EA201691327A1 - Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она - Google Patents
Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-онаInfo
- Publication number
- EA201691327A1 EA201691327A1 EA201691327A EA201691327A EA201691327A1 EA 201691327 A1 EA201691327 A1 EA 201691327A1 EA 201691327 A EA201691327 A EA 201691327A EA 201691327 A EA201691327 A EA 201691327A EA 201691327 A1 EA201691327 A1 EA 201691327A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- purin
- propyl
- ftor
- chinazolin
- ilamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
В изобретении предложены полиморфы (S)-2-(1-(9Н-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3H)-она, содержащие их композиции, способы их получения и способы их применения.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261606870P | 2012-03-05 | 2012-03-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201691327A1 true EA201691327A1 (ru) | 2017-03-31 |
Family
ID=49117265
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491473A EA025407B1 (ru) | 2012-03-05 | 2013-03-05 | Полиморфная форма i (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она |
EA201691327A EA201691327A1 (ru) | 2012-03-05 | 2013-03-05 | Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она |
EA201690461A EA201690461A1 (ru) | 2012-03-05 | 2013-03-05 | Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491473A EA025407B1 (ru) | 2012-03-05 | 2013-03-05 | Полиморфная форма i (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690461A EA201690461A1 (ru) | 2012-03-05 | 2013-03-05 | Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она |
Country Status (32)
Country | Link |
---|---|
US (3) | US8865730B2 (ru) |
EP (1) | EP2834241B1 (ru) |
JP (2) | JP2015509537A (ru) |
KR (1) | KR20140133590A (ru) |
CN (2) | CN104334560A (ru) |
AP (1) | AP2014007875A0 (ru) |
AR (1) | AR090253A1 (ru) |
AU (1) | AU2013203620B2 (ru) |
BR (1) | BR112014021935A2 (ru) |
CA (1) | CA2864305C (ru) |
CL (1) | CL2014002358A1 (ru) |
CO (1) | CO7071131A2 (ru) |
CR (1) | CR20140460A (ru) |
EA (3) | EA025407B1 (ru) |
EC (1) | ECSP14020478A (ru) |
ES (1) | ES2848273T3 (ru) |
HK (1) | HK1206345A1 (ru) |
IN (1) | IN2014DN07105A (ru) |
MA (1) | MA37379A1 (ru) |
MD (1) | MD20140100A2 (ru) |
MX (1) | MX2014010656A (ru) |
NZ (1) | NZ629684A (ru) |
PE (1) | PE20141792A1 (ru) |
PH (1) | PH12014501920A1 (ru) |
PL (1) | PL2834241T3 (ru) |
PT (1) | PT2834241T (ru) |
SG (1) | SG11201405446PA (ru) |
SI (1) | SI2834241T1 (ru) |
TW (1) | TW201350486A (ru) |
UY (1) | UY34656A (ru) |
WO (1) | WO2013134288A1 (ru) |
ZA (1) | ZA201405870B (ru) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
HUE030950T2 (en) | 2004-05-13 | 2017-06-28 | Icos Corp | Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol |
PE20141792A1 (es) | 2012-03-05 | 2014-12-07 | Gilead Calistoga Llc | Formas polimorficas de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluor-3-fenilquinazolin-4(3h)-ona |
EA035391B1 (ru) | 2012-11-08 | 2020-06-05 | Ризен Фармасьютикалз Са | Фармацевтические композиции, содержащие ингибитор pde4 и ингибитор pi3-дельта или двойной ингибитор pi3-дельта-гамма киназы |
WO2015014315A1 (zh) * | 2013-08-01 | 2015-02-05 | 杭州普晒医药科技有限公司 | 一种抑制剂的晶型及其制备方法和用途 |
WO2015061204A1 (en) * | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
IN2013MU03641A (ru) | 2013-11-20 | 2015-07-31 | Cadila Healthcare Ltd | |
EP3083623A1 (en) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
CA2934531C (en) | 2013-12-20 | 2020-02-25 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
EP2979692A1 (en) | 2014-07-30 | 2016-02-03 | Sandoz Ag | Dosage form comprising a pressure sensitive solid form of an active pharmaceutical ingredient |
EP3031808B1 (en) * | 2014-12-09 | 2018-06-27 | ratiopharm GmbH | Salt of idelalisib |
EP3048104A1 (en) | 2015-01-20 | 2016-07-27 | Sandoz AG | Amorphous and crystalline forms of idelalisib and process for forming the same |
WO2016097314A1 (en) * | 2014-12-19 | 2016-06-23 | Sandoz Ag | Amorphous and crystalline forms of idelalisib and process for forming the same |
US20180064714A1 (en) * | 2015-03-13 | 2018-03-08 | Mylan Laboratories Ltd | Process for the Preparation of Amorphous Idelalisib and its Premix |
CN106146500A (zh) * | 2015-03-26 | 2016-11-23 | 江苏豪森药业集团有限公司 | 5-氟-3-苯基-2-[(1s)-1-(9h-嘌呤-6-基氨基)丙基]-4(3h)-喹唑啉酮晶型及其制备方法 |
CN106146501A (zh) * | 2015-03-26 | 2016-11-23 | 江苏豪森药业集团有限公司 | 一种无定型激酶抑制剂的制备方法 |
WO2016157136A1 (en) | 2015-04-02 | 2016-10-06 | Mylan Laboratories Ltd | Crystalline forms of idelalisib |
CN108033961A (zh) | 2015-04-15 | 2018-05-15 | 上海方楠生物科技有限公司 | 一种艾德力布的无定型物及其制备方法 |
CN106146503A (zh) * | 2015-04-16 | 2016-11-23 | 上海医药工业研究院 | 一种Idelalisib的制备方法 |
CZ2015347A3 (cs) | 2015-05-22 | 2016-11-30 | Zentiva, K.S. | Pevné formy 5-fluor-3-fenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]chinazolin-4-onu a jejich příprava |
CN106279171A (zh) * | 2015-06-09 | 2017-01-04 | 南京安源生物医药科技有限公司 | 一种Idelalisib的制备方法 |
CN111848643A (zh) | 2015-07-02 | 2020-10-30 | 豪夫迈·罗氏有限公司 | 苯并氧氮杂*噁唑烷酮化合物及其使用方法 |
CN112062778B (zh) | 2015-07-02 | 2024-04-19 | 豪夫迈·罗氏有限公司 | 苯并氧氮杂䓬噁唑烷酮化合物及其使用方法 |
EP3322708A1 (en) * | 2015-07-13 | 2018-05-23 | Synthon BV | Method for purifying idelalisib |
WO2017032679A1 (en) | 2015-08-21 | 2017-03-02 | Morphosys Ag | Combinations and uses thereof |
CZ2015575A3 (cs) * | 2015-08-26 | 2017-03-08 | Zentiva, K.S. | Soli 5-fluoro-3-fenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4-onu a jejich příprava |
CN106565716B (zh) * | 2015-10-10 | 2021-06-15 | 上海创诺制药有限公司 | 一种Idelalisib晶型A及其制备方法 |
HU231016B1 (hu) * | 2015-11-30 | 2019-11-28 | Egis Gyógyszergyár Zrt. | Idelalisib új polimorf és szolvát formája |
WO2017175184A1 (en) * | 2016-04-07 | 2017-10-12 | Laurus Labs Limited | Process for preparation of amorphous form of idelalisib |
EP3272348A1 (en) | 2016-07-21 | 2018-01-24 | LEK Pharmaceuticals d.d. | Pharmaceutical composition comprising idelalisib |
CN106632337B (zh) * | 2016-10-18 | 2018-11-20 | 湖北生物医药产业技术研究院有限公司 | 艾代拉里斯的晶型、药物组合物、制备方法和用途 |
WO2018198131A1 (en) | 2017-04-24 | 2018-11-01 | Natco Pharma Limited | Process for the preparation of amorphous idelalisib |
CN107573345B (zh) * | 2017-09-12 | 2020-01-10 | 浙江乐普药业股份有限公司 | 一种艾代拉利司及其中间体的制备方法 |
CN109575027A (zh) * | 2017-09-29 | 2019-04-05 | 宁波爱诺医药科技有限公司 | 一种抗肿瘤药物艾德力布的一水合物及其制备方法 |
WO2019178596A1 (en) | 2018-03-16 | 2019-09-19 | Johnson Matthey Public Limited Company | Pyridine or n,n-dimethyl acetamide solvated solid state forms of solvated idelalisib, their use and preparation |
US20220040324A1 (en) | 2018-12-21 | 2022-02-10 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
GB202109006D0 (en) * | 2021-06-23 | 2021-08-04 | Anglo American Minerio De Ferro Brasil S/A | Method of and system for operating a grinding mill |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1249281B (ru) | 1963-05-18 | |||
US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
DE2027645A1 (de) | 1970-06-05 | 1971-12-09 | Byk Gulden Lomberg Chemische Fa bnk GmbH, 7750 Konstanz | Piperazinylalkyl chinazolon (4) den vate, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel |
US3897432A (en) | 1971-04-21 | 1975-07-29 | Merck & Co Inc | Substituted benzimidazole derivatives |
NL7204972A (ru) | 1971-04-21 | 1972-10-24 | ||
CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
DE2644265C2 (de) | 1976-09-30 | 1983-02-10 | Bayer Ag, 5090 Leverkusen | Chinazoline |
US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
US4183931A (en) | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
DE2812635A1 (de) | 1978-03-22 | 1979-09-27 | Bayer Ag | Heterocyclische verbindungen |
JPS55118918A (en) | 1979-03-06 | 1980-09-12 | Mitsubishi Electric Corp | Production of quinazolone ring-containing epoxy resin |
JPS55118917A (en) | 1979-03-06 | 1980-09-12 | Mitsubishi Electric Corp | Production of quinazolone ring-containing epoxy resin |
US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
JPS6017375B2 (ja) | 1979-06-20 | 1985-05-02 | 三菱電機株式会社 | ポリアミド樹脂の製造方法 |
JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
USRE35862E (en) | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
AU610083B2 (en) | 1986-08-18 | 1991-05-16 | Clinical Technologies Associates, Inc. | Delivery systems for pharmacological agents |
US6696250B1 (en) | 1986-12-03 | 2004-02-24 | Competitive Technologies, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
US5225347A (en) | 1989-09-25 | 1993-07-06 | Innovir Laboratories, Inc. | Therapeutic ribozyme compositions and expression vectors |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
FR2675803B1 (fr) | 1991-04-25 | 1996-09-06 | Genset Sa | Oligonucleotides fermes, antisens et sens et leurs applications. |
DE69209183T2 (de) | 1991-06-18 | 1996-08-08 | American Home Prod | Verwendung von Rapamycin zur Behandlung von T-Zellen Lymphom/Leukämie bei Erwachsenen |
ATE156158T1 (de) | 1992-04-14 | 1997-08-15 | Cornell Res Foundation Inc | Makromoleküle auf basis von dendritischen polymeren und verfahren zur herstellung |
US5658780A (en) | 1992-12-07 | 1997-08-19 | Ribozyme Pharmaceuticals, Inc. | Rel a targeted ribozymes |
GB9301000D0 (en) | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
US5378725A (en) | 1993-07-19 | 1995-01-03 | The Arizona Board Of Regents | Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof |
GB9404485D0 (en) | 1994-03-09 | 1994-04-20 | Cancer Res Campaign Tech | Benzamide analogues |
FI951367A (fi) | 1994-03-28 | 1995-09-29 | Japan Energy Corp | Puriinijohdannaiset ja tulehdustautien tukahduttajat (suppressantit) |
US5480906A (en) | 1994-07-01 | 1996-01-02 | Eli Lilly And Company | Stereochemical Wortmannin derivatives |
EP0771204A4 (en) | 1994-08-12 | 1999-10-20 | Pro Neuron Inc | METHODS OF TREATING SEPSIA OR INFLAMMATORY DISEASES WITH OXYPURINE-BASED NUCLEOSIDES |
US5561138A (en) | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
US6043062A (en) | 1995-02-17 | 2000-03-28 | The Regents Of The University Of California | Constitutively active phosphatidylinositol 3-kinase and uses thereof |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
US5948664A (en) | 1996-02-29 | 1999-09-07 | The Regents Of The University Of California | PI 3-kinase polypeptides |
EP0904107B1 (en) | 1996-03-18 | 2004-10-20 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
KR100375155B1 (ko) | 1996-05-15 | 2003-08-19 | 화이자 인코포레이티드 | 신규한2,3-이치환된-4(3에이치)-퀴나졸리논 |
GB9611460D0 (en) | 1996-06-01 | 1996-08-07 | Ludwig Inst Cancer Res | Novel lipid kinase |
WO1997041097A2 (en) | 1996-12-31 | 1997-11-06 | Dr. Reddy's Research Foundation | Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
US5858753A (en) | 1996-11-25 | 1999-01-12 | Icos Corporation | Lipid kinase |
TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
GB9702701D0 (en) | 1997-02-01 | 1997-04-02 | Univ Newcastle Ventures Ltd | Quinazolinone compounds |
KR100358636B1 (ko) | 1997-02-28 | 2002-10-31 | 화이자 프로덕츠 인코포레이티드 | 3-아릴-4(3에이치)-퀴나졸리논의 회전장애이성질체 및 에이엠피에이-수용체 길항물질로서 그의 용도 |
ATE303997T1 (de) | 1997-06-09 | 2005-09-15 | Pfizer Prod Inc | Chinazolin-4-on ampa antagonisten |
AU8280798A (en) | 1997-07-03 | 1999-01-25 | Thomas Jefferson University | An improved method for design and selection of efficacious antisense oligonucleotides |
IL125950A0 (en) | 1997-09-05 | 1999-04-11 | Pfizer Prod Inc | Methods of administering ampa receptor antagonists to treat dyskinesias associated with dopamine agonist therapy |
AU2108299A (en) | 1998-01-08 | 1999-07-26 | University Of Virginia Patent Foundation | A2A adenosine receptor agonists |
AU1120599A (en) | 1998-04-23 | 1999-03-08 | Dr. Reddy's Research Foundation | New heterocyclic compounds and their use in medicine, process for their reparation and pharmaceutical compositions containing them |
US6048970A (en) | 1998-05-22 | 2000-04-11 | Incyte Pharmaceuticals, Inc. | Prostate growth-associated membrane proteins |
US6100090A (en) | 1999-06-25 | 2000-08-08 | Isis Pharmaceuticals Inc. | Antisense inhibition of PI3K p85 expression |
US6046049A (en) | 1999-07-19 | 2000-04-04 | Isis Pharmaceuticals Inc. | Antisense modulation of PI3 kinase p110 delta expression |
EP1686120A3 (en) | 1999-10-27 | 2007-05-30 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
KR20020071931A (ko) | 2000-01-07 | 2002-09-13 | 트렌스폼 파마수티컬스 인코퍼레이티드 | 다양한 고체-형태들의 고도의 자료 처리 편성, 확인 및분석 |
DK1257537T3 (da) | 2000-01-24 | 2007-10-01 | Astrazeneca Ab | Terapeutiske morpholino-substituerede forbindelser |
WO2001057034A1 (en) | 2000-02-07 | 2001-08-09 | Bristol-Myers Squibb Co. | 3-aminopyrazole inhibitors of cyclin dependent kinases |
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
SI2223922T1 (sl) | 2000-04-25 | 2016-04-29 | Icos Corporation | Inhibitorji humane fosfatidil-inositol 3-kinazne delta izoforme |
US7026330B2 (en) | 2002-05-30 | 2006-04-11 | The Children's Hospital Of Philadelphia | Methods for treatment of acute lymphocytic leukemia |
BR0312752A (pt) | 2002-07-10 | 2005-04-26 | Applied Research Systems | Derivados de benzeno fundido de azolidinona-vinil |
US20040092561A1 (en) | 2002-11-07 | 2004-05-13 | Thomas Ruckle | Azolidinone-vinyl fused -benzene derivatives |
GB0217777D0 (en) | 2002-07-31 | 2002-09-11 | Novartis Ag | Organic compounds |
US20040023390A1 (en) | 2002-08-05 | 2004-02-05 | Davidson Beverly L. | SiRNA-mediated gene silencing with viral vectors |
CA2400254A1 (en) | 2002-09-19 | 2004-03-19 | University Health Network | Compositions and methods for treating heart disease |
SI1549652T1 (sl) | 2002-09-30 | 2009-04-30 | Bayer Healthcare Ag | Kondenzirani azolpirimidinski derivati |
BR0316386A (pt) | 2002-12-06 | 2005-09-27 | Warner Lambert Co | Benzoxazin-3-onas e seus derivados como inibidores de p13k |
EP1581529A1 (en) | 2002-12-20 | 2005-10-05 | Warner-Lambert Company | Benzoxazines and derivatives thereof as inhibitors of pi3ks |
NZ542475A (en) | 2003-04-03 | 2009-04-30 | Semafore Pharmaceuticals Inc | PI-3 kinase inhibitor prodrugs |
BRPI0410913A (pt) | 2003-06-05 | 2006-06-27 | Warner Lambert Co | benzotiofenos substituìdos com cicloalquil e heterocicloalquil como agentes terapêuticos |
EP1644364A1 (en) | 2003-06-05 | 2006-04-12 | Warner-Lambert Company LLC | Tetrazol benzofurancarboxamides with pi3k activity as therapeutic agents |
WO2004108708A1 (en) | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | 3-substituted indoles and derivatives thereof as therapeutic agents |
US20040259926A1 (en) | 2003-06-05 | 2004-12-23 | Bruendl Michelle M. | 3-Aryloxy and 3-heteroaryloxy substituted benzo[b]thiophenes as therapeutic agents |
MXPA05012953A (es) | 2003-06-05 | 2006-02-13 | Warner Lambert Co | Benzo[b]tiofenos 3-arilsulfanil y 3-heteroarilsulfanil sustituidos como agentes terapeuticos. |
DE602004007268D1 (de) | 2003-06-05 | 2007-08-09 | Warner Lambert Co | CYCLOALKYLSULFANYL-SUBSTITUIERTE BENZOiBöTHIOPHENE ALS THERAPEUTISCHE MITTEL |
US20050054614A1 (en) | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
WO2005016348A1 (en) | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
WO2005067901A2 (en) | 2004-01-08 | 2005-07-28 | Michigan State University | Methods for treating and preventing hypertension and hypertension-related disorders |
CA2566436C (en) | 2004-05-13 | 2011-05-10 | Vanderbilt University | Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis |
HUE030950T2 (en) | 2004-05-13 | 2017-06-28 | Icos Corp | Quinazolinones as 3-kinase delta inhibitors of human phosphatidylinositol |
CA2567883A1 (en) | 2004-05-25 | 2005-12-15 | Icos Corporation | Methods for treating and/or preventing aberrant proliferation of hematopoietic cells |
CN101123968A (zh) | 2004-06-04 | 2008-02-13 | 艾科斯有限公司 | 肥大细胞病的治疗方法 |
WO2006089106A2 (en) | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
US20090131512A1 (en) | 2007-10-31 | 2009-05-21 | Dynavax Technologies Corp. | Inhibition of type I in IFN production |
CA3092449A1 (en) * | 2008-11-13 | 2010-05-20 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
WO2010065923A2 (en) | 2008-12-04 | 2010-06-10 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Phosphatidylinositol-3-kinase p110 delta-targeted drugs in the treatment of cns disorders |
JP5719779B2 (ja) | 2008-12-24 | 2015-05-20 | プラナ バイオテクノロジー リミティッド | キナゾリノン化合物 |
EP2411391A1 (en) | 2009-03-24 | 2012-02-01 | Gilead Calistoga LLC | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
ES2548253T3 (es) | 2009-04-20 | 2015-10-15 | Gilead Calistoga Llc | Métodos para el tratamiento de tumores sólidos |
JP2013504604A (ja) | 2009-09-18 | 2013-02-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ウイルスポリメラーゼ阻害剤としてのキナゾリノン誘導体 |
CA2802484A1 (en) * | 2010-06-11 | 2011-12-15 | Gilead Calistoga Llc | Methods of treating hematological disorders with quinazolinone compounds in selected patients |
WO2013082540A1 (en) * | 2011-12-02 | 2013-06-06 | Gilead Calistoga Llc | Compositions and methods of treating a proliferative disease with a quinazolinone derivative |
PE20141792A1 (es) | 2012-03-05 | 2014-12-07 | Gilead Calistoga Llc | Formas polimorficas de (s)-2-(1-(9h-purin-6-ilamino)propil)-5-fluor-3-fenilquinazolin-4(3h)-ona |
EP3083623A1 (en) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
-
2013
- 2013-03-05 PE PE2014001310A patent/PE20141792A1/es not_active Application Discontinuation
- 2013-03-05 EA EA201491473A patent/EA025407B1/ru unknown
- 2013-03-05 CA CA2864305A patent/CA2864305C/en active Active
- 2013-03-05 PT PT137572301T patent/PT2834241T/pt unknown
- 2013-03-05 KR KR1020147027588A patent/KR20140133590A/ko not_active Application Discontinuation
- 2013-03-05 EA EA201691327A patent/EA201691327A1/ru unknown
- 2013-03-05 MX MX2014010656A patent/MX2014010656A/es unknown
- 2013-03-05 EP EP13757230.1A patent/EP2834241B1/en active Active
- 2013-03-05 EA EA201690461A patent/EA201690461A1/ru unknown
- 2013-03-05 UY UY0001034656A patent/UY34656A/es not_active Application Discontinuation
- 2013-03-05 TW TW102107672A patent/TW201350486A/zh unknown
- 2013-03-05 AU AU2013203620A patent/AU2013203620B2/en active Active
- 2013-03-05 NZ NZ629684A patent/NZ629684A/en unknown
- 2013-03-05 BR BR112014021935A patent/BR112014021935A2/pt not_active IP Right Cessation
- 2013-03-05 JP JP2014561048A patent/JP2015509537A/ja not_active Withdrawn
- 2013-03-05 ES ES13757230T patent/ES2848273T3/es active Active
- 2013-03-05 WO PCT/US2013/029157 patent/WO2013134288A1/en active Application Filing
- 2013-03-05 AP AP2014007875A patent/AP2014007875A0/xx unknown
- 2013-03-05 PL PL13757230T patent/PL2834241T3/pl unknown
- 2013-03-05 SG SG11201405446PA patent/SG11201405446PA/en unknown
- 2013-03-05 AR ARP130100721A patent/AR090253A1/es unknown
- 2013-03-05 SI SI201331843T patent/SI2834241T1/sl unknown
- 2013-03-05 US US13/786,222 patent/US8865730B2/en active Active
- 2013-03-05 CN CN201380011784.1A patent/CN104334560A/zh active Pending
- 2013-03-05 CN CN201610547374.4A patent/CN106146506A/zh active Pending
- 2013-03-05 IN IN7105DEN2014 patent/IN2014DN07105A/en unknown
- 2013-03-05 MD MDA20140100A patent/MD20140100A2/ru not_active Application Discontinuation
-
2014
- 2014-08-11 ZA ZA2014/05870A patent/ZA201405870B/en unknown
- 2014-08-26 PH PH12014501920A patent/PH12014501920A1/en unknown
- 2014-09-05 CL CL2014002358A patent/CL2014002358A1/es unknown
- 2014-09-12 CO CO14202424A patent/CO7071131A2/es unknown
- 2014-09-22 US US14/493,261 patent/US9469643B2/en active Active
- 2014-09-26 EC ECIEPI201420478A patent/ECSP14020478A/es unknown
- 2014-09-26 MA MA37379A patent/MA37379A1/fr unknown
- 2014-10-01 CR CR20140460A patent/CR20140460A/es unknown
-
2015
- 2015-07-21 HK HK15106935.8A patent/HK1206345A1/xx unknown
-
2016
- 2016-03-04 JP JP2016042418A patent/JP2016104823A/ja active Pending
- 2016-09-06 US US15/257,053 patent/US10730879B2/en active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201691327A1 (ru) | Полиморфные формы (s)-2-(1-(9h-пурин-6-иламино)пропил)-5-фтор-3-фенилхиназолин-4(3h)-она | |
CR20140229A (es) | Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona | |
CR20140529A (es) | Anticuerpos e inmunoconjugados contra ly6e y métodos de uso | |
EA201591420A1 (ru) | Гетероарильные соединения и их применение | |
EA201171367A1 (ru) | Винилиндазолильные соединения | |
CO7061071A2 (es) | Procesos para la preparación de (s)-1-(3-etoxi-4-metoxifenil)-2-metansulfoniletilamina | |
UY34824A (es) | Nucleósidos de espirooxetano de uracilo | |
EA201691353A1 (ru) | 5-фтор-4-имино-3-(алкил/замещенный алкил)-1-(арилсульфонил)-3,4-дигидропиримидин-2(1h)-он и способы их получения | |
IN2014DN09346A (ru) | ||
EA201491811A1 (ru) | АНТИ-LgR5 АНТИТЕЛА И ИММУНОКОНЪЮГАТЫ | |
PH12015501059A1 (en) | Anti-hemagglutinin antibodies and methods of use | |
EA201591728A1 (ru) | Гетероциклические соединения и способы их применения | |
EA201490778A1 (ru) | АНТИТЕЛА ПРОТИВ HtrA1 И СПОСОБЫ ПРИМЕНЕНИЯ | |
JO3755B1 (ar) | تركيبات تستوستيرون | |
EA201290642A1 (ru) | Соединения и способы | |
EP3365061A4 (en) | AMINOISOXAZOLIN COMPOUNDS AS AGONISTS OF ALPHA7 NICOTINE ACETYLCHOLIN RECEPTORS | |
PH12016500683B1 (en) | Synthetic route to 2`-deoxy-2`,2`-difluorotetrahydrouridines | |
IN2014DN09450A (ru) | ||
EP3307269A4 (en) | AMINOBENZIS OXAZOL COMPOUNDS AS AGONISTS OF A7 NICOTINE ACETYLCHOLIN RECEPTORS | |
EA201391199A1 (ru) | Композиции из hyr1-производных и способы лечения ими | |
SG10201908881PA (en) | Fused bicyclic compounds for the treatment of disease | |
ECSP13012679A (es) | Composiciones farmacéuticas que comprenden alisporivir | |
BR112015005627A2 (pt) | composto, composição farmacêutica, uso de composto, método de tratamento e invenção. | |
IN2015DN03132A (ru) | ||
EA201690263A1 (ru) | Улучшенные способы получения перампанеля |