoglobine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
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USRE34271E (en) * 1984-06-27 1993-06-01 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
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US4301144A (en) 1981-11-17
CA1146858A (en) 1983-05-24
FR2460674A1 (fr) 1981-01-30
FR2460674B1 (enExample) 1983-06-24
GB2055868A (en) 1981-03-11

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